The gross tumor volume was outlined on pulmonary CT windows, excluding soft tissue densities with standard uptake values (SUV) on PET less than 2 (likely to be atelectasis). No additional margin was added for possible microscopic extension. An institution appropriate error margin beyond this gross tumor volume (defined as the planning target volume) which included both set-up error and error related to motion, was limited to no more than 5 mm in the axial dimension and 10 mm in the craniocaudal dimension.
Patients received 60 Gy in 3 fractions of 20 Gy per fraction, which was prescribed to the edge of the planning target volume. Each fraction was separated by at least 40 hours (at most 8 days). The entire 3 fraction regimen was required to be completed within 14 days. Only 4 to 10 MV photon beams were allowed. For planning, no tissue density heterogeneity correction was allowed. Later analysis using proper accounting of density heterogeneity showed RTOG 0236 over-predicted the actual planning target volume dose such that the delivered dose was actually closer to 54 Gy in 3 fractions of 18 Gy11 (link).
Image guidance capable of confirming the position of the target with each treatment was required. Tumor motion related to respiration was required to be quantified using fluoroscopy or 4-dimensional (4-D) CT scans. If the motion confirmed with free breathing was greater than the maximum planning target volume expansions allowed by the protocol, a method of motion control such as abdominal compression, gating, breath holding was required.
Adequate target coverage was achieved when 95% of the planning target volume was covered by 60 Gy and when 99% of the planning target volume received at least 54 Gy. High dose conformality was controlled such that the volume of tissue outside of the planning target volume receiving a dose greater than 63 Gy must be less than 15% of the planning target volume and the target conformality index (ratio of the volume receiving 60 Gy to the planning target volume) was ≤1.2. Moderate dose conformality and gradient quality were controlled by the parameters listed inTable 1 . The treatment plans also had to meet a number of contoured organ dose constraints (Table 2 ).
Patients received 60 Gy in 3 fractions of 20 Gy per fraction, which was prescribed to the edge of the planning target volume. Each fraction was separated by at least 40 hours (at most 8 days). The entire 3 fraction regimen was required to be completed within 14 days. Only 4 to 10 MV photon beams were allowed. For planning, no tissue density heterogeneity correction was allowed. Later analysis using proper accounting of density heterogeneity showed RTOG 0236 over-predicted the actual planning target volume dose such that the delivered dose was actually closer to 54 Gy in 3 fractions of 18 Gy11 (link).
Image guidance capable of confirming the position of the target with each treatment was required. Tumor motion related to respiration was required to be quantified using fluoroscopy or 4-dimensional (4-D) CT scans. If the motion confirmed with free breathing was greater than the maximum planning target volume expansions allowed by the protocol, a method of motion control such as abdominal compression, gating, breath holding was required.
Adequate target coverage was achieved when 95% of the planning target volume was covered by 60 Gy and when 99% of the planning target volume received at least 54 Gy. High dose conformality was controlled such that the volume of tissue outside of the planning target volume receiving a dose greater than 63 Gy must be less than 15% of the planning target volume and the target conformality index (ratio of the volume receiving 60 Gy to the planning target volume) was ≤1.2. Moderate dose conformality and gradient quality were controlled by the parameters listed in