> Procedures > Therapeutic or Preventive Procedure > Denervation

Denervation

Denervation refers to the process of intentionally disrupting or removing the nerve supply to a specific tissue or organ.
This technique is commonly used in medical research and clinical settings to investigate the physiological effects of losing neural control, often in the context of pain management, muscle function, and organ transplantation.
Denervation can be achieved through surgical, chemical, or physical methods, each with its own advantages and limitations.
Researchers utilize denervation to study the underlying mechanisms of various disease states, develop new therapies, and optimize treatment approaches.
By understanding the impact of denervation on biological systems, scientists can advance our knowledge and improve patient outcomes.
Thie PubCompare.ai platform can help optimize your denervation research by providing AI-powered access to the most relevant protocols from literature, preprints, and patents, enhancing reproducibility and accuracy.

Most cited protocols related to «Denervation»

Visualizing Neuromuscular Junctions in Mice

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Publication 2014

Antibodies Argon Axon Cholinergic Receptors Cross Reactions Denervation Dental Plaque Dyes Fluorescence Forceps Helium Neon Gas Lasers IgG1 Immunoglobulins Laser Scanning Microscopy Light Mice, House Microscopy Muscle Tissue Nerve Endings Nerve Tissue Neurofilaments Neuromuscular Junction Submersion Synapses Synaptic Vesicles Synaptophysin tetramethylrhodamine Triton X-100 Z 300

Immunohistochemistry for Renal Denervation

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Publication 2014

Anabolism Arteries Calcitonin Gene-Related Peptide Catecholamines Cells Denervation Dissection Dopa Dopa Decarboxylase Dopamine Elastica Elastic Fibers Enzymes Ganglia Glial Fibrillary Acidic Protein High Blood Pressures Kidney Nerve Fibers Nervousness Neurofilament Proteins Neuroglia Neurons Neurotransmitters Norepinephrine S100 Proteins Substance P Tissues trichrome stain Tyrosine Tyrosine 3-Monooxygenase

Denervation Effects on Gastric Cancer

We used 581 mice divided into 14 experimental groups. In each experiment, mice were randomly divided into different subgroups (fig. S1 and table S1). INS-GAS mice with spontaneous gastric cancer were used as previously described (18 (link), 19 (link)). Denervation was achieved by subdiaphragmatic bilateral truncal vagotomy, unilateral vagotomy, or Botox local injection. The tumor prevalence/incidence, tumor size, tumor regeneration, pathological changes, gene expression profiles, and immunohisto-chemical biomarkers were examined after denervation. In vitro gastric organoid culture was performed as described previously (9 (link)). We also performed three cohort studies of human primary gastric cancer and gastric stump cancer, as well as gene expression profiling and KEGG pathway analysis. All studies and procedures involving animals and hu man subjects were approved by the Norwegian National Animal Research Authority, the Columbia University Institutional Animal Care and Use Committee, Gifu University, and the National Cancer Center Hospital East, Japan. Statistical comparisons were performed between experimental groups, between the anterior and posterior sides of the stomachs, and between groups of patients. See the Supplementary Materials for the complete Materials and Methods.

Zhao C.M., Hayakawa Y., Kodama Y., Muthupalani S., Westphalen C.B., Andersen G.T., Flatberg A., Johannessen H., Friedman R.A., Renz B.W., Sandvik A.K., Beisvag V., Tomita H., Hara A., Quante M., Li Z., Gershon M.D., Kaneko K., Fox J.G., Wang T.C, & Chen D. (2014). Denervation suppresses gastric tumorigenesis. Science translational medicine, 6(250), 250ra115.

Publication 2014

Amputation Stumps Animals Biological Markers Botox Denervation Gastric Cancer Gastric Stump Homo sapiens Institutional Animal Care and Use Committees Malignant Neoplasms Mus Neoplasms Organoids Patients Regeneration Stomach Vagotomy Vagotomy, Truncal

Lumbar Facet Intervention Guidelines

The decision to convene a multispecialty working group to develop lumbar facet intervention guidelines was approved by the American Society of Regional Anesthesia and Pain Medicine Board of Directors on 20 November 2018. Stakeholder societies and other organizations (eg, Department of Veteran Affairs) with a vested interest in facet interventions were identified, and formal request-for-participation letters were sent to those societies, who all approved involvement in January 2019. Each society then nominated one or two members to serve on the committee based on their expertise, clinical experience and academic interests (see online supplementary appendix A for a list of participating societies and representatives). For the Department of Defense representative, the US Army Pain Medicine Consultant was selected, who has traditionally represented the Department of Defense in interagency and task force guidelines.28
The Lumbar Facet Intervention Guidelines Committee was charged with preparing guidelines on the use of facet blocks and RFA that span the entire spectrum of care to include patient selection, optimizing accuracy, interpreting results and risk mitigation. Questions and formats were developed by the committee chair based on input from the committee, and refined during conference calls. Guidelines for individual study questions were developed by subcommittees (modules) composed of four to five committee members, with one or two persons designated as the ‘leads’ responsible for task delegation. Once a module came to consensus on an answer, the committee chair assisted with editing and formatting, and the section was sent to the entire committee for open-forum comments and revisions. A modified Delphi method was used to tabulate comments, incorporate changes and converge the answers toward consensus over teleconference or electronic correspondence rounds. At the initial conference call, the committee decided that >50% panel agreement was sufficient to report a recommendation, but ≥75% agreement was required for consensus. After the task force completed the guidelines, the document was sent to the organizations’ boards of directors for approval, with only minor changes permitted at this stage. For organizational agreement, we determined that consensus required at least ≥75% agreement, with dissensions tabulated for each individual question.
Search engines used during composition of the various sections included MEDLINE, Embase, Google Scholar and Cochrane Database of Systematic Reviews, in addition to examination of the reference sections of all manuscripts. There were no limitations on language or types of articles used to develop the guidelines, such that experimental studies were considered for the sections on physical examination and technical parameters, and case reports were considered for sections pertaining to risk mitigation and complications. Keywords used to address guideline topics were tailored to individual questions and included ‘facet’, ‘low back pain’, ‘zygapophysial’, ‘zygapophyseal’, ‘radiofrequency’, ‘denervation’, ‘ablation’ and ‘arthritis’. Conclusions for each topic were graded on a scale from A to D, or as insufficient, according to the US Preventative Services Task Force grading of evidence guidelines, with the level of certainty rated as high, medium or low (tables 1–3).29 This system, which has been modified for use in interventional pain management guidelines drafted by the American Society of Regional Anesthesia & Pain Medicine, American Academy of Pain Medicine, American Society of Anesthesiologists, American Society of Interventional Pain Physicians (ASIPP) and the International Neuromodulation Society,30–33 (link) was chosen over others because of its flexibility,34 35 which permits high-grade recommendations in absence of high-quality level I studies, which are challenging to conduct for invasive procedures.36 (link)

Cohen S.P., Bhaskar A., Bhatia A., Buvanendran A., Deer T., Garg S., Hooten W.M., Hurley R.W., Kennedy D.J., McLean B.C., Moon J.Y., Narouze S., Pangarkar S., Provenzano D.A., Rauck R., Sitzman B.T., Smuck M., van Zundert J., Vorenkamp K., Wallace M.S, & Zhao Z. (2020). Consensus practice guidelines on interventions for lumbar facet joint pain from a multispecialty, international working group. Regional Anesthesia and Pain Medicine, 45(6), 424-467.

Publication 2020

Analgesics Anesthesia, Conduction Anesthesiologist Arthritis Committee Members Conferences Consultant Denervation Low Back Pain Lumbar Region Management, Pain Pain Physical Examination Physician Executives Physicians Veterans

Establishing Diverse Muscle Atrophy Models

Eight-week-old male C57BL/6 or BALB/c mice and 7–8-week-old male Sprague Dawley rats were used in this study. Multiple muscle atrophy models were established as follows: (1) the denervation-induced muscle atrophy was generated in rats or C57BL/6 mice by cutting off the mid-thigh region of the right sciatic nerve. The sham was generated by the same process but without cutting off sciatic nerve. Rats or mice were killed at 3, 5, 7 and 14 days after denervation, respectively. (2) The Dex-induced muscle atrophy model was induced by treating C57BL/6 mice with either Dex or phosphate-buffered saline (PBS; control) via intraperitoneal injections at a dose of 25 mg kg⁻¹ per day. All mice were killed after 1 week. (3) For fasting-induced muscle atrophy, C57BL/6 mice were maintained for 48 h with no food but free access to water, and the control mice were fed normally. (4) For ageing-induced muscle atrophy model, 10-week-old C57BL/6 mice were served as control and 23-month-old mice were collected as the ageing group. (5) For immobilization-induced muscle atrophy, the right ankle joint of C57BL/6 mice was fixed at 90° of flexion by insertion of a screw (0.4 × 8 mm) through the calcaneus and talus into the shaft of the tibia1 (link). All mice were killed after 1 week. (6) For cancer cachexia-induced muscle atrophy model, BALB/c mice were subcutaneously inoculated with 10⁶ of mouse colon cancer C26 cells. All mice were killed after 2 weeks.

Li J., Chan M.C., Yu Y., Bei Y., Chen P., Zhou Q., Cheng L., Chen L., Ziegler O., Rowe G.C., Das S, & Xiao J. (2017). miR-29b contributes to multiple types of muscle atrophy. Nature Communications, 8, 15201.

Publication 2017

Atrophy Cachexia Calcaneus Cancer of Colon Cancer of Muscle Cells Denervation Food Immobilization Injections, Intraperitoneal Joints, Ankle Males Malignant Neoplasms Mice, Inbred BALB C Mice, Inbred C57BL Mus Muscle Denervation Muscular Atrophy Nerves, Femoral Phosphates Rats, Sprague-Dawley Rattus norvegicus Saline Solution Sciatic Nerve Talus

Most recents protocols related to «Denervation»

Electromyography of Murine ALS Model

Female mice 12 belonging to C57BL/6JOlaHsd (7 G93A, 5NTG), 10 belonging to 129S2/Sv (6 G93A, 4 NTG) strain were anaesthetised with 2.5-3% isoflurane during the procedure. The anaesthetised mice were stimulated with supramaximal monophasic square wave via two monopolar subdermal needles with the cathode near the ischiatic nerve and recording bilaterally from gastrocnemius muscles through a belly-tendon montage. A semiquantitative electromyographic evaluation of the gastrocnemius denervation pattern was performed bilaterally. Averaged data from the right and left sides at the presymptomatic stage was analysed.
Electromyography registrations were performed through a single-use coaxial electrode (Spes Medica, length 30 mm, diameter 0.35 mm, registration area 0.07 mm²) and analysed with Electromyographs System Plus Evolution MYOQUICK Matrix Line (Micromed, Mogliano Veneto [TV], Italy). The heavy band was set between 5 Hz and 5 KHz; 5 resting denervation potentials were measured (sensibility 50 μV/division) in the right and left gastrocnemius muscles.

Margotta C., Fabbrizio P., Ceccanti M., Cambieri C., Ruffolo G., D’Agostino J., Trolese M.C., Cifelli P., Alfano V., Laurini C., Scaricamazza S., Ferri A., Sorarù G., Palma E., Inghilleri M., Bendotti C, & Nardo G. (2023). Immune-mediated myogenesis and acetylcholine receptor clustering promote a slow disease progression in ALS mouse models. Inflammation and Regeneration, 43, 19.

Publication 2023

Biological Evolution Denervation Electromyography Isoflurane Mice, Inbred C57BL Mus Muscle, Gastrocnemius Needles Nervousness Resting Potentials Sciatica SpeA protein, Streptococcus pyogenes Strains Tendons Woman

Multimodal Assessment for Ventricular Tachycardia Substrate

The process of target determination is shown in Figure 1. In Step 1 (Figure 1, Left panel), an electrophysiologist estimated the VT substrate or lesion site. We followed the method used by the Washington University team.⁸ (link) The areas with findings obtained from electrophysiological, structural, and functional information were virtual points plotted on a 17-segment model. Currently, the weighting of the 3 types of scores for each segment is not defined: the findings were converted to 1 point each, and the points calculated for each area were used as the total score.
Figure 1.

Study protocol. After registration with the Japan Registry for Clinical Trials, target and radiation planning comprised 3 steps. As part of Step 1, electrical, structural, and functional data were combined. Step 2 involved estimation of VT substrates and foci, as well as risk assessment of surrounding organs. Planning is repeated with targeting and contouring. Step 3 involves repeated calculation and determination of the optimal target volume, with permanent follow-up after radiotherapy. ECG, electrocardiogram; EPS, electrophysiological study; EVM, electroanatomic voltage mapping; ¹⁸F-FDG-PET, 18F-fluorodeoxyglucose positron emission tomography; HR, high resolution; ¹²³IMIBG, 123I-metaiodobenzylguanidine; MRI, magnetic resonance imaging; NSVT, non-sustained ventricular tachycardia; OAR, organ at risk; PVC, premature ventricular contraction; ^{99 m}Tc-TF, 99 m-technetium tetrofosmin; TCT, thoracic computer tomography; UCG, ultrasound cardiography; VT, ventricular tachycardia.

Electrophysiological assessment for predicting the origin of VT using 12-lead ECG during VT or non-sustained VT (NSVT) was based on the algorithm published by Andreu et al.⁹ (link) EPS is useful for detecting VT-supporting channels considered potential substrates of scar-related VT, which were referenced by induced VT morphology, cut-off adjustment of the voltage map, and pace mapping during sinus rhythm.¹⁰ (link)
Structural substrate information was acquired from ultrasound cardiography (UCG), CT, MRI, and electroanatomic voltage mapping (EVM). Myocardial foci were noted on the basis of myocardial wall thinning, calcification, and areas of gadolinium-delayed contrast.
Single-photon emission CT (SPECT) and positron emission CT (PET) were used to obtain functional substrate information. Scintigraphy included 99 m-technetium tetrofosmin (^{99 m}Tc-TF), ¹²³I-metaiodobenzylguanidine (MIBG), and ¹²³I-β-methyl-p-iodophenyl pentadecanoic acid (BMIPP).¹¹ (link) Arrhythmic substrates were assessed by calculating the area of poor perfusion and denervation, perfusion/innervation mismatch,¹² (link)^,¹³ (link) decreased heart-to-mediastinum (H/M) ratio,¹⁴ (link) and increased regional washout in the myocardium.¹⁵ (link)

Amino M., Kabuki S., Kunieda E., Hashimoto J., Sugawara A., Sakai T., Sakama S., Ayabe K., Ohno Y., Yagishita A., Kobayashi Y., Ikari Y, & Yoshioka K. (2023). Interim Report of a Japanese Phase II Trial for Cardiac Stereotactic Body Radiotherapy in Refractory Ventricular Tachycardia　― Focus on Target Determination ―. Circulation Reports, 5(3), 69-79.

Publication 2023

3-Iodobenzylguanidine Cicatrix Denervation Electricity Electrocardiogram Electrocardiography, 12-Lead Electrophysiologic Study, Cardiac F18, Fluorodeoxyglucose Gadolinium Health Risk Assessment Heart Iodine-123 iodofiltic acid Mediastinum Myocardium pentadecanoic acid Perfusion Physiologic Calcification Positron-Emission Tomography Radionuclide Imaging Radiotherapy Scan, CT PET Sinuses, Nasal Tachycardia, Ventricular Technetium-99 Tomography Ultrasonography Ventricular Contractions, Premature

Sciatic Nerve Transection in Opg-/- Mice

All animal experiments were performed under a project license (No. 2021-X17-69), which was reviewed and approved by the Institutional Animal Care and Use Committee of Chinese PLA General Hospital. All experiments were performed in compliance with the national guidelines for the care and use of animal.
Homozygote Opg^−/− (Tnfrsf11b^tm1Smoc, NM-KO-00004) mice and WT mice were purchased from the Shanghai Research Center for Model Organisms. All mice were housed in specific-pathogen-free conditions under a 12/12-h light/dark cycle, and movement and feeding were not restricted. Mouse genotypes were determined via PCR amplification of DNA isolated from their tails. Twelve-week-old male WT and Opg^−/− mice were used in our experiments to exclude the influence of hormones in female mice. A random allocation was performed for each genotype.
Sciatic nerve transection procedures were as follows: Mice were anesthetized using an intraperitoneal injection of 1% sodium pentobarbital. The sciatic nerve of the right hind limb was exposed and transected to a length of 10 mm (den group). The sciatic nerve of the left hind limb was exposed without transection (sham group). Body weight and gait of all mice were evaluated at the indicated time points. The mice were sacrificed before denervation, as well as days 3, 7, and 14 post denervation, and the bilateral gastrocnemius (GAS) muscles of all mice were harvested, weighed, and stored according to standard methods. The wet weight ratio was calculated by dividing the weight of the operative side by that of the sham-operated side.

Zhang M., Chen M., Li Y., Rao M., Wang D., Wang Z., Zhang L., Yin P, & Tang P. (2023). Delayed denervation-induced muscle atrophy in Opg knockout mice. Frontiers in Physiology, 14, 1127474.

Publication 2023

Animals Chinese Denervation Females Genotype Hindlimb Homozygote Hormones Injections, Intraperitoneal Institutional Animal Care and Use Committees Males Mice, House Movement Muscle, Gastrocnemius Pentobarbital Sodium Sciatic Nerve Specific Pathogen Free Tail

Gait Analysis in Denervated Mice

To evaluate changes in footprint and obtain gait images and parameters, CatWalk XT 9.0 (Noldus Information Technology, Wageningen, Netherlands) was used. Before and after denervation, mice were placed on a 1.3 m walkway and images of the footprints were captured using a high-speed camera. Three consecutive runs were conducted for each test. CatWalk XT software was used to analyze the footprint parameters, including stride length (length between successive placements of the same paw) and sway length (average width of the hind paws).

Zhang M., Chen M., Li Y., Rao M., Wang D., Wang Z., Zhang L., Yin P, & Tang P. (2023). Delayed denervation-induced muscle atrophy in Opg knockout mice. Frontiers in Physiology, 14, 1127474.

Publication 2023

Denervation Mice, House

In vivo Electroporation for Gene Modulation

In vivo electroporation experiments were performed in 3 months old C57BL/6 J female mice (25–28 g) either in the TA or in the flexor digitorum brevis (FDB). Mice that were used for in vivo electroporation experiments were housed under standard 12:12-h light/dark cycle and were fed with a standard chow diet (4RF21, Mucedola, Italy) and water. TA or FDB muscles were exposed through a small incision and plasmids of interest were injected intramuscularly (20 µg of plasmid for the TA and 10 µg for the FDB)^{4 (link),64 (link)}. Electric pulses were then applied using 2 stainless steel spatula electrodes placed on each side of the isolated muscle belly (TA: 21 V/cm, 20 ms pulse length, and 200 ms pulse interval, for a total of 5 pulses; FDB: 100 V/cm, 20 pulses, 1 s intervals). 7-10 days after electroporation, FDB muscle fibers were isolated enzymatically with collagenase (3 mg/mL) for 1 h 50 min at 37 °C and then mechanically separated. Fibers were then plated in Matrigel overnight at 37 °C. Fibers were then fixed using 4% paraformaldehyde in PBS for 20 min at room temperature for subsequent confocal analysis. One leg was electroporated with control vectors and the other leg with vectors of interest. To silence Mytho expression, a Mytho sh-RNA vector was generated using Invitrogen BLOCK-iTTM Pol II miR RNAi Expression vector kit. The sequence targeting MYTHO (5’ to 3’) is available in supplementary Table S1. For denervation experiments, shMytho or shScramble were transfected 5 days before the denervation procedure and for cancer cachexia model the transfection was performed 7 days after tumor inoculation. To overexpress Mytho, the coding sequence of the 230025D16Rik gene (1239 bp) was amplified from cDNA of the cancer cachexia mouse model and cloned in peGFP-N3 vector (4.7 kb) with KOD Hot Start DNA polymerase (Merck Millipore). The primers used for the amplification are detailed in supplementary Table S2.

Leduc-Gaudet J.P., Franco-Romero A., Cefis M., Moamer A., Broering F.E., Milan G., Sartori R., Chaffer T.J., Dulac M., Marcangeli V., Mayaki D., Huck L., Shams A., Morais J.A., Duchesne E., Lochmuller H., Sandri M., Hussain S.N, & Gouspillou G. (2023). MYTHO is a novel regulator of skeletal muscle autophagy and integrity. Nature Communications, 14, 1199.

Publication 2023

Cachexia Cancer Vaccines Cardiac Arrest Collagenase Denervation Diet DNA, Complementary DNA-Directed DNA Polymerase Electricity Electroporation Therapy Genes Malignant Neoplasms matrigel Mice, Inbred C57BL Mice, Laboratory Muscle Denervation Muscle Tissue Oligonucleotide Primers Open Reading Frames paraform Plasmids Pulse Rate Pulses RNA Interference RNA Polymerase II Stainless Steel Transfection Woman

Top products related to «Denervation»

6 ohda by Merck Group

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6-OHDA is a chemical compound used as a laboratory tool in neuroscience research. It has the molecular formula C₈H₁₁NO₂. 6-OHDA is primarily employed as a neurotoxin to induce selective degeneration of dopaminergic and noradrenergic neurons in animal models, enabling the study of Parkinson's disease and related neurological disorders.

C57bl 6j mice by Jackson ImmunoResearch

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C57BL/6J mice are a widely used inbred mouse strain. They are a commonly used model organism in biomedical research.

6 hydroxydopamine 6 ohda by Merck Group

Sourced in United States, Japan

6-hydroxydopamine (6-OHDA) is a chemical compound used in research laboratories. It is a selective neurotoxin that is primarily used to induce dopaminergic neurodegeneration in experimental models. The core function of 6-OHDA is to selectively target and damage dopamine-producing neurons, which can be useful for studying Parkinson's disease and other neurological disorders.

Apomorphine by Merck Group

Sourced in United States, Germany

Apomorphine is a laboratory equipment product manufactured by Merck Group. It is a chemical compound used in various research and analytical applications. Apomorphine serves as a core function in specific laboratory procedures and experiments.

Wire knife by Kopf Instruments

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The Wire Knife is a precision cutting tool designed for use in laboratory environments. It features a thin, sharp wire that can be used to cleanly cut a variety of materials. The device is constructed with durable materials to ensure reliable performance.

Sprague dawley rat by Charles River Laboratories

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Sprague-Dawley rats are an outbred albino rat strain commonly used in laboratory research. They are characterized by their calm temperament and reliable reproductive performance.

Male c57bl 6 mice by Charles River Laboratories

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Male C57BL/6 mice are a commonly used mouse strain in biomedical research. They are inbred and genetically homogeneous, providing a consistent model for scientific studies. These mice have a black coat color and are known for their docile temperament and suitability for a variety of research applications.

Cd 1 mice by Charles River Laboratories

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Symplicity flex by Medtronic

Sourced in United States

The Symplicity Flex is a medical device designed for use in the treatment of hypertension. It is a catheter-based tool that is used to perform renal denervation, a procedure that targets the nerves surrounding the renal arteries to reduce blood pressure. The Symplicity Flex provides a minimally invasive approach to this treatment.

Zen software by Zeiss

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ZEN software is a comprehensive imaging and analysis platform designed for microscopy applications. It provides a user-friendly interface for image acquisition, processing, and analysis, supporting a wide range of Zeiss microscopy instruments.

What are the main methods used to achieve denervation?

Denervation can be achieved through several methods, including surgical, chemical, and physical techniques. Surgical denervation involves the physical removal or disruption of the nerve supply to the target tissue or organ. Chemical denervation utilizes agents like local anesthetics or neurotoxins to temporarily or permanently block nerve impulses. Physical denervation methods, such as radiofrequency ablation or cryotherapy, use thermal energy or extreme cold to selectively destroy the nerves.

What are some common applications of denervation in medical research and clinical settings?

Denervation is used in various contexts, including pain management, muscle function studies, and organ transplantation. For example, denervation is often employed to investigate the physiological effects of losing neural control, such as changes in pain perception, muscle tone, and organ function. Researchers utilize denervation to better understand the underlying mechanisms of diseases and develop new therapies. In clinical settings, denervation techniques may be used to alleviate chronic pain conditions, manage muscle spasticity, or prepare organs for transplantation.

How can PubCompare.ai help optimize denervation research?

PubCompare.ai can significantly enhance your denervation research by providing AI-powered access to the most relevant protocols from literature, preprints, and patents. The platform's seamless comparisons allow you to easily identify the most effective protocols for your specific research goals, improving reproducibility and accuracy. By leveraging the power of AI-driven analysis, PubCompare.ai can help you pinpoint critical insights and make more informed decisions about the best denervation techniques to employ in your studies. Experince seamless denervation research optimization with PubCompare.ai.

What are some common challenges or considerations when working with denervation techniques?

One key challenge with denervation is the potential for unintended or off-targte effects, as disrupting the nerve supply can have far-reaching consequences on the body's physiological functions. Researchers must carefully consider the specificity and reversibility of their denervation methods to minimize collateral damage. Additionally, the timing and duration of denervation can be crucial, as prolonged denervation may lead to irreversible changes or tissue degeneration. Proper monitoring and follow-up are essential to ensure the denervation protocols are achieving the desired outcomes without causing undue harm.

More about "Denervation"

Denervation is the process of intentionally disrupting or removing the nerve supply to a specific tissue or organ, commonly used in medical research and clinical settings.
This technique is utilized to investigate the physiological effects of losing neural control, often in the context of pain management, muscle function, and organ transplantation.
Denervation can be achieved through surgical, chemical, or physical methods, each with its own advantages and limitations.
Researchers employ denervation to study the underlying mechanisms of various disease states, develop new therapies, and optimize treatment approaches.
By understanding the impact of denervation on biological systems, scientists can advance their knowledge and improve patient outcomes.
Related terms and concepts include 6-OHDA (6-hydroxydopamine), which is a neurotoxin commonly used to induce selective degeneration of dopaminergic neurons in animal models, often in C57BL/6J mice.
Sprague-Dawley rats and Male C57BL/6 mice are also commonly used in denervation research.
Additionally, the Wire knife and Symplicity Flex are among the physical methods used to achieve denervation.
Apomorphine, a dopamine receptor agonist, is a common tool used to assess the functional consequences of denervation in animal models.
The ZEN software is often utilized in the analysis and visualization of denervation-related data.
By incorporating these related terms and concepts, researchers can enhance their understanding and optimization of denervation research, improving reproducibility and accuracy of their findings.