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Cholangiopancreatography, Magnetic Resonance

Magnetic Resonance Cholangiopancreatography (MRCP) is a non-invasive imaging technique used to visualize the bile and pancreatic ducts.
It utilizes magnetic resonance imaging (MRI) to generate detailed images of the hepatobiliary and pancreatic system, allowing for the evaluation of various conditions affecting these structures.
MRCP is particularly useful in the diagnosis of biliary tract diseases, pancreatic disorders, and other hepatobiliary pathologies.
The PubCompare.ai platform helps researchers optimize their MRCP research workflow by providing intelligent protocol comparisons from literature, pre-prints, and patents, ensuring they discover the most effective solutions for their studies.
This AI-driven approach enhances the accuracy and efficiency of MRCP research, leading to improved patient outcomes.

Most cited protocols related to «Cholangiopancreatography, Magnetic Resonance»

Between 1989 and 2012, 484 TP-IATs were performed at the University of Minnesota and University of Minnesota Amplatz Children’s Hospital. Of these, 75 were done in children and formed the study population. Our criteria for selection of patients with CP for TP-IAT has evolved over the years and have been standardized for the last 5 years.17 (link) Currently, to qualify for TP-IAT, the patient must have had abdominal pain of > 6 months duration with impaired quality of life e.g., inability to attend school, inability to participate in ordinary activities, repeated hospitalizations, or constant need for narcotics, each coupled with failure to respond to maximal medical treatment or endoscopic pancreatic duct drainage procedures. In addition, there must be objective findings of CP, including at least one of the following: (1) pancreas calcifications on CT scan, or abnormal ERCP, or ≥ 6/9 criteria on endoscopic ultrasound( EUS); or (2) any two of following three: (1) ductal or parenchymal abnormalities on secretin stimulated magnetic resonance cholangiopancreatography (MRCP), EUS of pancreas with 6/9 criteria positive, or abnormal pancreatic function tests with peak bicarbonate < 80 mmol/L).; or (2) Histopathologic confirmed diagnosis of chronic pancreatitis from previous operations; or (3) Hereditary pancreatitis (PRSS1 gene mutation, (SPINK1 gene mutation, CFTR gene mutations), with a compatible clinical history ; or (4) History of recurrent acute pancreatitis with > 3 episodes of pain associated with imaging diagnostic of acute pancreatitis and/or elevated serum amylase or lipase 3 times normal.17 (link)The current study was approved by the University of Minnesota Institutional Review Board. Informed consent and assent were obtained from parents and patients for all patients participating in quality of life assessments.
Publication 2014
Abdominal Pain Acidic Pancreatic Trypsin Inhibitor Bicarbonates Child Cholangiopancreatography, Magnetic Resonance Congenital Abnormality Cystic Fibrosis Transmembrane Conductance Regulator Diagnosis Drainage Endoscopic Retrograde Cholangiopancreatography Ethics Committees, Research Hereditary pancreatitis Hospitalization Hyperamylasemia Lipase Mutation Narcotics Pain Pancreas Pancreatic Duct Pancreatic Function Test Pancreatitis, Acute Parent Patients Physiologic Calcification PRSS1 protein, human Secretin Serum Surgical Endoscopy X-Ray Computed Tomography

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Publication 2014
Abdomen Cholangiopancreatography, Magnetic Resonance Disease Progression Endoscopic Retrograde Cholangiopancreatography Ethics Committees, Research Genetic Predisposition to Disease Hereditary pancreatitis Pancreatic Diseases Pancreatitis Patients Physiologic Calcification Radionuclide Imaging Replicon X-Ray Computed Tomography
This study was approved by the Institutional Review Board of our Hospital. Informed consent was signed by the guardians of each child. We retrospectively reviewed the medical records of 75 patients with PBM (24 males; 51 females; age range 2 months to 13 years) who were hospitalized between January 2002 and December 2011. The gold standard for the selection of PBM patients was defined as >5 mm common channel as detected by MRCP, intraoperative cholangiography and CT [4 (link)]. PBM was classified based on Komi’s method [5 ] to the following three types: type I joining of common bile duct with pancreatic duct at approximately 90°, type II joining of pancreatic duct with common bile duct usually at 90°, type III complex arrangement of pancreatic duct and terminal portion of common bile duct.
All patients underwent intraoperative cholangiography. Computed tomography (CT; Philips, Amsterdam, Netherlands) was performed using the anteroposterior projection with the child lying supine. The CT protocols and technical parameters included 5 mm collimation at 10 mm intervals. Ultrasonography (US) (LOGIQ 5 PRO; GE Healthcare, Little Chalfont, UK) was carried out with 5–12 MHz curved and linear abdominal transducers. Magnetic resonance cholangiopancreatography (MRCP) was performed (under sedation for subjects at <10 years of age) on a Symphony 1.5 T scanner (Siemens, Erlangen, Germany) with an abdominal phased array coil under the following modes: T1-weighted and T1-weighted fast spin series (field of view 24–28 cm, repetition time [TR] 173 ms, echo time [TE] 2.64 ms, flip angle 70, matrix 256 × 128, radiofrequency (RF) bandwidth 260 Hz/Px) and a T2-weighted sequence (TR 1,000 ms, TE 60 ms, RF bandwidth 230 Hz/Px). For MRCP, half fourier acquisition single shot turbo spin echo (HASTE) was used with multilayer thin coronal and axial T2-weighted imaging (TR 1,200 ms, TE 80 ms, slice thickness 4 mm). Oblique thick slabs were acquired in the planes of the common bile duct and pancreatic duct. For multi-angle imaging, TR was 4,500 ms, TE 950 ms and slice thickness 60 mm.
Two radiologists who were unaware of the pathological findings independently reviewed the images and reached consensus through discussion. A diagnosis of PBM was established if the common channel is longer than 5 mm. They also assess the shape of the intrahepatic bile duct and gallbladder, pancreatitis, surgical pathology, symptom profiles, operative notes and pathological records were compared with the imaging findings.
Publication 2012
Abdomen Bile Child Cholangiography Cholangiopancreatography, Magnetic Resonance Choledochus CT protocol Diagnosis ECHO protocol Electron Transport Complex III Ethics Committees, Research Females Gallbladder Gold Intrahepatic Bile Duct Legal Guardians Males Pancreatic Duct Pancreatitis Patients Radiologist Sedatives Transducers Ultrasonography X-Ray Computed Tomography
The present study included 248 black and 911 white subjects with CP enrolled in the NAPS2 studies that also had clinical data available for analysis. Supplementary Table 1 shows detailed information on the number of participating centers and CP patients enrolled in individual NAPS2 studies. CP was defined by the presence of definitive changes on imaging studies—computerized tomography scan, magnetic resonance imaging/magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography (Cambridge classification), or endoscopic ultrasound (presence of 5 or more findings or presence of calcifications) or histology. Disease duration was defined as age at enrollment minus earliest age at first attack of pancreatitis or the development of symptoms compatible with CP according to physician reporting.
Publication 2016
Cholangiopancreatography, Magnetic Resonance Endoscopic Retrograde Cholangiopancreatography Pancreatitis Patients Physicians Physiologic Calcification Radionuclide Imaging Ultrasonography, Endoscopic X-Ray Computed Tomography

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Publication 2014
Abdominal Pain Acidic Pancreatic Trypsin Inhibitor Bicarbonates Cholangiopancreatography, Magnetic Resonance Congenital Abnormality Cystic Fibrosis Transmembrane Conductance Regulator Diagnosis Drainage Endoscopic Retrograde Cholangiopancreatography Ethics Committees, Research Hereditary pancreatitis Hospitalization Hyperamylasemia Lipase Mutation Narcotics Pain Pancreas Pancreatic Duct Pancreatic Function Test Pancreatitis Pancreatitis, Acute Pancreatitis, Chronic Patients Physiologic Calcification PRSS1 protein, human Reproduction Secretin Serum Surgical Endoscopy X-Ray Computed Tomography

Most recents protocols related to «Cholangiopancreatography, Magnetic Resonance»

All patients complained of abdominal pain. They were diagnosed with choledocholithiasis through magnetic resonance cholangiopancreatography. Informed consent was obtained from the patients for the publication of this case’s report details.
Publication 2023
Abdominal Pain Cholangiopancreatography, Magnetic Resonance Choledocholithiasis Patients
PSC is progressive biliary fibrosis affecting intra and/or extrahepatic bile ducts[12 (link)] and diagnosed by laboratory tests [(cholestasis, Antineutrophil cytoplasmic antibodies (ANCA)], radiology [abdominal ultrasonography (US), abdominal computed tomography (CT), endoscopic retrograde cholangiopancreatography (ERCP), or magnetic resonance cholangiopancreatography (MRCP)], and liver biopsy. Primary biliary cholangitis (PBC) is characterized by the loss of small and medium-sized bile ducts on liver biopsy, elevated anti-mitochondrial antibodies, and altered gamma-glutamyl transferase and alkaline phosphatase (ALP) levels[13 (link)]. Non-alcoholic fatty liver disease (NAFLD) is characterized by fat storage in ≥ 5% of hepatic steatosis in the absence of concomitant liver disease (chronic viral hepatitis), use of steatosis-inducing medications (amiodarone or tamoxifen), autoimmune hepatitis, hemochromatosis, Wilson's disease, or excessive alcohol consumption[14 (link)]. Diagnosis of NAFLD was made by liver biopsies or US[15 (link)], and the severity score was previously stated[16 (link)]. Autoimmune hepatitis diagnosis based on the International Autoimmune Hepatitis Group criteria with a score of > 15 points consisting of demographic, histologic, and laboratory markers, including antinuclear antibodies with a titer of at least 1:40 and liver histology[17 (link)]. An aseptic liver abscess is diagnosed based on IBD history, US, and CT[18 (link)]. Ultrasound, colour Doppler, and/or CT scans were used to detect portal vein thrombosis.
Publication 2023
Abdomen Alkaline Phosphatase Amiodarone Anti-Antibodies Antibodies, Antinuclear Antineutrophil Cytoplasmic Antibodies Asepsis Autoimmune Chronic Hepatitis Bile Bile Ducts, Extrahepatic Biopsy Cholangiopancreatography, Magnetic Resonance Cholestasis Duct, Bile Endoscopic Retrograde Cholangiopancreatography Fatty Liver Fibrosis gamma-Glutamyl Transpeptidase Hemochromatosis Hepatic Duct Hepatitis, Chronic Hepatolenticular Degeneration Liver Liver Abscess Liver Diseases Mitochondria Non-alcoholic Fatty Liver Disease Pharmaceutical Preparations Primary Biliary Cholangitis Radiography Radionuclide Imaging Steatohepatitis Tamoxifen Thrombosis Ultrasonography Veins, Portal Venous Thrombosis X-Ray Computed Tomography
For histological assessment, a cross-sectional sample of distal donor bile duct was taken at the end of cold ischemia just before liver implantation. Specimens were processed in 10% neutral buffered formalin and stained in hematoxylin and eosin. They were examined independently by 2 blinded hepatobiliary pathologists‚ and discrepancies in scores were resolved with multiheader consensus. Bile duct injury was scored using a bile duct injury scoring system as described by Op den Dries et al.4 (link) This is a semiquantitative systematic histological scoring system for bile duct injury that examines the biliary epithelium, mural stroma, vascular plexus, peribiliary glands, inflammation, bleeding‚ and thrombosis within bile duct samples. This histological scoring system has been shown to correlate with biliary complications.4 (link)Recipients were managed intraoperatively and postoperatively in the standard fashion at the ANLTU. Recipients were followed up for 24 mo‚ and medical records were comprehensively reviewed for outcome data. The clinical endpoint was biliary complications occurring within 24 mo from transplantation. Biliary complications were diagnosed by clinical or biochemical suspicion, and routine imaging was not performed because of low diagnostic yield in asymptomatic patients.15 (link) No threshold for liver biochemistry was used to trigger biliary investigation. Biliary complications included biliary strictures and bile leaks. Biliary strictures were defined as any narrowing of the donor biliary tree on magnetic resonance cholangiopancreatography or endoscopic retrograde cholangiopancreatography.16 (link),17 (link) Not all cases of biliary strictures underwent endoscopic retrograde cholangiopancreatography because of anatomic location or severity of clinical symptoms. Biliary strictures were subcategorized into anastomotic strictures (AS) and non-AS (NASs). AS was defined as strictures localized to the biliary anastomosis. NAS was defined as any stricture in the donor biliary tree away from the biliary anastomosis. Bile leak was defined as the presence of bilirubin in the posttransplant drain or extravasation of bile on biliary imaging.
This trial was prospectively registered on the Australian and New Zealand Clinical Trials Registry (U1111-1179-9801) and approved by the Sydney Local Health District Ethics Review Committee (Approval Number X15-0444).
Publication 2023
Bile Bilirubin Blood Vessel Cholangiopancreatography, Magnetic Resonance Desiccation Diagnosis Donors Duct, Bile Endoscopic Retrograde Cholangiopancreatography Eosin Epithelium Formalin Inflammation Injuries Ischemia, Cold Liver Ovum Implantation Pathologists Patients Precipitating Factors Stenosis Surgical Anastomoses System, Biliary Thrombosis Transplantation
Prospectively collected data of all patients who underwent extended hepatectomy at the department of surgical gastroenterology from October 2012 to April 2022 were analyzed retrospectively. Ethical approval to conduct the study was obtained from the Institutional Review Committee of the Institute of Medicine with reference number 210(6-11)E2.
Preoperative assessment
The standard preoperative assessment included a detailed history and physical examination, hematological and biochemical investigations including liver function test, hepatitis B/C status, biomarkers (mainly CEA, CA19.9, and AFP), ultrasonography of the abdomen, and contrast-enhanced computer tomography (CECT) of the abdomen with liver volumetric assessment. Magnetic resonance cholangiopancreatography (MRCP) was done in selected patients requiring assessment of biliary tract anatomy like hilar cholangiocarcinoma. Patients presenting with biliary obstruction and cholangitis had biliary drainage using percutaneous transhepatic biliary drainage (PTBD) to decrease the level of bilirubin and resolve cholangitis.
A standard FLR (sFLR) was calculated in all patients by measuring the ratio of CT-measured FLR with total estimated liver volume (TELV) by using the formula TELV= -794.41 + 1267.28 X BSA) [6 (link)]. More than 25% of sFLR was considered safe. Patients with low FLR underwent liver augmentation by either portal vein embolization (PVE) (Fig 1), portal vein ligation (PVL), or partial ALPPS. A repeat CT scan was done in three weeks in cases with PVE and 10 days in cases with partial ALPPS to assess the extent of compensatory liver hypertrophy. A surgical decision was then made based on CT volumetry.
Surgical techniques
Staging laparoscopy was done in selected cases of malignancy (a total of 10 cases, six cases of carcinoma gallbladder, and two cases of hilar cholangiocarcinoma). A modified Makuuchi incision was given in all cases. Complete mobilization of the liver was done and inflow and outflow control were taken. Parenchymal transection was aided by a Hanging maneuver [7 (link)]. Transaction techniques (Kelly-clysis, harmonic scalpel, or monopolar cautery) were at the surgeon’s discretion. After completion of the transection, bilioenteric anastomosis was done by Roux en Y hepaticojejunostomy.
For patients undergoing partial ALPPS, first-stage surgery was partial transection of liver parenchyma along with ligation of the right portal vein. Second-stage surgery comprises of completion of the transection with Roux-en-Y hepaticojejunostomy (Figure 2).
Data collection
All variables (demographics, intraoperative, and postoperative) that were recorded in the departmental database were reviewed. Missing data were obtained from hospital record files. The 30-day postoperative outcomes including follow up were reviewed.
Outcomes and definitions
The outcomes measured were overall and hepatectomy-specific complications, a comparison of postoperative outcomes among the liver volume augmentation group versus no augmentation group, and perioperative factors affecting major complications. Hepatectomy-specific complications like PHLF and bile leak were defined as per the International Study Group of Liver Surgery (ISGLS) 2011 [8 (link)-9 (link)]. Small-for-size syndrome (SFSS) for extended hepatectomy was defined by the University of Heidelberg (2015) [10 (link)]. Other complications were defined and graded as per the Clavein Dindo grading system [11 (link)]. Perioperative mortality was defined as mortality within 30 days of surgery.
Statistical analysis
We analyzed data using SPSS version 25 (IBM Corp., Armonk, NY). Data were presented in numbers, mean ± SD, and percentages where appropriate. The correlation between variables was analyzed using Fischer’s exact test for categorical variables and sample t-test for continuous variables. A p-value of <0.05 was taken as statistically significant.
Publication 2023
Abdomen Bile Bilirubin Biological Markers CA-19-9 Antigen Cancer of Gallbladder Cauterization Cholangiopancreatography, Magnetic Resonance Cholangitis Cholestasis Drainage Embolization, Therapeutic Hepatectomy Hepatitis C virus Klatskin Tumor Laparoscopy Ligation Liver Liver Function Tests Malignant Neoplasms Operative Surgical Procedures Patients Physical Examination Roux-en-Y Anastomosis Surgeons Surgical Anastomoses Syndrome System, Biliary Tomography Tomography, Spiral Computed Ultrasonography Veins, Portal X-Ray Computed Tomography
A retrospective study was done utilizing the preoperative planning magnetic resonance cholangiopancreatography (MRCP) performed for living donor liver transplantation (LDLT). Sixty-five donor MRCP examinations performed for LDLT between January 2013 and July 2018 at the Global Hospitals Group (Chennai and Bengaluru, India) and Aster Medcity (Kochi, India) were studied retrospectively to evaluate the frequency of anatomical variations of the biliary tree. The age group of the donors was in the range of 20 to 51 years. A total of 105 MRCP studies performed for potential liver donors during the period were evaluated. We excluded 25 MRCP studies as there were no intraoperative cholangiograms available for us to compare, and we also excluded an additional 15 MRCP studies that had respiratory movement artifacts that prevented us from having a meaningful interpretation. The remaining 65 MRCP examinations were included in the study.
Inclusion and Exclusion Criteria
All the completed MRCP studies, without significant respiratory movement artifacts, performed as a part of the preoperative planning protocol for LDLT were included in the study. Donors who were not able to complete the study or whose images contained respiratory movement artifacts impeding accurate interpretation were excluded. We also excluded donors if the intraoperative cholangiogram images were not made available for us to compare.
The institutional review board approved the retrospective study. Informed consent was waived.
As a part of the pre-transplantation donor workup, MRI with MRCP was performed on a 1.5T MRI GE machine for all these candidates. A single-shot fast spin echo sequence (SSFSE, GE Medical Systems) was performed for all the donors after the planning sequences. A respiratory-gated three-dimensional turbo spin echo sequence was also performed that offered a high signal-to-noise ratio, improved spatial resolution, and high contrast-to-noise ratio. Each donor received a phased-array body coil. We preferred to do the procedure after an overnight fast. Sometimes, we also gave pineapple juice to the donors as an oral negative contrast for a better appreciation of the biliary tract.
MRCP source data sets were processed with maximum intensity projections, surface shading, and multi-planar reconstructions. The images were reviewed by two radiologists and compared with an intraoperative cholangiogram. Intraoperative cholangiograms performed via cystic duct cannulation were considered the gold standard. Sensitivity, specificity, and accuracy were calculated based on the findings.
Publication 2023
Age Groups Anatomic Variation Aster Plant Cannulation Cholangiography Cholangiopancreatography, Magnetic Resonance Donors Ducts, Cystic ECHO protocol Ethics Committees, Research Gold Human Body Hypersensitivity Liver Liver Transplantations Living Donors Movement Physical Examination Pineapple Radiologist Reconstructive Surgical Procedures Respiratory Rate System, Biliary Transplantation Vibration

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More about "Cholangiopancreatography, Magnetic Resonance"

Magnetic Resonance Cholangiopancreatography (MRCP) is a non-invasive imaging technique that utilizes magnetic resonance imaging (MRI) to generate detailed visualizations of the bile and pancreatic ducts.
This advanced modality, also known as MR Cholangio-Pancreatography, is particularly useful for the evaluation of various hepatobiliary and pancreatic conditions, including biliary tract diseases, pancreatic disorders, and other pathologies affecting these structures.
The MRCP procedure involves the use of specialized MRI equipment, such as the Ingenia, Achieva 3.0T, or Signa HDxt V16.0 systems, to capture high-quality images of the hepatobiliary and pancreatic systems.
During the imaging process, a contrast agent, such as Gd-DTPA (Magnevist) or CV-290, may be administered to enhance the visualization of the ducts and associated structures.
The resulting MRCP images can be analyzed using advanced software tools, like Synapse 3D, to aid in the diagnosis and management of a wide range of conditions.
The data can also be processed and interpreted using statistical analysis software, such as SPSS version 23.0 or 21.0, to gain deeper insights and support research efforts.
The PubCompare.ai platform leverages artificial intelligence to assist researchers in optimizing their MRCP research workflow.
By providing intelligent protocol comparisons from literature, pre-prints, and patents, the platform helps users discover the most effective solutions for their studies, ultimately enhancing the accuracy and efficiency of MRCP research and leading to improved patient outcomes.