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Hemodilution

Hemodilution is a medical procedure where the concentration of blood components is reduced by the addition of fluids, typically crystalloids or colloids.
This process can be used to improve blood flow and oxygen delivery in various clinical conditions, such as cardiovascular surgeries, acute ischemic stroke, and critical care.
Hemodilution may help reduce blood viscosity, prevent thromboembolic complications, and enhance tissue perfusion.
Accurate selection and optimization of hemodilution protocols is crucial for maximizing patient outcomes and reproducibility in clinical research.
PubCompare.ai offers a powerful AI-driven platform to streamline the discovery and comparision of hemodilution protocols from literature, pre-prints, and patents, enabling researchers to identify the most effective strategies and products for their studies.

Most cited protocols related to «Hemodilution»

1
Cerebral Autoregulation Monitoring During Surgery
Cited 29 times
Patients were attached to either an INVOS (Somenetics, Inc., Troy, MI) or Foresight (CAS Medical Systems, Branford, CT) NIRS monitor, depending on availability. Electrodes for monitoring NIRS were placed on the right and left forehead using the respective manufacturer’s recommendations and after first cleaning the skin with an alcohol swab. Transcranial Doppler monitoring (Doppler Box, DWL, Compumedics, USA, Charlotte, NC) of the middle cerebral arteries was with two 2.5-MHz transducers fitted on a headband. The depth of insonation varied between 35 and 52 mm until representative spectral artery flow was identified.
Analog arterial pressure data from the operating room hemodynamic monitor, TCD, and NIRS signals were sampled with an analog-to-digital converter at 60 Hz and then processed with ICM+ software version 6.1 (University of Cambridge, Cambridge, UK). These signals were time-integrated as non-overlapping 10-second mean values, which is equivalent to applying a moving average filter with a 10-second time window and re-sampling at 0.1 Hz. This operation was used to eliminate high-frequency noise from the respiratory and pulse frequencies, while allowing detection of oscillations and transients that occur below 0.05 Hz. Doppler, oximetry, and arterial blood pressure waveforms were further high pass filtered with a DC cutoff set at 0.003 Hz. This step removed slow drifts associated with hemodilution at the onset of bypass, blood transfusions, cooling, and rewarming. A continuous, moving Pearson’s correlation coefficient was calculated between the MAP and TCD blood flow velocities and between MAP and NIRS data, rendering the variables Mx (mean velocity index) and COx (cerebral oximetry index), respectively. Of note, MAP is used in this calculation and not cerebral perfusion pressure since intracranial pressure data are not available and since central venous pressure is often negative as a result of suction assisted venous drainage to the CPB reservoir. Consecutive, paired, 10-second averaged values from 300 seconds duration were used for each calculation, incorporating 30 data points for each index. Intact CBF autoregulation is indicated by an Mx value of approximately zero (CBF and MAP are not correlated), and CBF dysautoregulation is indicated by an Mx value approaching +1 (CBF and MAP correlated). Similar findings occur experimentally with COx.13 (link)
Brady K., Joshi B., Zweifel C., Smielewski P., Czosnyka M., Easley R.B, & Hogue CW J.r. (2010). Real Time Continuous Monitoring of Cerebral Blood Flow Autoregulation using Near-Infrared Spectroscopy in Patients Undergoing Cardiopulmonary Bypass. Stroke, 41(9), 1951-1956.
Publication 2010
Arteries Blood Flow Velocity Blood Transfusion Drainage Ethanol Forehead Hemodilution Hemodynamic Monitoring High-Frequency Ventilation Homeostasis Indwelling Catheter Intracranial Pressure Middle Cerebral Artery Oximetry Patients Pulse Rate Skin Spectroscopy, Near-Infrared Suction Drainage Transducers Transients Venous Pressure, Central
2
Randomized Trial of Surgical Strategies in d-TGA
Cited 12 times
Subjects were enrolled between April 1988 and February 1992. Eligibility criteria and trial methods for the earlier evaluations were previously described.7 (link)–10 (link) Admission criteria included a diagnosis of d-TGA with intact ventricular septum (IVS) or ventricular septal defect (VSD), scheduled repair by three months of age, and coronary-artery anatomy suitable for the ASO. Exclusion criteria were birth weight <2.5 kg, a recognizable syndrome of congenital anomalies, an associated extra-cardiac anomaly of greater than minor severity, previous cardiac surgery, or associated cardiovascular anomalies requiring aortic arch reconstruction or additional open surgical procedures.
Infants were randomly assigned to a predominant support strategy of DHCA or LFBP during hypothermic cardiopulmonary bypass using an alpha-stat pH strategy and crystalloid hemodilution to a hematocrit of approximately 20%. Ultrafiltration was not utilized. Postoperative management typically included the use of continuous infusions of neuromuscular blockade and high-dose Fentanyl for analgesia, with a median duration of mechanical ventilation of 4 days.12 (link) Randomization was stratified by septal status (IVS, VSD) and surgeon. This study was approved by the Institutional Review Board and conducted in accordance with institutional guidelines. Parents of adolescents provided informed consent, and adolescents provided assent.
We recruited a referent group of adolescents for the MRI studies because there is no nationally representative standardization sample for brain MRIs. This group was also used as referents for test scores for which national norms are unavailable. Criteria for the referent group were adapted from those used in the NIH MRI study of normal brain development.13 (link) Because the goal of that study is to provide reference ranges for brain development, children with known risk factors for brain disorders are excluded (e.g., intra-uterine exposures to toxicants, history of closed head injury with loss of consciousness, history of a language disorder or Axis 1 psychiatric disorder, first degree relative with a lifetime history of an Axis 1 psychiatric disorder, abnormality on neurological examination). We also excluded subjects with disorders that would prevent completion of the assessments (e.g., pacemaker, metal implants), other forms of congenital heart disease requiring surgical correction, or primary language other than English.
Bellinger D.C., Wypij D., Rivkin M.J., DeMaso D.R., Robertson RL J.r., Dunbar-Masterson C., Rappaport L.A., Wernovsky G., Jonas R.A, & Newburger J.W. (2011). Adolescents with d-Transposition of the Great Arteries Corrected with the Arterial Switch Procedure: Neuropsychological Assessment and Structural Brain Imaging. Circulation, 124(12), 1361-1369.
Publication 2011
Adolescent Arch of the Aorta Artery, Coronary Birth Weight Brain Brain Diseases Cardiopulmonary Bypass Cardiovascular Abnormalities Child Congenital Abnormality Congenital Heart Defects Diagnosis Eligibility Determination Epistropheus Ethics Committees, Research Fentanyl Hemodilution Infant Injuries, Closed Head Language Disorders Management, Pain Mechanical Ventilation Mental Disorders Metals Nervous System Abnormality Neuromuscular Block Operative Surgical Procedures Pacemaker, Artificial Cardiac Parent Reconstructive Surgical Procedures Solutions, Crystalloid Surgeons Surgical Procedure, Cardiac Syndrome Ultrafiltration Uterus Ventricular Septal Defects Ventricular Septum Volumes, Packed Erythrocyte
3
Comprehensive Cardiovascular Risk Assessment Protocol
Cited 5 times
After selection of interview items, a pilot study was performed to test the instruments and logistics of data collection. Slight modifications were made before the main phase of RHESA-CARE started in January 2015. The CATI includes classical and psychosocial cardiovascular risk factors as well as factors of alerting behaviour, first aid, and utilization of medical and rehabilitation services. We use highly standardized and validated instruments of data collection which have been applied in several completed or ongoing studies to ensure qualitiy of data and comparability. Questionnaire items were selected and adapted from:

MONICA/KORA myocardial infarction registry (Cooperative Health Research in the Region of Augsburg) and it‘s postal questionnaire wave in 2011 (KORA-DMP) [19 (link), 21 , 22 (link)],

CARLA study (CARdiovascular disease, Living and Ageing in Halle) [23 (link)],

DIOS study (Diagnosis Optimisation Study) [24 (link)], and

IRENA (evaluation of the Intensified Rehabilitation Aftercare Program) [25 (link)].

For some special items we developed questions. Details on the sources of the questionnaire modules are listed in Table 3.

Topics, sub-categories, and sources of the responder questionnaire used in RHESA-CARE

TopicSub-categoriesSource
Cardiovascular diseasePrevious MI, cardiac interventionsAdopted from CARLA
symptomatic, situation while AMI, stroke, angina pectoris, dyspnoea, fluid retention, atrial fibrillation, blood pressure, cholesterol levelsAdopted from MONICA/KORA and KORA-DMP
First aidRHESA-CARE
DiabetesType of diabetes, intervention, blood sugar concentration, interval of measurementAdopted from MONICA/KORA
Utilization of medical servicesConsultation rates, medical assistance, patient education (blood pressure, diabetes, haemodilution), DMP programsAdopted from MONICA/KORA and KORA-DMP
family doctorRHESA-CARE
RehabilitationCardiac rehabilitation, heart training groupsRHESA-CARE
Life styleSmoking behaviourAdopted from BGS98-Questionaire [27 ]
BMI, physical activityAdopted from MONICA/KORA
MedicationMedication before/after AMI, medication useAdopted from MONICA/KORA, MMAS4 ([28 (link), 29 ]) also used in MONICA/KORA
Health conditionHealth conditionEQ-5D-3L [30 ] also used in MONIKA/KORA
DepressionGDS [31 (link), 32 (link)]
Care dependencyCare level before/after AMI, use of care service before/after AMIAdopted from MONICA/KORA
Social statusSocio-economic and employment statusAdopted from CARLA, DIOS [33 ], and IRENA
Health insuranceAdopted from MONICA/KORA
We used a non-responder questionnaire to identify possible structural differences between responder and non-responder. This questionnaire is a short version of the responder questionnaire and contains 15 items for cardiovascular disease, rehabilitation, body mass index (BMI), health condition, need for care, and social status. Furthermore, we prepared a questionnaire for the family doctor (FDQ). The FDQ contains the items: blood values, blood pressure, medication before/after AMI, and German disease management program (DMP) [18 (link)].
Hirsch K., Bohley S., Mau W, & Schmidt-Pokrzywniak A. (2016). The RHESA-CARE study: an extended baseline survey of the regional myocardial infarction registry of Saxony-Anhalt (RHESA) design and objectives. BMC Cardiovascular Disorders, 16, 159.
Publication 2016
Aftercare Angina Pectoris Atrial Fibrillation BLOOD Blood Glucose Blood Pressure Cardiovascular Diseases Cerebrovascular Accident Cholesterol Diabetes Mellitus Disease Management Dyspnea Education of Patients First Aid Heart Hemodilution Index, Body Mass Myocardial Infarction Pharmaceutical Preparations Physical Examination Physicians Rehabilitation Retention (Psychology) Tests, Diagnostic
4
Standardized ICP and CPP-Oriented Protocol for Severe Aneurysmal SAH
Cited 4 times
Patients were treated in accordance with our standardized ICP- and CPP-oriented treatment protocol to avoid secondary insults [4 (link)]. The treatment protocol remained unchanged throughout the study period. Treatment goals were ICP ≤ 20 mm Hg, CPP ≥ 60 mm Hg, systolic blood pressure > 100 mm Hg, central venous pressure (CVP) 0–5 mm Hg before the aneurysm was occluded and 5–10 mm Hg afterward, pO2 > 12 kPa, arterial glucose 5–10 mmol/L (mM), electrolytes within normal ranges, normovolemia and body temperature < 38 °C.
Patients who were unconscious (GCS M < 6) were intubated and mechanically normoventilated. Those patients were sedated with propofol and received morphine as analgesia. Wake-up tests were repeatedly performed. The patients were treated with early aneurysm occlusion, including endovascular embolization or surgical clipping, and all patients received nimodipine (first as infusion of 2 mg/h and later as tablets 60 mg × 6 for 3 weeks in total). The dosage of infusion was reduced temporarily in case of hypotension to avoid negative hemodynamic effects. In unconscious (GCS M < 6) patients, an external ventricular drain (EVD) was inserted to monitor and to drain cerebrospinal fluid (CSF) in case of high ICP. The EVD was initially kept closed to measure ICP and assess the need for CSF drainage. If ICP was above 20 mm Hg the EVD was opened at 15 mm Hg. In severe cases when basal ICP treatment was insufficient, thiopental coma treatment and/or decompressive craniectomy (DC) were last-tier treatments. Arterial blood pressure was maintained with fluids. Inotropes (dobutamine or in second hand norepinephrine) were only used if CPP was below 60 mm Hg and the patient did not respond to intravenous fluid treatment.
DCI was defined as new neurological deficits and/or decreased level of consciousness when other causes, e.g., hydrocephalus and hematomas, were excluded. If a manifest cerebral infarction was excluded, triple-H therapy (hypertension, hypervolemia, and hemodilution) including 500 ml dextran-40 solution (100 mg/ml, Meda AB) and 200 ml albumin (200 mg/ml) were administered for 5 days. Cerebral intra-arterial nimodipine was given in case of refractory vasospasm and angioplasty was performed in case of refractory large-vessel vasospasm. The main target for triple-H therapy was elevation of blood pressure but only to moderately elevated levels in relation to baseline, i.e., in general CPP to around 70–80 mm Hg and systolic blood pressure to around 140–160 mm Hg. Secondary targets were erythrocyte volume fraction (EVF) 32% and CVP 8–14 mm Hg, although these goals were in general met automatically by the fluid therapy given. The targeted levels were increased stepwise if clinical improvement was not seen.
Svedung Wettervik T., Howells T., Lewén A., Ronne-Engström E, & Enblad P. (2021). Temporal Dynamics of ICP, CPP, PRx, and CPPopt in High-Grade Aneurysmal Subarachnoid Hemorrhage and the Relation to Clinical Outcome. Neurocritical Care, 34(2), 390-402.
Publication 2021
Albumins Aneurysm Angioplasty Arteries Blood Pressure Blood Vessel Body Temperature Cerebral Infarction Cerebrospinal Fluid Comatose Decompressive Craniectomy Dental Occlusion Dextran 40 Dobutamine Electrolytes Embolization, Therapeutic Fluid Therapy Glucose Heart Ventricle Hematoma Hemodilution Hemodynamics High Blood Pressures Hydrocephalus Inotropism Intravenous Infusion Leak, Cerebrospinal Fluid Management, Pain Morphine Nimodipine Norepinephrine Operative Surgical Procedures Patients Propofol Systolic Pressure Therapeutics Thiopental Treatment Protocols Venous Pressure, Central Vision Volume, Erythrocyte
5
Quantifying Hemoglobin Distribution via PAM
Cited 4 times
Statistical analysis of the PAM signal can reveal the Possion distribution-governed Brownian motion of hemoglobin-carrying RBCs in vivo22 (link). Briefly, the average RBC count within the detection volume of PAM can be derived as:

in which and respectively denote the mean and variance operation, is the amplitude of the PAM signal, and is the electronic thermal noise of our PAM system. In the present study, is quantified by analyzing 100 successive A-lines acquired at 532 nm. Since each RBC contains ~15 pg of hemoglobin on average27 , the total amount of hemoglobin within the detection volume is pg. Given that the lateral resolution of PAM is 2.7 μm and the 1/e penetration of 532-nm light in rodent blood is 46 μm29 , the detection volume of our system is 263 μm3. Thus, the CHb (g/L) can be estimated as:

To examine the accuracy of this method in vitro, we prepared 10 samples with CHb evenly distributed over the range of 15–150 g/L using fresh defibrinated bovine blood (910–100, Quad Five). As shown in Supplementary Fig. S7, the PAM-measured CHb values agreed with the preset concentrations (linearity: but became inaccurate when the CHb was diluted to below 30 g/L. This inaccuracy is likely due to the insufficient signal-to-noise ratio of PAM under the severe and non-physiological hemodilution.
Ning B., Sun N., Cao R., Chen R., Kirk Shung K., Hossack J.A., Lee J.M., Zhou Q, & Hu S. (2015). Ultrasound-aided Multi-parametric Photoacoustic Microscopy of the Mouse Brain. Scientific Reports, 5, 18775.
Publication 2015
BLOOD Cattle Erythrocyte Count Hemodilution Hemoglobin Light physiology Rodent

Most recents protocols related to «Hemodilution»

1
Cardiac Surgery Anesthesia and CPB Protocol
All surgical procedures, including CABG surgery, valve surgeries, LVAD implants, and surgeries on the ascending aorta/aortic root, were performed under CPB under the same protocol of general anesthesia. A non-pulsatile roller pump was used as a conventional CPB circuit (Stockert s5, Sorin Group Germany, Munich, Germany) with moderate hypothermia (32–34 °C).
Cardiac arrest was induced by antegrade infusion of cold crystalloid cardioplegic solution (CustodiolTM, KoehlerChemie, Alsbach-Haehnlein, Germany) immediately after cross-clamping. Extracorporeal circulation was performed with a non-pulsatile pump flow of 2.2 L min−1 m−2. Patients were weaned from CPB after rewarming and aortic declamping resulting in sufficient reperfusion. Blood transfusion was applied to maintain hemoglobin levels above 7.5 mg/dL, and hemodilution was limited by maintaining hematocrit levels above 21%. The vasopressor noradrenaline and, in inotropic doses, epinephrine were applied when required during and after the operation. Immediately after the procedure, all patients were transferred to the ICU. Thrombosis prophylaxis with unfractionated heparin was initiated as soon as possible after cardiac surgery. If indicated, therapeutic anticoagulation was initialized and maintained during the ICU stay for patients who had no active bleeding. The patients developing prolonged postoperative atrial fibrillation were anticoagulated with intravenous PTT-guided therapeutic doses of unfractionated heparin.
Deininger M.M., Schnitzler S., Benstoem C., Simon T.P., Marx G., Panagiotidis D., Ziles D., Schnoering H., Karasimos E, & Breuer T. (2023). Standardized pharmacological management of delirium after on-pump cardiac surgery reduces ICU stay and ventilation in a retrospective pre-post study. Scientific Reports, 13, 3741.
Publication 2023
Aorta Ascending Aorta Atrial Fibrillation Blood Transfusion Cardiac Arrest Common Cold Coronary Artery Bypass Surgery crystalloid cardioplegic solution Epinephrine Extracorporeal Circulation General Anesthesia Hemodilution Hemoglobin Heparin Norepinephrine Patients Plant Roots Pulsatile Flow Reperfusion Surgical Procedure, Cardiac Therapeutics Thrombosis Vasoconstrictor Agents Volumes, Packed Erythrocyte
2
Reinfusion Techniques in Cardiac Surgery
Additional PBM techniques were employed. In both the conventional and pressure field groups, subjects were administered antifibrinolytics (viz. tranexamic acid) at induction and during surgery, there was careful attention to hemostasis, and the cardiopulmonary bypass circuit was primed with Ringer’s solution. In the conventional group, pump blood was directly reinfused at the completion of bypass. In the pressure field group, pump blood was directly reinfused at the completion of bypass in 48 patients; in 17 patients a cell-saver was used to scavenge blood in the surgical field, and on completion of bypass the scavenged and pump blood was spun down and reinfused as a red cell concentrate. Acute normovolemic hemodilution was not used in either group.
Woodford S.F., Butlin M., Wei B., Chao W, & Avolio A. (2023). The pressure field as a methodology for fluid management and red cell preservation during cardiac surgery. Journal of Cardiothoracic Surgery, 18, 36.
Publication 2023
Antifibrinolytic Agents Attention BLOOD Cardiopulmonary Bypass Cells Erythrocytes Hemodilution Hemostasis Operative Surgical Procedures Patients Pressure Ringer's Solution Tranexamic Acid Vascular Surgical Procedures
3
Neurocognitive Deficits Following Subarachnoid Hemorrhage
Forty patients who were admitted to our department between December 2008 and January 2013 and could undergo both GABA(+)-MRS and RT tasks were enrolled in this study. Among these patients, 14 were men and 26 were women, with a mean age of 61.8 ± 8.56 (range, 39–78) years. The diagnosis of aneurysmal SAH was confirmed through computed tomography scans. The severity of hemorrhage was graded using the Fisher scale (23 (link)), and the clinical presentation was assessed based on the World Federation of Neurological Surgeons (WFNS) scale (24 (link)). Additionally, a total of 10 healthy right-handed participants (four men and six women) aged 38–68 years (mean, 60.8 ± 11.83 years) were included as controls. Only patients without severely impaired motor function who, upon examination, (1) had almost clear consciousness, (2) had no other neurological deficits, except for prompt and fine motor dysfunction, (3) underwent intravascular or surgical treatment, (4) had no history of neurological or psychiatric illness, and (5) were not taking psychotropic medications were included. Patient characteristics are shown in Supplementary Table 1. Most patients exhibited “prompt and fine motor dysfunction” without definite motor palsy. Patients with normal motor performance diagnosed by a senior neurologist independent of this study are indicated with an asterisk in Supplementary Table 1. All participants provided written informed consent to participate in this study. The experimental protocols were approved by the Ethics Committee of the School of Medicine, Oita University (approval number: 374). Informed consent for clinical and research procedures was obtained after the SAH intravascular or surgical treatment was completed. Patients with delayed ischemic neurological deficits were treated with standard hemodynamic therapy (hypertension, hypervolemia, and hemodilution) (25 (link)). Rho kinase inhibitor fasudil hydrochloride, currently the only effective drug for preventing vasospasm, was administered prophylactically to reduce the risk of cerebral ischemia (26 (link)). The mean time from the onset of SAH to examination was 19.02 ± 6.88 (range, 8–31) days. All participants were right-handed according to the Edinburgh Handedness Inventory (Figure 1) (28 (link)).
Sugita K., Anan M., Matsuta H., Shimomura T., Fudaba H., Hata N, & Fujiki M. (2023). Quantitative GABA magnetic resonance spectroscopy as a measure of motor learning function in the motor cortex after subarachnoid hemorrhage. Frontiers in Neurology, 14, 1173285.
Publication 2023
Aneurysm Cerebral Ischemia Consciousness Ethics Committees fasudil hydrochloride gamma Aminobutyric Acid Healthy Volunteers Hemodilution Hemodynamics Hemorrhage High Blood Pressures Mental Disorders Neurologists Neurosurgeon Operative Surgical Procedures Patients Pharmaceutical Preparations Psychotropic Drugs Radionuclide Imaging rho-Associated Kinases Woman X-Ray Computed Tomography
4
Acute Normovolemic Hemodilution in Surgery
The patients were randomized into two groups using the random number table: the ANH group that received moderate acute normovolemic hemodilution and the routine control group that received no hemodilution. In the ANH group, blood was removed through the radial artery from patients at a speed of 200 mL/10 min after stably inducing anesthesia. The formula of blood volume collected is as follows:
Blood volume collected = estimated blood volume (EBV) × 2 × (Hctactual - Hctset) / (Hctactual + Hctset). EBV is estimated blood volume in the human body, which is calculated by body weight. EBV is 70 mL/kg for males and 60 mL/kg for females.
Hctactual is hematocrit measured by preoperative blood gas analysis, and Hctset is hematocrit set after hemodilution. In our study, the set Hct is 28–30%. The collected blood was stored in ACD blood storage bags at room temperature. Hydroxyethyl starch 130/0.4 injection was transfused at a ratio of 1:1 (colloidal fluid to blood volume collected). Hydroxyethyl starch 130/0.4 injection or compound sodium lactate was infused at 10 ml·kg− 1·h− 1 during the operation, to maintain hemodynamic stability. Patients in the ANH group were transfused with the collected autologous blood immediately after the operation. The control group was transfused with allogeneic blood when Hct was less than 25%. The fluctuation of intraoperative blood pressure was controlled within 20% of the base value.
Liu T., Bai Y., Yin L., Wang J.H., Yao N., You L.W, & Guo J.R. (2023). Effect of acute normovolemic hemodilution on anesthetic effect, plasma concentration, and recovery quality in elderly patients undergoing spinal surgery. BMC Geriatrics, 23, 689.
Publication 2023
Anesthesia Arteries, Radial BLOOD Blood Gas Analysis Blood Pressure Blood Volume Body Weight Females Hemodilution Hemodynamics Homo sapiens Hydroxyethyl Starch 130-0.4 Lactate, Sodium Males Patients
5
Cirrhosis Prognostic Factors Analysis
Cited 2 times
Thirty-four indicators, including demographic and baseline clinicopathological data, were collected and summarized as follows: (1) demographic data: age, gender, the history of antiviral, hypertension and diabetes mellitus; (2) etiology of cirrhosis: HBV, HCV, ALD, co-infection, and others (NAFLD, primary biliary cirrhosis, autoimmune hepatitis, drug-induced liver injury, Budd–Chiari syndrome, etc.); (3) blood routine examination: white blood cell, neutrophil, lymphocyte, monocyte, hemoglobin, platelet; (4) liver and renal function examination: Child–Pugh class; alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), total protein (TP), albumin, globulin, γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (ALP), prealbumin, total bile acid (TBA), cholinesterase (ChE), cholesterol; (5) coagulation markers: prothrombin time (PT), prothrombin time activity (PTA), international normalized ratio (INR), fibrinogen, activated partial thromboplastin time (APTT), thrombin time (TT); (6) other indicators: alpha fetoprotein (AFP) and viral load.
Compared with albumin or globulin alone, the albumin-to-globulin ratio (A/G ratio) is not easily affected by changes in body fluids, such as hemoconcentration or hemodilution. In modeling, therefore, we included the A/G ratio, which can be used as a more objective and stable clinical parameter to assess the risk of cancer occurrence in patients with cirrhosis.
Wang Q., Guo D., Gao W., Yuan C., Li J., Zhang Y., He N., Zhao P., Zheng J, & Zhang Y. (2023). Individual surveillance by competing risk model for patients with hepatocellular carcinoma occurrence in all-cause cirrhosis. Journal of Cancer Research and Clinical Oncology, 149(14), 13403-13416.
Publication 2023
Activated Partial Thromboplastin Time Albumins Alkaline Phosphatase alpha-Fetoproteins Antiviral Agents Aspartate Transaminase Autoimmune Chronic Hepatitis Bile Acids Bilirubin BLOOD Blood Platelets Body Fluids Budd-Chiari Syndrome Child Cholesterol Cholinesterases Coagulation, Blood Coinfection D-Alanine Transaminase Diabetes Mellitus Drug-Induced Liver Disease Fibrinogen gamma-Glutamyl Transpeptidase Gender Globulins Hemodilution Hemoglobin High Blood Pressures International Normalized Ratio Kidney Leukocytes Liver Liver Cirrhosis Lymphocyte Malignant Neoplasms Monocytes Neutrophil Non-alcoholic Fatty Liver Disease Patients Prealbumin Primary Biliary Cholangitis Proteins Times, Prothrombin Times, Reptilase

Top products related to «Hemodilution»

1
Voluven by Fresenius
Sourced in Germany, Sweden, France
Voluven is a colloid solution that is used to replace or maintain blood volume. It contains hydroxyethyl starch, which helps to maintain fluid balance in the body.
2
Vacuette by Greiner
Sourced in Austria, Germany, United States, United Kingdom, Belgium, Switzerland, Italy, France, Spain, Brazil
The Vacuette is a laboratory equipment designed to collect and store blood samples. It provides a closed vacuum system to draw blood samples efficiently and safely.
3
Vettest analyzer by IDEXX
Sourced in United States
The VetTest Analyzer is a diagnostic instrument used in veterinary laboratories to perform biochemical analyses on animal samples. It is designed to measure various analytes, such as enzymes, proteins, and metabolites, in order to provide veterinarians with information to aid in the diagnosis and management of animal health conditions. The VetTest Analyzer is a compact and automated system that can efficiently process multiple samples simultaneously.
4
Legendplex nhp mix and match subpanel by BioLegend
Sourced in United States
The LEGENDplex™ NHP Mix-and-Match Subpanel is a bead-based multiplex assay that allows for the simultaneous measurement of multiple analytes in a single sample. The assay is designed for non-human primate (NHP) research applications.
5
Victor v3 by PerkinElmer
Sourced in France, United States
The Victor V3 is a multi-mode microplate reader designed for high-throughput screening and quantitative analysis. It offers a wide range of detection modes, including absorbance, fluorescence, and luminescence, allowing researchers to perform a variety of assays. The Victor V3 is a versatile instrument suitable for use in various fields, such as biochemistry, cell biology, and drug discovery.
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Rimadyl is a veterinary pharmaceutical product manufactured by Pfizer. It is a non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation and pain in dogs and cats. The active ingredient in Rimadyl is carprofen.
7
Volulyte by Fresenius
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Volulyte is an intravenous solution used for fluid replacement and volume expansion. It is a colloid solution containing hydroxyethyl starch and electrolytes. Volulyte is designed to maintain or restore blood volume in patients who require fluid therapy.
8
Phd 2000 by Harvard Apparatus
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The PHD 2000 is a programmable syringe pump that provides precision fluid control for laboratory applications. It offers a wide range of flow rates and can accommodate a variety of syringe sizes. The device is designed for ease of use and includes features such as a user-friendly interface and the ability to create customized dispensing programs.
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Duoset elisa kit by R&D Systems
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DuoSet ELISA kits are laboratory reagent kits used for the quantitative measurement of specific proteins in a variety of sample types. The kits include a matched antibody pair and other necessary reagents to perform a sandwich enzyme-linked immunosorbent assay (ELISA). The assay measures the concentration of the target analyte in the sample.
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Hl 20 by Getinge
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The HL-20 is a laboratory centrifuge designed for general-purpose use. It features a maximum speed of 20,000 rpm and a maximum relative centrifugal force (RCF) of 48,400 x g. The HL-20 can accommodate a variety of sample volumes and tube sizes.

More about "Hemodilution"

Hemodilution, also known as blood dilution or volume expansion, is a medical procedure used to reduce the concentration of blood components by adding fluids, typically crystalloids or colloids.
This process can be employed to improve blood flow and oxygen delivery in various clinical settings, such as cardiovascular surgeries, acute ischemic stroke, and critical care.
Hemodilution may help lower blood viscosity, prevent thromboembolic complications, and enhance tissue perfusion.
Accurate selection and optimization of hemodilution protocols is crucial for maximizing patient outcomes and ensuring reproducibility in clinical research.
PubCompare.ai, a powerful AI-driven platform, can streamline the discovery and comparison of hemodilution protocols from literature, pre-prints, and patents, enabling researchers to identify the most effective strategies and products for their studies.
Related terms and subtopics include volume expansion, blood thinning, fluid management, vascular resistance, Voluven (a colloid solution), Vacuette (blood collection system), VetTest Analyzer (for blood analysis), LEGENDplex™ NHP Mix-and-Match Subpanel (for cytokine/chemokine quantification), Victor V3 (a microplate reader), Rimadyl (an anti-inflammatory drug), Volulyte (a balanced crystalloid solution), PHD 2000 (a syringe pump), and DuoSet ELISA kits (for protein quantification).
By incorporating these relevant concepts and tools, researchers can enhance the accuracy and reproducibility of their hemodilution studies.