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Acoustic Stimulation

Acoustic Stimulation refers to the use of sound-based interventions to elicit physiological, cognitive, or behavioral responses.
This technique has a wide range of applications in research and clinical settings, including auditory perception studies, tinnitus management, and neurorehabilitation.
Acoustic Stimulation can involve the use of pure tones, complex sounds, or naturalistic auditory environments to investigate the auditory system's functioning and its interactions with other sensory modalities.
Reserchers leveraging this approach must carefully select and optimize the stimulation protocols to ensure reliable and reproducuible results.
PubCompare.ai offers an AI-driven platform to streamline this process, empowering scientists to quickly identify the most effective Acoustic Stimulation protocols from published literature and leverage advanced analysis tools to enhance the quality and accuracy of their experiments.

Most cited protocols related to «Acoustic Stimulation»

1
Whisker Removal and Sensory Stimulation Protocol

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Publication 2013
Acoustics Acoustic Stimulation Animals Cortex, Cerebral Dissection DNA Chips Food Forceps Fostex Hypersensitivity isolation Ketamine Light Medulla Oblongata Mice, House Pharmaceutical Preparations Photic Stimulation Pressure Sound Tamoxifen Vibrissae Xylazine
2
Acoustic and Pharmacological Induction of Seizures in Mice
Seizures and seizure-induced sudden death were evoked either by acoustic stimulation or by the proconvulsant PTZ, as described previously.22 (link),30 (link) To induce AGSz in DBA/1 mice, each mouse was placed in a cylindrical acrylic glass chamber in a sound-isolated room. AGSz were induced by acoustic stimulation using an electric bell (96 dB SPL) (UC4-150, Zhejiang People’s Electronics, China). The acoustic stimulus was given for a maximum duration of 60 s or until the mouse exhibited tonic seizures, which culminated in tonic hindlimb extension and S-IRA. Mice with S-IRA were resuscitated within 5 s after the final respiratory gasp using a rodent respirator (Harvard Apparatus 680, Holliston, MA, U.S.A.).22 (link) The susceptibility to S-IRA in primed DBA/1 mice was always reconfirmed 24 h before drug or vehicle administration. In the acute treatment protocol, 5-HTP (100–150 mg/kg) or vehicle was administered intraperitoneally 1 h before induction of S-IRA. In the repeated treatment protocol, 5-HTP (50–100 mg/kg, i.p.) or vehicle was administered once a day for 2 days, and induction of S-IRA was performed 1 h after the second administration. The volume injected was 0.1–0.3 ml for each mouse. S-IRA and AGSz behaviors were videotaped for offline analysis. Recovery of S-IRA susceptibility in DBA/1 mice was tested 24 h after drug administration or at 24-h intervals thereafter until the S-IRA susceptibility returned.
Generalized clonic and/or tonic–clonic seizures were also induced in separate groups of DBA/1 and C57BL/6J mice by systemic administration of PTZ (75 mg/kg, i.p.). 5-HTP (100–200 mg/kg) or vehicle was administered once a day for 2 days, and i.p. PTZ was administered 1 h after the second treatment.
5-HTP (Cat # 107751) and PTZ (Cat # P6500) were purchased from Sigma-Aldrich (St. Louis, MO, U.S.A.) and dissolved in saline for systemic administration.
Zhang H., Zhao H., Yang X., Xue Q., Cotten J.F, & Feng H.J. (2016). 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. Epilepsia, 57(8), 1228-1235.
Publication 2016
5-Hydroxytryptophan Acoustics Acoustic Stimulation Clonic Seizures, Tonic Electricity Hindlimb Mechanical Ventilator Mice, Inbred C57BL Mice, Inbred DBA Mus Pharmaceutical Preparations Respiratory Rate Rodent Saline Solution Seizures Sound Sudden Death Susceptibility, Disease Tonic Seizures Treatment Protocols
3
Auditory Cortex Responses to Click Trains

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Publication 2015
A 300 Acoustics Acoustic Stimulation Electrocorticography Transients
4
Multi-Modal Neuroimaging Protocol for Alzheimer's
All subjects underwent a standardized MRI imaging protocol at 3.0 T, which included a 3D magnetization prepared rapid acquisition gradient echo sequence (repetition time/echo time/T1 = 2300/3/900 ms; flip angle 8°, 26-cm field of view; 256 × 256 in-plane matrix with a phase field of view of 0.94, slice thickness of 1.2 mm, in-plane resolution 1) and a single-shot echo-planar diffusion tensor imaging pulse sequence (repetition time = 10 200 ms; in-plane matrix 128/128; in-plane resolution 2.7, field 35 cm; phase field of view 0.66; 42 diffusion encoding steps and four non-diffusion weighted T2 images; 2.7 mm isotropic resolution). Parallel imaging with a sensitivity encoding factor of 2 was used for the diffusion tensor imaging acquisition.
All PET scans were acquired using a PET/CT scanner (GE Healthcare) operating in 3D mode. For fluorodeoxyglucose-PET, subjects were injected with fluorodeoxyglucose (average, 459 MBq; range, 367–576 MBq) in a dimly lit room with minimal auditory stimulation. After a 30-min uptake period an 8-min fluorodeoxyglucose scan was performed consisting of four 2-min dynamic frames following a low dose CT transmission scan. For PiB-PET, subjects were injected with PiB (average, 614 MBq; range, 414–695 MBq) and after a 40–60-min uptake period a 20 min PiB scan was obtained consisting of four 5-min dynamic frames following a low dose CT transmission scan. Standard corrections were applied. Individual frames of the fluorodeoxyglucose and PiB dynamic series were realigned if motion was detected and then a mean image was created. Emission data were reconstructed into a 256 × 256 matrix with a 30-cm field of view. The image thickness was 3.75 mm.
Josephs K.A., Duffy J.R., Strand E.A., Machulda M.M., Senjem M.L., Master A.V., Lowe V.J., Jack CR J.r, & Whitwell J.L. (2012). Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain, 135(5), 1522-1536.
Publication 2012
Acoustic Stimulation CAT SCANNERS X RAY Diffusion ECHO protocol F18, Fluorodeoxyglucose factor A Hypersensitivity Positron-Emission Tomography Pulse Rate Radionuclide Imaging Reading Frames Transmission, Communicable Disease X-Ray Computed Tomography
5
Vestibular Evoked Myogenic Potentials in Pediatrics
For each subject, a test ear was selected at random, with the opposite ear serving as the control, non-test ear. VEMP recordings were completed in the test ear using an ICS Chartr 200 Evoked Potential System (GN Otometrics, Taastrup, DK). Air conduction stimuli were delivered monaurally via ER-3A insert earphones. Stimuli used were 4 msec rarefaction, 500 Hz tone bursts at a repetition of rate of 5.1 per second (Blackman gating window, 1 cycle rise/fall time, 0 cycle plateau). Stimuli were presented at 125 dB SPL in adults and 120 dB SPL in children. Published VEMP stimulus parameters and guidelines often anywhere from 125–133 dB SPL as the intensity in which VEMP stimuli are delivered (Janky & Shepard 2009 (link); Krause et al. 2013 (link); Piker et al. 2015 ). Few reports have investigated the potential for noise induced hearing loss secondary to the high intensity stimulation level on changes in cochlear status; these investigations are limited to adult populations which is difficult to generalize to the pediatric population.
For cVEMP testing, an active electrode was placed on the muscle belly of the sternocleidomastoid (SCM) muscle, an electromyography (EMG) electrode just below the SCM electrode, a reference electrode on the manubrium of the sternum, and a ground electrode on the chin. For oVEMP testing, an active electrode was placed under the contralateral eye medio-laterally with a reference electrode on the chin and ground electrode on the manubrium of the sternum. One hundred sweeps were averaged for each cVEMP test, and 150 sweeps were averaged for each oVEMP test. Two trials were completed for each cVEMP and oVEMP recording. For c-and oVEMP, a band-pass filter of 10–1000 Hz and 2–500 Hz was used, respectively.
All subjects lay in a semi-recumbent position for both c-and oVEMP testing. For cVEMP, subjects were instructed to turn their head away from the ear being stimulated and lift their head in response to acoustic simulation to contract the SCM muscle. EMG was recorded from the ipsilateral SCM between the range of 100–300 (μV). Measurements included p13 and n23 latencies (msec) and the p13 to n23 peak-to-peak amplitude (uV). For oVEMP, subjects were instructed to direct their gaze to a mark on the ceiling set at 30 degrees up gaze in response to acoustic stimulation. Measurements included n10 and p16 latencies (msec) and the n10 to p16 peak-to-peak amplitude (uV). For c-and-oVEMP, the presence of a response was considered normal, while an absent response was considered abnormal.
Rodriguez A.I., Megan L.A., Thomas D.F, & Janky K.L. (2018). Effects of High Sound Exposure During Air-conducted Vestibular Evoked Myogenic Potential Testing in Children and Young Adults. Ear and hearing, 39(2), 269-277.
Publication 2017
Acoustics Acoustic Stimulation Adult Child Chin Cochlea Electric Conductivity Electromyography Evoked Potentials Head Manubrium Muscle Tissue Noise-Induced Hearing Loss

Most recents protocols related to «Acoustic Stimulation»

1
Tonotopic Labeling of Auditory Neurons
For auditory stimulation, mice at P16–P30 were housed in a custom soundproof box, and received sound stimulation as illustrated in Figure 1A. After three quiet hours, continuous sound was delivered for 6 h at ∼90 dB using BioSigRP software (Tucker-Davis Technologies). A 15-kHz tone of 20-ms duration with 2-ms rise and fall time was presented at a rate of 41 Hz (leaving 4.4-ms gaps). The sound was produced by a PC sound card, processed by RZ6 Multi-I/O Processer (Tucker-Davis Technologies), and delivered via a speaker (Ignite) mounted directly above the animals. The sound was paused for no more than 5 min after the first 3 h to administer an intraperitoneal injection of 160 mg/kg Tamoxifen or 50 mg/kg 4-OHT. Tamoxifen was first dissolved in absolute EtOH, then diluted 1/10 by volume with sunflower oil followed by 2-h sonication or overnight nutation, and stored at 4°C in the dark for up to one week. 4-OHT was first dissolved in absolute EtOH at 20 mg/ml, and diluted with Chen oil (a 1:4 mixture of castor oil:sunflower seed oil) to 10 mg/ml for injection (Guenthner et al., 2013 (link)). After sound stimulation, mice were kept in quiet for another 3 h before returning to their home cage, and killed 4–5 d later for experiments. This protocol has been shown to produce tonotopic labeling in DCN and VCN from TRAP mice crossed with the Ai14 reporter line (Guenthner et al., 2013 (link)). The time line is consistent with the time window determined by the pharmacodynamics of 4-OHT in mice (Robinson et al., 1991 (link)).
Ma Y., Shu W.C., Lin L., Cao X.J., Oertel D., Smith P.H, & Jackson M.B. (2023). Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus. eNeuro, 10(3), ENEURO.0465-22.2023.
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Publication 2023
4,17 beta-dihydroxy-4-androstene-3-one Acoustic Stimulation Animals Castor oil Ethanol Injections, Intraperitoneal Mice, House Oil, Sunflower Sound Tamoxifen TimeLine
2
Smartphone-Delivered Alpha Frequency Stimulation for Chronic Pain
The hBET programme is a smartphone application specifically developed by the Human Pain Research Group (32 ) (a collaboration between researchers at the Universities of Manchester, Leeds and Liverpool, UK) to provide repetitive stimulation at 10 Hz by either visual or auditory modalities for investigation of the treatment of chronic pain. Development of the application (33 ) and user co-design (34 (link)) have been reported. The 10 Hz frequency was chosen as it is at the centre of the alpha band, and was found to more effectively reduce experimental pain than high (12 Hz) or low (8 Hz) alpha (23 (link)). This is an example of open-loop stimulation, as the programme feeds in 10 Hz stimulation with no reference to participants' online brainwave state or individualised peak alpha (35 (link)). The visual programme uses the smartphone screen to create 10 Hz visual flicker by alternating between white and black screen at this frequency. A virtual reality headset is used to hold the phone in front of participants' eyes and exclude external light sources. Participants have their eyes closed during the stimulation. The screen brightness is pre-set at mid-range, but is under participants' control. The auditory programme utilises binaural beats to create 10 Hz stimulation since a 10 Hz tone is below the range of human hearing. A binaural beat is produced when different tones are presented to each ear, with the binaural beat frequency being the difference between the two tones (36 (link)). Tones at 400 Hz and 410 Hz are used in hBET as this range has been shown to produce the binaural beat effect most strongly (37 (link)). It is therefore necessary that headphones are used rather than an external speaker. For increased comfort in a lying position, participants are provided with a sleep headband with integrated headphones [model PT28, Perytong, Shenzhen, China]. The volume of auditory stimulation is under participants' control. The equipment participants used in the study is shown in Figure 1.
Halpin S.J., Casson A.J., Tang N.K., Jones A.K., O’Connor R.J, & Sivan M. (2023). A feasibility study of pre-sleep audio and visual alpha brain entrainment for people with chronic pain and sleep disturbance. Frontiers in Pain Research, 4, 1096084.
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Publication 2023
Acoustic Stimulation Auditory Perception Brain Waves Eye Homo sapiens Light Management, Pain Pain Sleep
3
Finger-Thumb Evaluation for Dexterity Assessment
First, the maximum distance from index finger to thumb at rest was measured by each participant and defined as r-Amplitude as one of the calibrations before the F-T evaluation. We then recorded the performance of repetitive F-T both not timing-regulated and timing-regulated conditions by participants for 15 s each of the non-dominant and the dominant hand. F-T test was performed in the order of at a spontaneous pace, at rates of 1.0 and 2.0 Hz by auditory stimulation with a metronome, and at the maximum effort pace (as quickly and as big as possible). Participants were instructed to close their fingers together when auditory stimuli were given. Furthermore, the patients were evaluated for F-T before and after shunt surgery.
Shimizu Y., Tanikawa M., Horiba M., Sahashi K., Kawashima S., Kandori A., Yamanaka T., Nishikawa Y., Matsukawa N., Ueki Y, & Mase M. (2023). Clinical utility of paced finger tapping assessment in idiopathic normal pressure hydrocephalus. Frontiers in Human Neuroscience, 17, 1109670.
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Publication 2023
Acoustic Stimulation Auditory Perception Fingers Operative Surgical Procedures Patients Thumb
4
Multimodal Spatial Perception Experiment
Participants sat in a quiet, dark room, 180 cm away from the center of a 24 modules custom-made array (Fig 1A) spanning ± 36° of visual angle (with 0° being the center of the array, negative and positive values indicating leftward and rightward position, respectively). All testing procedures took place in total darkness so that the array was not visible to the participants, excluding the possibility that responses were influenced by contextual cues (such as the array’s silhouette). Each module could deliver either visual or auditory stimulation. Visual stimuli were red flashes with a diameter of 3° of visual angle at participant’s viewing position, while auditory stimuli were 2 kHz sine wave pulses with 60 dB Sound Pressure Level (SPL). Every module could deliver only one stimulus at a time, i.e., a module could produce either a sound or a flash, never both simultaneously (even though participants were unaware of that). The array was linked to the computer used to run the experiment through a USB cable. The connection between the array and the laptop was also powered via a dedicated host. The experiment was developed and run using MATLAB (v. 2013b).
Domenici N., Sanguineti V., Morerio P., Campus C., Del Bue A., Gori M, & Murino V. (2023). Computational modeling of human multisensory spatial representation by a neural architecture. PLOS ONE, 18(3), e0280987.
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Publication 2023
Acoustic Stimulation Auditory Perception Darkness DB 60 Pulse Pressure Short Interspersed Nucleotide Elements Sound
5
Multimodal Recording System for Neuroscience
The overall recording system consisted of several main elements. An acquisition system (Plexon, Omniplex system) recorded analog and digital signals and was coupled with CinePlex Studio (Plexon) for synchronized top RGB camera recordings (Pike Camera F-032C, Allied Vision, Campden Instruments). The Radiant software was used to create optogenetics stimulation protocols and control the global timing of experiments via PlexBright analog and digital outputs. An RZ6 multi-processor (Tucker-Davis Technologies) was used to deliver acoustic stimulations via a multi-field magnetic speaker (MF1, Tucker-Davis Technologies), control the shocks delivered by the stimulus isolator and overall provide online processing and synchronization via a MATLAB/ActiveX/RPvdsEx interplay (MATLAB2019b, The MathWorks; RPvdsEx, Tucker-Davis Technologies). In particular, a fast initial train of TTLs followed by a 1 Hz signal was generated and broadcasted to the different systems for offline alignment. Temperature data were acquired with a long wavelength infrared camera (A655sc, FLIR), via FLIR’s SDK within MATLAB. A custom GUI was used for pre-recording calibration and focus, and to visualize the movie in real time. Recordings were triggered by MATLAB after the running signal was broadcasted by PlexBright and received by the RZ6, and similarly stopped. Thermal data was directly saved into a.seq file and MATLAB was periodically saving the current number of acquired frames which allowed for offline synchronization. ECG data were acquired at 5 kHz via an amplifier (DPA-2FX, npi) connected to the OmniPlex system. Depending on the quality of the signal for the two electrodes, signal was saved differentially or from single electrodes.
Signoret-Genest J., Schukraft N., L. Reis S., Segebarth D., Deisseroth K, & Tovote P. (2023). Integrated cardio-behavioral responses to threat define defensive states. Nature Neuroscience, 26(3), 447-457.
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Publication 2023
Acoustic Stimulation Esocidae Fingers Magnetic Fields Optogenetics Reading Frames Shock Vision

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More about "Acoustic Stimulation"

sound-based interventions, auditory perception, tinnitus management, neurorehabilitation, pure tones, complex sounds, naturalistic auditory environments, audio stimulation, MATLAB, Presentation software, E-Prime software, Custom Sound EP (v. 5.1), LabVIEW, GE Advance tomograph, Moveable Objective Microscope, Rompun, E-Prlme, Neurofax EEG-1200