Sixty-five patients were enrolled (10–22 patients per site). Inclusion criteria included age 18–70 years, presence of diabetes mellitus, a sural nerve amplitude response of 1.0 µV or more and the presence of symmetrical distal DSP as defined by the modified San Antonio Criteria, in which two of symptoms, signs, abnormal nerve conduction parameters or abnormal vibration perception thresholds (VPT) were required [14 (link)]. Patients were stratified for disease severity on the basis of the TCNS in order to determine the performance of the mTCNS across the full range of disease severity [9 (link)]. Patients were excluded if they had known non-diabetic causes of neuropathy (for example, vitamin deficiencies, uraemia, thyroid disease, lumbar or cervical radiculopathy, inflammatory neuropathy or presence of alcoholism).
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Nerve Conduction
Nerve Conduction
Nerve Conduction: The transmission of electrical impulses along the peripheral nerves, a key process in the assessment of nerve function.
PubCompare.ai enhances this critical area of research by helping users identify the best protocols from literature, pre-prints, and patents.
Their AI-driven comparisons streamline the research process, enabling researchers to find the optimal protocols and products to take their nerve conduction studies to the nect level.
Discover how PubCompare.ai can elevate your nerve conduction research and improve reproducibility.
PubCompare.ai enhances this critical area of research by helping users identify the best protocols from literature, pre-prints, and patents.
Their AI-driven comparisons streamline the research process, enabling researchers to find the optimal protocols and products to take their nerve conduction studies to the nect level.
Discover how PubCompare.ai can elevate your nerve conduction research and improve reproducibility.
Most cited protocols related to «Nerve Conduction»
Alcoholic Intoxication, Chronic
Avitaminosis
Diabetes Mellitus
Diabetic Neuropathies
Inflammation
Lumbar Region
Nerve Conduction
Patients
Radiculopathy, Cervical
Sural Nerve
Thyroid Diseases
Transcobalamin
Uremia
Vibration
Diabetes Mellitus
Hypersensitivity
Nerve Conduction
Nervous System Disorder
Patient Representatives
Patients
Polyneuropathy
Incident diabetic neuropathy was defined by clinical and electrophysiological criteria according to the consensus of the American Association of Neurology, the American Academy of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation (15 (link)). Based on this consensus, incident case definition generally required the presence of electrophysiological polyneuropathy as defined by abnormality of three or more parameters in two or more nerves in combination with the presence of more than one neuropathic symptom or sign of peripheral neuropathy. This same criterion was used to both exclude the presence of diabetic neuropathy at baseline and to define incident neuropathy during follow-up.
For the electrophysiological component of incident case definition, evaluation of the unilateral median, ulnar, peroneal, tibial, and sural nerves was performed at baseline and subsequent examinations were performed using standardized nerve conduction studies (16 (link)). These were performed using the Counterpoint instrument (Natus Medical, San Carlos, CA) according to the standards of the American Association for Neuromuscular and Electrodiagnostic Medicine and the Canadian Society of Clinical Neurophysiology. Low interobserver and intraobserver variabilities have been observed for these measurements using the techniques described (17 (link)). Individual nerve conduction parameters were scored as normal or abnormal according to laboratory reference values.
For the electrophysiological component of incident case definition, evaluation of the unilateral median, ulnar, peroneal, tibial, and sural nerves was performed at baseline and subsequent examinations were performed using standardized nerve conduction studies (16 (link)). These were performed using the Counterpoint instrument (Natus Medical, San Carlos, CA) according to the standards of the American Association for Neuromuscular and Electrodiagnostic Medicine and the Canadian Society of Clinical Neurophysiology. Low interobserver and intraobserver variabilities have been observed for these measurements using the techniques described (17 (link)). Individual nerve conduction parameters were scored as normal or abnormal according to laboratory reference values.
Diabetic Neuropathies
Nerve Conduction
Nervousness
Peripheral Nervous System Diseases
Pharmaceutical Preparations
Physical Examination
Polyneuropathy
Rehabilitation
Study, Nerve Conduction
Sural Nerve
Tibia
anti-IgG
Epidemics
Infection
Nerve Conduction
Patients
Precipitating Factors
Zika Virus
Zika Virus Infection
Congenital Abnormality
Median Neuropathy
Mononeuropathies
Nerve Conduction
Nerves, Median
Nervousness
Ulnar Nerve
Wrist Joint
Most recents protocols related to «Nerve Conduction»
The outcome was the occurrence of DPN. DPN was diagnosed by a combination of symptoms, signs and nerve conduction function consistent with the guideline provided by the 2010 Toronto Consensus (17 (link)).
Nerve Conduction
Biochemical indices including complete blood count; levels of serum calcium (Ca), phosphonium (P), and alkaline phosphatase (ALP); liver and kidney functions; and levels of creatine kinase (CK) and its MB isoenzyme (CK-MB), 25-hydroxyvitamin D (25OHD), the intact parathyroid hormone (PTH) bone formation marker serum osteocalcin (OC), and the bone resorption marker serum beta cross-linked C-terminal telopeptide of type 1 collagen (β-CTX) were measured. Measurements of bone mineral density (BMD) of the lumbar spine and left femur neck were performed by dual-energy X-ray absorptiometry (Lunar iDXA, GE Healthcare, Madison, WI, USA). The results were transformed into age- and sex-specific Z-scores using reference data [13 (link)]. X-ray radiographs of thoracic and lumbar vertebrae, hips, knees, and ankles were obtained. The left leg muscle was examined by magnetic resonance imaging (MRI). Electromyography was performed and nerve conduction was analysed.
Alkaline Phosphatase
Ankle
Bone Density
Bone Resorption
Calcifediol
Calcium, Dietary
Complete Blood Count
Coxa
Creatine Kinase
Dual-Energy X-Ray Absorptiometry
Electromyography
ICTP peptide
Isoenzyme CPK MB
Isoenzymes
Kidney
Knee
Liver
Muscle Tissue
Neck, Femur
Nerve Conduction
Osteocalcin
Osteogenesis
Parathyroid Hormone
Radiography
Radiography, Thoracic
Serum
Silver
Vertebrae, Lumbar
Motor and sensory nerve conduction studies were performed using standard techniques (Viking Select ™, Madison, WI, USA). Motor nerve conduction examinations were performed for the median, ulnar, peroneal, and tibial nerves. Measured parameters included the CMAP amplitude, distal motor latency, motor nerve conduction velocity, and minimal F-wave latency. Orthodromic sensory nerve conduction examinations were performed for the median, ulnar, superficial peroneal, and sural nerves. Examinations were performed immediately, 1 week, and 1 month after admission.
Nerve Conduction
Nerve Conduction Velocity Tests
Physical Examination
Study, Nerve Conduction
Sural Nerve
Tibial Nerve
Between 2019 and 2021, 28 patients with PNP were prospectively recruited at the Department of Neurology, University of Würzburg, Germany, where they were seen for diagnostic work-up. In addition, 10 patients with acute headaches of unclear etiology were used as disease controls for the CSF analysis, and serum data from twelve healthy volunteers were included in the analysis to determine the inflammatory state of the headache group. Our study was approved by the Würzburg Medical Faculty Ethics Committee (# 15/19 and # 242/17) and all participants gave written informed consent prior to inclusion.
Diagnoses were based on history taking and neurological examination, laboratory studies, and nerve conduction examinations. All patients underwent laboratory tests including full blood count, electrolytes, kidney and liver function tests, C-reactive protein, thyroid stimulating hormone, vitamin B12, HbA1c, oral glucose tolerance test (OGTT), screening for autoimmune antibodies (i.e., ANA, ENA, ANCA, anti-ganglioside antibodies), and lumbar puncture. Electrophysiological assessment with nerve conduction studies of the affected nerves including tibial motor nerve and sural sensory nerve was performed in all PNP patients.
To rate the severity of the neuropathy, we used standardized scales, including the modified Toronto clinical neuropathy score (mTCNS), the overall disability sum score (ODSS) and the Medical Research Council-sumscore (MRC-sumscore). Depression was assessed with the “Allgemeine Depressionsskala” (ADS) (37 (link)). Pain was evaluated by a numerical rating scale (NRS) from 0 (no pain) to 10 (worst pain), the neuropathic pain symptom inventory (NPSI) and the graded chronic pain scale (GCPS). After the diagnostic work-up, the examining neurologists categorized the neuropathies into a mild (1), moderate (2) or severe (3) clinical phenotype.
Diagnoses were based on history taking and neurological examination, laboratory studies, and nerve conduction examinations. All patients underwent laboratory tests including full blood count, electrolytes, kidney and liver function tests, C-reactive protein, thyroid stimulating hormone, vitamin B12, HbA1c, oral glucose tolerance test (OGTT), screening for autoimmune antibodies (i.e., ANA, ENA, ANCA, anti-ganglioside antibodies), and lumbar puncture. Electrophysiological assessment with nerve conduction studies of the affected nerves including tibial motor nerve and sural sensory nerve was performed in all PNP patients.
To rate the severity of the neuropathy, we used standardized scales, including the modified Toronto clinical neuropathy score (mTCNS), the overall disability sum score (ODSS) and the Medical Research Council-sumscore (MRC-sumscore). Depression was assessed with the “Allgemeine Depressionsskala” (ADS) (37 (link)). Pain was evaluated by a numerical rating scale (NRS) from 0 (no pain) to 10 (worst pain), the neuropathic pain symptom inventory (NPSI) and the graded chronic pain scale (GCPS). After the diagnostic work-up, the examining neurologists categorized the neuropathies into a mild (1), moderate (2) or severe (3) clinical phenotype.
Anti-Antibodies
Antineutrophil Cytoplasmic Antibodies
Autoantibodies
BAD protein, human
Chronic Pain
Cobalamins
Complete Blood Count
C Reactive Protein
Diagnosis
Disabled Persons
Electrolytes
Ethics Committees
Faculty, Medical
Gangliosides
Headache
Healthy Volunteers
Inflammation
Kidney
Liver Function Tests
Nerve Conduction
Neuralgia
Neurologic Examination
Neurologists
Oral Glucose Tolerance Test
Patients
Phenotype
Physical Examination
Punctures, Lumbar
Serum
Sural Nerve
Thyrotropin
Tibial Nerve
Vision
Neonatal mice (1-day postnatal, P1) were collected and placed in a separate cage. P1 mice were anaesthetised at a low temperature (hypothermia can provide anaesthesia by reducing nerve conduction and synaptic transmission). Subsequently, the mice were placed under a stereomicroscope, and the skin was disinfected with a cotton swab dipped in betadine. Microsurgical scissors cut the skin from left to right between the third and fourth ribs of mice, and the rib cage was exposed after the blunt separation of the intercostal muscles. Surgical scissors removed about 15% of the apex tissue from the left ventricle. After surgery, the heart was gently returned to the chest using a saline swab, and the ribs and skin were closed layer by layer using surgical sutures (6-0). Finally, the mice were placed under an infrared physiotherapy lamp to restore body temperature. When the skin was rosy and the limbs began to move, the mice were put back in the cage. After the operation of all mice, all mice were sent to the mother mice. The sham group performed the same procedure described above without AR. A specific scheme of combined adenovirus injection in AR of mice (AR + Ad5-cTNT-INK4ai or AR + Ad5-cTNT-NC): 10% Trypan blue solution with PBS, and adenovirus stock solution was diluted 1 : 9 in Trypan blue solution (the total amount of injected virus was 1∗109 pfu/virus). A microsyringe with a 36 G needle was used to drain the virus diluent. The needle was injected slowly at three locations around the apex of the heart (anterior, lateral, and posterior wall: 2 μl each). Under the microscope, the edge of the myocardium can be seen to be stained blue, indicating successful injection.
Adenoviruses
Anesthesia
Betadine
Body Temperature
Chest
Cold Temperature
Gossypium
Heart
Infant, Newborn
Intercostal Muscle
Left Ventricles
Mice, House
Microscopy
Mothers
Myocardium
Needles
Nerve Conduction
Rib Cage
Ribs
Rosa
Saline Solution
Skin
Surgical Scissors
Sutures
Synaptic Transmission
Therapy, Physical
Tissues
Trypan Blue
Virus
Vision
Top products related to «Nerve Conduction»
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Keypoint is a versatile lab equipment product designed for various applications. It functions as a diagnostic tool, providing precise measurements and analysis capabilities. The core purpose of Keypoint is to assist researchers and professionals in conducting thorough evaluations and assessments within the laboratory setting.
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Capsaicin solution is a laboratory product manufactured by Merck Group. It is a clear, colorless liquid that contains the active compound capsaicin, which is derived from chili peppers. The solution is designed for use in various research and analysis applications.
Sourced in United States, Australia, United Kingdom, New Zealand
The PowerLab 26T is a versatile data acquisition system designed for laboratory research and educational applications. It features 26 high-resolution analog input channels, enabling the simultaneous recording of multiple physiological signals. The PowerLab 26T provides researchers and educators with a reliable and flexible platform for data collection and analysis.
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Pentobarbital sodium is a laboratory chemical compound. It is a barbiturate drug that acts as a central nervous system depressant. Pentobarbital sodium is commonly used in research and scientific applications.
Sourced in Japan
The MEB-9200K is a multi-channel electroencephalogram (EEG) system designed for clinical and research applications. It features high-quality amplifiers and a digital signal processing unit to acquire and analyze electrical activity from the brain. The MEB-9200K is capable of recording EEG data from multiple channels simultaneously, providing a comprehensive assessment of brain function.
Sourced in United States
The Axon Digidata 1550 Digitizer is a high-performance data acquisition system designed for electrophysiology applications. It features 16 analog input channels, 8 digital input/output channels, and can sample at rates up to 500 kHz. The device offers precise data capture and low-noise performance to support a wide range of electrophysiology experiments.
Sourced in United States
The Electromyography (EMG) machine is a medical device used to measure the electrical activity generated by skeletal muscles. It records the electrical signals produced by the muscles during contraction and at rest, providing insights into muscle function and nerve health. The EMG machine is a valuable tool for diagnosing and monitoring various neuromuscular disorders, muscle injuries, and other related conditions.
Sourced in United Kingdom
The MedlecSynergy is a laboratory equipment product from Oxford Instruments. It is a high-performance analytical system designed for advanced materials characterization. The core function of the MedlecSynergy is to provide detailed information about the physical and chemical properties of materials through advanced spectroscopic techniques.
Sourced in United States, United Kingdom, Japan, Germany
SPSS is a software package used for statistical analysis. It provides a graphical user interface and a robust set of tools for data manipulation, analysis, and visualization. SPSS is designed to handle a wide range of data types and supports a variety of statistical techniques, including regression analysis, factor analysis, and time series analysis.
Sourced in United Kingdom
The Magstim Rapid2 is a transcranial magnetic stimulation (TMS) device designed for use in research and clinical settings. It generates a rapidly changing magnetic field to induce electrical currents in the brain, allowing for non-invasive stimulation of specific brain regions. The Rapid2 offers adjustable stimulation parameters and can be used to investigate brain function and neural activity.
More about "Nerve Conduction"
Nerve conduction studies (NCS) are a critical diagnostic tool used to assess the function and integrity of the peripheral nervous system.
This process involves the transmission of electrical impulses along the nerves, a key physiological mechanism that can be measured and analyzed to detect various neurological conditions.
PubCompare.ai is a powerful AI-driven platform that enhances nerve conduction research by helping researchers identify the best protocols and products from the literature, preprints, and patents.
By streamlining the research process, PubCompare.ai enables researchers to find the optimal protocols and equipment, such as PowerLab 26T, Axon Digidata 1550 Digitizer, and Electromyography (EMG) machines like MedlecSynergy, to take their nerve conduction studies to the next level.
Nerve conduction velocity (NCV) is a widely used parameter in NCS, measuring the speed at which electrical impulses travel along a nerve.
Factors like myelination, axon diameter, and temperature can affect NCV, and researchers often use techniques like Keypoint or MEB-9200K to assess this metric.
Additionally, the use of pharmacological agents like Pentobarbital sodium or Capsaicin solution can provide insights into nerve function and pathologies.
Improving the reproducibility and efficiency of nerve conduction research is crucial, and PubCompare.ai's AI-driven comparisons can streamline this process.
Researchers can use the platform to identify the best protocols and products, such as the Magstim Rapid2 stimulator, to enhance their studies and ensure more consistent and reliable results.
By leveraging PubCompare.ai, researchers can explore new frontiers in nerve conduction research and improve patient outcomes through more accurate diagnoses and targeted interventions.
The integration of advanced technologies, like SPSS version software for statistical analysis, further enhances the capabilities of nerve conduction research, enabling researchers to gain deeper insights and make more informed decisions.
PubCompare.ai's comprehensive approach to protocol and product comparison is a valuable tool for researchers, clinicians, and medical device companies, helping to drive innovation and progress in the field of peripheral nerve assessment.
This process involves the transmission of electrical impulses along the nerves, a key physiological mechanism that can be measured and analyzed to detect various neurological conditions.
PubCompare.ai is a powerful AI-driven platform that enhances nerve conduction research by helping researchers identify the best protocols and products from the literature, preprints, and patents.
By streamlining the research process, PubCompare.ai enables researchers to find the optimal protocols and equipment, such as PowerLab 26T, Axon Digidata 1550 Digitizer, and Electromyography (EMG) machines like MedlecSynergy, to take their nerve conduction studies to the next level.
Nerve conduction velocity (NCV) is a widely used parameter in NCS, measuring the speed at which electrical impulses travel along a nerve.
Factors like myelination, axon diameter, and temperature can affect NCV, and researchers often use techniques like Keypoint or MEB-9200K to assess this metric.
Additionally, the use of pharmacological agents like Pentobarbital sodium or Capsaicin solution can provide insights into nerve function and pathologies.
Improving the reproducibility and efficiency of nerve conduction research is crucial, and PubCompare.ai's AI-driven comparisons can streamline this process.
Researchers can use the platform to identify the best protocols and products, such as the Magstim Rapid2 stimulator, to enhance their studies and ensure more consistent and reliable results.
By leveraging PubCompare.ai, researchers can explore new frontiers in nerve conduction research and improve patient outcomes through more accurate diagnoses and targeted interventions.
The integration of advanced technologies, like SPSS version software for statistical analysis, further enhances the capabilities of nerve conduction research, enabling researchers to gain deeper insights and make more informed decisions.
PubCompare.ai's comprehensive approach to protocol and product comparison is a valuable tool for researchers, clinicians, and medical device companies, helping to drive innovation and progress in the field of peripheral nerve assessment.