All control subjects were at least 60 years of age and matched according to age, gender, and ethnicity to the enrolled index cases. Controls were chosen to be five years older than their corresponding case to minimize the enrollment of controls who might later develop FECD and confound analysis. To qualify, each control subject was required to be grade 0 on the FECD grading scale, have no family history of a possibly inherited corneal disorder (e.g., FECD, keratoconus, stromal dystrophy), exhibit refractive astigmatism of less than 3.50D and have normal corneas with no abnormalities upon slit lamp examination other than the following noted exceptions: 1) peripheral degenerative changes related to age, including arcus senilis and limbal-girdle of Vogt, 2) corneal scar from infection or penetrating trauma, 3) pterygium or pterygium surgery, 4) inactive superficial vascularization of the epithelium and/or subepithelial layer, 5) previous glaucoma, or retina-vitreous surgery in one eye where the other eye had not had surgery and the endothelium was normal, 6) previous intraocular laser surgery. Bilateral pseudophakes who received an FECD grade of 0 and were FECD negative preoperatively also qualified. The limbal/peripheral corneal incisions related to cataract surgery were judged unlikely to affect the central cornea and, thus, the ability to assess the FECD phenotype. Subjects were excluded from participation as controls if they displayed any signs of corneal dystrophy or degeneration, had previous/active interstitial keratitis or anterior uveitis, or active/previous infectious keratitis or vascularization of the epithelium and/or stroma. Subjects were also excluded if they had previously undergone bilateral corneal surgery or had experienced perforating corneal trauma resulting in scarring.
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Laser Surgery
Laser Surgery
Laser surgery, also known as laser-assisted surgery, is a minimally invasive medical procedure that uses highly focused laser light to precisely cut, vaporize, or ablate tissue.
This technique has revolutionized many fields of medicine, including ophthalmology, dermatology, and oncology, by offering improved precision, reduced recovery time, and enhanced patient outcomes.
Laser surgery can be used to treat a variety of conditions, such as refractive errors, skin lesions, and cancerous tumors.
The use of lasers allows for more accuarate and reproducible procedures, enhancing the safety and effectiveness of these interventions.
Researchers continue to explore new applications and advancements in laser surgery, driven by the pursuit of improved patient care and outcomes.
This technique has revolutionized many fields of medicine, including ophthalmology, dermatology, and oncology, by offering improved precision, reduced recovery time, and enhanced patient outcomes.
Laser surgery can be used to treat a variety of conditions, such as refractive errors, skin lesions, and cancerous tumors.
The use of lasers allows for more accuarate and reproducible procedures, enhancing the safety and effectiveness of these interventions.
Researchers continue to explore new applications and advancements in laser surgery, driven by the pursuit of improved patient care and outcomes.
Most cited protocols related to «Laser Surgery»
Arcus Senilis
Astigmatism
Cataract Extraction
Congenital Abnormality
Cornea
Cornea Injuries
Corneal Diseases
Endothelium
Epithelium
Ethnicity
Gender
Glaucoma
Hereditary Corneal Dystrophy
Infection
Keratitis
Keratoconus
Laser Surgery
Limbus Corneae
Ocular Refraction
Operative Surgical Procedures
Ophthalmologic Surgical Procedures
Pathologic Neovascularization
Phenotype
Pterygium Of Conjunctiva And Cornea
Retina
Slit Lamp Examination
Uveitis, Anterior
Wounds, Penetrating
Bevacizumab
Eye
Hypersensitivity
Infant
Laser Surgery
Recurrence
Retinopathy of Prematurity
Vision
Animals
Axon
Caenorhabditis elegans
Cells
Helminths
Laser Surgery
Medical Devices
Microchip Analytical Devices
Protocol full text hidden due to copyright restrictions
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Cells
Chameleons
Epistropheus
Eye
Immersion
Laser Surgery
Lens, Crystalline
Light
Microscopy
Movement
Nerve Tissue
Ovarian Failure, Premature
Sound Waves
Transducers
Ultrasonics
Adult
Animals
Axon
Dendrites
Larva
Laser Surgery
Most recents protocols related to «Laser Surgery»
The campaign was performed at the top of the Säntis mountain (2,502 m altitude) in north-eastern Switzerland, on the summit of which stands a 124-m-tall telecommunication tower. A general view of the experimental set-up is presented in Extended Data Fig. 1 . The laser system was located in the radome building, sheltered in an air-tight, air-conditioned and thermally isolated tent. After exiting the tent, the laser output was directed downwards by a conduit through the radome wall to the terrace, where a 4′ folding mirror directed the beam into a beam-expanding sending telescope featuring a 7.14 magnification ratio. The entire laser path toward the telescope—presented in Extended Data Fig. 1a —was protected by an isolated aluminium housing to prevent any beam leakage and to reduce the perturbation from the environment.
The telescope was composed of an additional folding mirror, a secondary 100 mm spherical mirror and a 430-mm diameter off-axis aspheric (elliptic) primary mirror29 (link). The beam output, which had a diameter of 250 mm, was sent toward the tower tip with a vertical angle of 7°. Translation stages on the secondary mirror allowed us to focus the beam near the tower tip in order to set the onset of the filamentation process in the desired area in which upward lightning is initiated. The focal length of the telescope was set to 150 m to produce a dense filamentation area of 30–50 m above the tower tip.
Note that during the entire laser operation time, the airspace was closed by the air-traffic authority. Furthermore, air traffic was monitored by an automatic dependent surveillance–broadcast transceiver automatically switching off the laser in case of aircraft incursion into the temporary closed airspace zone.
The telescope was composed of an additional folding mirror, a secondary 100 mm spherical mirror and a 430-mm diameter off-axis aspheric (elliptic) primary mirror29 (link). The beam output, which had a diameter of 250 mm, was sent toward the tower tip with a vertical angle of 7°. Translation stages on the secondary mirror allowed us to focus the beam near the tower tip in order to set the onset of the filamentation process in the desired area in which upward lightning is initiated. The focal length of the telescope was set to 150 m to produce a dense filamentation area of 30–50 m above the tower tip.
Note that during the entire laser operation time, the airspace was closed by the air-traffic authority. Furthermore, air traffic was monitored by an automatic dependent surveillance–broadcast transceiver automatically switching off the laser in case of aircraft incursion into the temporary closed airspace zone.
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Aluminum
Epistropheus
Laser Surgery
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Telescopes
This was a single-surgeon, retrospective study of patients undergoing femtosecond laser-assisted cataract surgery with arcuate incisions for the reduction of astigmatism. Arcuate incision anatomy was calculated using the LaserArcs online nomogram. The primary endpoint of this study was the percent reduction in absolute magnitude of astigmatism in the subject population based upon the absolute difference of postoperative manifest refraction. Postoperative manifest cylinder was the exploratory endpoint.
All patients had undergone a preoperative manifest refraction, and keratometry was determined using an IOLmaster V (Carl Zeiss Meditec, Oberkochen, Germany) with software version 5.2.1 to 5.4 or a LenStar LS900 (Haag-Streit, Bern, Switzerland) version 4.2.1 to 4.4.0, which are comparable instruments for the purposes of corneal power measurement.12 (link) Posterior corneal astigmatism and central topography were both included in these calculations. Biometry data was manually uploaded to the online LaserArcs software for calculation, and a graphical printout (Figure 1 ) was generated for use in surgery.
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A sample size estimation was performed using results from an independent data set of 400 eyes and determined that 50 unilateral eyes would provide >90% statistical power to demonstrate a clinically meaningful percent reduction of astigmatism with a target reduction of 60%. All enrolled subjects were required to be 22 years of age or older and had cataracts but otherwise healthy eyes, not exhibiting any significant ocular morbidity that would be expected to influence outcome measures. All patients had preoperative keratometric astigmatism greater than 0.25 D and were implanted with a non-toric IOL, and all patients’ laser astigmatic keratotomy was planned using the LaserArcs nomogram. Patients with visually significant co-morbidities that could affect their visual outcome after surgery, like corneal, retinal, or optic nerve disease, were excluded, and all patients had a preoperative corneal topography screening for ectasia, higher-order aberrations, or other abnormalities and would be excluded from treatment if significant corneal pathology were identified. Patients with surgical complications either during or after surgery (capsule tears, iris trauma, decentered IOL, cystoid macular edema, etc.) that would, in the judgment of the investigator, influence the outcome measures of the study, and patients with previous refractive surgery prior to cataract surgery were also excluded.
Prior to collection of retrospective data, this study was registered on ClinicalTrials.gov as NCT 05278442. It was also approved by WCG IRB (Puyallup, Washington) as protocol 20220599 and adhered to both the Declaration of Helsinki and good clinical practices as defined by the U.S. Food and Drug Administration. A waiver of written informed consent was provided by the IRB. Reasonable requests for de-identified patient data relating to the study findings will be available through the corresponding author for 5 years following the publication date.
All patients had undergone a preoperative manifest refraction, and keratometry was determined using an IOLmaster V (Carl Zeiss Meditec, Oberkochen, Germany) with software version 5.2.1 to 5.4 or a LenStar LS900 (Haag-Streit, Bern, Switzerland) version 4.2.1 to 4.4.0, which are comparable instruments for the purposes of corneal power measurement.12 (link) Posterior corneal astigmatism and central topography were both included in these calculations. Biometry data was manually uploaded to the online LaserArcs software for calculation, and a graphical printout (
The LaserArcs software graphical output. Reprinted with permission from LaserArcs.
A sample size estimation was performed using results from an independent data set of 400 eyes and determined that 50 unilateral eyes would provide >90% statistical power to demonstrate a clinically meaningful percent reduction of astigmatism with a target reduction of 60%. All enrolled subjects were required to be 22 years of age or older and had cataracts but otherwise healthy eyes, not exhibiting any significant ocular morbidity that would be expected to influence outcome measures. All patients had preoperative keratometric astigmatism greater than 0.25 D and were implanted with a non-toric IOL, and all patients’ laser astigmatic keratotomy was planned using the LaserArcs nomogram. Patients with visually significant co-morbidities that could affect their visual outcome after surgery, like corneal, retinal, or optic nerve disease, were excluded, and all patients had a preoperative corneal topography screening for ectasia, higher-order aberrations, or other abnormalities and would be excluded from treatment if significant corneal pathology were identified. Patients with surgical complications either during or after surgery (capsule tears, iris trauma, decentered IOL, cystoid macular edema, etc.) that would, in the judgment of the investigator, influence the outcome measures of the study, and patients with previous refractive surgery prior to cataract surgery were also excluded.
Prior to collection of retrospective data, this study was registered on ClinicalTrials.gov as NCT 05278442. It was also approved by WCG IRB (Puyallup, Washington) as protocol 20220599 and adhered to both the Declaration of Helsinki and good clinical practices as defined by the U.S. Food and Drug Administration. A waiver of written informed consent was provided by the IRB. Reasonable requests for de-identified patient data relating to the study findings will be available through the corresponding author for 5 years following the publication date.
Astigmatism
Capsule
Cataract
Cataract Extraction
Congenital Abnormality
Cornea
Corneal Astigmatism
Corneal Topography
Eye
Hepatitis A Antigens
Iris
Laser Surgery
Lens, Crystalline
Lens Implantation, Intraocular
Macular Edema, Cystoid
Neural-Optical Lesion
Ocular Refraction
Operative Surgical Procedures
Pathological Dilatation
Patients
Retina
Surgeons
Surgeries, Refractive
Tears
Vision
Wounds and Injuries
This was an observational cross-sectional study. A total of 100 healthy volunteers were enrolled from the Physical Examination Center of Guangdong Provincial People’s Hospital who underwent physical examinations from January 2020 to June 2020. Participants were between the age of 18 to 52 years (M = 34.43, SD = 8.75) and the diopter range of −8.94D to +1.63D (M = 2.91, SD = 2.42); 47 were males (47%) and 53 were females (53%). Grouped by age and diopter (Table 1 ). The daily time spent in near work was ranging from 2 h to more than 12 h (M = 7.65, SD = 3.11).
The inclusion criteria for participants were as followed: (1) Age range of 18–55 years, with good comprehension and communication skills; (2) Best corrected visual acuity 20/20 or above; (3) Normal eye movement.
The exclusion criteria for participants were as followed: (1) With a history of organic ocular disease or ocular surgery (except excimer laser surgery); (2) Dominant strabismus and other eye position errors detected by the 33 cm Hirschberg test and alternate cover test; (3) Those who were unable to complete the study or were required to withdraw due to any discomfort during the study.
The inclusion criteria for participants were as followed: (1) Age range of 18–55 years, with good comprehension and communication skills; (2) Best corrected visual acuity 20/20 or above; (3) Normal eye movement.
The exclusion criteria for participants were as followed: (1) With a history of organic ocular disease or ocular surgery (except excimer laser surgery); (2) Dominant strabismus and other eye position errors detected by the 33 cm Hirschberg test and alternate cover test; (3) Those who were unable to complete the study or were required to withdraw due to any discomfort during the study.
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Eye Movements
Females
Healthy Volunteers
Lasers, Excimer
Laser Surgery
Males
Operative Surgical Procedures
Physical Examination
Strabismus
Vision
Visual Acuity
This nonrandomized prospective case series included patients scheduled for FLACS (FLACS group) or conventional cataract surgery (CCS group) in Vithas Eurocanarias Instituto Oftalmológico, Las Palmas de Gran Canaria, Spain. Written informed consent was obtained from each subject after receiving a full explanation of the procedure and the nature of the study. The study was approved by the local ethics committee and was performed in compliance with the tenets of the Declaration of Helsinki.
Inclusion criteria for both groups were age over 45 years old, cortical nuclear sclerotic grade II-III cataracts according to the Lens Opacities Classification System (LOCS) III classification, and axial length between 21.0 and 25.5 millimetres (mm). Exclusion criteria were previous ocular surgery, history of any systemic or ocular diseases (e.g., glaucoma, ocular hypertension, age related macular degeneration), any condition that could alter OCT results (e.g., peripapillary atrophy, difficulties in fixation, corneal opacities), low quality OCT images (image quality under 15), spherical equivalent refraction over 3 diopters, and intraoperative or postoperative complications. After a detailed explanation of both techniques, patients chose which surgical option they preferred; those who decided to have cataract surgery with femtosecond laser assistance comprised the FLACS group and the rest comprised the CCS group.
Inclusion criteria for both groups were age over 45 years old, cortical nuclear sclerotic grade II-III cataracts according to the Lens Opacities Classification System (LOCS) III classification, and axial length between 21.0 and 25.5 millimetres (mm). Exclusion criteria were previous ocular surgery, history of any systemic or ocular diseases (e.g., glaucoma, ocular hypertension, age related macular degeneration), any condition that could alter OCT results (e.g., peripapillary atrophy, difficulties in fixation, corneal opacities), low quality OCT images (image quality under 15), spherical equivalent refraction over 3 diopters, and intraoperative or postoperative complications. After a detailed explanation of both techniques, patients chose which surgical option they preferred; those who decided to have cataract surgery with femtosecond laser assistance comprised the FLACS group and the rest comprised the CCS group.
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Age-Related Macular Degeneration
Atrophy
Cataract
Cataract Extraction
Cortex, Cerebral
Eye
Glaucoma
Granisetron
Laser Surgery
Ocular Hypertension
Ocular Refraction
Operative Surgical Procedures
Patients
Postoperative Complications
Regional Ethics Committees
Sclerosis
From our institutional database of patients diagnosed with laryngeal cancer between January 1980 and December 2021, we retrospectively extracted patients who experienced a locoregional recurrence after initial treatment for early glottic cancer, collecting their clinical and pathological information, such as age at first diagnosis, sex, smoking and alcohol abuse status, initial TNM stage at diagnosis, type of initial treatment (e.g., radiotherapy, transoral laser surgery, partial or total laryngectomy), disease-free interval, follow-up period, and cause of death. For each recurrence, we retrieved the rTNM, CLRSS, and CLRSS-2 stages, the chosen salvage treatment, distant metastases, and disease-free interval.
We included patients with an initial early glottic cancer (T1-T2 patients according to the 8th edition of the American Joint Committee on Cancer (AJCC), without lymph node involvement) [15 ] who had experienced recurrent disease after a disease-free interval of at least 3 months, and with a histological diagnosis of squamous-cell carcinoma. We excluded non-squamous-cell histology, patients who underwent a palliative treatment without curative intent, and patients with incomplete data.
The follow-up protocol, both for primary tumors and recurrences, was conducted by the medical staff (seniors and residents in otolaryngology) of our department, and it usually consisted of direct/indirect laryngoscopy every 4–8 weeks for the first 2 years, every 3 months for the 3rd year, every 6 months during the 4th and 5th years, and then once a year.
We included patients with an initial early glottic cancer (T1-T2 patients according to the 8th edition of the American Joint Committee on Cancer (AJCC), without lymph node involvement) [15 ] who had experienced recurrent disease after a disease-free interval of at least 3 months, and with a histological diagnosis of squamous-cell carcinoma. We excluded non-squamous-cell histology, patients who underwent a palliative treatment without curative intent, and patients with incomplete data.
The follow-up protocol, both for primary tumors and recurrences, was conducted by the medical staff (seniors and residents in otolaryngology) of our department, and it usually consisted of direct/indirect laryngoscopy every 4–8 weeks for the first 2 years, every 3 months for the 3rd year, every 6 months during the 4th and 5th years, and then once a year.
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Abuse, Alcohol
Cancer of Tongue
Diagnosis
Joints
Laryngeal Cancer
Laryngectomy
Laryngoscopy
Laser Surgery
Malignant Neoplasms
Medical Staff
N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide
Neoplasm Metastasis
Neoplasms
Nodes, Lymph
Palliative Care
Patients
Radiotherapy
Recurrence
Salvage Therapy
Squamous Cell Carcinoma
Squamous Epithelial Cells
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