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Otoacoustic Emissions, Spontaneous

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Most cited protocols related to «Otoacoustic Emissions, Spontaneous»

1
Auditory Neural Responses and Otoacoustic Emissions in Mice
Mice were anesthetized with ketamine (100mg/kg, i.p.) and xylazine (10 mg/kg i.p.). Acoustic stimuli were delivered via a custom acoustic assembly consisting of two electrostatic drivers as sound sources (EC-1, Tucker Davis Technologies) and a miniature electret microphone at the end of a probe tube to measure sound pressure in situ. Auditory brainstem responses (ABRs) were recorded via subdermal needle electrodes (vertex -ventrolateral to pinna). For compound action potentials (CAPs) of the cochlear nerve, the recording electrode was placed at the round window niche. Stimuli were 5 msec tone pips with a 0.5 msec rise-fall time delivered at 30/sec (ABR) or 16/sec (CAP). The response from the electrodes was amplified, filtered, and averaged (512 samples, for ABR, or 128 samples, for CAP; polarity alternating). Sound level was incremented in 5 dB steps, from ~10 dB below threshold to 90 dB SPL. Threshold for ABR was defined as the lowest stimulus level at which a repeatable wave I could be identified in the response waveform. CAP threshold was defined as the sound pressure required to produce a wave I response of 6 μV peak to peak. For both neural responses, the wave I component was identified and the peak to peak amplitude computed by offline analysis of stored waveforms. Distortion product otoacoustic emissions (DPOAEs) were recorded for primary tones with a frequency ratio of 1.2, and with the level of the f2 primary 10 dB less than f1 level, incremented together in 5 dB steps. Ear-canal sound pressure was amplified and digitally sampled, then FFTs were computed and averaged by both waveform and spectral averaging. The 2f1-f2 DPOAE amplitude and surrounding noise floor were extracted. Iso-response contours were interpolated from plots of amplitude vs. sound level. ‘Threshold’ is defined as the f1 level required to produce a DPOAE of -5 dB SPL. To avoid distortion of non-physiologic origin, stimulus levels were kept below 80 dB SPL; in all cases, however, the range of noise-induced threshold shifts did not exceed the dynamic range available for response monitoring; i.e., there was no artificial ‘ceiling’ limiting the measured threshold shifts. ABRs and DPOAEs were recorded from all animals, CAPs from subsets of animals just before tissue recovery for histological processing.
Kujawa S.G, & Liberman M.C. (2009). Adding Insult to Injury: Cochlear Nerve Degeneration after “Temporary” Noise-Induced Hearing Loss. The Journal of Neuroscience, 29(45), 14077-14085.
Publication 2009
Acoustics Action Potentials Animals Auditory Brainstem Responses Cochlear Nerve Ear Auricle Electrostatics External Auditory Canals Fenestra Cochleae Iodine Ketamine Mus Needles Nervousness Otoacoustic Emissions, Spontaneous physiology Pressure Reproduction Sound Tissues Xylazine
2
Distortion Product Otoacoustic Emission Measurement

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Publication 2010
Acoustics Body Temperature DB 60 External Auditory Canals Inhalation Isoflurane Obstetric Delivery Otoacoustic Emissions, Spontaneous Sound Transducers
3
Comprehensive Audiological Evaluation and Ototoxicity Monitoring
Various audiological testing methods were used to assess hearing dependent upon the patient’s age, cognitive and developmental abilities, and level of cooperation. Tympanometry was reviewed to determine the integrity of the conductive mechanism at the time of testing. Pure-tone air conduction thresholds were evaluated at frequencies 0.25, 0.5, 1, 2, 3, 4, 6, and 8 kHz in decibel (dB) hearing level (HL). Pure tone bone conduction thresholds were assessed at frequencies 0.25, 0.5, 1, 2, 3, and 4 kHz to determine the nature of the hearing impairment (i.e., conductive, sensorineural, or mixed). Click and tone-burst auditory brainstem response (ABR), auditory steady-state response, and/or distortion-product otoacoustic emissions (DPOAE) measurements were evaluated on patients who were unable to participate in conventional audiometric testing due to young age, cognitive or developmental delay, or lack of cooperation. The ototoxicity monitoring schedule consisted of an evaluation at the following time points: baseline (occurred within 2 weeks of initiation of radiation therapy), prior to each high dose cisplatin chemotherapy cycle, and at 9, 12, 15, and 24 months following diagnosis. Audiometric data from St. Jude and the nine collaborative sites were reviewed and assigned an ototoxicity grade by a single research audiologist at St. Jude (JKB). Each audiological evaluation was given an ototoxicity grade based on the Chang Ototoxicity Grading Scale [20 (link)] and the International Society of Pediatric Oncology Ototoxicity Scale (Table I) [1 (link)]. The latest audiometric evaluation that occurred between 5.5–24 months from on-treatment date was used for the analysis.
Bass J.K., Huang J., Onar-Thomas A., Chang K.W., Bhagat S.P., Chintagumpala M., Bartels U., Gururangan S., Hassall T., Heath J.A., McCowage G., Cohn R.J., Fisher M.J., Robinson G., Broniscer A., Gajjar A, & Gurney J.G. (2013). Concordance between the Chang and the International Society of Pediatric Oncology (SIOP) ototoxicity grading scales in patients treated with cisplatin for medulloblastoma. Pediatric blood & cancer, 61(4), 601-605.
Publication 2013
Audiologist Audiometry Auditory Brainstem Responses Bone Conduction Cisplatin Cognition Diagnosis Electric Conductivity Hearing Hearing Impairment Neoplasms Otoacoustic Emissions, Spontaneous Ototoxicity Patients Pharmacotherapy Radiotherapy Tympanometry
4
Tinnitus Evaluation and Hyperacusis Assessment
From November 2011 to December 2012, the final version of HQ was administered to 117 consecutive outpatients [64 male (54.7%) and 53 female (45.3%), age range 14-88 years, (mean 53)], with a primary complaint of tinnitus to improve population homogeneity. All patients had tinnitus for at least 3 months. All questionnaires were filled in by patients in a self-administered way. Exclusion criteria were the presence of recruitment and Ménière's disease evaluated with anamnesis and audiological data. Patients with a previous diagnosis of psychiatric disease were also excluded. Informed consent was obtained from each participant before examination.
Patients were also asked to complete the Italian version of Tinnitus Handicap Inventory (THI).
All patients underwent ENT clinical examination with anamnesis, otoscopy and audiometric evaluation. Pure-tone audiometry was performed at 0.125, 0.25, 0.5, 1, 2, 3, 4, 6 and 8 kHz. Pitch and loudness tinnitus matching was carried out for each patient using the method of adjustment by Newman et al. 26 (link). Hyperacusis measurement includes uncomfortable loudness levels (ULL) which were measured at 0.25, 0.5, 1, 2, 4 and 8 kHz. Mild hyperacusis was considered in presence of ULL at 80-90 dB in 2 or more frequencies, moderate hyperacusis in presence of ULL at 65-75 dB in 2 or more frequencies and severe hyperacusis in presence of ULL at 60 dB or lower in 2 or more frequencies 27 .
Otoacoustic emissions with distortion product (DPOAE) determined the hypothetical influence of hyperacusis on DPOAE parameters in tinnitus patients. DPOAE were recorded with f1/f2 = 1.22 and intensities of 65 dB (f1) and 55 dB (f2) SPL.
FIORETTI A., TORTORELLA F., MASEDU F., VALENTI M., FUSETTI M, & PAVACI S. (2015). Validity of the Italian version of Khalfa's Questionnaire on hyperacusis. Acta Otorhinolaryngologica Italica, 35(2), 110-115.
Publication 2015
Audiometry Audiometry, Pure-Tone Diagnosis Diagnosis, Psychiatric Hyperacusis Immunologic Memory Males Meniere Disease Mental Disorders Otoacoustic Emissions, Spontaneous Otoscopy Outpatients Patients Physical Examination Tinnitus Woman
5
Auditory Function Evaluation in Animals
The hearing status of each animal was assessed using click auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAEs) both before surgery and 2 weeks postoperatively.
ABRs and DPOAEs were measured using an Etymotic Research ER10B1 probe microphone (Elk Grove, IL) coupled to two Tucker Davis Technologies MF1 Multi-Field Magnetic Speakers (Alachua, FL). Stimulus presentation and recording were controlled using custom software running on a PC connected to a 24-bit external sound card (Motu UltraLite mk3).
A custom-built differential amplifier with a gain of 1,000 dB amplified acoustic ABR responses. The output was passed through 6-pole Butterworth high-pass (100 Hz) and low-pass (3 kHz) filters and then to a 16-bit analog-to-digital converter (100,000 samples/s). Responses were recorded using standard signal-averaging techniques. Typically, 500 to 2,000 sweeps were used in each averaged response, depending on signal-to-noise conditions as determined by the experimenter.
DPOAEs were measured using frequency glides rather than the standard paradigm of testing one frequency at a time. The glide method is faster than the standard method, yields comparable results in terms of DPOAE magnitude, and allows variable, finely spaced frequency analysis. Stimuli consisted of linear frequency glides from 1 to 18 kHz, changing at a rate of approximately 5.7 kHz/s (3 seconds per sweep). The primary frequency glides f1 and f2 had a constant frequency ratio of f2/f1 = 1.22. The levels of the primaries were fixed at 65 dB SPL and 55 dB SPL for f1 and f2, respectively. An in situ level calibration was performed before each measurement, and the levels of the electrical stimulus drives were adjusted to create a flat acoustic amplitude response at the calibrated probe microphone. Standing waves were not expected to affect the measurements, because the distance between the inlet of the probe microphone and the eardrum was approximately 0.3 cm, effectively placing the highest quarter-wavelength null at a frequency >18 kHz.
Recorded waveforms were bandpass filtered (0.8–18.2 kHz) using a finite impulse-response filter. Filter group delay (30 milliseconds) was corrected for. Each measurement consisted of the bi-squares-weighted average of 15 stimulus presentations. This method controlled artifact by down-weighting noisy samples in the recorded waveforms. The cubic distortion products and associated noise floors were extracted by a custom-designed digital heterodyne filtering operation. Two noise floor calculations (1/12th octave above and below the cubic distortion frequency) were averaged to give a single noise floor estimate.
Soken H., Robinson B.K., Goodman S.S., Abbas P.J., Hansen M.R, & Kopelovich J.C. (2013). Mouse Cochleostomy: A Minimally Invasive Dorsal Approach for Modeling Cochlear Implantation. The Laryngoscope, 123(12), E109-E115.
Publication 2013
A-A-1 antibiotic Acoustics Animals Auditory Brainstem Responses Cuboid Bone Electricity Filtering Surgery Magnetic Fields Neoplasm Metastasis Operative Surgical Procedures Otoacoustic Emissions, Spontaneous Sound Tympanic Membrane

Most recents protocols related to «Otoacoustic Emissions, Spontaneous»

1
Otoacoustic Emissions Protocol for Hearing Loss
Statistical analyses were done in R studio, version 1.4.1717. The Fisher exact test and Mann-Whitney U test were used to compare groups, and a stratified Wilcoxon-Mann-Whitney combined analysis was used to perform comparisons of emissions with respect to age and sex. Spearman's rank test was applied for the correlation analysis between PTA and ETL levels. A P value <.05 was considered significant.
Loss of (otoacoustic) emissions upon admission (in dB) was calculated as the difference between the patient's ETL (mean of both ears) and the mean ETL in the age- and sex-matched control group.
Changes in ETL during admission were calculated as the difference from the patient's own ETL on admission. A recovery or decline of ≥2.5 dB was considered significant, and changes <2.5 dB were registered as 0 (zero). A recovery or decline in ETL was only registered at the first interval where this was observed (days 1–3, days 5–7, or days 10–14).
Jensen E.S., Cayé-Thomasen P., Bodilsen J., Nielsen H., Friis-Hansen L., Christensen T., Christiansen M., Kirchmann M, & Brandt C.T. (2023). Hearing Loss in Bacterial Meningitis Revisited—Evolution and Recovery. Open Forum Infectious Diseases, 10(3), ofad056.
Publication 2023
Ear Otoacoustic Emissions, Spontaneous
2
Hearing Loss in Acute Bacterial Meningitis
In this prospective observational cohort study, SNHL was evaluated by audiometry and repeated measures of distortion product otoacoustic emissions (DPOAEs) in adults with ABM. Patients were recruited consecutively at the Department of Infectious Diseases, Nordsjællands Hospital, from November 2016 to July 2019 and from November 2016 to April 2017; patients were also recruited at the Department of Infectious Diseases, Aalborg University Hospital.
Jensen E.S., Cayé-Thomasen P., Bodilsen J., Nielsen H., Friis-Hansen L., Christensen T., Christiansen M., Kirchmann M, & Brandt C.T. (2023). Hearing Loss in Bacterial Meningitis Revisited—Evolution and Recovery. Open Forum Infectious Diseases, 10(3), ofad056.
Publication 2023
Adult Audiometry Communicable Diseases Otoacoustic Emissions, Spontaneous Patients
3
Cochlear Implant Outcomes in Pediatric Sensorineural Hearing Loss
Forty children (21 males, mean age  ±  standard deviation (SD): 5.09  ±  3.79
years old) with sensorineural hearing loss who received their first CI in our
hospital from September 2018 to June 2020 were included in this study. These
children were right-handed according to an assessment with the Edinburgh
Handedness Inventory (Oldfield, 1971 (link)). They started to use hearing aids at a mean age of
2.30  ±  1.21 years old, and had used hearing aids with a mean duration of
2.79  ±  3.26 years and for at least 4 h per day in their daily life. These
children had auditory responses to environmental sounds during the initial
period of hearing aid fitting. To confirm the effectiveness of hearing aid
fitting in the daily life, their auditory performance was reexamined by the
Meaningful Auditory Integration Scale (MAIS) and Categories of Auditory
Performance (CAP) at least every 8 months. The MAIS includes 10 questions
reflecting children's confidence in hearing devices, auditory sensitivity and
ability to connect sounds with meaning. The highest score is 40 and indicates
the best performance for meaningful sound use in everyday situations. The CAP is
an eight-score hierarchical scale that evaluates receptive auditory abilities
and ranges from no awareness of environmental sounds (1 score) to telephone use
with a familiar talker (8 scores). When hearing aid outcomes were poor and the
ABR thresholds estimated by the click and 500-Hz tone burst were above 90 dB
nHL, the hearing-impaired child received a CI. Before the CI surgery, the ABR,
40-Hz auditory evoked potential, multi-frequency steady state potential (MFSSP),
distortion product otoacoustic emission (DPOAE) and acoustic impedance had been
performed to confirm profound sensorineural hearing loss (hearing threshold ≥90
dB nHL). The 40-Hz auditory evoked potential (Lynn et al., 1984 (link)) and MFSSP (Johnson & Brown,
2005) tests were performed for hearing threshold estimation using the
500-Hz tone burst and sinusoidally amplitude modulated tones (1, 2 and 4 kHz),
respectively. Only 24 children finished the pure-tone audiometry and their
unaided pure tone averages (averaged over 0.25, 0.5, 1, 2, 4 and 8 kHz) were
above 90 dB HL. Participants who had a mental disability, intracranial lesions
or head trauma were excluded from this study. Of children in our study, 20 had
IEMs assessed by computerized tomography (CT) and magnetic resonance imaging
(MRI) according to previously published criteria (Sennaroglu & Bajin, 2017 (link)).
Detailed information for all children is provided in Table 1. All procedures performed in
this study involving human participants were in accordance with the ethical
standards of the institutional and/or national research committee and with the
1964 Helsinki declaration and its later amendments or comparable ethical
standards. The protocols and experimental procedures in the present study were
reviewed and approved by the Anhui Provincial Hospital Ethics Committee. Each
participant's guardians provided written informed consent.
Chen L., Zhang J.G., Zhu H.Y., Hou X.Y., Tang Z.Q., Sun J.W., Sun J.Q, & Guo X.T. (2023). Electrically Evoked Auditory Brainstem Responses in Children Fitted with Hearing Aids Prior to Cochlear Implantation. Trends in Hearing, 27, 23312165221148846.
Full text: Click here
Publication 2023
Acoustics Adult Audiometry, Pure-Tone Auditory Evoked Potentials Awareness Child Craniocerebral Trauma Disabled Persons Ethics Committees, Clinical Hearing Aids Homo sapiens Hypersensitivity Legal Guardians Males Meaningful Use Medical Devices Mycobacterium avium Complex Only Child Operative Surgical Procedures Otoacoustic Emissions, Spontaneous Sensorineural Hearing Loss Sound X-Ray Computed Tomography
4
Unilateral Full-Frequency ISSNHL Protocol
Adult patients diagnosed with unilateral full-frequency ISSNHL admitted to our department from January 2018 to June 2021 were enrolled in the study. The medical records were retrospectively investigated. Eligible subjects must not have had either a prior episode of SSNHL or a history of Ménière’s disease or other cochlear lesions, and must have received prompt treatment within two weeks of symptom onset. Otoscopy and audiometric examinations were performed in all involved patients, including pure tone and speech audiometry, tympanometry, distortion product otoacoustic emission (DPOAE), and auditory brainstem response (ABR), to confirm the diagnosis of ISSNHL. Magnetic resonance imaging (MRI) of the brain and internal auditory canals was also conducted to evaluate the presence of retrocochlear pathology. Those with middle ear diseases or abnormal MRI findings, such as labyrinthine hemorrhage, vestibular schwannoma, or other cerebellopontine angle tumors, were excluded. Patients with comorbidities of hypertension or diabetes, or taking any lipid-lowering drugs, anticoagulants, antiplatelet or fibrinolytic agents, were also excluded. Clinical data of all enrolled patients were collected and analyzed, including age, sex, laterality, the time to initial treatment, the severity of hearing loss, accompanying tinnitus, vertigo, and aural fullness, and cigarette-smoking history. Peripheral blood samples were obtained on admission for basic blood tests and biochemistry studies.
Zhu Y., He S., Liao K., Li M., Zhao Z, & Jiang H. (2023). Clinical Profiles and Prognoses of Adult Patients with Full-Frequency Sudden Sensorineural Hearing Loss in Combination Therapy. Journal of Clinical Medicine, 12(4), 1478.
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Publication 2023
Acoustic Neuroma Adult Anticoagulants Audiometry Audiometry, Speech Auditory Brainstem Responses BLOOD Brain Cerebellopontine Angle Tumor Cochlea Diabetes Mellitus Diagnosis Ear Ear Diseases External Auditory Canals Fibrinolytic Agents Functional Laterality Hemorrhage High Blood Pressures Hospital Admission Tests Hypolipidemic Agents Labyrinth Meniere Disease Otoacoustic Emissions, Spontaneous Otoscopy Patients Physical Examination Tinnitus Tympanometry Vertigo
5
Auditory Function Evaluation in Mice
Mice received 5 daily Tamoxifen injections. Minimally two days (and more often at least 5 days) elapsed between the last tamoxifen injection and collection of basal ABR data. Prior to auditory physiological measurements, mice were housed in a walk-in sound-attenuating chamber (Industrial Acoustics Co., North Aurora, IL, USA,).
For all lines of mice, both sexes were used. To assess sex effects, we used Bayesian inferential modeling. Otherwise, data from both sexes were compiled and analyzed in the same batch. Auditory thresholds, peak 1 amplitudes and latencies were assessed via the auditory brainstem response (ABR). The 2f1–f2 distortion product otoacoustic emission (DPOAE) amplitudes were also recorded. Mice were anaesthetized with a mixture of ketamine (100 mg/kg, IP) and xylazine (10 mg/kg, IP). Body temperature was maintained at 37 ± 1 °C with a heating pad controlled by monitoring body temperature via a rectal probe (FHC temperature regulation system). Subcutaneous needle leads were placed at the tail (ground), under the right pinna (reference) and at the vertex of the head (active). A custom produced speaker/microphone probe (contact Eaton Peabody Labs (Boston, MA, USA) engineering for stereolithography files) was lowered to the outside of the right ear canal. Custom LabView software (Cochlear Function Test Suite, Eaton Peabody Labs (Boston, MA, USA), Mass. Eye and Ear Infirmary) was used to present sound stimuli to the ear canal and record DPOAEs and ABRs. Recording frequencies spanned from 5.66 to 45.25 kHz and were presented in half-octave steps as previously described [112 (link)]. The ABR neural trace stack and the 2f1–f2 DPOAE was saved to the lab computer and then exported to a personal laptop for offline analysis. The ABR operator recorded initial decisions of ABR thresholds. As a secondary check on threshold, ABR Peak Analysis software was used to independently identify auditory thresholds and determine peak amplitude and latency of ABR wave 1 [131 (link)] (for software code see [132 (link)]).
Barnes C.C., Yee K.T, & Vetter D.E. (2023). Conditional Ablation of Glucocorticoid and Mineralocorticoid Receptors from Cochlear Supporting Cells Reveals Their Differential Roles for Hearing Sensitivity and Dynamics of Recovery from Noise-Induced Hearing Loss. International Journal of Molecular Sciences, 24(4), 3320.
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Publication 2023
Acoustics Auditory Brainstem Responses Auditory Perception Brain Stem Cochlea External Auditory Canals External Ear Gender Head Ketamine Mus Needles Nervousness Otoacoustic Emissions, Spontaneous Rectum Sound Stereolithography Tail Tamoxifen Xylazine

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More about "Otoacoustic Emissions, Spontaneous"

Explore the fascinating realm of Spontaneous Otoacoustic Emissions (SOAEs), a captivating auditory phenomenon.
SOAEs, also known as Spontaneous Emissions, are subtle sounds generated within the inner ear that can be detected using advanced instrumentation.
Uncover the secrets of this intriguing process with the help of cutting-edge AI technology from PubCompare.ai.
Dive into the research protocols that have been meticulously curated from the vast landscape of literature, preprints, and patents.
Leverage intelligent comparisons to identify the most robust and reliable protocols, enhancing the accuracy and reliability of your studies.
Discover how to optimize your research journey with seamless protocol selection and refinement, powered by PubCompare.ai's innovative solutions.
Delve into the complexities of the ER-10B microphone probe, the ER-10C close-field speakers, and the Real-time signal processing system, all of which play a crucial role in the detection and analysis of SOAEs.
Understand the capabilities of the TDT System 3, the AuDX Pro, and the AC40 clinical audiometer, as you navigate the technical aspects of your research.
Explore the intriguing connections between SOAEs and related concepts, such as the Rompun 2 anesthetic and the MEC-1000 system.
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