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> Procedures > Therapeutic or Preventive Procedure > Cardiopulmonary Bypass

Cardiopulmonary Bypass

Cardiopulmonary Bypass: An advanced medical technique that temporarily takes over the function of the heart and lungs during surgical procedures.
This critical process ensures oxygenated blood continues to circulate throughout the body, enabling complex operations to be performed with precision and safety.
PubCompare.ai's AI-driven platform helps researchers quickly locate, compare, and optimize the best cardiopulmonary bypass protocols from literature, preprints, and patents, ensuring unparallelled reproducibilty and accuracy in their cardiovascular research.

Most cited protocols related to «Cardiopulmonary Bypass»

1
Randomized Trial of Surgical Strategies in d-TGA
Cited 12 times
Subjects were enrolled between April 1988 and February 1992. Eligibility criteria and trial methods for the earlier evaluations were previously described.7 (link)–10 (link) Admission criteria included a diagnosis of d-TGA with intact ventricular septum (IVS) or ventricular septal defect (VSD), scheduled repair by three months of age, and coronary-artery anatomy suitable for the ASO. Exclusion criteria were birth weight <2.5 kg, a recognizable syndrome of congenital anomalies, an associated extra-cardiac anomaly of greater than minor severity, previous cardiac surgery, or associated cardiovascular anomalies requiring aortic arch reconstruction or additional open surgical procedures.
Infants were randomly assigned to a predominant support strategy of DHCA or LFBP during hypothermic cardiopulmonary bypass using an alpha-stat pH strategy and crystalloid hemodilution to a hematocrit of approximately 20%. Ultrafiltration was not utilized. Postoperative management typically included the use of continuous infusions of neuromuscular blockade and high-dose Fentanyl for analgesia, with a median duration of mechanical ventilation of 4 days.12 (link) Randomization was stratified by septal status (IVS, VSD) and surgeon. This study was approved by the Institutional Review Board and conducted in accordance with institutional guidelines. Parents of adolescents provided informed consent, and adolescents provided assent.
We recruited a referent group of adolescents for the MRI studies because there is no nationally representative standardization sample for brain MRIs. This group was also used as referents for test scores for which national norms are unavailable. Criteria for the referent group were adapted from those used in the NIH MRI study of normal brain development.13 (link) Because the goal of that study is to provide reference ranges for brain development, children with known risk factors for brain disorders are excluded (e.g., intra-uterine exposures to toxicants, history of closed head injury with loss of consciousness, history of a language disorder or Axis 1 psychiatric disorder, first degree relative with a lifetime history of an Axis 1 psychiatric disorder, abnormality on neurological examination). We also excluded subjects with disorders that would prevent completion of the assessments (e.g., pacemaker, metal implants), other forms of congenital heart disease requiring surgical correction, or primary language other than English.
Bellinger D.C., Wypij D., Rivkin M.J., DeMaso D.R., Robertson RL J.r., Dunbar-Masterson C., Rappaport L.A., Wernovsky G., Jonas R.A, & Newburger J.W. (2011). Adolescents with d-Transposition of the Great Arteries Corrected with the Arterial Switch Procedure: Neuropsychological Assessment and Structural Brain Imaging. Circulation, 124(12), 1361-1369.
Publication 2011
Adolescent Arch of the Aorta Artery, Coronary Birth Weight Brain Brain Diseases Cardiopulmonary Bypass Cardiovascular Abnormalities Child Congenital Abnormality Congenital Heart Defects Diagnosis Eligibility Determination Epistropheus Ethics Committees, Research Fentanyl Hemodilution Infant Injuries, Closed Head Language Disorders Management, Pain Mechanical Ventilation Mental Disorders Metals Nervous System Abnormality Neuromuscular Block Operative Surgical Procedures Pacemaker, Artificial Cardiac Parent Reconstructive Surgical Procedures Solutions, Crystalloid Surgeons Surgical Procedure, Cardiac Syndrome Ultrafiltration Uterus Ventricular Septal Defects Ventricular Septum Volumes, Packed Erythrocyte
2
Imputing PF Ratio from SpO2 Data
Cited 9 times
In group 1, the intraoperative data points were obtained from a computerized query of the Microsoft SQL2003 database providing storage for data from Vanderbilt University's electronic anesthesiology documentation system, the Vanderbilt Perioperative Informatics Medical System (VPIMS)©. Data queried from the database included intraoperative pulse oximetry (SpO2) values (Nellcor pulse oximeters via a Philips Intellivue MP 90 monitor) and time correlated intraoperative partial pressure of oxygen (PaO2) determinations made by arterial blood sampling (Laboratory Gem Premier 3000, Instrumentation Technology) in all mechanically ventilated (MV) adults, undergoing general anesthesia. We excluded patients who were scheduled for cardiovascular surgeries, due to the potential effect of cardiopulmonary bypass and hypothermia on blood gas data, and those having thoracotomies with resultant lung resection or hypo-inflation for surgical purposes. In group 2, PaO2 and corresponding SpO2 values were obtained form the ARMA study database of patients with acute respiratory distress syndrome (ARDS).(8 (link))
In our discussions with experts in the field - both clinicians and researchers - the unmet need in this area was to develop an easy to use and reliable imputation for PF ratios by using SF threshold values, without having the clinicians and research personnel perform difficult calculations, incorporating the covariates that may have played a role in this relationship. Hence a decision was made first to develop a model without any covariates, enabling the calculation of the SOFA score when only SpO2 was available in a broad range of patients. To study the possible contribution of PEEP to the predictive value of SF and PF, we evaluated a second model to determine the relationship between SF and PF ratios within 3 categories of PEEP support: <8 centimeters of water (cm H2O), 8–12 cm H2O and > 12 cm H2O.
Pandharipande P.P., Shintani A.K., Hagerman H.E., St Jacques P.J., Rice T.W., Sanders N.W., Ware L.B., Bernard G.R, & Ely E.W. (2009). Derivation and validation of SpO2/FiO2 ratio to impute for PaO2/FiO2 ratio in the respiratory component of the Sequential Organ Failure Assessment (SOFA) Score. Critical care medicine, 37(4), 1317-1321.
Publication 2009
Adult Arteries BLOOD Cardiopulmonary Bypass Cardiovascular Surgical Procedures General Anesthesia Lung Operative Surgical Procedures Oximetry, Pulse Oxygen Partial Pressure Patients Positive End-Expiratory Pressure Pulse Rate Respiratory Distress Syndrome, Acute Saturation of Peripheral Oxygen Thoracotomy
3
Predictors of Prolonged Hospital Stay
Cited 8 times
Continuous variables were presented as means with SD, while categorical variables were presented as frequencies. LOS at CICU and postoperative LOS were dichotomised to designate two groups (normal LOS and prolonged LOS). We defined prolonged LOS as ≥75th centile. In the absence of a prescribed LOS in the literature and to confirm the appropriateness of our selection, we consulted the surgeons for their judgement who agreed on this cut-off value. In general, there is a variability in medical research for defining the period at which a stay is considered as prolonged.14 (link) Moreover, the use of the LOS at the 75th centile is consistent with other studies. Postoperative LOS was defined as the time between the day of surgery and discharge from the hospital, while CICU LOS was defined as the time in days between the admission and discharge from CICU. For identifying difference between groups, we used t-tests for continuous variables, Mann-Whitney for non-normally distributed variables and χ2 for categorical variables.
For identifying predictors of postoperative LOS, a univariate logistic regression was first performed to select variables that are significantly related to the postoperative LOS. Factors with p<0.10 were then included in the multivariate analysis. These included sex, age, body mass index (BMI), history of diabetes, history of renal failure, history of cerebrovascular disease, history of respiratory disease, pulmonary hypertension, congestive heart failure (CHF) at current admission, preoperative arrhythmia, preoperative inotropic support, left ventricular ejection fraction (≥40% vs <40%), preoperative haematocrit (Hct) level, non-elective surgery, type of surgery, use of cardiopulmonary bypass (CPB) machine, inotropic support after operation, use of packed red blood cells (PRBC) and number of complications. A backward stepwise logistic regression was used to identify factors that had an independent effect on the postoperative LOS. A p value of 0.1 to enter a factor and 0.2 to remove it were used.
Almashrafi A., Alsabti H., Mukaddirov M., Balan B, & Aylin P. (2016). Factors associated with prolonged length of stay following cardiac surgery in a major referral hospital in Oman: a retrospective observational study. BMJ Open, 6(6), e010764.
Publication 2016
Cardiac Arrhythmia Cardiopulmonary Bypass Cerebrovascular Disorders Congestive Heart Failure Diabetes Mellitus Elective Surgical Procedures Erythrocytes Factor X Index, Body Mass Kidney Failure Patient Discharge Properdin Pulmonary Hypertension Respiration Disorders Surgeons Surgery, Day Ventricular Ejection Fraction
4
Pediatric Cardiac Surgery Biomarkers Study
Cited 8 times
The cohort of children was prospectively enrolled from 3 pediatric sites: Cincinnati Children’s Hospital Medical Center, Montreal Children’s Hospital, and Yale New-Haven Children's Hospital as part of the consortium investigating new biomarkers in AKI known as the Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI). Enrollment started in July 2007, November 2007, and November 2008, respectively, and completed in December 2009. Cincinnati has a dedicated pediatric cardiac care unit (CCU) with approximately 225 cardiopulmonary bypass cases annually and both Montreal and Yale have mixed medical surgical units including cardiac patients with approximately 60 cardiopulmonary bypass cases annually. This study was approved by the Institutional Review Board or Research Ethics Board of each institution. Written informed consent from legal guardians and assent from patients were obtained before enrollment.
All patients less than 18 years of age undergoing cardiac surgery with cardiopulmonary bypass were eligible for the study. Exclusion criteria included history of prior renal transplantation, dialysis requirement, or participation in a conflicting research study. We utilized the Risk Adjustment for Congenital Heart Surgery 1 (RACHS-1) consensus-based scoring system to categorize the complexity of surgery (24 (link)). This method of risk stratification is a widely accepted tool for the evaluation of differences in outcomes of surgery for congenital heart disease. We only retained children older than 1 month for this study, since defining AKI in neonates is unclear and likely different than the AKI definition in older children (25 (link)).
Li S., Krawczeski C.D., Zappitelli M., Devarajan P., Thiessen-Philbrook H., Coca S.G., Kim R.W, & Parikh C.R. (2011). Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery – a prospective multicenter study. Critical Care Medicine, 39(6), 1493-1499.
Publication 2011
Biological Markers Cardiopulmonary Bypass Child Congenital Heart Defects Coronary Artery Bypass Surgery Dialysis Ethics Committees, Research Heart Infant, Newborn Kidney Failure, Acute Kidney Transplantation Legal Guardians Only Child Operative Surgical Procedures Patients Surgical Procedure, Cardiac
5
PARDIE: Pediatric Acute Respiratory Distress International Study
Cited 7 times

Protocol full text hidden due to copyright restrictions

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Publication 2018
Arteries Biphasic Continuous Positive Airway Pressure Blood Cardiopulmonary Bypass Cell Respiration Chest Child Continuous Positive Airway Pressure Cyanosis Diagnosis Ethics Committees, Research Heart Heart Diseases Heart Failure Hispanic or Latino Lung Diseases Mechanical Ventilation Noninvasive Ventilation Nose Oxygen Saturation Patient Discharge Patients Pharmaceutical Preparations Pulse Rate Radiologist Respiratory Failure Saturation of Peripheral Oxygen

Most recents protocols related to «Cardiopulmonary Bypass»

1
SCD Cartridges for CPB-Mediated SIRS
Not available on PMC !

Example 3

Systemic Inflammatory Response Syndrome (SIRS) can occur in association with cardiopulmonary bypass (CPB) surgery, resulting in multiple organ dysfunction (MOD). Activated neutrophils have been implicated as major inciting factors in this process. This example describes in vitro and in vivo experiments that evaluate the effect of SCD cartridges for use during CPB surgery. The results demonstrate that the usage of SCD cartridges may disrupt the systemic leukocyte response during CPB surgery, leading to improved outcomes for CPB-mediated MOD.

US11866730B2. Cytopheresis cartridges and use thereof (2024-01-09). SeaStar Medical, Inc. [US]. Inventors: H. David Humes [US], Deborah A. Buffington [US], Christopher J. Pino [US].
Full text: Click here
Patent 2024
Cardiopulmonary Bypass Leukocytes Medical Devices Neutrophil Systemic Inflammatory Response Syndrome
2
Pulmonary Endarterectomy Under Deep Hypothermia
PEA was performed from median sternotomy, the patient was cooled to 18°C to 20°C using cardiopulmonary bypass (CBP), and bilateral PEA was performed under deep hypothermic circulatory arrest. Unfractionated heparin (Leo Pharmaceutical Products, Denmark) was used for intraoperative anticoagulation monitored by activated clotting time (ACT) (target > 480 s Kaolin-ACT, Medtronic.Inc. ACTII, Minneapolis, MN, USA). Before the initiation of CBP, 500 to 1000 ml of blood was harvested, and returned to the patient after weaning off CPB, heparin reversal by protamine sulfate, and decannulation. During CPB to maintain patients’ volume status and to minimize the use of crystalloids (plasmalyte 50 mg/ml, Baxter) and possible volume overload autologous blood transfusion (cell saver), allogenic red blood cell (RBC) transfusions (Hb < 60 g/l), 2 to 6 units of solvent-detergent treated standardized plasma (Octaplas®, Octapharma AG, Lachen, Switzerland) or albumin 20% were used. Tranexamic acid was used 30 mg/kg intravenously before the surgical incision and again 15 mg/kg every 2 h for the duration of CPB. ACT was controlled every 20 min on CPB and 3 min after each heparin bolus. After CPB, administration of protamine and harvested blood infusion, coagulation status was controlled (heparinase-ACT, complete blood count, APTT, PT, fibrinogen, AT and D-dimer). Postoperatively in the operation room allogenic RBC were transfused if Hb < 90 g/l or Hct < 30%. The threshold for platelet transfusion was the platelet count <100 ×109/l and for standardized plasma, Octaplas®, PT < 30%.
Myllylahti L., Ropponen J., Lax M., Lassila R, & Nykänen A.I. (2023). Upregulation of Coagulation Factor VIII and Fibrinogen After Pulmonary Endarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension. Clinical and Applied Thrombosis/Hemostasis, 29, 10760296231158369.
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Publication 2023
Activated Partial Thromboplastin Time Albumins BLOOD Blood Transfusion, Autologous Cardiopulmonary Bypass Cells Circulatory Arrest, Deep Hypothermia Induced Complete Blood Count Detergents Erythrocytes fibrin fragment D Fibrinogen Heparin Heparin Lyase Kaolin Median Sternotomy Patients Pharmaceutical Preparations Plasma Plasmalyte A Platelet Counts, Blood Platelet Transfusion Protamines Red Blood Cell Transfusion Solutions, Crystalloid Solvents Sulfate, Protamine Surgical Wound Tranexamic Acid
3
Cardiac Dysfunction in Pediatric VSD with PAH
Our study cohort included eight children aged 6–10 years who were hospitalised in the Affiliated Hospital of Southwest Medical University, China on June 2022. Four of the children were diagnosed by echocardiography as VSD without PAH (control group, n = 4) and the other four were diagnosed by echocardiography and right cardiac catheterisation as moderate or severe PAH secondary to VSD (PAH group, n = 4). A diagnosis of PAH by right-heart catheterisation was defined as a mean pulmonary arterial pressure >25 mmHg at rest, a pulmonary capillary wedge pressure <15 mmHg and a pulmonary vascular resistance of >3 Wood units. We excluded patients receiving targeted therapy for PAH and those diagnosed with other intracardiac malformations, such as patent ductus arteriosus, large atrial septal defect, or other related conditions, like congenital lung disease, bronchial asthma and congenital pulmonary vascular malformation.
During the cardiac operation, atrial appendage specimens were collected from all patients before cardiopulmonary bypass and blood samples were collected via the jugular vein before performing the midline sternotomy. The plasma and right atrial appendage specimens were then aliquoted and stored at −80°C until RNA extraction.
Yang Q., Fan W., Lai B., Liao B, & Deng M. (2023). lncRNA-TCONS_00008552 expression in patients with pulmonary arterial hypertension due to congenital heart disease. PLOS ONE, 18(3), e0281061.
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Publication 2023
Asthma Atrial Septal Defects Atrium, Right Auricular Appendage BLOOD Blood Vessel Cardiopulmonary Bypass Catheterizations, Cardiac Child Congenital Abnormality Congenital Disorders Echocardiography Jugular Vein Lung Lung Diseases Median Sternotomy Patent Ductus Arteriosus Patients Plasma Pulmonary Wedge Pressure Surgical Procedure, Cardiac Therapeutics Vascular Malformations
4
Myxoma Surgical Outcomes Analysis
The statistical analysis was performed with SPSS version 22.0. Analysis of independent variables such as sex, age, recurrence of the disease, specific site of myxoma development, cardiopulmonary bypass time, ischemia bypass time, use of intra-aortic balloon pump, Intensive Care Unit (ICU) length of stay, in-hospital length of stay and survival was conducted. For the comparison of proportions Chi-square and Fisher's exact tests were used. All reported P values are two-tailed and the statistical significance was set at P value ≤ 0.05.
Nektaria M., Theologou S., Christos C., George S., Rokeia E., Dimitrios S, & Ioanna P. (2023). Cardiac Myxomas: A Single-Center Case Series of 145 Patients Over a 32-Year Period Study. Annals of Cardiac Anaesthesia, 26(1), 17-22.
Publication 2023
Cardiopulmonary Bypass Intra-Aortic Balloon Pumping Ischemia Myxoma Recurrence
5
Diabetes Management in Cardiac Surgery
The present study was a randomized control trial following CONsolidated Standards of Reporting Trials (CONSORT) guideline. After institutional review board (IRB) approval (November 19, 2019), the trial was conducted in DM patients who were set for cardiac surgery undergoing cardiopulmonary bypass (CPB) at the Cardiac Center, King Chulalongkorn Memorial Hospital. Inclusion criteria were 20–80 years of age, DM Type 2 (T2DM), and scheduling for elective valvular heart surgery (VHS) or coronary artery bypass graft (CABG). Exclusion criteria were 1) DM Type 1, 2) insulin-dependent T2DM, 3) BG <60 or >300 mg/dL from 6 pm of the day before surgery, 4) preoperative administration of insulin, glucose, or dextrose solution, 5) preoperative inotropes/vasopressors infusion or mechanical cardiovascular support devices, 6) history of postoperative nausea or vomiting (PONV), 7) thyroid cancer or endocrine neoplasia syndromes, 8) chronic pancreatitis or previous surgery of pancreas, 9) recent steroid administration, 10) pregnancy, and 11) current treatment with GLP-1 analogs. Written informed consent was obtained from all the enrolled samples.
Sindhvananda W., Poopuangpairoj W., Jaiprasat T, & Ongcharit P. (2023). Comparison of Glucose Control by Added Liraglutide to Only Insulin Infusion in Diabetic Patient Undergoing Cardiac Surgery: A Preliminary Randomized-Controlled Trial. Annals of Cardiac Anaesthesia, 26(1), 63-71.
Publication 2023
Carcinoma, Thyroid Cardiopulmonary Bypass Cardiovascular System Coronary Artery Bypass Surgery Elective Surgical Procedures Endocrine Gland Neoplasms Ethics Committees, Research Glucagon-Like Peptide 1 Glucose Heart Heart Valves Inotropism Insulin Medical Devices Operative Surgical Procedures Pancreas Pancreatitis, Chronic Patients Pregnancy Steroids Surgical Procedure, Cardiac Syndrome Vasoconstrictor Agents

Top products related to «Cardiopulmonary Bypass»

1
Allprotect tissue reagent by Qiagen
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The Allprotect Tissue Reagent is a solution designed to stabilize and preserve RNA, DNA, and proteins in tissue samples. It is intended for use in the collection, storage, and transport of biological samples prior to analysis.
2
Da vinci surgical system by Intuitive Surgical
Sourced in United States
The da Vinci Surgical System is a robotic-assisted surgical device designed for minimally invasive procedures. It consists of a surgeon's console, a patient-side cart with four robotic arms, and a high-definition 3D vision system. The system allows the surgeon to perform complex surgical maneuvers with enhanced dexterity, precision, and control.
3
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4
Sas version 9 by SAS Institute
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SAS version 9.4 is a statistical software package. It provides tools for data management, analysis, and reporting. The software is designed to help users extract insights from data and make informed decisions.
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R version 4.0.2 is the latest stable release of the R Project for Statistical Computing, a free and open-source software environment for statistical computing and graphics. R version 4.0.2 provides a wide range of statistical and graphical techniques, and is widely used in various fields for data analysis, visualization, and modeling.
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Excel 2013 by IBM
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Excel 2013 is a spreadsheet software application developed by Microsoft. It provides tools for data organization, calculation, and visualization. Excel 2013 allows users to create and manipulate spreadsheets, perform complex calculations, and generate charts and graphs.
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Duran ancore band by Medtronic
The Duran AnCore Band is a laboratory equipment product manufactured by Medtronic. It is designed to provide a secure and reliable solution for holding and positioning various types of laboratory samples or equipment during experiments or analyses. The core function of the Duran AnCore Band is to offer a versatile and adjustable clamping mechanism to facilitate the setup and organization of laboratory workspaces.
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Ie33 ultrasound system by Philips
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The Philips IE33 ultrasound system is a compact and versatile diagnostic imaging device. It utilizes advanced ultrasound technology to capture high-quality images of internal structures within the body. The core function of the IE33 is to provide healthcare professionals with a tool for non-invasive diagnostic examinations.
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X7 2t tee probe by Philips
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The X7-2t TEE probe is a medical device designed for transesophageal echocardiography (TEE) procedures. It is a component of Philips' diagnostic imaging equipment used to capture high-quality ultrasound images of the heart and related structures. The probe transmits and receives ultrasound waves, enabling the visualization of the cardiac anatomy and function. The X7-2t TEE probe operates within a specific frequency range and is compatible with Philips imaging systems.
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More about "Cardiopulmonary Bypass"

Cardiopulmonary Bypass, CPB, CABG, Heart Valve Replacement, Congenital Heart Defect, PubCompare.ai, SAS 9.4, R version 4.0.2, Excel 2013, Da Vinci Surgical System, Duran AnCore Band, IE33 ultrasound system, X7-2t TEE probe, Allprotect Tissue Reagent