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General Anesthesia

General anesthesia is a state of controlled, reversible unconsciousness induced by the administration of one or more anesthetic agents.
It allows for safe and painless medical procedures by depressing the central nervous system and blocking pain sensations throughout the body.
This comprehensive medical intervention is widely used in surgical, obstetric, and other medical settings to facilitate various procedures and ensure patient comfort and safety.
The effects of general anesthesia can be carefully monitored and adjusted by trained healthcare professionals to provide the optimal level of unconsciousness and pain relief for the duration of the medical intervention.

Most cited protocols related to «General Anesthesia»

Two adult rhesus monkeys (Macaca mulatta) were used for the experiments. All procedures for animal care and experimentation were approved by the Institute Animal Care and Use Committee and complied with the Public Health Service Policy on the humane care and use of laboratory animals. A plastic head holder and plastic recording chamber were fixed to the skull under general anesthesia and sterile surgical conditions. The recording chamber was placed over the fronto-parietal cortex, tilted laterally by 35 degrees, and was aimed at the SNc and VTA. Two search coils were surgically placed under the conjunctiva of the eyes. The head holder, the recording chamber and the eye coil connectors were all embedded in dental acrylic that covered the top of the skull and were connected to the skull by acrylic screws. We conditioned two monkeys using a Pavlovian procedure with an appetitive US (liquid reward) and an aversive US (airpuff). During the Pavlovian procedure, we recorded the activity of dopamine neurons in and around the SNc and VTA. We estimated the position of the SNc and VTA by MRI and identified dopamine neurons by their electrophysiological properties. After the end of recording sessions in one monkey, we confirmed the recording sites histologically. We analyzed anticipatory licking, anticipatory blinking and neuronal responses during the Pavlovian procedure. We focused on three kinds of neuronal responses: 1) responses elicited by CS presentation, 2) responses elicited by US delivery, and 3) responses elicited by US omission. Details of the Pavlovian procedure, identification of dopamine neurons, analysis methods, and histological procedure can be found in Full Methods.
Publication 2009
Adult Animals Animals, Laboratory Conjunctiva, Bulbar Cranium Dental Health Services Dopaminergic Neurons General Anesthesia Head Histological Techniques Macaca mulatta Monkeys Neurons Obstetric Delivery Operative Surgical Procedures Parietal Lobe Sterility, Reproductive

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Publication 2011
Cortex, Cerebral Craniotomy Cranium Drug Resistant Epilepsy Dura Mater Ethics Committees, Research General Anesthesia Hemorrhage Occipital Lobe Operative Surgical Procedures Ovum Implantation Parietal Lobe Patients Platinum Seizures Silastic Woman
The first quantitative measurements of blood pressure were performed in animals by Hales in 1733 [24 , 25 (link)]. Early reports of intra-arterial pressure measurement in the human are from 1912, when Bleichröder [26 ] cannulated his own radial artery. It is unlikely that he recorded his BP although it would have been possible at that time: Frank developed accurate and fast manometers that could measure pulsatile pressure in 1903 [27 ]. Invasive measurement of BP was confined to the physiology labs for quite some time [28 (link), 29 (link)]. However in the 1950s and 1960s, with the development of refined insertion techniques [30 (link)] and Teflon catheters it became standard clinical practice. High fidelity catheter-tip manometers, such as used to measure pressure gradients across a coronary stenosis, were introduced by Murgo and Millar in 1972 [31 ]. Table 1 gives an overview of BP methods.

Methods for measurement of blood pressure and cardiac output

SystemMethodCompanyCOBP
NexfinFinger cuff technology/pulse contour analysisBMEYE+___+___
FinometerFinger cuff technology/pulse contour analysisFMS+___+___
LIFEGARD® ICGThoracic electrical bioimpedanceCAS Medical Systems, Inc.+___+
BioZ MonitorImpedance cardiographyCardioDynamics International Corporation+___+
Cheetah reliant“Bioreactance”Cheetah Medical+___+
Cardioscreen/NiccomoImpedance cardiography and impedance plethysmographyMedis Medizinische Messtechnik GmbH+___+
AESCULONElectrical “velocimetry”Osypka Medical GmbH+___+
HIC-4000Impedance cardiographyMicrotronics Corp Bio Imp Tech, Inc.+___
NICaSRegional impedanceNImedical+___
IQ23-dimensional impedanceNoninvasive Medical Technologies+___
ICONElectrical “velocimetry”Osypka Medical GmbH+___
PHYSIO FLOWThoracic electrical bioimpedanceManatec biomedical+___
AcQtracThoracic impedanceVäsamed+___
esCCOPulse wave transit timeNihon Kohden+___
TEBCOThoracic electrical bioimpedanceHEMO SAPIENS INC.+___
NCCOM 3Impedance cardiographyBomed Medical Manufacturing Ltd+___
RheoCardioMonitorImpedance cardiographyRheo-Graphic PTE+___
HemoSonic™ 100transesophageal DopplerArrow Critical Care Products+___
ECOMEndotracheal bioimpedanceConMed Corporation+___
CardioQ-ODM™Oesophageal DopplerDeltex+___
TECOTransesophageal DopplerMedicina+___
ODM IITransesophageal DopplerAbbott+___
HDI/PulseWave™ CR-2000Pressure waveform analysisHypertension Diagnostics, Inc+_ _+_ _
USCOM 1ATransthoracic DopplerUscom+_ _
NICORebreathing FickPhilips Respironics+
InnocorRebreathing FickInnovision A/S+
Vigileo/FloTracPulse contour analysisEdwards Lifesciences______
LiDCOplus PulseCOTranspulmonary lithium dilution/pulse contour analysisLiDCO Ltd______
PiCCO2Transpulmonary thermodilution/pulse contour analysisPULSION Medical Systems AG______
MOSTCARE PRAMPulse contour analysisVytech______
VigilancePulmonary artery catheter thermodilutionEdwards Lifesciences___
DDGDye-densitogram analyzerNihon Kohden
TruccomPulmonary artery catheter thermodilutionOmega Critical Care
COstatusUltrasound dilutionTransonic Systems Inc.+
CNAP Monitor 500Finger cuff technologyCNSystems Medizintechnik AG+___
SphygmoCor® CPV SystemApplanation tonometryAtCor Medical+_ _
TL-200 T-LINEApplanation tonometryTensys Medical, Inc.+_ _

+ noninvasive, – invasive, ___ continuous, _ _ semi-continuous, … intermittent

Practical noninvasive (intermittent) BP measurement became possible when Riva-Rocci presented his air-inflatable arm cuff connected to a manometer in 1896 [32 , 33 (link)]. By deflating the cuff and feeling for the pulse, systolic BP could be determined. In 1905 Korotkoff [34 , 35 (link)] advanced the technique further with the auscultatory method making it possible to determine diastolic pressure as well. In 1903 Cushing recommended BP monitoring using the Riva-Rocci sphygmomanometer for patients under general anesthesia [36 (link)]. Nowadays, automated assessment of BP with oscillometric devices is commonly used. These devices determine BP by analyzing the oscillations measured in the cuff-pressure. The pressure in the cuff is first brought above systolic pressure and then deflated to below diastolic pressure. Oscillations are largest when cuff pressure equals mean arterial pressure. Proprietary algorithms determine systolic and diastolic values from the oscillations. Oscillometers may be inaccurate [37 ], and provided values that are frequently lower than direct BP measurements in critically ill patients, [38 (link), 39 (link)] whereas detection of large BP changes is unreliable [40 (link)]. Due to its intermittent nature hyper- and hypotensive periods may be missed [2 (link)].
“Semi-continuous noninvasive methods” based on radial arterial tonometry require an additional arm cuff to calibrate arterial pressure [41 (link)–43 (link)]. The use of these devices may become problematic under conditions with significant patient motion or surgical manipulation of the limbs [43 (link), 44 (link)]. However, tonometry devices have contributed greatly to the knowledge of the relation between the pressure wave shape and cardiovascular function [45 (link), 46 (link)].
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Publication 2012
Animals Arteries Arteries, Radial Auscultation Cardiovascular Physiological Phenomena Catheters Cheetahs Coronary Stenosis Critical Care Critical Illness Determination, Blood Pressure Diagnosis Diastole Electricity Esophagus General Anesthesia Heart Homo sapiens Lithium Manometry Medical Devices Operative Surgical Procedures Oscillometry Patients physiology Pressure Pressure, Diastolic Pulse Rate Reliance resin cement Sphygmomanometers Systole Systolic Pressure Technique, Dilution Teflon Thermodilution Tonometry Velocimetry
To test the effects of load duration on the joint changes, we subjected the left tibiae of twenty-one young (10-week-old) C57Bl/6 male mice (Jackson Laboratories, Bar Harbor, ME) to cyclic compressive loading for 1, 2, and 6 weeks at a 9.0N peak load. We also loaded the tibiae of forty-two adult (26-week-old) C57Bl/6 male mice at 4.5N and 9.0N peak loads for 1, 2, and 6 weeks. A load level of 9.0N generates 1200με in the tibial mid-shaft of 10-week-old mice based on in vivo strain gauging (20 (link)). In vivo tibial loading was applied for 1200 cycles at 4 Hz for 5 days per week at each peak load under general anesthesia (2% Isoflurane, 1.0 L/min, Webster). The applied loading was based on protocols demonstrated previously to have an anabolic effect on the tibial metaphysis in growing and adult mice (Supp Figure 1) (20 (link)–22 (link)). The left limb was loaded, and the right limb served as the non-loaded control. In preliminary studies in our laboratory, we found that metaphyseal bone mass and architecture of the non-loaded control (right) limbs were not affected by loading of the left limbs. After the specified duration, the mice were euthanized, and the intact knee joints were dissected and fixed in 10% formalin overnight. All experimental procedures were approved by the Institutional Animal Care and Use Committee.
Publication 2013
Adult Anabolic Effect Bone Density Formalin General Anesthesia Institutional Animal Care and Use Committees Isoflurane Joints Knee Joint Males Mice, Inbred C57BL Mus Strains Tibia

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Publication 2011
Animals Circadian Rhythms Ear General Anesthesia Mice, Laboratory proparacaine hydrochloride Skin Tail Topical Anesthetics

Most recents protocols related to «General Anesthesia»

Example 2

In another example, the medical device (1) may be implanted immediately after mastectomy, when the patient has been given general anesthesia. The procedure may include:

    • inserting the at least one insertion member (70) into the balloon (5) of the medical device via the membrane-covered port (55) that is exposed from the shell (80);
    • placing the medical device (1) with a shell (80) into the tissue of the patient by operating the handle (75) of the insertion apparatus (65);
    • separating the shell (80) into the first half (86) and the second half (87) by operating the tab (88);
    • removing the first half (86) and the second half (87) of the shell from the tissue; removing the insertion apparatus (65) from the medical device (1); and
    • suturing the incision, leaving the balloon (5) inside the tissue.

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Patent 2024
General Anesthesia Mastectomy Medical Devices Patients Tissue, Membrane Tissue Expansion Devices Tissues
Prior to administration, the data regarding the demographic characteristics, such as, pain duration, pain severity, and involved nerve root were extracted. Two radiologists retrospectively analyzed and recorded the IDP on postintervention CT scanning images. The injection spread patterns in the cross-sectional CT images included the following: Zone I: extra-foraminal; Zone II: the foraminal spaces; Zone III: intra-foraminal (Figure 3).

The injection distribution area in the cross section of CT image: Line A is from anterolateral vertebral body to the lateral margin of the facet. Line B is from posterior-lateral vertebral body to the interior margin of the facet. Line C is the axial centerline of the epidural space. Zone I The out space of line A is extra-foraminal; Zone II: Between line A and B is the foraminal spaces; Zone III: Between line B and C is intra-foraminal/epidural spaces.

An investigator blinded to the patient assignments/treatments performed patient follow-ups, and recorded pain scores, particularly, NRS during hospital visits at 2 hours, 1 week, and 4 weeks after injection.
Safety was assessed as follows: Bleeding situation: Prior to drug injection, we recorded whether there was blood upon withdrawal, and verified the presence or absence of hematoma via CT scan. Other adverse reactions, including, puncture point pain, shortness of breath, paresthesias, motor deficit, hematoma, dizziness, headache, vomiting, general spinal anesthesia, and so on.
Publication 2023
BLOOD Dyspnea General Anesthesia Headache Hematoma Nervousness Pain Paresthesia Patients Pharmaceutical Preparations Plant Roots Punctures Radiologist Safety Severity, Pain Spaces, Epidural Vertebral Body X-Ray Computed Tomography
In the case of recurrence after rectal prolapse surgery, the surgical procedures were performed with the opposite approaches considering the patient’s condition. If the patient initially underwent an abdominal approach, reoperation was performed with a perineal approach. When the risks of general anesthesia are high, such as when the patient is elderly, has a high ASA PS classification, or has a severe underlying disease, perineal approach surgery under spinal anesthesia was performed according to the recommendation of the anesthesiologist. For patients who underwent radiotherapy in the abdominal cavity, abdominal approach was selected. All elective rectal prolapse surgeries were performed by 2 experienced colorectal surgeons.
Publication 2023
4-azidosalicylic acid-phosphatidylserine Abdomen Abdominal Cavity Aged Anesthesiologist Elective Surgical Procedures General Anesthesia Operative Surgical Procedures Patients Perineum Radiotherapy Rectal Prolapse Recurrence Second Look Surgery Spinal Anesthesia Surgeons
In general, the perineal approach to rectal prolapse is performed in fragile patients who cannot tolerate the abdominal approach, such as elderly patients, patients with severe heart or lung disease, patients at high risk of general anesthesia, or patients with a history of abdominal surgery. The authors performed Delorme procedure, Altemeier procedure, and the stapled transanal rectal resection (STARR) procedure through a perineal approach, depending on the degree of rectal prolapse. The STARR procedure was used for mucosal prolapses less than 3 cm from the anus, Delorme procedure for prolapses larger than 3 cm, and Altemeier procedure for full-thickness prolapses.
Publication 2023
Abdomen Aged Anus General Anesthesia Heart Lung Diseases Mucous Membrane Operative Surgical Procedures Patients Perineum Proctectomy Prolapse Rectal Prolapse
All abdominal surgical approaches were performed using the laparoscopic ventral rectopexy method under general anesthesia regardless of the degree of rectal prolapse. All patients were placed in the lithotomy and Trendelenburg position after anesthesia, and a 12-mm trocar was inserted into the umbilicus for laparoscopic camera insertion, and four 5-mm trocars were inserted in each of the left and right upper and lower abdominal quadrants. The bowel was pulled out of the pelvis and the sigmoid colon was retracted to the left lateral side. The peritoneal opening was made in an inverted J-shape from the sacral cape to the left edge of the peritoneal reflex. The sterile polypropylene mesh (Prolene, Ethicon) was designed to have a length of 15 cm and a width of 2 cm. The mesh was properly positioned in the peritoneal opening, the lower end was sutured to the anterior wall of the rectum 2–3 cm from the edge of the anus, and the upper end was fixed to the right side of the periosteum of the sacral cape using ProTack (Covidien). The peritoneum opening was closed with continuous sutures using V-loc (Covidien) to prevent contact of the mesh with other organs in the abdomen.
Publication 2023
Abdomen Abdominal Cavity Anesthesia Anus CM 2-3 General Anesthesia Intestines Laparoscopy Operative Surgical Procedures Patients Pelvis Periosteum Peritoneum Polypropylenes Prolene Rectal Prolapse Rectum Reflex Sacrum Sigmoid Colon Sterility, Reproductive Sutures Trocar Umbilicus

Top products related to «General Anesthesia»

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Rompun is a veterinary drug used as a sedative and analgesic for animals. It contains the active ingredient xylazine hydrochloride. Rompun is designed to induce a state of sedation and pain relief in animals during medical procedures or transportation.
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Zoletil is a general anesthetic and analgesic used in veterinary medicine. It is a combination of two active compounds, tiletamine and zolazepam, that work together to induce a state of deep sedation and pain relief in animals. The product is administered by injection and is commonly used for a variety of veterinary procedures, including surgery, diagnostic imaging, and minor treatments. Zoletil is intended for use under the supervision of licensed veterinary professionals.
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Zoletil 50 is a veterinary anesthetic medication used in dogs, cats, and other animals. It contains the active ingredients tiletamine and zolazepam. Zoletil 50 is used to induce general anesthesia and provide sedation for medical procedures.
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Ketalar is a general anesthetic medication used to induce and maintain anesthesia. It is a clear, colorless, water-soluble compound that is administered via injection. The active ingredient in Ketalar is the chemical compound ketamine hydrochloride.
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Fetal Bovine Serum (FBS) is a cell culture supplement derived from the blood of bovine fetuses. FBS provides a source of proteins, growth factors, and other components that support the growth and maintenance of various cell types in in vitro cell culture applications.
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Sprague-Dawley rats are an outbred albino rat strain commonly used in laboratory research. They are characterized by their calm temperament and reliable reproductive performance.
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IsoFlo is a laboratory equipment product offered by Abbott. It is designed for use in clinical and research settings. IsoFlo serves as a tool for analysis and measurement, but a detailed description of its core function cannot be provided while maintaining an unbiased and factual approach.
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Pentobarbital sodium is a laboratory chemical compound. It is a barbiturate drug that acts as a central nervous system depressant. Pentobarbital sodium is commonly used in research and scientific applications.
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Isoflurane is a volatile anesthetic agent used in the medical field. It is a clear, colorless, and nonflammable liquid that is vaporized and administered through inhalation. Isoflurane is primarily used to induce and maintain general anesthesia during surgical procedures.
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Matrigel is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in extracellular matrix proteins. It is widely used as a substrate for the in vitro cultivation of cells, particularly those that require a more physiologically relevant microenvironment for growth and differentiation.

More about "General Anesthesia"

General anesthesia, also known as full anesthesia or complete anesthesia, is a state of controlled, reversible unconsciousness induced by the administration of one or more anesthetic agents.
This comprehensive medical intervention is widely used in surgical, obstetric, and other medical settings to facilitate various procedures and ensure patient comfort and safety.
The effects of general anesthesia can be carefully monitored and adjusted by trained healthcare professionals to provide the optimal level of unconsciousness and pain relief for the duration of the medical intervention.
Synonyms for general anesthesia include total anesthesia, complete anesthesia, and full anesthesia.
Related terms and abbreviations include GA (general anesthesia), MAC (minimum alveolar concentration), and ASA (American Society of Anesthesiologists).
Key subtopics include anesthetic agents (e.g., Rompun, Zoletil, Ketalar), anesthesia induction and maintenance, monitoring vital signs (e.g., FBS, Sprague-Dawley rats), and anesthesia safety and complications.
Anesthetic agents like Isoflurane, Pentobarbital sodium, and Matrigel are commonly used in general anesthesia to induce and maintain the desired state of unconsciousness.
Healthcare professionals must carefully consider factors such as patient characteristics, procedure type, and potential interactions to ensure the safe and effective use of general anesthesia.