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Keratomileusis, Laser In Situ

Keratomileusis, Laser In Situ is a refractive surgical procedure that uses an excimer laser to selectively remove corneal stromal tissue, thereby changing the refractive power of the eye.
This technique is used to correct refractive errors such as myopia, hyperopia, and astigmatism.
The laser is applied to the inner layers of the cornea after a thin flap is created using a microkeratome.
This minimally-invasive approach allows for precise, customized reshaping of the corneal surface to improve vision.
PubCompare.ai's AI-driven platform can help you discover the most effective protocols and approches from published research, preprints, and patents to optimize your studies in this dynamic field.

Most cited protocols related to «Keratomileusis, Laser In Situ»

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Publication 2018
Allergic Conjunctivitis Anesthesia Congenital Abnormality Contact Lenses Cornea Dietary Supplements Dreams Drugs, Non-Prescription Dry Eye Eligibility Determination Eyelids Glaucoma Infection Inflammation Keratomileusis, Laser In Situ Lubricant Eye Drops Operative Surgical Procedures Patients Pharmaceutical Preparations Slit Lamp Examination Vision
This prospective interventional case series study received approval by the Ethics Committee of our Institution, adherent to the tenets of the Declaration of Helsinki. Informed consent was obtained from each subject at the time of the intervention. The study was conducted on patients in our clinical practice, during scheduled pre- and postoperative procedure visits.
The 109 consecutive patients enrolled in the study underwent uncomplicated primary bilateral LASIK performed by the same surgeon (AJK) using the same refractive surgery platform (WaveLight FS200 Femtosecond Laser and WaveLight EX500 Excimer Laser; Alcon Laboratories, Ft Worth, TX, USA), between September 2009 and September 2010.
Preoperative spherical equivalent (SE) was between 0.00 and −8.00 diopters (D), and up to 4.25 D of cylinder refractive error.
Exclusion criteria for the LASIK operation were: systemic or ocular diseases, eyes with history of corneal dystrophy or herpetic eye disease, topographic evidence of keratoconus (as evidenced by Placido topography) or warpage from contact lenses, corneal scaring, glaucoma, severe dry eye, and collagen vascular diseases. The average flap thickness (planned 110 μm) was 107 ± 5 μm. The average flap diameter (planned 8.00 mm) was 7.95 ± 0.05 mm. Flap thickness was measured by subtracting the central cornea pachymetry, measured with the EX500 following flap creation, from the central cornea pachymetry, measured preoperatively with the WaveLight Oculyzer II diagnostic device (Alcon Laboratories) (with integrated Scheimpflug topography camera) and the WaveLight OB820 biometer (Alcon Laboratories) that were both integrated within the platform.17 (link)
All eyes were evaluated preoperatively for best corrected distance visual acuity (CDVA) and postoperatively for uncorrected distance visual acuity (UDVA). Preoperative evaluations included wavefront analysis, pupillometry, and contrast sensitivity. Postoperative examination included manifest and dilated refraction, slit-lamp microscopy, tonometry, and keratometry, by means of corneal topography and tomography assessment.
Postoperative follow-up examinations were conducted at 1 week, 3 months, 6 months, and 1 year. Data processed in this study represent the 3-, 6-, and 12-month visits.
Data were loaded and processed using web-based refractive analysis software (IBRA Ophthalmic Outcome Analysis System; Zubisoft GmbH, Oberhasli, Switzerland).18 (link)
Publication 2013
Blood Vessel Collagen Collagen Diseases Contact Lenses Contrast Sensitivity Cornea Corneal Pachymetry Corneal Topography Diagnosis Dry Eye Eye Eye Disorders Glaucoma Hereditary Corneal Dystrophy Institutional Ethics Committees Keratoconus Keratomileusis, Laser In Situ Lasers, Excimer Medical Devices Ocular Refraction Patients Physical Examination Postoperative Procedures Refractive Errors Slit Lamp Examination Surgeons Surgeries, Refractive Surgical Flaps Tomography Tonometry, Ocular Vascular Diseases Vision Visual Acuity
This was a retrospective analysis of the first 50 primary LASIK corrections of 26 patients performed by one surgeon (MM) at one center using Contoura measured astigmatism and axis (as per the Layer Yolked Reduction of Astigmatism [LYRA] Protocol) within the FDA indications of myopia up to −8.00D with astigmatism no >−3.00D. We included eyes with a myopic goal for monovision. We monitored all eyes for at least 3 months post LASIK via visual acuity, refraction, and Topolyzer Vario HOAs to determine if the eye was accurately treated and the LYRA Protocol was successful.
All surgeries were performed by one surgeon (MM) at one center in San Diego, CA, USA, using a WaveLight® EX500 with Contoura (WaveLight) and the Topolyzer Vario (WaveLight). All LASIK flaps were made with the Moria M2 Microkeratome (Moria Surgical, Antony, France) with 110 micron calibrated blades from Microspecialties, LLC, Middletown, CT, USA. All surgical planning was done using the Wavenet Server and the Contoura planning system using the LYRA Protocol, which is described below.
The measured Contoura astigmatism and axis were obtained from the surgical planning page in the Contoura planning software. This page is after the Topolyzer images are processed, and after the information is entered for the patient’s manifest refraction, pachymetry, and pupil size. On this page, the surgeon can enter their final input for sphere, astigmatism, and axis, and the effect on the ablation pattern will be shown as the values change. Zeroing out the sphere and astigmatism correction shows only the HOA removal, and the HOA pattern can be resolved. Entering the astigmatism and axis will create a pattern that can be compared with the anterior elevation of a Pentacam Scheimflug analyzer scan (Oculus, Wetzlar, Germany) (a Ziemer Gallelei [Ziemer Ophthalmic Systems, Port, Switzerland] will output similar scans). This demonstrates that using the measured Contoura astigmatism and axis creates an ablation pattern that closely matches the elimination of the anterior elevation on Pentacam, which results in a more uniform cornea.
This study included 50 eyes from 26 patients of which 10 were male and 16 were female. Patients’ ages ranged from 19 to 62 years, with an average age of 31.65 years. Preoperative evaluation included best corrected visual acuity, manifest/cycloplegic manifest refraction, anterior exam, posterior dilated exam, tonometry, pachymetry via Pentacam, autorefraction with the Nidek OPD (Nidek Co., Ltd, Gamagori, Japan), and topographic analysis with the Topolyzer Vario.
Specific attention was paid to obtaining high quality reproducible scans with the Topolyzer Vario. A patient would have 8–12 scans taken per eye, and at least 4 accurate similar scans with appropriate iris registration and complete data (as indicated by the Topolyzer Vario) were necessary to proceed with surgical planning. If the scans were too variable, or not enough scans with high quality information were taken, the scans were repeated until enough scans to create an accurate, reproducible, consistent picture were obtained. Great care was taken not to induce astigmatism when holding the eyelids open for scans, and blinks were allowed to prevent the corneal surface from desiccation.
Patients were not included if they had prior refractive surgery, could not achieve 20/20 vision preoperatively, were not within the FDA treatment parameters, had anterior segment abnormalities or findings that could affect the outcome such as keratoconus or corneal ectasia, recurring eye disease such as iritis or herpetic keratitis, severe dry eye, uncontrolled diabetes or hypertension, or were pregnant.
All patients provided written consent to have their data published in this paper.
Publication 2017
Astigmatism Attention Blinking Congenital Abnormality Cornea Cycloplegics Desiccation Diabetes Mellitus Dry Eye Epistropheus Eye Disorders Eyelids High Blood Pressures Iris Iritis Keratitis, Herpetic Keratoconus Keratomileusis, Laser In Situ Males Monocular Vision Myopia Ocular Refraction Operative Surgical Procedures Pathological Dilatation Patients Pupil Radionuclide Imaging Surgeons Surgeries, Refractive Surgical Flaps Tonometry, Ocular Vision Visual Acuity Woman
In this retrospective study, performed at the Salerno University Hospital, the data of 295 eyes of 295 patients that underwent cataract extraction and IOL implantation, following refractive surgery, were examined.
The study was performed according to the Declaration of Helsinki guidelines. A written informed consent was acquired from all the participants. This study was approved by the local Institutional Review Board, Cometico Campania Sud, Italy, (protocol. number 16544). None of the eyes in this study were used to develop either the R factor or the ALxK method.
Preoperative cataract surgery keratometry and axial length values were measured using the IOL Master 500 (Carl Zeiss Meditec, Dublin, CA) and patients’ postoperative refractions were obtained through both subjective and objective methods. Patients with a best corrected visual acuity less than 20/20, with moderate and severe dry eye, pterygium, eye surface diseases, unknown refraction after cataract extraction, unknown implanted IOL power, with refractive surgery different from myopia or refractive techniques other than PRK and LASIK were excluded from the study.
After applying the inclusion and exclusion criteria, 91 eyes of 91 patients were selected for the study (group A). This group presented the following parameters: keratometry 37.99 ± 2.59 D (median: 38.32 D), axial length 27.71 ± 2.03 mm (median: 27.50 mm).
The zeroing of the mean error (ME) was not achievable for all the selected eyes, because in some of them the implanted IOL constant but not the model was known or the IOL models were implanted in less than 3 patients, making the zeroing unreliable. This benchmark resulted in the selection of a 68 eyes sample (group B) that was appropriate for zeroing out the mean error. Group B had these parameters: keratometry 37.71±2.50 D (median: 38.01 D), axial length 28.02±2.01 mm (median: 27.91 mm). Other characteristics of both Groups are reported in Table 1.
Because ME error reflects the systematic bias of a method, checking its difference from zero was performed before zeroing it out [23 (link)].
To zero out the mean error, the Excel software (Microsoft Corporation) was utilized and the following steps were performed:
In both A and B groups, the following absolute values were calculated for both R factor and ALxK methods:
Moreover, the parameter AL*K, where AL = axial length and K = mean keratometry value, was identified. Each group was then divided into two subpopulations, based on the AL*K value:
ALMA method was obtained combining R Factor results when AL*K <1060 and the ALxK results when AL*K> 1060. ALMA, R Factor and ALxK formulas in A and B groups were compared.
Descriptive statistics, performed with the Excel software (Microsoft Corporation), were used to describe population’s characteristics and IOL power calculation’s accuracy. Statistical analysis was performed with SPSS 23.0 (SPSS, Inc., Chicago, IL). The normality of data was examined by the Kolmogorov-Smirnov test before zeroing out the mean error. For screening whether the ME was significantly different from zero, one-sample T-test or Wilcoxon-signed-rank test were used. The Wilcoxon-signed-rank test was performed to compare the median absolute errors of the different methods analyzed in group A. Bootstrapped estimates were applied to perform T tests and confidence intervals within group B, as per Hoffer et al. [26 (link)]. Bootstrapped estimates were preferred to non-parametric test because when transforming the data the older methods established on ranks tend to be underpowered; they tend to be less likely to detect a statistically significant difference, with the high risk running into a type II error [26 (link)]. A P value of less than 0.05 was considered statistically significant.
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Publication 2020
Cataract Extraction Diet, Formula Dry Eye Ethics Committees, Research Eye Eye Disorders Keratomileusis, Laser In Situ Myopia Ocular Refraction Ovum Implantation Patients Pterygium Of Conjunctiva And Cornea R Factors Surgeries, Refractive
These patients were included for the study:

At least one of eight dry eye symptoms (Supplementary Fig. 1—questionnaire modified after Schein et al. [23 (link)]) was experienced “often” or “all the time.”

At least one MG opening with pouting and a visible plug above the eyelid margin that cannot be removed by gentle wiping with a cotton tip.

No ocular pathology requiring treatment other than eye lubricant and conventional eyelid hygiene within the last month and during the study.

Participants with data at baseline and 1 month after treatment.

These patients were excluded from the study:

Known diagnosis of thyroid dysfunction and rheumatoid arthritis.

Ocular surgery within the previous 6 months and laser-assisted in situ keratomileusis (LASIK) within the previous year.

Central nervous system and hormonal drugs required within the last month and during the study.

Active ocular infection or presence of pterygium.

Necessity to wear contact lens during the study.

Living in the same household as another participant of the study.

Publication 2014
Administration, Ophthalmic Aftercare Central Nervous System Contact Lenses Diagnosis Dry Eye Eye Infection Eyelids Gossypium Households Keratomileusis, Laser In Situ Patients Pharmaceutical Preparations Pterygium Of Conjunctiva And Cornea Rheumatoid Arthritis Thyroid Gland

Most recents protocols related to «Keratomileusis, Laser In Situ»

LVC was performed by the same experienced operator (LH). The VisuMax femtosecond laser (Carl Zeiss Meditec AG, Jena, Germany) was utilized during the SMILE procedure. It involved removing a stromal lenticule, with a 110 µm-thick cap. For FS-LASIK, the lamellar flap with a superior hinge was created by a femtosecond laser (Ziemer Ophthalmic Systems AG, Port, Switzerland). The maximum thickness ranged from 90 to 110 µm. Tissue ablation was then performed using an Amaris 750 Hz excimer laser (Schwind eye-tech-solutions, Kleinostheim, Germany). Both groups received one drop of tobramycin/dexamethasone (Tobradex) shortly after surgery. A bandage contact lens (Oasys; Johnson & Johnson Vision, Santa Ana, USA) was placed on the cornea after FS-LASIK surgery. Sodium hyaluronate 0.1% (Hylo-comod) and topical fluorometholone 0.1% were then used 4 times a day for one week. The fluorometholone dosage was tapered each subsequent week until termination one month, while the Hylo-comod dosage remained unaltered.
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Publication 2023
Amaris Bandage Contact Lenses Cornea Eye Fluorometholone Keratomileusis, Laser In Situ Lasers, Excimer Operative Surgical Procedures Ophthalmic Solution Sodium Hyaluronate Surgical Flaps Tissues Tobramycin, Dexamethasone Drug Combination Vision
23andme is a private company offering genotyping. Consenting customers were asked the following questions: ‘Have you ever been diagnosed by a doctor with near-sightedness (near objects are clear, far objects are blurry)?’ and ‘Are you near-sighted (near objects are clear, far objects are blurry)?’; and with the same descriptor, ‘What vision problems do you have?’ and ‘Prior to your LASIK eye surgery, what vision problems did you have?’. These questions identified 106 086 probable myopia cases and 85 757 controls used in subsequent meta-analysis (N = 191 841).33
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Publication 2023
Keratomileusis, Laser In Situ Myopia Ophthalmologic Surgical Procedures Physicians
All patients underwent optical coherence tomography of the anterior segment of the eye (AS-OCT) (DRI OCT, Triton, Topcon, Warsaw, Poland) before surgery (0 day) and on the 1st, 7th, 60th, and 180th days after surgery, which allowed for obtaining images of the patients’ corneas before and after the PRK, FS-LASIK, and SMILE procedures. CET was assessed at the center and at a distance of 1.5 mm from the center in 4 meridians: positions 12, 6, 3, and 9. The CET measurement is performed based on a pachymetric map of the cornea. The pachymetric map provides a color map over its entire area from seam to seam. Its numerical value is expressed in μm.
Publication 2023
Cornea Keratomileusis, Laser In Situ Meridians Operative Surgical Procedures Patients Segment, Anterior Eye Tomography, Optical Coherence
The analysis included 120 patients of the 226 recruited for the study. Fourteen patients were excluded from the PRK group due to moderate myopia, while 47 patients were excluded from the LS-LASIK group due to either hyperopia (35 cases) or astigmatism (12 cases). From the SMILE group, we excluded 45 patients (21 cases due to hyperopia; 24 cases due to astigmatism). Figure 1 contains the randomization graph.
Publication 2023
Astigmatism Hyperopia Keratomileusis, Laser In Situ Myopia Patients
Fifty patients (92 eyes; 39.1±1.2 years) were qualified for FS-LASIK, of whom 34 were female (68%) and 16 were male (32%) with diagnosed myopia (sphere maximum −6.0 diopters; cylinder −5.0 D). Mild myopia was found in 27 patients and moderate myopia in 23.
Publication 2023
Eye Keratomileusis, Laser In Situ Males Myopia Patients Woman

Top products related to «Keratomileusis, Laser In Situ»

Sourced in Germany
The VisuMax is a medical device manufactured by Zeiss. It is a laser system designed for ophthalmological procedures. The VisuMax utilizes a femtosecond laser to perform precise corneal cuts and modifications.
Sourced in Germany
The Mel 80 excimer laser is a medical device designed for ophthalmic procedures. It utilizes ultraviolet laser light to precisely reshape the cornea, a process known as photorefractive keratectomy (PRK) or laser-assisted in-situ keratomileusis (LASIK). The Mel 80 excimer laser operates at a wavelength of 193 nanometers and is capable of delivering controlled pulses of laser energy to the corneal surface.
Sourced in Germany
The VisuMax femtosecond laser system is a precision medical device designed for ophthalmic surgical procedures. It utilizes femtosecond laser technology to perform highly accurate and controlled tissue removal or modification within the cornea. The core function of the VisuMax system is to enable the creation of corneal flaps or lenticules for vision correction procedures.
Sourced in United States
The WaveLight FS200 is a femtosecond laser system designed for ophthalmic surgical procedures. It is a precision instrument used to create corneal flaps during LASIK eye surgery.
Sourced in United States
The WaveLight EX500 is a medical device used for refractive surgery procedures. It is designed to generate a laser beam for corneal reshaping, with the aim of correcting vision impairments.
Sourced in Germany, United States, Japan
The Pentacam is a diagnostic device that captures a 3D image of the anterior segment of the eye. It uses rotating Scheimpflug camera technology to obtain detailed measurements of the cornea, anterior chamber, lens, and iris.
Sourced in Germany
The VisuMax femtosecond laser is a precision ophthalmic device designed for refractive surgery procedures. It utilizes femtosecond laser technology to create corneal flaps or lenticules with high accuracy and reproducibility.
Sourced in Japan, Ireland, China, United States
Cravit is a laboratory equipment product. It is used for conducting scientific experiments and analyses.
Sourced in United States
The Technolas is a lab equipment product manufactured by Bausch & Lomb. It is a multi-functional device designed to perform various tasks in a laboratory setting. The core function of the Technolas is to facilitate the measurement, analysis, and processing of samples or materials.
Sourced in Germany, Japan, United States
The Pentacam HR is an advanced corneal topography and anterior segment imaging system. It utilizes a rotating Scheimpflug camera to capture high-resolution, three-dimensional images of the anterior eye. The Pentacam HR provides detailed measurements of the cornea, anterior chamber, and other anterior segment structures.

More about "Keratomileusis, Laser In Situ"

Keratomileusis, Laser In Situ (LASIK) is a refractive surgical procedure that uses an excimer laser to selectively remove corneal stromal tissue, thereby changing the refractive power of the eye.
This minimally-invasive technique, also known as laser-assisted in-situ keratomileusis, is commonly used to correct refractive errors such as myopia (nearsightedness), hyperopia (farsightedness), and astigmatism.
The LASIK procedure involves creating a thin, hinged flap on the cornea using a microkeratome or femtosecond laser, such as the VisuMax or WaveLight FS200.
The excimer laser, like the Mel 80 or WaveLight EX500, is then used to selectively remove corneal tissue from the inner layers, precisely reshaping the corneal surface to improve vision.
The Pentacam or Pentacam HR systems are often used to map the corneal topography and guide the customized laser treatment.
LASIK is a popular and effective refractive surgery option, with advancements like the Cravit and Technolas laser systems providing even more precise and customized treatments.
By leveraging the insights from published research, preprints, and patents, platforms like PubCompare.ai can help researchers and clinicians optimize LASIK protocols and approaches to deliver the best possible outcomes for patients.