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Cerebrovascular Circulation

Cerebrovascular Circulation refers to the blood flow and vascular dynamics within the brain and surrounding structures.
This encompasses the complex network of arteries, veins, and capillaries that supply oxygenated blood and remove deoxygenated blood from the cerebral tissue.
Proper cerebrovascular circulation is critical for neuronal function and overall brain health.
Studying this physiological process can provide valuable insights into the pathogenesis and treatment of conditions like stroke, vascular dementia, and other neurological disorders.
Researcheers can leverage innovative AI-driven tools like PubCompare.ai to optimize their cerebrovascular circulation studies, easily locating relevant protocols and leveraging advanced comparisons to identify the best approaches.
This can enhance reproducibility, accuracy, and the overall impact of this important area of biomedical research.

Most cited protocols related to «Cerebrovascular Circulation»

1
Quantifying Motion Correction Performance

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Publication 2013
Cardiac Arrest Cerebrovascular Circulation Hemodynamics Neoplasm Metastasis physiology
2
Multiparametric Evaluation of Cerebral Hemodynamics
MR experiments (3 Tesla, Siemens Medical Solutions, Erlangen, Germany) were performed on a total of 39 healthy subjects (age 31±7 years, range 19–48 years, 23 males and 16 females). The protocol was approved by Institutional Review Board. Informed written consent was obtained for each participant. The body coil was used for RF transmission and a head coil was used for receiving. Foam paddings were used to stabilize the head to minimize motion. The subjects were instructed not to fall asleep during the experiments (verified after the session), as the cerebral blood flow and venous oxygenation may change during sleep. Four effective TEs were used: 0ms, 40ms, 80ms and 160ms, corresponding to 0, 4, 8 and 16 refocusing pulses in the T2-preparation (τCPMG=10ms). Other Imaging parameters: FOV=230mm, matrix=64×64, single-shot EPI, slice thickness=5mm, TR=8000ms, TE=19ms, TI=1200ms, repetition=4, thickness of labeling slab = 50 mm, gap between labeling slab and imaging slice = 25 mm, scan duration 4 minutes and 16 seconds.
In a sub-group of healthy subjects (n=6), the intra-session reproducibility was evaluated by performing five TRUST MRI scans at approximately 10 minute intervals. The same slice locations and imaging parameters were used for the five scans.
In a sub-group of healthy subjects (n=5), TR dependence of the measurement was investigated by performing TRUST MRI using TR values of 1.5 seconds to 8 seconds at 0.5 second intervals (14 different TR values). All other parameters were identical as specified above. The durations for the scans depended on TR and varied from 48 seconds to 4 minutes and 16 seconds. In one subject, the TI dependence was investigated (with fixed TR) and the TI values varied from 200ms to 2600ms (13 different TI values). All other parameters were identical as specified above.
In two healthy subjects, hypercapnia challenge (by breathing through a plastic tube with 600ml of volume, thereby increasing the dead-space (25 (link))) was induced and TRUST MRI was performed before, during, and after the challenge. End-tidal CO2 (EtCO2) was monitored throughout the experiment and was compared to MRI results.
In three healthy subjects, TRUST MRI was performed before and after 200mg caffeine tablet ingestion (26 (link)). The pre-caffeine scan was first performed. Then, while still inside the head coil, the subject was instructed to open his or her mouth for the researcher to place one tablet inside, and a small amount of water was administered via a straw to assist with swallowing. The MRI table was then repositioned to the iso-center. Twenty minutes later, the post-caffeine TRUST scan was performed. During the twenty minute waiting time, other anatomical scans (e.g. T1-weigthed anatomical imaging) were performed.
In three subjects, TRUST MRI was performed before and after the intravenous administration of Gd-DTPA contrast agent (Magnevist, Berlex Laboratories, Wayne, NY) at standard dosage (0.1 mmol/kg). The post-contrast TRUST was performed approximately 6 minutes after the injection of the contrast agent so that the agent concentration remained relatively constant for the duration of the TRUST scan.
Lu H, & Ge Y. (2008). Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 60(2), 357-363.
Publication 2008
Caffeine Cell Respiration Cerebrovascular Circulation Contrast Media Ethics Committees, Research Females Gadolinium DTPA Head Healthy Volunteers Human Body Intravenous Infusion Magnevist Males MRI Scans Neoplasm Metastasis Oral Cavity Pulses Radionuclide Imaging Sleep Tablet Transmission, Communicable Disease Veins
3
Diagnostic Criteria for Idiopathic Normal Pressure Hydrocephalus
The candidates for this study were patients with suspected iNPH. After obtaining written informed consent, the eligible patients were pre-registered and received lumbar puncture. The inclusion criteria were (1) age between 60 and 85 years, (2) presence of one or more symptom(s) of the triad (gait disturbance, cognitive impairment, and urinary symptoms), which were measurable on the iNPH Grading Scale (iNPHGS) [14 (link)], (3) MRI features of iNPH, i.e., both ventriculomegaly of Evans' index > 0.3 and tight high-convexity and medial subarachnoid spaces on coronal T1-weighted MRI (Figure 1) [10 (link)], (4) absence of known disorders causing ventriculomegaly, and (5) normal cerebrospinal fluid (CSF) content (protein ≤ 50 mg/dl and cell count ≤ 3 μm3) and pressure (≤ 20 cmH2O). Exclusion criteria were (1) presence of musculoskeletal, cardiopulmonary, renal, hepatic, or mental disorders that would make it difficult to evaluate changes of symptoms, (2) obstacles to one-year follow-up, and (3) hemorrhagic diathesis or anticoagulant medication. For the evaluation of the MRIs, Evans' index, size of the Sylvian fissures rated according to the protocol of Kitagaki et al. [10 (link)], presence or absence of focal dilatation of the cerebral sulci, and white-matter changes according to scale of Fazekas et al. [15 (link)], were assessed on each site and recorded.
The candidates were pre-registered before CSF examination via a web-based case report system. MRI was reviewed by each site in the pre-registration phase, and the final eligibility of the subjects was judged by the central MRI review committee, which consist of neurosurgeons, neurologists, and a neuroradiologist. The central MRI review committee excluded those whose MRI did not fulfil the inclusion criteria. After the confirmation of normal CSF content and pressure, the investigator was notified of registration via the web system. Tap test was carried out in all subjects with 30 ml CSF removal via lumbar puncture. CT cisternography was carried out 1 week after the tap test with iohexol (Omnipaque®: 180 mg/ml) 30 mg/kg. Cerebral blood flow was measured using 123I-Iodoamphetamine and single photon emission computed tomography at baseline. However, the results of these measures were not considered for the eligibility.
Hashimoto M., Ishikawa M., Mori E, & Kuwana N. (2010). Diagnosis of idiopathic normal pressure hydrocephalus is supported by MRI-based scheme: a prospective cohort study. Cerebrospinal Fluid Research, 7, 18.
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Publication 2010
Anticoagulants Cerebrospinal Fluid Cerebrovascular Circulation Dilatation Disorders, Cognitive Eligibility Determination Hemorrhagic Disorders Iodine-123 Iohexol Kidney Mental Disorders Neurologists Neurosurgeon Omnipaque Patients Pressure Proteins Punctures, Lumbar Subarachnoid Space Tomography, Emission-Computed, Single-Photon Triad resin Urine White Matter
4
Ketamine for Treatment-Resistant Depression
Eligible participants included men and women, ages 18 to 65 years. Subjects with MDD had been diagnosed with recurrent MDD without psychotic features using the Structured Clinical Interview for Axis I DSM-IV Disorders (SCID)-Patient Version (40 ). Subjects were required to have a score ≥20 on the Montgomery-Åsberg Depression Rating Scale (MADRS) at screening and before each infusion. Subjects had to have not responded to at least one adequate antidepressant trial during their current episode, as assessed using the Antidepressant Treatment History Form (41 ), and the current episode had to have lasted at least four weeks. Subjects were free from psychotropic medications in the two weeks before randomization (five weeks for fluoxetine, three weeks for aripiprazole). A patient sample size of 34 individuals was necessary to have 80% power to detect an antidepressant effect of ketamine (d=0.5) with p<0.05, two-tailed.
Healthy control subjects consisted of males and females, 18–65 years old with no Axis I disorder as determined by SCID-NP, and no family history of Axis I disorders in first degree relatives. Healthy control subjects were free of medications affecting neuronal function or cerebral blood flow or metabolism. Subjects in both groups were in good physical health as determined by medical history, physical exam, blood labs, electrocardiogram, chest x-ray, urinalysis, and toxicology. The study was approved by the National Institutes of Health (NIH) Combined Neuroscience Institutional Review Board. All subjects provided written informed consent before entry into the study (NCT00088699).
Nugent A.C., Ballard E., Gould T.D., Park L.T., Moaddel R., Brutsche N.E, & Zarate CA J.r. (2018). Ketamine Has Distinct Electrophysiological and Behavioral Effects in Depressed and Healthy Subjects. Molecular psychiatry, 24(7), 1040-1052.
Publication 2017
Antidepressive Agents Aripiprazole BLOOD Cerebrovascular Circulation Electrocardiography Epistropheus Ethics Committees, Research Females Fluoxetine Healthy Volunteers Ketamine Males Mental Disorders Metabolism Neurons Patients Pharmaceutical Preparations Physical Examination Psychotropic Drugs Radiography, Thoracic SCID Mice Urinalysis Woman
5
Reversible Focal Cerebral Ischemia in Mice
Cerebral ischemia was induced by 90 min of reversible MCAO under isoflurane anesthesia, as described previously [26 (link), 32 (link), 56 (link)]. In brief, a midline ventral neck incision was made, and unilateral right MCAO was performed by advancing a 6.0 silicone-coated nylon monofilament (Doccol Corporation, CA) into the internal carotid artery 6 mm from the internal carotid–pterygopalatine artery bifurcation via an external carotid artery stump. Rectal temperatures were monitored with a temperature control system (Fine science tools, Canada) and temperature was maintained with an automatic heating pad at ~37 °C during surgery and ischemia. Cerebral blood flow measurements by laser Doppler flowmetry (DRT 4/Moor Instruments Ltd, Devon, UK) confirmed ischemic occlusion (reduction to 85 % of baseline) during MCAO and restoration of blood flow during reperfusion. Surgical controls are used for molecular analysis, a sham surgery in which the suture was not advanced into the internal carotid artery (controls). All mice are allowed to emerge from anesthesia after the initial suture advancement into the MCA and placed back into their home cage until re-anesthetized for reperfusion. This allows for the assessment of intra-ischemic behavioral deficits to confirm successful suture placement.
Venna V.R., Weston G., Benashski S.E., Tarabishy S., Liu F., Li J., Conti L.H, & McCullough L.D. (2012). NF-κB contributes to the detrimental effects of social isolation after experimental stroke. Acta neuropathologica, 124(3), 425-438.
Publication 2012
Amputation Stumps Anesthesia Blood Circulation Cerebral Ischemia Cerebrovascular Circulation Dental Occlusion External Carotid Arteries Internal Carotid Arteries Ischemia Isoflurane Laser-Doppler Flowmetry Mus Neck Nylons Operative Surgical Procedures Rectum Reperfusion Silicones Sutures

Most recents protocols related to «Cerebrovascular Circulation»

1
Quantitative Spectroscopic Analysis of Ischemic Stroke
The ischaemic area (cerebral blood flow <30% of the normal value and Tmax >6 s) was automatically measured using F-STROKE perfusion software. As the obtained examination data were transferred to a dedicated workstation (spectral diagnostic suite [SPD]; Philips Healthcare), effective atomic number (Zeff) maps, iodine density maps, and iodine–no-water maps were obtained in real time in a post-processing workstation.
The Zeff characterizes the measured attenuation energy sensitivity of an unknown compound in terms of a resultant atomic number, which was estimated by the monochromatic attenuation ratio method since the monochromatic attenuation ratio is a monotonic as a function of effective atomic number (17 (link), 18 (link)).
First, the brain perfusion defect area was identified according to the color difference on the fusion map of the iodine density map and effective atomic number. Then, referring to the results of F-STROKE software, the largest layer of the abnormal perfusion area was selected, and the ROI of the perfusion defect area and contralateral mirror brain area was manually drawn. We selected the core infarct area as the ROI and measured it manually three times to get the average value (Figures 2–4). The selection of ROI should avoid blood vessels and calcification as much as possible and then switch to the effective atomic number map, iodine density map and anhydrous iodine map. We measured and recorded the values of the spectroscopic quantitative parameters (effective atomic number [Zeff value], iodine identity value, and iodine-no water value) in the ischaemic area and comparative normal area. All measurements were performed independently by 2 radiologists who had more than 6 years of experience in neural imaging diagnosis. They were blinded to the spectral data measurements on the corresponding values of the spectroscopic quantitative parameters.
Huang J., Chen J., Wang X., Hao L., Zhang J., Zhang X., Sheng Z, & Liu K. (2023). The diagnostic value of quantitative parameters on dual-layer detector-based spectral CT in identifying ischaemic stroke. Frontiers in Neurology, 14, 1056941.
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Publication 2023
Blood Vessel Brain Cerebrovascular Accident Cerebrovascular Circulation Diagnosis Hypersensitivity Infarction Iodine Microtubule-Associated Proteins Nervousness Perfusion Physiologic Calcification Radiologist Spectrum Analysis
2
Multimodal CT Imaging for Acute Stroke
Baseline CT imaging included brain non-contrast CT, CTP, and CTA, obtained with different CT scanners (64, 128, 256, or 320 detectors, with Toshiba [Tokyo, Japan], Siemens [Munich, Germany], or GE [Cleveland, OH, USA] scanners). The axial coverage ranged from 80 to 160 mm.
The CTP data were processed by commercial software MIStar (Apollo Medical Imaging Technology, Melbourne, Vic, Australia). CTP parameters were generated by applying the mathematical algorithm of singular value decomposition with delay and dispersion correction (20 (link), 21 (link)). The following four CTP parameters were generated: cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and delay time (DT). The penumbra and core volume were measured on acute CTP with dual threshold setting (22 (link)): DT at the threshold of 3 s for whole ischemic lesion volume and CBF at the threshold setting of 30% for acute core volume. The collateral index was defined by the ratio of DT >6 s/DT >2 s volume.
Wang X., Zhang H., Wang Q., Li G., Shen H., Xiao Y., Xu L., Long Y., Chen C., Huang Z, & Zhang Y. (2023). Effect of intravenous thrombolysis on core growth rate in patients with acute cerebral infarction. Frontiers in Neurology, 14, 1096605.
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Publication 2023
Brain CAT SCANNERS X RAY Cerebral Blood Volume Cerebrovascular Circulation Maritally Unattached
3
Validating Acute Stroke Perfusion Imaging
We analyzed CTP images from the International Stroke Perfusion Imaging Registry (INSPIRE), which is a database of acute stroke perfusion imaging and associated clinical information. For this study we used consecutive patients presenting with acute ischemic stroke who had whole brain CTP and who were recruited into INSPIRE between 2010 and 2017 at the John Hunter Hospital, Newcastle, Australia. For standardization, only one site was used at this stage. As is routine in INSPIRE, patients all underwent baseline multimodal CT imaging with non-contrast CT, CTA, and CTP. Written informed consent was obtained from all participants, and the INSPIRE study was approved by the site's ethics committee (23 (link)).
To obtain the perfusion images, a total of 19 acquisitions occurred over 60 s. The CTP data were processed by commercial software MIStar (Apollo Medical Imaging Technology, Melbourne, VIC, Australia). CTP parameters were generated by applying the mathematical algorithm of singular value decomposition with delay and dispersion correction (24 (link)). The following four CTP parameters were generated: cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and delay time (DT). The penumbra and core volumes were defined with dual thresholds: DT at the threshold of 3 s for total ischemic lesion volume and CBF at the threshold setting of 30% for acute core volume (8 (link), 16 (link), 25 (link)). After single-value thresholding, core/penumbra areas were limited to a single lesion and artifactual or erroneous regions were removed. The resulting map was used as the ground truth (GT). Core/penumbra were reviewed by experts to ensure they were accurate.
To develop the model, we used 86 acute ischemic stroke patients with a large vessel occlusion (LVO): M1 segment of the middle cerebral artery (MCA) or internal carotid artery (ICA). To provide additional testing and external validation, 25 patients were used, with both LVO and non-LVO occlusions. This was done to observe whether a model trained only on lesions resulting from an occlusion of large vessel will perform as well when testing on a variety of occlusion sites. Each patient in the test set underwent follow-up MR diffusion-weighted imaging (DWI) between 24 and 72 h after onset. The volume (mL) of the infarct core, as estimated by MR-DWI, was recorded and used for external validation. On follow-up imaging, all patients had a thrombolysis in cerebral infarction (TICI) score of at least 2b, indicating relatively complete reperfusion of initially hypoperfused regions. In these cases, the volume of the acute CTP core should more closely match that of the follow-up infarct core and could therefore be used to validate the predictions.
Werdiger F., Parsons M.W., Visser M., Levi C., Spratt N., Kleinig T., Lin L, & Bivard A. (2023). Machine learning segmentation of core and penumbra from acute stroke CT perfusion data. Frontiers in Neurology, 14, 1098562.
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Publication 2023
Acute Cerebrovascular Accidents Acute Ischemic Stroke Blood Vessel Brain Cerebral Blood Volume Cerebral Infarction Cerebrovascular Accident Cerebrovascular Circulation Dental Occlusion Diffusion Ethics Committees Fibrinolytic Agents Infarction Internal Carotid Arteries Middle Cerebral Artery Multimodal Imaging Patients Perfusion Reperfusion
4
Retrospective Study of Arterial Stenosis Diagnosis
This retrospective study was approved by Gifu University Institutional Review Board. The requirement of informed consent was waived due to the retrospective nature of the study. A series of 306 consecutive participants who underwent DTARG at our institution from January 2016 to December 2020 was included in the subsequent analysis. Overall, 12 of the 306 participants were excluded because they were under 20 years of age. The remaining 294 participants (mean age, 66 ± 15 years; age range, 20–89 years; 195 men; mean body weight, 61 ± 11 kg; body weight range, 37–106 kg) were included in this study (Fig 1). Of these 294 participants, one had normal blood flow, and 293 had abnormal blood flow in DTARG, diagnosed by one radiologist (____with 7 years of post-training experience in nuclear medicine). Furthermore, 176 participants had internal carotid artery stenosis or occlusion (right, 82; left, 54; bilateral, 40), 50 had middle cerebral artery stenosis or occlusion (right, 17; left, 30; bilateral, three), 39 participants had moyamoya disease, seven had vertebral artery stenosis or occlusion (right, three; left, two; bilateral, two), three had basilar artery stenosis, two had subclavian artery stenosis (right, one; bilateral, one), one had bilateral common carotid artery stenosis, one had dual arteriovenous fistula, and 15 participants had multiple cervical and/or intracranial arterial stenosis or occlusion. Of the 294 participants, 54 were examined after treatment for cerebral circulation.
Kaga T., Kato H., Imai T., Ando T., Noda Y., Miura T., Enomoto Y., Hyodo F., Iwama T, & Matsuo M. (2023). Non-invasive regional cerebral blood flow quantification in the 123I-IMP autoradiography using artificial neural network. PLOS ONE, 18(3), e0281958.
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Publication 2023
Aftercare Arteries Basilar Artery Stenosis Blood Circulation Body Weight Cerebrovascular Circulation Common Carotid Artery Stenosis Dental Occlusion Ethics Committees, Research Fistula, Arteriovenous Internal Carotid Artery Stenosis Middle Cerebral Artery Moyamoya disease 1 Neck Radiologist Radionuclide Imaging Stenosis Subclavian Steal Syndrome Vertebral Artery Stenosis
5
Transient Cerebral Ischemia in Mice
Focal brain ischemia was induced by transient intraluminal MCAO using a monofilament. Animals were first anesthetized with 2.5% avertin (20 µl/g, i.p.). A midline ventral neck skin incision was made, the temporal muscle was retracted, and the left carotid artery was exposed and isolated. After the common carotid artery and the external carotid artery were ligated, a silicone-coated monofilament (Doccol, Sharon, MA, USA) was inserted into the left internal carotid artery through an incision in the common carotid artery until it reached the origin of the left MCA where mild resistance was encountered (9–10 mm). One hour after blocking the MCA, the monofilament was withdrawn to restore the blood flow, and the skin was sutured. Transcranial laser-Doppler flowmetry (PeriMed) was utilized to monitor the regional cerebral blood flow (CBF) and ensure successful ischemia and reperfusion. MCA occlusion was determined by a reduction of more than 70% in CBF compared to that at baseline. The body temperature of each mouse was maintained at 37 °C ± 0.5 °C with an electric blanket pad throughout the procedure. No significant differences were noted between Vdr-cKO and control mice in regional CBF at baseline, during ischemia and reperfusion (Additional file 1: Fig. S2G, H), as well as in body temperature and blood pressure during MCAO or sham procedure. Mice were returned to the cages after regaining consciousness.
Cui P., Lu W., Wang J., Wang F., Zhang X., Hou X., Xu F., Liang Y., Chai G, & Hao J. (2023). Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model. Journal of Neuroinflammation, 20, 63.
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Publication 2023
Animals Blood Circulation Blood Pressure Body Temperature Brain Ischemia Cerebrovascular Circulation Common Carotid Artery Consciousness Dental Occlusion Electricity External Carotid Arteries Internal Carotid Arteries Ischemia Laser-Doppler Flowmetry Mice, House Neck Regional Cerebral Blood Flow Reperfusion Silicones Skin Temporal Muscle Transients tribromoethanol

Top products related to «Cerebrovascular Circulation»

1
Periflux system 5000 by Perimed
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The PeriFlux System 5000 is a comprehensive laser Doppler perfusion monitoring system designed for clinical and research applications. It provides continuous, non-invasive measurement of microvascular blood flow, perfusion, and oxygen tissue saturation.
2
Laser doppler flowmetry by Moor Instruments
Sourced in United Kingdom, United States
Laser Doppler flowmetry is a non-invasive technique used to measure blood flow. It utilizes the Doppler effect to detect the movement of red blood cells within the microcirculation. The technique provides real-time, continuous measurements of tissue perfusion.
3
Pericam psi system by Perimed
Sourced in Sweden, United States, China
The PeriCam PSI System is a non-invasive imaging device used to measure and visualize tissue perfusion. It utilizes laser speckle contrast imaging technology to provide real-time assessment of microvascular blood flow.
4
Periflux system 5010 by Perimed
Sourced in Sweden
The Periflux System 5010 is a multi-channel laser Doppler perfusion monitoring system. It measures microcirculatory blood flow in a non-invasive and continuous manner.
5
Periflux 5000 by Perimed
Sourced in Sweden
The PeriFlux 5000 is a laser Doppler perfusion monitoring system designed for clinical and research applications. It measures microvascular blood flow and tissue perfusion using laser Doppler technology.
6
Matlab by MathWorks
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MATLAB is a high-performance programming language and numerical computing environment used for scientific and engineering calculations, data analysis, and visualization. It provides a comprehensive set of tools for solving complex mathematical and computational problems.
7
Laser doppler flowmetry by Perimed
Sourced in Sweden, United States, France
Laser Doppler flowmetry is a non-invasive technique used to measure tissue perfusion. It utilizes a low-power laser to detect the Doppler shift of light, which is proportional to the velocity of blood cells moving within the tissue. This technology provides a quantitative assessment of microvascular blood flow without the need for exogenous tracers or dyes.
8
Moorvms ldf2 by Moor Instruments
Sourced in United Kingdom
The MoorVMS-LDF2 is a laser Doppler flowmeter that measures blood perfusion in tissue. It provides quantitative measurements of microvascular blood flow and tissue perfusion.
9
Moorflpi 2 by Moor Instruments
Sourced in United Kingdom
The MoorFLPI-2 is a full-field laser perfusion imager that utilizes laser Doppler technology to measure microvascular blood flow. The device is capable of producing real-time, high-resolution blood flow images and measurements.
10
Powerlab by ADInstruments
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PowerLab is a data acquisition system designed for recording and analyzing physiological signals. It provides a platform for connecting various sensors and transducers to a computer, allowing researchers and clinicians to capture and analyze biological data.

More about "Cerebrovascular Circulation"

cerebral circulation, brain blood flow, vascular dynamics, arterial supply, venous drainage, perfusion, neuronal function, neurological disorders, stroke, vascular dementia, PubCompare.ai, Laser Doppler flowmetry, PeriCam PSI System, Periflux System 5010, PeriFlux 5000, MATLAB, MoorVMS-LDF2, MoorFLPI-2, PowerLab