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Corneal Topography

Corneal Topography is a non-invasive imaging technique that maps the surface curvature of the cornea, the clear front part of the eye.
This data provides valuable insights into the shape and irregularities of the cornea, which is crucial for diagnosis and management of various eye conditions such as keratoconus, astigmatism, and refractive errors.
Corneal topography can also be used to guide surgical procedures like LASIK and corneal transplants.
By analyzing the detailed corneal surface data, clinicians can optimize treatment plans and improve patient outcomes.
Researchers leveraging corneal topography can gain a deeper understaning of corneal biomechanics and explore new diagnostic and therapeutic approaches.

Most cited protocols related to «Corneal Topography»

This prospective interventional case series study received approval by the Ethics Committee of our Institution, adherent to the tenets of the Declaration of Helsinki. Informed consent was obtained from each subject at the time of the intervention. The study was conducted on patients in our clinical practice, during scheduled pre- and postoperative procedure visits.
The 109 consecutive patients enrolled in the study underwent uncomplicated primary bilateral LASIK performed by the same surgeon (AJK) using the same refractive surgery platform (WaveLight FS200 Femtosecond Laser and WaveLight EX500 Excimer Laser; Alcon Laboratories, Ft Worth, TX, USA), between September 2009 and September 2010.
Preoperative spherical equivalent (SE) was between 0.00 and −8.00 diopters (D), and up to 4.25 D of cylinder refractive error.
Exclusion criteria for the LASIK operation were: systemic or ocular diseases, eyes with history of corneal dystrophy or herpetic eye disease, topographic evidence of keratoconus (as evidenced by Placido topography) or warpage from contact lenses, corneal scaring, glaucoma, severe dry eye, and collagen vascular diseases. The average flap thickness (planned 110 μm) was 107 ± 5 μm. The average flap diameter (planned 8.00 mm) was 7.95 ± 0.05 mm. Flap thickness was measured by subtracting the central cornea pachymetry, measured with the EX500 following flap creation, from the central cornea pachymetry, measured preoperatively with the WaveLight Oculyzer II diagnostic device (Alcon Laboratories) (with integrated Scheimpflug topography camera) and the WaveLight OB820 biometer (Alcon Laboratories) that were both integrated within the platform.17 (link)
All eyes were evaluated preoperatively for best corrected distance visual acuity (CDVA) and postoperatively for uncorrected distance visual acuity (UDVA). Preoperative evaluations included wavefront analysis, pupillometry, and contrast sensitivity. Postoperative examination included manifest and dilated refraction, slit-lamp microscopy, tonometry, and keratometry, by means of corneal topography and tomography assessment.
Postoperative follow-up examinations were conducted at 1 week, 3 months, 6 months, and 1 year. Data processed in this study represent the 3-, 6-, and 12-month visits.
Data were loaded and processed using web-based refractive analysis software (IBRA Ophthalmic Outcome Analysis System; Zubisoft GmbH, Oberhasli, Switzerland).18 (link)
Publication 2013
Blood Vessel Collagen Collagen Diseases Contact Lenses Contrast Sensitivity Cornea Corneal Pachymetry Corneal Topography Diagnosis Dry Eye Eye Eye Disorders Glaucoma Hereditary Corneal Dystrophy Institutional Ethics Committees Keratoconus Keratomileusis, Laser In Situ Lasers, Excimer Medical Devices Ocular Refraction Patients Physical Examination Postoperative Procedures Refractive Errors Slit Lamp Examination Surgeons Surgeries, Refractive Surgical Flaps Tomography Tonometry, Ocular Vascular Diseases Vision Visual Acuity
The morphogeometric modeling used in the current study has been previously defined in detail and validated by our research group5 (link). The procedure can be summarized in the following steps:
Step 1: Export of corneal topography files. All these files were exported in.csv format from the corneal topographer.
Step 2: Preparation of the point cloud. Exported CSV topography files provide raw data of the spatial points that conform both anterior and posterior corneal surfaces, indicating the coordinates of every scanned point in polar format (radii and semi-meridians), so an algorithm developed in Matlab software was used to convert data into Cartesian coordinates (X, Y, Z). For such purpose, every row of the CSV file was considered to represent a circle in the corneal map and every column a semi-meridian, providing a total of 256 points for each radius. Each i-th row sampled a map on a circle of i * 0.2 mm radius (0, 0.2, 0.4…6 mm), and each j-th column sampled a map on a semi-meridian in the direction of j * 360/256°, so each value of the matrix [i, j] represented the elevation of the point P (i * 0.2, j * 360/256°) in polar coordinates. However, due to the presence of extrinsic patient factors during the measurement process, such as the stability of the tear film, or an obstruction of the visual field by tabs or inadequate eyelid opening at the moment of the data collection, data provided by the Sirius device for determined points of the peripheral zones can be invalid, obtaining in these cases a value of −1000 in the corresponding matrix cells. Because of the presence of these erroneous values, a filtering process is performed to all the CSV files generated for each cornea, selecting for the study only those cases that contain in their first 21 rows (radii from 0 mm to 4 mm with respect to the normal corneal vertex) correct values (256 values for each row), discarding from the study any case in which an invalid −1000 value was detected within this range. This filtering process ensured that all data used for the generation of the point clouds was real and no interpolation was performed5 (link).
Step 3: Geometric Surface Reconstruction. The point cloud representing the corneal geometry was imported into the surface reconstruction software Rhinoceros v5.0. The surface that best fits the point cloud was generated with the Rhinoceros’s patch surface function that tries to minimize the nominal distance between the 3D point cloud and the solution surface. The settings of the function were configured as follows: sample point spacing 256, surface span planes 255 for both u and v directions, and stiffness of the solution surface 10–3 (mm).
Step 4: Solid Modeling. The resulting surface was imported into the solid modeling software SolidWorks v2012. With this software, the solid model representing the custom and actual geometry of each cornea was generated.
Step 5: Definition and evaluation of the volumetric parameters.
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Publication 2017
Cells Cornea Corneal Topography Eyelids MAP2 protein, human Medical Devices Meridians Patients Radius Reconstructive Surgical Procedures Seizures Strains Tears
All subjects underwent AS-OCT using CASIA2. The CASIA2 uses a 1310 nm swept-source laser wavelength at a frequency of 0.3 seconds, producing 16 AS-OCT images from 16 different angles and a 3-dimensional analysis of the results. Further, it automatically measures the tilt and decentration of the crystalline lens or the IOL relative to the corneal topographic axis. All subjects were measured two times under non-mydriatic conditions and two times under mydriatic conditions. A mixture of 0.5% tropicamide and 0.5% phenylephrine hydrochloride (Mydrin-P, Santen, Osaka, Japan) was used to induce mydriasis. All AS-OCT measurements were taken after at least one week passed following cataract surgery [16 (link)]. All measurements were performed by a single ophthalmologist for each subject.
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Publication 2017
Cataract Extraction Corneal Topography Epistropheus Lens, Crystalline Mydriasis Mydriatics Neoplasm Metastasis Ophthalmologists Phenylephrine Hydrochloride Tropicamide
All the eyes underwent routine preoperative examinations including best-corrected visual acuity (BCVA), intraocular pressure (IOP), cycloplegic and manifest refraction, anterior segment examination by slit-lamp, corneal topography and tomography measurements. The eyes were divided into three groups according to the manifest SE: low myopia (− 3.00 D < SE ≤  − 0.50 D), moderate myopia (− 6.00 D < SE ≤  − 3.00 D) and high myopia (SE ≤  − 6.00 D). The eyes were also divided into five groups according to the MA: MA < 0.50 D, 0.50 D ≤ MA < 1.00 D, 1.00 D ≤ MA < 2.00 D, 2.00 D ≤ MA < 3.00 D, MA ≥ 3.00 D.
Pentacam examination was performed by experienced technicians. The Pentacam instrument (Pentacam HR, Oculus GmbH, Wetzlar, Germany) was calibrated regularly on a weekly basis. The patients were positioned in front of the Pentacam instrument with the forehead and chin properly supported and both lateral canthi aligned with the marks. The patients were asked to blink 2–3 times to have the tear film evenly distributed on the cornea and then open the eyes wildly to stare at the fixation target while the instrument was proceeded to the cornea. Once the red cross on the screen coincided the red circle at the pupil center, the instrument automatically captured 50 rotational Scheimpflug images within 2 s. The power and axis of the keratometric astigmatism and PCA were measured within the central 3 mm using a default refractive indexes for the cornea (1.376) and aqueous humor (1.336). The procedure was performed again if the patient’s eye blinked during the measurement or quality of the scan was poor (comment on the display marked yellow or red). Only image covered at least central 8.0 mm of corneal surface and image quality labelled with ‘OK’ on the display was accepted. Pentacam data of the eyes were retrieved from the machine and only results with image quality labelled with ‘OK’ were included.
ACA was defined as WTR when the steepest meridian was 90° ± 30°, as ATR when the steepest meridian was between 0–30° or 150–180°, and as OBL when the steepest meridian > 30° and < 60°, or > 120° and < 150°. Because the posterior corneal surface has negative refractive power (divergent), we used other classification labels for the PCA to avoid confusion with the ACA. The PCA was defined as SMV when the steepest meridian was 90° ± 30°, as SMH when the steepest meridian was between 0°–30° and 150°–180°, and as SMO in the rest. Aggregate PCA was calculated as previously described30 (link).
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Publication 2020
Aqueous Humor Astigmatism Chin Cornea Corneal Topography Cycloplegics Epistropheus Eye Forehead Lateral Canthus Meridians Myopia Ocular Refraction Patients Physical Examination Pupil Radionuclide Imaging Slit Lamp Examination Tears Tomography Tonometry, Ocular Vision Visual Acuity
All patients underwent a complete eye examination including the following tests: anamnesis, measurement of uncorrected (UDVA) and corrected (CDVA) distance visual acuity, manifest refraction, slit-lamp biomicroscopy, and corneal analysis by the Sirius system (Costruzione Strumenti Oftalmici, Italy). Repeatability of the topographic measurements provided by the Sirius system in keratoconic eyes are demonstrated in previous studies [17 (link)]. All tests were performed by a single experienced examiner. A minimum of three corneal topographies were successively obtained for each cornea and the best one (the topography with the highest acquisition quality for the Scheimpflug image and keratoscopy) selected to provide data for this study. All corneal topography files were exported in.csv format. Likewise, all cases were classified according to the Amsler-Krumeich grading system [1 (link)].
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Publication 2017
Cornea Corneal Topography Eye Immunologic Memory Ocular Refraction Patients Slit Lamp Examination Visual Acuity

Most recents protocols related to «Corneal Topography»

The BCVA examination with Snellen chart, intraocular pressure (IOP) measurement with Goldmann applanation tonometer, biomicroscopic anterior segment examination, and fundus examination were performed by the same ophthalmologist in each patient. Cases detected glaucoma in fundus examination and IOP measurements according to the European Glaucoma Society guidelines (10 ) were excluded from the study. The eyes of the participants were evaluated for (UEH; easily everted upper eyelids) and FES. It was considered as UEH if tarsal plate turn easily with gentle traction on the upper eyelid. If papillary conjunctivitis was accompanied by UEH, it was defined as FES (11 (link)). All ophthalmic examinations and measurements were done for each individual in the identical testing room under standard condition by same experienced person (II) in the same time zone (between 9 and 12 a.m) without pupil dilation. Participants were also compared with regard to systemic conditions such as systemic HT and body-mass index (BMI). Corneal topography and anterior segment measurements were obtained by the Scheimpflug method by Sirius Topography system (CSO SIRIUS 3D Rotating Scheimpflug Camera and Topography System V.3.2).
Publication 2023
Conjunctivitis Corneal Topography Europeans Eyelids Glaucoma Index, Body Mass Mydriasis Ophthalmologists Patients Physical Examination Slit Lamp Examination Tonometry Traction
This was a single-surgeon, retrospective study of patients undergoing femtosecond laser-assisted cataract surgery with arcuate incisions for the reduction of astigmatism. Arcuate incision anatomy was calculated using the LaserArcs online nomogram. The primary endpoint of this study was the percent reduction in absolute magnitude of astigmatism in the subject population based upon the absolute difference of postoperative manifest refraction. Postoperative manifest cylinder was the exploratory endpoint.
All patients had undergone a preoperative manifest refraction, and keratometry was determined using an IOLmaster V (Carl Zeiss Meditec, Oberkochen, Germany) with software version 5.2.1 to 5.4 or a LenStar LS900 (Haag-Streit, Bern, Switzerland) version 4.2.1 to 4.4.0, which are comparable instruments for the purposes of corneal power measurement.12 (link) Posterior corneal astigmatism and central topography were both included in these calculations. Biometry data was manually uploaded to the online LaserArcs software for calculation, and a graphical printout (Figure 1) was generated for use in surgery.

The LaserArcs software graphical output. Reprinted with permission from LaserArcs.

All arcuate incisions were made to an 8.0 mm diameter at a depth 80% of the corneal thickness as measured by the OCT corneal depth measurement of the LenSx (Alcon, Ft Worth) femtosecond laser. Laser arcuate incisions were not further manipulated or opened by the surgeon. The femtosecond laser was also used to create an anterior capsulotomy of 5.5 mm and for lens fragmentation. No other incisions were made with the femtosecond laser. No toric lens implants were used in study eyes, and an attempt was made to include about 30% of patients receiving multifocal implants with preoperative cylinder less than 0.7 D, so the study could evaluate the common scenario of correcting astigmatism with a multifocal implant where a sufficiently low toric power is not available. All postoperative refraction data was collected one month after surgery.
A sample size estimation was performed using results from an independent data set of 400 eyes and determined that 50 unilateral eyes would provide >90% statistical power to demonstrate a clinically meaningful percent reduction of astigmatism with a target reduction of 60%. All enrolled subjects were required to be 22 years of age or older and had cataracts but otherwise healthy eyes, not exhibiting any significant ocular morbidity that would be expected to influence outcome measures. All patients had preoperative keratometric astigmatism greater than 0.25 D and were implanted with a non-toric IOL, and all patients’ laser astigmatic keratotomy was planned using the LaserArcs nomogram. Patients with visually significant co-morbidities that could affect their visual outcome after surgery, like corneal, retinal, or optic nerve disease, were excluded, and all patients had a preoperative corneal topography screening for ectasia, higher-order aberrations, or other abnormalities and would be excluded from treatment if significant corneal pathology were identified. Patients with surgical complications either during or after surgery (capsule tears, iris trauma, decentered IOL, cystoid macular edema, etc.) that would, in the judgment of the investigator, influence the outcome measures of the study, and patients with previous refractive surgery prior to cataract surgery were also excluded.
Prior to collection of retrospective data, this study was registered on ClinicalTrials.gov as NCT 05278442. It was also approved by WCG IRB (Puyallup, Washington) as protocol 20220599 and adhered to both the Declaration of Helsinki and good clinical practices as defined by the U.S. Food and Drug Administration. A waiver of written informed consent was provided by the IRB. Reasonable requests for de-identified patient data relating to the study findings will be available through the corresponding author for 5 years following the publication date.
Publication 2023
Astigmatism Capsule Cataract Cataract Extraction Congenital Abnormality Cornea Corneal Astigmatism Corneal Topography Eye Hepatitis A Antigens Iris Laser Surgery Lens, Crystalline Lens Implantation, Intraocular Macular Edema, Cystoid Neural-Optical Lesion Ocular Refraction Operative Surgical Procedures Pathological Dilatation Patients Retina Surgeons Surgeries, Refractive Tears Vision Wounds and Injuries

Medical equipment: Any equipment intended for use in the diagnosis of disease or other condition or for use in the life support and monitoring of patients in the study hospitals which included chemistry a analyzer, electrolyte analyzer, hematology analyzer, coagulation analyzer, PCR machine, ELISA machine, microscopy, centrifuges, CD4 count machine, X-ray Machine, Ultrasound machine, magnetic resonance imaging (MRI), CT scan, ECG Monitor, ventilators, Anesthesia machine, ABGA machine, corneal topography, and Visual Yag III laser system.

Use coefficient (UC): UC was applied to assess the utilization of equipment, ie, whether the equipment was optimally utilized or underutilized. It was measured by the following formula; UC = (A × B/C × D) × 100, where, A is the number of days, the medical diagnostic equipment was actually used during for 12 months from July 01, 2020 to June 30, 2021. B is the number of hours the equipment was actually used on a working day during the 12-month period from July 01, 2020 to June 30, 2021 (average time taken by a procedure by that equipment average number of procedures performed on a working day). “C” is the number of days the medical diagnostic equipment could have been available (if the equipment was put in working order). For this, the total number of working days in 12 months from July 01, 2020 to June 30, 2021, was found out as mentioned above. “D” is the number of hours the medical equipment could have been available on a working day (if the equipment was put in working order).19 To assess the UC of the equipment, the working hours of the study hospitals were recorded. If the UC is ˂50%, it is considered to be underutilized and hence a bad investment due to inefficient utilization.3 (link)

Efficient utilization: If the percentage of the average number of hours the medical equipment was used per day divided by the maximum number of hours the equipment could be used per day in study hospitals was ≥50% for the past 12 months from July 01, 2020 to June 30, 2021.

Equipment related factors: Any factors that were expected to be inherited from the selected medical equipment in the study hospitals and could affect the efficient utilization of the equipment for the past 12 months from July 01, 2020 to June 30, 2021.

Institutional related factors: Any factors related to the study referral hospitals that could affect the efficient utilization of the selected equipment in the study hospitals for the past 12 months, from July 01, 2020, to June 30, 2021.

Professional operated related factors: Any factors related to the professional personnel in charge of operating the medical equipment that could have an impact on the efficient utilization of the selected equipment in study hospitals over the previous 12 months, from July 01, 2020 to June 30, 2021.

Publication 2023
Anesthesia CD4+ Cell Counts Coagulation, Blood Corneal Topography Diagnosis Diagnostic Equipment Electrolytes Enzyme-Linked Immunosorbent Assay Hospital Referral Medical Devices Microscopy Patient Monitoring Radiography Ultrasonography Ventilators X-Ray Computed Tomography YAG Lasers
All patients underwent a complete ophthalmologic examination before ICRS surgery and one and six months after surgery. This examination included determinations of uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) on manifest refraction. A Scheimpflug camera with a Placido disc was used to obtain simulated corneal topography, asphericity and corneal aberrometry data. An AS-OCT pachymetry map (16 mm scan diameter, 25 radials, 1024 axial scans) was used to provide an 8 mm diameter scan of total corneal thickness and epithelial thickness mapping data (the central 3 mm zone and 24 peripheral sites in the 3 mm to 8 mm zones centered on the pupillary axis).
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Publication 2023
Aberrometry Cornea Corneal Topography Epistropheus Ocular Refraction Operative Surgical Procedures Ophthalmologic Surgical Procedures Patients Pupil Radionuclide Imaging Visual Acuity
Corneal topography (Keratograph 5 M, type 77,000, Germany) was applied. After the subject placed his head in the specified area, the BUT function option of the software, OCULUS Keratograph, was selected. The subject was instructed to look forward without blinking. The value of BUT was obtained after the examination.
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Publication 2023
Corneal Topography Eye Head

Top products related to «Corneal Topography»

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The Pentacam is a diagnostic device that captures a 3D image of the anterior segment of the eye. It uses rotating Scheimpflug camera technology to obtain detailed measurements of the cornea, anterior chamber, lens, and iris.
Sourced in Germany, Japan, United States
The Pentacam HR is an advanced corneal topography and anterior segment imaging system. It utilizes a rotating Scheimpflug camera to capture high-resolution, three-dimensional images of the anterior eye. The Pentacam HR provides detailed measurements of the cornea, anterior chamber, and other anterior segment structures.
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The IOL Master is a non-contact optical biometry device used to measure various parameters of the eye, including axial length, anterior chamber depth, and corneal curvature. It provides precise measurements that are essential for calculating the appropriate intraocular lens power for cataract surgery.
Sourced in United States, Germany, Switzerland
The Orbscan II is a diagnostic device designed to measure the topography of the cornea. It uses a slit-scanning technique to capture detailed images of the anterior and posterior surfaces of the cornea, providing precise measurements and analysis of the corneal structure.
Sourced in Germany, United States, Ireland, Italy, Japan
The IOLMaster 700 is an optical biometry device designed for accurate measurement of the eye's components. It utilizes optical coherence tomography (OCT) technology to provide precise data on the axial length, anterior chamber depth, and corneal curvature of the eye.
Sourced in Germany, United States, Japan, Ireland, Switzerland, China
The IOLMaster 500 is a non-contact optical biometry device designed for ocular measurements. It utilizes optical coherence technology to precisely measure axial length, anterior chamber depth, and corneal curvature. The IOLMaster 500 is a diagnostic tool used in pre-operative evaluations for cataract and refractive surgery.
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The OPD-Scan III is a diagnostic device designed for comprehensive eye examinations. It provides objective measurements of the eye's optical properties, including wavefront aberrations, corneal topography, and pupillometry, to assist eye care professionals in evaluating and managing various vision conditions.
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The Orbscan IIz is a diagnostic device designed for ophthalmic examinations. It utilizes slit-scan technology to capture high-resolution images of the anterior segment of the eye, including the cornea. The device provides objective measurements and data that can assist eye care professionals in assessing corneal health and shape.
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The TMS-4 is a laboratory equipment designed for precise measurement and analysis. It is capable of performing a range of tasks, but a detailed description of its core function cannot be provided while maintaining an unbiased and factual approach without extrapolation.
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The SP-2000P is a lab equipment product designed for spectroscopic analysis. It features a high-resolution optical system and advanced data processing capabilities to provide accurate and reliable measurements. The core function of the SP-2000P is to perform spectroscopic analysis of various samples.

More about "Corneal Topography"

Corneal Topography: Unveiling the Cornea's Secrets for Better Eye Care.
Corneal Topography, also known as Corneal Mapping or Corneal Analysis, is a non-invasive imaging technique that provides a detailed 3D map of the corneal surface curvature.
This revolutionary technology allows clinicians to gain valuable insights into the shape and irregularities of the cornea, which is crucial for the diagnosis and management of various eye conditions such as keratoconus, astigmatism, and refractive errors.
Leveraging advanced imaging systems like the Pentacam, Pentacam HR, IOL Master, Orbscan II, IOLMaster 700, IOLMaster 500, OPD-Scan III, Orbscan IIz, TMS-4, and SP-2000P, corneal topography enables clinicians to optimize treatment plans and improve patient outcomes.
By analyzing the detailed corneal surface data, doctors can identify the optimal surgical procedures, such as LASIK and corneal transplants, and tailor the treatments to each individual's unique eye structure.
Corneal topography also plays a pivotal role in the field of corneal biomechanics research, allowing scientists to gain a deeper understanding of the complex interplay between the cornea's shape, structure, and function.
This knowledge paves the way for the development of innovative diagnostic and therapeutic approaches, revolutionizing the way we address eye health challenges.
Whether you're a clinician seeking to enhance your patient care or a researcher exploring new frontiers in corneal science, corneal topography offers a wealth of opportunities to unlock the secrets of the cornea and drive advancements in eye health.
Experince the power of data-driven insights to take your corneal topography studies to the nnext level.