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> Procedures > Therapeutic or Preventive Procedure > Fluid Therapy

Fluid Therapy

Fluid therapy is the administration of liquids to maintain proper fluid balance and hydration within the body.
It is a critical component of medical care, used to treat a variety of conditions such as dehydration, shock, and electrolyte imbalances.
Pubcompare.ai is an innovative AI-driven platform that optimizes fluid therapy research by streamlining the process of locating and comparing protocols from literature, pre-prints, and patents.
This tool leverages intelligent comparisons to help identify the best fluid therapy protocols and products, allowing researchers to accelerate their work and experince the future of fluid therapy optimization.

Most cited protocols related to «Fluid Therapy»

1
Fluid Resuscitation Strategies in African Children
Fluid Expansion As Supportive Therapy (FEAST) in critically ill African children trial is underway in six hospitals across three African countries [6 ]. The trial examines three different fluid resuscitation strategies on 48 hour and 28 day survival. The design is pragmatic as children are enrolled on clinical criteria alone and it is being conducted in hospitals with facilities typical of many district hospitals across sub Saharan Africa. The main objective of the trial is to facilitate clinicians and policy makers working in sub-Saharan Africa in deciding the best strategy to adopt in managing children with febrile illness and features of shock.
For this late phase clinical trial of fluid resuscitation http://feast-trial.org/ or ISCTRN 69856593 we conducted a narrative review of international recommendations and guidelines, and of empirical literature, to inform our process of consent. Following a detailed review of international regulatory body requirements in these settings, we searched the academic literature through combining keywords in pubmed.org including "emergency", "consent", "clinical trial", "assent", "waiver", "paediatric", "community consultation "and "children". In particular, we considered two important practical and ethical aspects of the consent process: community consultation, and alternatives to prior full written consent among populations with diminished autonomy. Information from this review fed into consent discussions in trial planning meetings.
Maitland K., Molyneux S., Boga M., Kiguli S, & Lang T. (2011). Use of deferred consent for severely ill children in a multi-centre phase III trial. Trials, 12, 90.
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Publication 2011
Child Critical Illness Emergencies Fever Fluid Therapy Human Body Negroid Races Policy Makers Population Group Resuscitation Shock
2
Healthy Late Preterm Infants Cohort
We sampled 599 eligible healthy late preterm infants from 795 preterm infants who were born in January 2014 to April 2017 and got regular health care service in Child Health Care Center. Ethical approval was obtained from the Research and Ethics Committee of Shandong Qianfoshan Hospital before commencement. For all eligible infants, an informed consent was obtained from the parents before enrollment.
The criteria for inclusion and exclusion were as follows: ①PMA at birth: Late preterm birth, defined as 34–36 completed weeks of gestation calculated by last menstrual date, confirmed by early ultrasound measurements; ②No severe neonatal complications: Infants with any neonatal complications(such as severe neonatal asphyxia, hypoxic-ischemic encephalopathy, intracranial hemorrhage, respiratory distress syndrome, necrotizing enterocolitis, etc) which needed parenteral nutrition and intravenous fluid therapy were excluded; ③No congenital malformations and syndromes;④PMA at visit(week): Calculated as PMA at birth(week) + (Date of visit - Date of birth)/7. As the end time-point of this study—PMA at visit should be strictly at 40 weeks(term-corrected age), but it was difficult to control in practice. For better controlling the possible bias, we set the PMA at visit in the range of 37.7–42.3 weeks, equivalent to ±0.5 month chronological age(CA) from the expected date of delivery. Infants with PMA at visit beyond this range were excluded. The flow chart of the recruitment of healthy late preterm infants was shown in Fig. 1.

Flow chart showing the recruitment of healthy late preterm infants

Zhang L., Li Y., Liang S., Liu X.J., Kang F.L, & Li G.M. (2019). Postnatal length and weight growth velocities according to Fenton reference and their associated perinatal factors in healthy late preterm infants during birth to term-corrected age: an observational study. Italian Journal of Pediatrics, 45, 1.
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Publication 2019
Asphyxia Neonatorum Birth Childbirth Congenital Abnormality Ethics Committees, Clinical Fluid Therapy Hypoxic-Ischemic Encephalopathy Infant Infant, Newborn Intracranial Hemorrhage Menstruation Necrotizing Enterocolitis Obstetric Delivery Parent Parenteral Nutrition Pregnancy Premature Birth Respiratory Distress Syndrome, Newborn Syndrome Ultrasonography
3
Wound Healing in Irradiated Mice
B6D2F1/J female mice were purchased from Jackson Laboratory (Bar Harbor, ME) and used when 12–20 wk old. Male mice were not used in this study because of aggression, which in these experiments could lead to further damage to wound sites and enhanced infection. All mice were randomly assigned to experimental groups. Eight mice were housed per filter-topped polycarbonate cage (MicroIsolator) in conventional holding rooms. Rooms were provided 20 changes of 100% fresh air per h, conditioned to 72 ± 2°F with relative humidity of 50 ± 20%. Mice were maintained on a 12-h 6 am light/6 pm dark, full-spectrum-light cycle with no twilight. Research was conducted in a facility accredited by the Association for Assessment and Accreditation of Laboratory Animal Care-International (AAALAC-I). All procedures involving animals were reviewed and approved by the AFRRI Institutional Animal Care and Use Committee. Euthanasia was carried out in accordance with recommendations [48 ,49 ] and guidelines [50 ].
Prior to experiments, hair of the dorsal surface of mice was removed under anesthesia (methoxyflurane inhalation) using electric clippers. Mice were placed in well-ventilated acrylic restrainers for irradiation or sham treatments. Within 1 h after irradiation or sham irradiation, mice were anesthetized by methoxyflurane inhalation, and wounding or sham wounding was performed. All mice received an i.p. injection of 0.5 ml sterile isotonic 0.9% NaCl as fluid therapy immediately after sham handling, irradiation, and/or wounding. After fluid therapy, mice were returned to their original cages. After irradiation and/or wounding, their water consumption for the first 7 days, body weights, wound closure, and survival for 30 days were measured as described previously [4 (link)].
Kiang J.G., Garrison B.R., Burns T.M., Zhai M., Dews I.C., Ney P.H., Cary L.H., Fukumoto R., Elliott T.B, & Ledney G.D. (2012). Wound trauma alters ionizing radiation dose assessment. Cell & Bioscience, 2, 20.
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Publication 2012
Anesthesia Animals Animals, Laboratory Body Weight Electricity Euthanasia Females Fluid Therapy Hair Humidity Infection Inhalation Institutional Animal Care and Use Committees Light Males Methoxyflurane Mice, House Normal Saline Placebos polycarbonate Radiotherapy Sterility, Reproductive Water Consumption Wounds
4
Ischemic Stroke Induction in Miniature Pigs
Surgical induction of ischemic stroke injury was first optimized in 4 male landrace pigs and once optimized; this study was performed in 7 male Yucatan miniature pigs (5 years old; weighing between 80.9-104.5 kg with mean weight 93.6 kg).
All pigs were administered antibiotics 30 minutes prior to surgery (Ceftiofur sodium (Naxcel®; 4 mg/kg IM). Pre-induction analgesia and sedation was obtained using xylazine (5 mg/kg IM), butorphanol (0.2 mg/kg IM) and glycopyrrolate (0.01 mg/kg IM). Anesthesia was induced with intravenous propofol to effect and prophylactic lidocaine (0.5 to 1.0 mL of 2% lidocaine) was administered topically to the laryngeal folds to facilitate intubation. Anesthesia was maintained with 1.5% inhalational isoflurane (Abbott Laboratories) in oxygen. Artificial ventilation was performed at a rate of 8–12 breaths per minute with tidal volume of 5–10 ml/kg. With the animal positioned in sternal recumbency, a venous catheter was placed in the left aural vein for fluid therapy. During surgery, lactated ringers solution was administered at a rate of 5 ml/kg/hour. Heart rate was monitored by Doppler probe placement on the ventral tail artery. Rectal temperature was recorded every 15 minutes using a digital thermometer.
The head was tilted to the left 45 degrees and secured to facilitate a right MCA approach, utilizing gravity to lift the cerebrum away from the bony skull base during intracranial surgery. Hair between the eye and ear was shaved and the skin was prepared in a routine manner for sterile surgery using Betadine and 70% alcohol. The surgical site was draped in a standard fashion.
Platt S.R., Holmes S.P., Howerth E.W., Duberstein K.J., Dove C.R., Kinder H.A., Wyatt E.L., Linville A.V., Lau V.W., Stice S.L., Hill W.D., Hess D.C, & West F.D. (2014). Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model. Experimental & Translational Stroke Medicine, 6, 5.
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Publication 2014
Anesthesia Animals Antibiotics, Antitubercular Arteries Base of Skull Betadine Bones Butorphanol Catheters ceftiofur sodium Cerebral Hemispheres Condoms Ethanol Fingers Fluid Therapy Glycopyrrolate Gravity Hair Head Inhalation Injuries, Surgical Intubation Isoflurane Lactated Ringer's Solution Laryngeal Prosthesis Lidocaine Males Management, Pain Naxcel Operative Surgical Procedures Oxygen Pigs Propofol Rate, Heart Rectum Respiration, Artificial Respiratory Rate Sedatives Skin Sterility, Reproductive Sternum Stroke, Ischemic Tail Thermometers Tidal Volume Veins Xylazine
5
Carbohydrate-Restricted Diet for T2DM
We recruited outpatients with T2DM having HbA1c levels of 9.0% or above between September 2005 and September 2007 in Haimoto Clinic, and followed their HbA1c levels, body mass index (BMI) and doses of antidiabetic drugs monthly for 6 months. We also followed their serum lipid profiles, serum creatinine and blood pressure. Patients with serum creatinine levels > 1.5 mg/dl, severe diabetes complications (proliferative retinopathy, symptomatic neuropathy and diabetic foot), ketoacidosis, soft drink ketosis [9 (link)] and malignant tumor were excluded. Five patients who developed ketosis received fluid therapy for a few days, and did not require any inpatient care or insulin therapy. We intended to taper the dose of sulfonylureas as soon as the patients' HbA1c levels were controlled, and to prescribe metformin, acarbose and pioglitazone. The patients were instructed to maintain their usual level of physical activity throughout the study. Changes in activity levels were investigated by questionnaire. The study protocol was identical to that of the previous study [8 (link)] and was approved by the Ethical Committee of the Nagoya Tokusyukai General Hospital. All patients provided written informed consent.
The main principle of the CRD was to eliminate carbohydrate-rich food twice a day at breakfast and dinner, or eliminate it three times a day at breakfast, lunch and dinner. Table 1 shows the list of foods that the subjects were instructed to avoid. There were no other restrictions. Patients on the CRD were permitted to eat as much protein and fat as they wanted, including saturated fat. Their details were described previously [8 (link)]. At the end of the study, dietary intake was assessed based on 3-day food records. Changes in HbA1c and BMI were assessed by the Friedman test, and changes in serum LDL-cholesterol, HDL-cholesterol, triglyceride, creatinine and blood pressure were assessed by the paired t-test.
Haimoto H., Sasakabe T., Wakai K, & Umegaki H. (2009). Effects of a low-carbohydrate diet on glycemic control in outpatients with severe type 2 diabetes. Nutrition & Metabolism, 6, 21.
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Publication 2009
Acarbose Antidiabetics Blood Pressure Carbohydrates Cholesterol, beta-Lipoprotein Complications of Diabetes Mellitus Creatinine Diabetic Foot Fluid Therapy Food High Density Lipoprotein Cholesterol Hospitalization Index, Body Mass Insulin Ketosis Lipids Malignant Neoplasms Metformin Outpatients Patients Pioglitazone Proteins Retinal Diseases Saturated Fatty Acid Serum Soft Drinks Sulfonylurea Compounds Therapeutics Triglycerides

Most recents protocols related to «Fluid Therapy»

1
Biotin and Diet Therapy for Acute Decompensation
Treatment including oral biotin and diet adjustment was commenced immediately after confirming the diagnosis. For patients during acute decompensation, the initial therapy included a low-protein diet, supplementation of biotin as well as L-carnitine, and intravenous fluid therapy with glucose as well as electrolytes. Then the treatment was adjusted according to their response to biotin and other personal condition. The recommended dosage of lifelong administered biotin was 10–40 mg/day [12 (link)].
Ling S., Qiu W., Zhang H., Liang L., Lu D., Chen T., Zhan X., Wang Y., Gu X, & Han L. (2023). Clinical, biochemical, and genetic analysis of 28 Chinese patients with holocarboxylase synthetase deficiency. Orphanet Journal of Rare Diseases, 18, 48.
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Publication 2023
Biotin Diagnosis Diet, Protein-Restricted Electrolytes Fluid Therapy Glucose Levocarnitine Patients Therapy, Diet
2
Respiratory Support for COVID-19 Patients
Nebulized 3% hypertonic saline solution, superficial nasal aspiration, and intravenous fluid therapy are used in our units, according to the latest guidelines and recent data from the literature (2 (link), 11 (link)–14 (link)). Intravenous fluid therapy is rapidly decreased when the clinical conditions are adequate to provide enteral feeding. Patients with persistent saturation levels below 92% and signs of respiratory distress (tachypnoea, chest retractions, etc.) or respiratory acidaemia on the venous blood gas analysis undergo high-flow nasal cannula (HFNC) as primary respiratory support: we provide a flow rate of 2 liters/minute per kilogram of body weight, starting with 4 liters/minute up to 10 liters/minute. We use nasal continuous positive airway pressure (nCPAP) or mechanical ventilation as rescue therapy for those patients with clinical deterioration. In the case of nCPAP, positive end-expiratory pressure (PEEP) is set between 5 and 7 cmH20.
De Rose D.U., Maddaloni C., Martini L., Braguglia A., Dotta A, & Auriti C. (2023). Comparison of three clinical scoring tools for bronchiolitis to predict the need for respiratory support and length of stay in neonates and infants up to three months of age. Frontiers in Pediatrics, 11, 1040354.
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Publication 2023
Blood Gas Analysis Body Weight Chest Clinical Deterioration Fluid Therapy Mechanical Ventilation Nasal Cannula Nasal Continuous Positive Airway Pressure Nose Patients Positive End-Expiratory Pressure Respiratory Rate Saline Solution, Hypertonic Therapeutics Training Programs Veins
3
Acute Care for Nursing Home Residents
The population comprised all activations between 1st November 2020 and 31st December 2021. All contacts were prospectively registered in the patient administrative system at OUH with a procedure code and a conclusive International classification of Diseases (ICD-10) diagnosis. Information regarding person identifiers, age, sex, dates and times of visits, final diagnoses and hospital admissions were extracted based on specific procedure codes. For the OUH registered data, we recorded the dates and times (index), hospital admissions, all acute hospital contacts within the past 2 years before the index visits and related discharge diagnoses until 30 days following the visits. The data were merged on an individual level and stored, prepared and assigned on a secure encrypted and logged server via OPEN Analyse, which is a secure analysis environment in the Region of Southern Denmark [20 ].
The following detailed information was registered on-site in the nursing homes for two time periods by the ED consultant: level of acuity of the dispatched ambulance and the ED-based acute care service (response levels: high acuity, moderate acuity, low acuity and very low acuity); information regarding the dispatch of ambulances; IV fluid therapy; procedures performed (point-of-care analyses and ultrasonography); medical treatment initiated; and any ensuing treatment at the nursing home prescribed by the ED consultant. The medical treatments initiated included intravenous antibiotics, analgesics, sedatives, diuretics and other medical treatments.
Udesen S.E., Rasmussen C.H., Mikkelsen S., Andersen N., Brabrand M, & Lassen A.T. (2023). Mobile emergency department care to nursing home residents: a novel outreach service. Age and Ageing, 52(3), afad025.
Publication 2023
Ambulances Analgesics Antibiotics Consultant Diagnosis Diuretics Fluid Therapy Patient Discharge Patients Point-of-Care Systems Sedatives Ultrasonography
4
Perioperative Management Protocol for Surgical Patients
Patients are administered 400 ml/50 g carbohydrate pre-surgery drink, premedicated and anesthetized according to the standardized protocol which defines: perioperative medication, fluid therapy, hemodynamic goals and management, diuresis, core temperature, transfusion threshold, and postoperative nausea, and vomiting prevention. The protocol also defines analgesia corresponding with randomization (including a detailed standard of care for thoracic epidural analgesia). All the data are recorded including the length of anesthesia and surgery, and a brief description of the type of surgery and observed radicality.
Postoperative care is standardized including postoperative analgesia corresponding with randomization, hemodynamic optimization, fluid therapy and transfusions, glycemic control, and postoperative nausea and vomiting management.
A detailed description of perioperative and postoperative management in all three arms of the study is displayed in Fig. 2. The patients with insufficient pain relief on the protocol medication will be provided rescue multimodal analgesia with a strong opioid and will be excluded from the final analysis of the CTCs.

Detailed protocol of perioperative management

All the data are recorded to the patient´s electronic CRF, using academic cloud operated software ClinData (https://clindata.imtm.cz), including pain intensity (using the Numerical Rating Scale) and sedation (using the Richmond Agitation-Sedation Scale), adverse effects and complications directly associated with PA, postoperative nausea and vomiting, core temperature, duration of postoperative ileus, laboratory tests, and cognitive function evaluation.
Berta E., Srovnal J., Dytrych P., Bruthans J., Ulrichova J., Prasil P., Vecera L., Gabrhelik T., Tolmaci B., Dusa J., Maca J., Mazancova M., Haiduk F., Kutej M., Ihnat P., Michalek P, & Hajduch M. (2023). Influence of opioid analgesia type on circulating tumor cells in open colorectal cancer surgery (POACC-1): study protocol for a prospective randomized multicenter controlled trial. BMC Anesthesiology, 23, 64.
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Publication 2023
Analgesia, Epidural Analgesics, Opioid Anesthesia Arm, Upper Blood Transfusion Carbohydrates Cognition Diuresis Fluid Therapy Glycemic Control Hemodynamics Ileus Management, Pain Multimodal Imaging Operative Surgical Procedures Pain Patients Pharmaceutical Preparations Postoperative Care Postoperative Nausea Sedatives Severity, Pain
5
Efficacy of Drug-Loaded Hydrogel for Canine Wound Treatment
The therapeutic efficacy of a drug-loaded hydrogel that was selected after the previous studies was evaluated through one in vivo case study; the case study involved a 13-year-old neutered male dog (Serra da Estrela breed), weighing 30 kg, that was admitted to the veterinary hospital (Hospital Veterinário de S. Bento, Lisbon, Portugal) with multiple dog bite wounds. Physical examination of the dog showed a body condition 3/9, hypotension, prostration, and exudative wounds on the left thoracic limb (two lesions: one caudal and another cranial) and the right pelvic limb (one dorsolateral lesion), with signs of severe pain. The animal had claudication of the left thoracic limb due to a previous identical episode. Biochemical and haemogram analyses were performed and revealed hypoalbuminemia (1.4 g/dL), compatible with protein-losing enteropathy. Initially, the animal required stabilisation with fluid therapy Ringer’s lactate (B. Braun®) through a venous catheter in the jugular (Introcan®). Analgesic, anti-inflammatory, and antibiotherapy management was performed.
The wounds on the left thoracic limb were cleaned with 1% chlorhexidine (desinclor®) until the animal was stable, and cryotherapy was performed two times a day for 20 days. After stabilisation, it was possible to perform trichotomy of the injured areas using an Oster® Golden A5® shearing machine and Oster CryogenX® No. 40 shearing blade. Thereafter, cleaning of the wounds was carried out with isotonic saline Ringer’s lactate (B. Braun®) associated with 1% chlorhexidine. Drug-loaded hydrogels dressings (8 × 8 cm2) were then applied to the two wounds of the left thoracic limb, gloved, and protected by 100% cotton surgical sterile gauze pads (Bastos Viegas®); they were attached to the limb with adhesive (3M™ Durapore™). The dressing was covered with a second layer of elastic bandage (Bastos Viegas®) and wrapped in a third layer of self-adhesive bandage (Peha-haht®). The procedure was performed in a way to avoid clog of the injured area, ischemia, oedema, or cell death. Dressings were changed daily for the first week and then every 48 h until resolution.
Wound management of the right pelvic limb was performed vi disinfection with 1% chlorhexidine associated with isotonic saline Ringer’s lactate, followed by application of 100% cotton surgical sterile gauze pads (Bastos Viegas®) that were fixed to the skin with a non-woven adhesive band (Omnifix®E). This management is commonly used in clinical practice in wounds whose closure is expected to occur via second-intention healing, without expected complications.
The study was approved by the Ethical Committee (CEBEA) of Faculdade de Medicina Veterinária da Universidade Lusófona (Ref. n◦27/2019); both the ARRIVE guidelines and EU Directive 2010/63/EU for animal experiments were followed.
Garcia L.V., Silva D., Costa M.M., Armés H., Salema-Oom M., Saramago B, & Serro A.P. (2023). Antiseptic-Loaded Casein Hydrogels for Wound Dressings. Pharmaceutics, 15(2), 334.
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Publication 2023
Analgesics Animals Anti-Inflammatory Agents Bandage Catheters Cell Death Chlorhexidine Compression Bandages Cranium Cryotherapy Dental Occlusion Disinfection Dressings Edema Fluid Therapy Gossypium Human Body Hydrogels Hypoalbuminemia Ischemia Jugular Vein Lactated Ringer's Solution Males Multiple Trauma Operative Surgical Procedures Pain Pelvis Pharmaceutical Preparations Physical Examination Protein-Losing Enteropathies Saline Solution Skin Sterility, Reproductive Therapeutics Thoracic Injuries Wounds

Top products related to «Fluid Therapy»

1
Flotrac by Edwards Lifesciences
Sourced in United States
The FloTrac is a minimally invasive hemodynamic monitoring system developed by Edwards Lifesciences. Its core function is to continuously measure and display a patient's cardiac output and other related hemodynamic parameters, providing clinicians with real-time data to guide patient management.
2
Voluven by Fresenius
Sourced in Germany, Sweden, France
Voluven is a colloid solution that is used to replace or maintain blood volume. It contains hydroxyethyl starch, which helps to maintain fluid balance in the body.
3
Plasma lyte a by Baxter
Sourced in United States, Switzerland, Canada, United Kingdom
Plasma-Lyte A is a sterile, nonpyrogenic solution for intravenous administration. It is a balanced isotonic electrolyte solution that contains sodium, potassium, magnesium, chloride, and acetate ions.
4
Spss pasw 18 by IBM
Sourced in United States
SPSS/PASW 18 is a statistical analysis software package designed for data management, analysis, and reporting. It provides a comprehensive set of tools for data manipulation, exploration, modeling, and visualization. The software is widely used in various industries and academic settings to analyze and interpret complex data.
5
Sevorane by Abbott
Sourced in Germany, United States, Switzerland, United Kingdom, Spain
Sevorane is a volatile anesthetic agent manufactured by Abbott. It is used for the induction and maintenance of general anesthesia.
6
Ketamine by Pfizer
Sourced in United States, Germany, United Kingdom, Sweden, Denmark
Ketamine is a general anesthetic used in medical settings. It is a dissociative drug that induces a trance-like state, providing pain relief, sedation, and temporary paralysis. Ketamine is primarily used for veterinary procedures and in emergency medicine for human patients.
7
Rompun by Bayer
Sourced in Germany, France, United States, United Kingdom, Canada, Italy, Brazil, Belgium, Cameroon, Switzerland, Spain, Australia, Ireland, Sweden, Portugal, Netherlands, Austria, Denmark, New Zealand
Rompun is a veterinary drug used as a sedative and analgesic for animals. It contains the active ingredient xylazine hydrochloride. Rompun is designed to induce a state of sedation and pain relief in animals during medical procedures or transportation.
8
Rocuronium by Organon
Sourced in Austria, China, Germany
Rocuronium is a type of non-depolarizing neuromuscular blocking agent. It is used in medical settings to induce muscle relaxation during surgical procedures or mechanical ventilation.
9
Volulyte by Fresenius
Sourced in Germany
Volulyte is an intravenous solution used for fluid replacement and volume expansion. It is a colloid solution containing hydroxyethyl starch and electrolytes. Volulyte is designed to maintain or restore blood volume in patients who require fluid therapy.
10
Stereotactic frame by Kopf Instruments
Sourced in United States, Germany
The Stereotactic Frame is a medical device used in neurosurgical procedures. It provides a three-dimensional coordinate system to precisely locate and target specific areas within the brain. The frame is attached to the patient's head, allowing for accurate and minimally invasive access to the targeted region.

More about "Fluid Therapy"

fluid management, fluid balance, hydration, dehydration, shock, electrolyte imbalances, FlotTrac, Voluven, Plasma-Lyte A, SPSS/PASW 18, Sevorane, Ketamine, Rompun, Rocuronium, Volulyte, stereotactic frame, fluid therapy optimization, Pubcompare.ai