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Pulmonary Wedge Pressure

Pulmonary Wedge Pressure: A measuement of the pressure within the pulmonary capillary bed, reflective of left atrial pressure.
This pressure is commonly used to assess left ventricular function and estimate pulmonary vascular resistance.
Accurate measurement of pulmonary wedge pressure is crucial for diagnosing and managing cardiovascular and pulmonary disorders.
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Most cited protocols related to «Pulmonary Wedge Pressure»

A whole-body impedance cardiography device (CircMonR, JR Medical Ltd, Tallinn, Estonia), which records the changes in body electrical impedance during cardiac cycles, was used to determine beat-to-beat HR, stroke index (stroke volume in proportion to body surface area, ml/m2), cardiac index (cardiac output/body surface area, l/min/m2), and PWV (m/s)
[29 (link)-31 (link)]. Left cardiac work index (kg*m/min/m2) was calculated by formula 0.0143*(MAP–PAOP)*cardiac index, which has been derived from the equation published by Gorlin et al.
[32 (link)]. MAP is mean radial arterial pressure measured by tonometric sensor, PAOP is pulmonary artery occlusion pressure which is assumed to be normal (default 6 mmHg), and 0.0143 is the factor for the conversion of pressure from mmHg to cmH2O, volume to density of blood (kg/L), and centimetre to metre. Systemic vascular resistance index (systemic vascular resistance/body surface area, dyn*s/cm5/m2) was calculated from the signal of the tonometric BP sensor and cardiac index measured by CircMonR.
To calculate the PWV, the CircMon software measures the time difference between the onset of the decrease in impedance in the whole-body impedance signal and the popliteal artery signal. From the time difference and the distance between the electrodes, PWV can be determined. As the whole-body impedance cardiography slightly overestimates PWV when compared with Doppler ultrasound method, a validated equation was utilized to calculate values that correspond to the ultrasound method (PWV = (PWVimpedance*0.696) + 0.864)
[30 (link)]. PWV was determined only in the supine position because of less accurate timing of left ventricular ejection during head-up tilt
[30 (link)]. A detailed description of the method and electrode configuration has been previously reported
[31 (link)]. PWV was also recorded after the head-up tilt in all subjects, and the average difference between the mean PWV before and after the head-up tilt was 0.024 ± 0.388 m/s (mean ± standard deviation), showing the good repeatability of the method (repeatability index R 98%, Bland-Altman repeatability index 0.8)
[33 ]. The cardiac output values measured with CircMonR are in good agreement with the values measured by the thermodilution method
[31 (link)], and the repeatability and reproducibility of the measurements (including PWV recordings) have been shown to be good
[34 (link),35 (link)].
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Publication 2013
Blood Volume Body Surface Area Cardiac Output Cardiography, Impedance Cerebrovascular Accident Head Heart Human Body Left Ventricles Medical Devices Popliteal Artery Pressure Pulmonary Wedge Pressure Stroke Volume Thermodilution Tonometry Total Peripheral Resistance Ultrasonography Ultrasounds, Doppler
This was a retrospective analysis of all consecutive patients undergoing invasive exercise testing for the evaluation of unexplained dyspnea between 2006 and 2016 at the Mayo Clinic in Rochester, MN. The data, analytic methods, and study materials will not be made available to other researchers for purposes of reproducing the results or replicating the procedure. Exclusion criteria included ejection fraction<50% (current or prior), significant valvular heart disease (>mild stenosis, >moderate regurgitation), pulmonary arterial hypertension, constrictive pericarditis, primary cardiomyopathies, or heart transplant. All patients referred for hemodynamic catheterization were evaluated by Mayo staff cardiologists and concluded to have dyspnea not explainable by pulmonary disease based upon evaluations performed at the discretion of the referring physicians.
HFpEF patients were identified by elevated pulmonary capillary wedge pressure at rest (≥15 mmHg) or during exercise (≥25 mmHg).7 (link), 8 (link) Non-cardiac dyspnea was defined as patients with no evidence of a cardiac etiology for dyspnea after exhaustive clinical evaluation, including normal rest and exercise hemodynamics. Data included in the study were authorized by the patient for use in research with informed consent, and the study was approved by the Mayo Clinic Institutional Review Board.
Publication 2018
Cardiologists Cardiomyopathies, Primary Catheterization Dyspnea Ethics Committees, Research Heart Heart Transplantation Hemodynamics Idiopathic Pulmonary Arterial Hypertension Lung Diseases Patients Pericarditis, Constrictive Pulmonary Wedge Pressure Stenosis Valve Disease, Heart
Patients were studied on their chronic medications in the fasted state after minimal sedation as previously described.5 (link), 6 (link), 18 (link)–21 (link) Right heart catheterization was performed through a 9 Fr sheath via the right internal jugular vein. Pressures in the right atrium (RA), right ventricular (RV), PA, and PCWP were measured at end expiration (mean of ≥3 beats) using 2 Fr high fidelity micromanometer-tipped catheters (Millar Instruments, Houston, TX) advanced through the lumen of a 7 Fr fluid-filled catheter (Balloon wedge, Arrow). Mean micromanometer pressures were calibrated to mean fluid-filled pressures at the beginning and throughout each case to avoid baseline drift. Transducers were zeroed at mid-axilla, measured by laser calipers in each patient.
Pressure tracings from the entire study were digitized (250 Hz) and stored for offline analysis by one investigator experienced in exercise hemodynamic assessment (BAB). Mean RA and PCWP were taken at mid A wave. PCWP position was verified by typical waveforms, appearance on fluoroscopy, and direct oximetry (PCWP blood saturation≥94%). Arterial blood pressure (BP) was measured through a 4–6 Fr radial arterial cannula throughout the tests. Arterial-venous O2 content difference (AVO2diff) was measured directly as the difference between systemic arterial and PA O2 content (=saturation*hemoglobin*1.34). Oxygen consumption (VO2) was measured from expired gas analysis (MedGraphics, St. Paul, MN) to calculate cardiac output (CO), by the direct Fick method (CO= VO2÷AVO2diff) at baseline, 20W and peak exercise. Stroke volume (SV) was determined from the quotient of CO and heart rate (HR).
Publication 2016
Arteries Atrium, Right Axilla BLOOD Cannula Cardiac Output Catheterizations, Cardiac Catheters Fluoroscopy FR liquid Hemodynamics Hemoglobin Jugular Vein Oximetry Oxygen Consumption Patients Pressure Pulmonary Wedge Pressure Rate, Heart Sedatives Stroke Volume Transducers Veins Ventricles, Right
RPA is calculated as (mean pulmonary artery (PA) pressure − PCWP)/cardiac output, expressed as mmHg•seconds•mL−1, CPA is estimated by stroke volume/PA pulse pressure, (mL•mmHg−1), as validated by several studies.1 , 4 (link), 9 RSA is (mean systemic arterial pressure − mean right atrial pressure)/cardiac output, and CSA = stroke volume/systemic arterial pulse pressure. The RC time (product of resistance and compliance) is therefore expressed as units of seconds.
Publication 2011
Cardiac Output Heart Atrium Lung Neoplasm Metastasis Pulmonary Artery Pulmonary Wedge Pressure Pulse Pressure Stroke Volume

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Publication 2010
Allografts Autopsy Bronchoscopy Diuresis Echocardiography, Transesophageal Extracorporeal Membrane Oxygenation Fever Grafts Leukocytosis Lung Lung Transplantation Nasal Cannula Operative Surgical Procedures Oxygen Patients Pneumonia Pulmonary Edema Pulmonary Wedge Pressure Radiography, Thoracic Secretions, Bodily Transplantation Veno-Occlusive Diseases, Pulmonary X-Rays, Diagnostic

Most recents protocols related to «Pulmonary Wedge Pressure»

We develop and validate our model using datasets from two different hospitals. Our first dataset consists of 7121 records from 3767 unique patients who underwent cardiac catheterization at Massachusetts General Hospital (Hospital 1). All patients had a diagnosis of HF (according to ICD 9/10 codes in their medical record) within the 1 year prior to their catheterization date.
This dataset is split into an 80% development set, used to train predictive models, and a 20% internal holdout test set, used for model evaluation. Datasets are constructed such that no data from a single patient appears in different data splits; i.e., all data splits are done on a per-patient basis. We further split the development set on a per-patient level using an 80–20 split into training and “dev” sets. The training set is used to train the model and the dev set is used to determine when training is completed.
Our second dataset consists of 2725 records from 1249 unique patients who underwent cardiac catheterization at the Brigham and Women’s Hospital (Hospital 2). As with data from MGH, these patients all had a diagnosis of heart failure (according to ICD 9/10 codes in their medical record) within the 1 year prior to their catheterization date. We used this entire dataset as an external validation set for model evaluation.
Each record in the datasets consists of: the mean Pulmonary Capillary Wedge Pressure (as measured by cardiac catheterization), a 10-s, 12-lead ECG recorded by the same system (GE Healthcare MUSE) on the same day as the catheterization procedure, and basic demographic information (age/sex). Dataset details are summarized in Table 2.

Model performance (AUROC) on test data. HFNet significantly outperforms the baseline logistic regression (LR) model.

ModelAUROC
Internal test setExternal holdout set
LR0.71 + − 0.010.67 + − 0.01
HFNet0.82 + − 0.01 *0.81 + − 0.01 *

Significant values are in bold.

Key: *: p value < 1e − 10.

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Publication 2023
Catheterization Catheterizations, Cardiac Diagnosis Electrocardiography, 12-Lead Heart Failure Muse Patients Pulmonary Wedge Pressure Woman
Our study cohort included eight children aged 6–10 years who were hospitalised in the Affiliated Hospital of Southwest Medical University, China on June 2022. Four of the children were diagnosed by echocardiography as VSD without PAH (control group, n = 4) and the other four were diagnosed by echocardiography and right cardiac catheterisation as moderate or severe PAH secondary to VSD (PAH group, n = 4). A diagnosis of PAH by right-heart catheterisation was defined as a mean pulmonary arterial pressure >25 mmHg at rest, a pulmonary capillary wedge pressure <15 mmHg and a pulmonary vascular resistance of >3 Wood units. We excluded patients receiving targeted therapy for PAH and those diagnosed with other intracardiac malformations, such as patent ductus arteriosus, large atrial septal defect, or other related conditions, like congenital lung disease, bronchial asthma and congenital pulmonary vascular malformation.
During the cardiac operation, atrial appendage specimens were collected from all patients before cardiopulmonary bypass and blood samples were collected via the jugular vein before performing the midline sternotomy. The plasma and right atrial appendage specimens were then aliquoted and stored at −80°C until RNA extraction.
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Publication 2023
Asthma Atrial Septal Defects Atrium, Right Auricular Appendage BLOOD Blood Vessel Cardiopulmonary Bypass Catheterizations, Cardiac Child Congenital Abnormality Congenital Disorders Echocardiography Jugular Vein Lung Lung Diseases Median Sternotomy Patent Ductus Arteriosus Patients Plasma Pulmonary Wedge Pressure Surgical Procedure, Cardiac Therapeutics Vascular Malformations
This study uses clinically de-identified RHC data from nine patients with confirmed PH: five with PAH and four with CTEPH. Three CTEPH and three PAH datasets are from Duke University, and one CTEPH and two PAH datasets are from the Scottish Pulmonary Vascular Unit. Static data include height (cm), weight (kg), sex (male (m) or female (f)), age (years), heart rate (bpm), and systolic, diastolic and mean systemic blood pressure (mmHg) measured by a blood pressure cuff. The patients underwent RHC, where a catheter is advanced from the right atrium, to the right ventricle, and to the main pulmonary artery. Dynamic pressure waveforms are recorded in each compartment. The pulmonary arterial wedge pressure (PAWP, mmHg), an estimate of left atrial pressure, is also recorded. CO (l min−1) is measured during the RHC by thermodilution. All pressure readings are obtained over 7–8 heartbeats. Demographics are provided in table 1.

Patient demographics; group 1: pulmonary arterial hypertension (PAH); group 4: chronic thromboembolic pulmonary hypertension (CTEPH).

patientPHage (years)sexheight (cm)weight (kg)CO (l min−1)
1164male164.072.64.0
2458male161.070.04.3
3127female151.081.12.6
4471female167.693.36.1
5451male179.1117.23.6
61male178.0108.06.4
71male179.074.06.3
81female183.082.05.6
94female154.967.44.0

CO, cardiac output; PH, pulmonary hypertension. For patients 6–9, age was not included in the medical records.

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Publication 2023
Atrium, Right Blood Pressure Blood Vessel Cardiac Output Catheters Diastole Idiopathic Pulmonary Arterial Hypertension Lung Males Patients Pressure Pulmonary Artery Pulmonary Hypertension Pulmonary Wedge Pressure Pulse Rate Rate, Heart Systole Thermodilution Ventricles, Right Woman
We retrospectively collected and studied adult treatment-naive patients with IPAH or PAH-CHD who were admitted to the Second Xiangya Hospital from November 2011 to June 2020. All recruited patients with IPAH or PAH-CHD met the following diagnostic criteria: mPAP ≥ 25 mmHg, PVR >3 WU and PAWP ≤15 mmHg during resting RHC (Galiè et al., 2016 (link)). Except for IPAH and PAH-CHD, patients with other types of PAH or PH belonging to groups 2–5 were also excluded. All recruited patients were prescribed PAH-specific therapy based on multiparameter risk stratification of contemporaneous guidelines, and cardiac function and haemodynamics parameters were assessed by means of echocardiography. In the 2022 ESC/ERS guideline for pulmonary hypertension, it was recommended to use a three-strata risk-assessment model to classify patients as low, intermediate, or high risk at initial assessment, and to use a four-strata model to classify patients as low, intermediate-low, intermediate-high, or high risk during follow-up (Humbert et al., 2022 (link)). Risk stratification can help guides treatment decisions in patients with PAH. Briefly, initial monotherapy with PDE-5i or ERAs was recommended for patients with PAH and cardiopulmonary comorbidities. In patients with PAH without cardiopulmonary complications, initial dual combination therapy of ERAs and PDE-5i was recommended for patients with low- or intermediate-risk of death, and triple combination therapy of ERAs, PDE-5i, and prostacyclin analogue is recommended for patients with high-risk of death. At follow-up, patients who reach low-risk status continued the initial regimen, and patients with medium-low risk were suggested to add prostacyclin receptor agonist or replace PDE-5i to sGC. In addition, intravenous or subcutaneous prostacyclin or evaluation for lung transplantation was recommended for patients who had insufficient treatment response and were still at intermediate-high or even high risk. PAH-specific medications in this study included PDE-5i (e.g., sildenafifil and tadalafifil), ERAs (e.g., bosentan, ambrisentan, and macitentan), prostacyclin analogues (e.g., intravenous or subcutaneous treprostinil, intravenous epoprostenol, and inhaled iloprost), prostacyclin receptor agonists (slexipag), and sGCs (e.g., riociguat). The study was approved by the Ethics Committee of the Second Xiangya Hospital.
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Publication 2023
Adult agonists ambrisentan Bosentan Combined Modality Therapy Diagnosis Echocardiography Epoprostenol estrogen receptor alpha, human Ethics Committees, Clinical Health Risk Assessment Heart Hemodynamics Iloprost Lung Transplantation macitentan Patients Pulmonary Hypertension Pulmonary Wedge Pressure Receptors, Epoprostenol riociguat Treatment Protocols treprostinil
Right-heart catheterization was performed with the Seldinger technique. Under X-ray fluoroscopic guidance, an 8F Swan-Ganz catheter (Baxter Healthcare, Irvine, CA, USA) was induced through the right internal jugular vein. After 10 min rest, the hemodynamic parameters including sPAP, dPAP, pulmonary capillary wedge pressure (PCWP), and cardiac output (CO) were obtained at end-expiration. The mPAP and pulmonary vascular resistance (PVR) were calculated.
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Publication 2023
Cardiac Output Catheterizations, Cardiac Catheters Fluoroscopy Hemodynamics Jugular Vein Pulmonary Wedge Pressure X-Rays, Diagnostic

Top products related to «Pulmonary Wedge Pressure»

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CathCorLX is a lab equipment product from Siemens. It is designed for performing cardiac catheterization procedures. The device provides real-time imaging to support medical professionals during these procedures, but a detailed description of its core function is not available while maintaining an unbiased and factual approach.
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The Swan Ganz catheter is a medical device used to measure hemodynamic parameters, such as cardiac output, pulmonary artery pressure, and central venous pressure. It is a long, flexible catheter that is inserted into a vein and threaded through the right side of the heart and into the pulmonary artery.
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The Swan-Ganz catheter is a medical device used to measure various hemodynamic parameters, such as cardiac output, pulmonary artery pressure, and central venous pressure. It is a long, thin, flexible tube that is inserted into a vein and advanced into the pulmonary artery, allowing for the monitoring of cardiovascular function.
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The 7F Swan-Ganz catheter is a medical device used to measure central venous pressure, pulmonary artery pressure, and cardiac output. It is a thin, flexible tube that is inserted into a vein and advanced into the pulmonary artery to obtain these measurements.
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The Vigilance II is a continuous cardiac output and mixed venous oxygen saturation monitoring system. It provides healthcare professionals with real-time data on a patient's hemodynamic status.
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The 7F Swan-Ganz catheter is a medical device used for hemodynamic monitoring. It is designed to measure various cardiovascular parameters, such as cardiac output, pulmonary artery pressure, and central venous pressure, to assist healthcare professionals in evaluating a patient's cardiovascular function.
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The Swan-Ganz is a medical device used for measuring various hemodynamic parameters, such as cardiac output, pulmonary artery pressure, and central venous pressure. It is a flexible, balloon-tipped catheter that is inserted into a vein and threaded through the heart to the pulmonary artery. The device allows healthcare professionals to monitor and assess the function of the heart and circulatory system.
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The 7.5-Fr Swan-Ganz catheter is a medical device used for hemodynamic monitoring. It is a flexible, balloon-tipped catheter designed to be inserted into a vein and passed through the heart to measure various cardiovascular parameters, such as blood pressure and cardiac output.
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More about "Pulmonary Wedge Pressure"

Pulmonary Wedge Pressure (PWP) is a crucial measurement in evaluating cardiovascular and pulmonary health.
It reflects the pressure within the pulmonary capillary bed, which is closely related to the pressure in the left atrium.
Accurate PWP measurement is essential for diagnosing and managing various disorders, such as heart failure, pulmonary hypertension, and other cardiovascular conditions.
The Swan-Ganz catheter, also known as the pulmonary artery catheter or CathCorLX, is a common device used to measure PWP.
This flexible, multi-lumen catheter is inserted into a vein, typically in the neck or groin, and then threaded through the right side of the heart into the pulmonary artery.
The wedge pressure, which corresponds to the pressure in the pulmonary capillaries, can be measured using the catheter's distal port.
The Vigilance II system is a device that can be used in conjunction with the Swan-Ganz catheter to continuously monitor PWP and other hemodynamic parameters, such as cardiac output and mixed venous oxygen saturation.
This real-time data can provide valuable insights into a patient's cardiovascular function and help guide clinical decision-making.
Researchers and clinicians can leverage the power of PubCompare.ai, the leading AI-driven platform, to enhance the reproducibility and accuracy of their Pulmonary Wedge Pressure research.
The platform allows users to easily locate relevant protocols from literature, preprints, and patents, and then utilize AI-driven comparisons to identify the best methods and products for their specific studies.
This can help optimize the research process and lead to more reliable and impactful findings.