42 Dutch patients were clinically assessed using a standard psychiatric interview by five psychiatrists experienced in obsessive-compulsive spectrum disorders. The general medical history as well as the psychiatric history was collected for all patients. Personality pathology was evaluated using the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) [6] . The following questionnaires were completed:
The Hamilton Depression Rating Scale (HAM-D) [7] (
link), a 17-item scale determining a patient’s level of depression.
The 14-item Hamilton Anxiety Rating Scale (HAM-A) [8] (
link), which measures the severity of anxiety symptoms.
The Symptom Checklist (SCL-90) [9] (
link), which is a widely used screening instrument for mental and physical dysfunctioning. The 90 items comprise eight subscales: Agoraphobia, Anxiety, Depression, Somatic complaints, Insufficiency in thinking and acting, Suspicion and interpersonal sensitivity, Hostility and Sleep problems. The total score is seen as a general index for psychoneuroticism.
To measure the severity of the misophonia symptoms, we developed an adapted version of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) [10] (
link), [11] (
link), which we have named the Amsterdam Misophonia Scale (A-MISO-S). Similar adaptations of the Y-BOCS have appeared to be reliable and valid measures of symptom severity in other obsessive-compulsive and impulse control disorders, such as pathological gambling (PG-YBOCS) [12] and body dysmorphic disorder (BDD-YBOCS) [13] .
On a 6-item scale (range 0–24) patients were asked about the (1) time they spent on misophonia; (2) interference with social functioning; (3) level of anger; (4) resistance against the impulse; (5) control they had over their thoughts and anger; and (6) time they spent avoiding misophonic situations. Scores from 0–4 are considered subclinical misophonic symptoms, 5–9 mild, 10–14 moderate, 15–19 severe, 20–24 extreme.
To rule out any potential hearing problems we randomly selected five patients to perform a standard hearing test, including pure tone, speech audiometry and loudness discomfort levels, which are commonly performed to objectify hearing loss or distortion [14] , [15] . One patient’s test showed unexplained conductive hearing loss. In the other four patients no significant audiological distortion was found and further testing was therefore omitted.
The medical ethics testing committee of the Academic Medical Center did not require approval because this study was anecdotal and observational. All patients gave written informed consent for publication.
Schröder A., Vulink N, & Denys D. (2013). Misophonia: Diagnostic Criteria for a New Psychiatric Disorder. PLoS ONE, 8(1), e54706.