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> Procedures > Therapeutic or Preventive Procedure > Pneumonectomy

Pneumonectomy

Pneumonectomy is a surgical procedure involving the removal of an entire lung, typically performed to treat lung cancer, infections, or other lung diseases.
This major procedure can have significant impact on a patient's respiratory function and overall health.
PubCompare.ai's cutting-edge technology helps researchers optimize Pneumonectomy research by easily locating the most reliable protocols from literature, preprints, and patents using AI-driven comparisons.
This enhances reproducibility and accuracy, advancing the field of Pneumonectomy research.
Discover how PubCompare.ai can revolutionize your Pneumonectomy studies today.

Most cited protocols related to «Pneumonectomy»

1
Hypoxia-Induced Pulmonary Fibroblast Characterization
Cited 8 times
Bovine pulmonary artery adventitial fibroblasts were isolated from control and hypoxic hypertensive calves. Human pulmonary artery fibroblasts were derived from patients with idiopathic PH or from patients undergoing lobectomy or pneumonectomy.
Cell proliferation was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Cell migration was evaluated by scrape assay.
Wang D., Zhang Z., Li M., Frid M.G., Flockton A.R., McKeon B.A., Yeager M.E., Fini M.A., Morrell N.W., Pullamsetti S.S., Velegala S., Seeger W., McKinsey T.A., Sucharov C.C, & Stenmark K.R. (2013). MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts. Circulation research, 114(1), 67-78.
Publication 2013
Adventitia Biological Assay Bos taurus Bromides Cell Proliferation diphenyl Fibroblasts Homo sapiens Hypoxia Migration, Cell Patients Pneumonectomy Pulmonary Artery Scheuermann's Disease Tetrazolium Salts
2
Alveolar Cell Isolation and Analysis
Cited 7 times
A detailed description of the materials and methods used in the study is provided in SI Appendix, SI Materials and Methods. Multiple mouse lines were used. Primary AT1 and AT2 cells isolation, single-cell RNA-seq analysis, immunostaining, pneumonectomy, lineage-tracing experiments, alveolar-like organoid culture, and quantitative RT-PCR were performed. The data reported in this paper have been deposited in the NCBI GEO database, https://www.ncbi.nlm.nih.gov/geo/ (accession no. GSE106960).
Wang Y., Tang Z., Huang H., Li J., Wang Z., Yu Y., Zhang C., Li J., Dai H., Wang F., Cai T, & Tang N. (2018). Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. Proceedings of the National Academy of Sciences of the United States of America, 115(10), 2407-2412.
Publication 2018
Cell Separation Mus Organoids Pneumonectomy Reverse Transcriptase Polymerase Chain Reaction Single-Cell RNA-Seq
3
Profiling miRNA Signatures in Lung Adenocarcinoma
Cited 6 times
To define miRNA signatures for lung adenocarcinoma, surgical specimens were obtained from 20 lung cancer patients who had either a lobectomy or a pneumonectomy. All cases were diagnosed with histologically confirmed stage I lung adenocarcinoma (Table 1). None of the patients had received preoperative adjuvant chemotherapy or radiotherapy. Tumor tissues were intraoperatively dissected from the surrounding lung parenchyma; paired normal lung tissues were also obtained from the same patients at an area distant from their tumors. Serial cryostat sections from the specimens were stained with hematoxylin and eosin to confirm the diagnosis based on the most recent WHO classification of tumors of the lung 10 .
To optimize a panel of miRNAs that could be detected in sputum, 36 stage I lung adenocarcinoma patients and an equal number of normal subjects were recruited. The case and control were matched in the ratio of 1:1 by age, gender, and smoking history as a nested case-control cohort (Supplement Table 1). Sputum was collected from the participants as described in our recent reports 8 (link), 11 (link)-2 (link). To further validate the identified sputum markers, we collected sputum specimens from a total of 64 NSCLC patients and 58 healthy controls. The demographic and clinical characteristics of the NSCLC patients are summarized in Table 2. Tumors were classified as peripheral or central on the basis of radiographic studies, bronchoscopic or operative findings, and pathologic analysis. The study was approved by Institutional Review Board.
Yu L., Todd N.W., Xing L., Xie Y., Zhang H., Liu Z., Fang H., Zhang J., Katz R.L, & Jiang F. (2010). Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers. International journal of cancer. Journal international du cancer, 127(12), 2870-2878.
Publication 2010
Adenocarcinoma of Lung Bronchoscopes Chemotherapy, Adjuvant Diagnosis Dietary Supplements Eosin Ethics Committees, Research Gender Lung Lung Cancer Lung Neoplasms MicroRNAs Neoplasms Non-Small Cell Lung Carcinoma Operative Surgical Procedures Patients Pneumonectomy Radiotherapy Sputum Tissues X-Rays, Diagnostic
4
Delays in Surgical Resection for NSCLC
Cited 5 times

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Open the protocol to access the free full text link

Publication 2015
Adult Caucasoid Races Diagnosis Ethics Committees, Research Gender Joints Lung Lung Cancer Malignant Neoplasms Neoplasms neuro-oncological ventral antigen 2, human Non-Small Cell Lung Carcinoma Operative Surgical Procedures Patients Pharmaceutical Preparations Pneumonectomy Surgeons Surgical Margins
5
Lung Ultrasound in COVID-19 Pneumonia
Cited 4 times
This is a multicenter prospective observational study. From March 1st, 2020 until May 30th, 2020, patients from 20 different hospitals were evaluated (Online Resource 1). In each hospital, the main local LUS expert was nominated as the site principal investigator and was responsible for patient enrollment and LUS image acquisition.
Inclusion criteria were: (1) clinical suspicion of SARS-CoV-2 infection leading to presentation to the ED, or admission to COVID Unit or Intensive Care Unit (ICU) of the enrolling Hospitals. Clinical suspicion was based on the following symptoms lasting for at least 3 days in the absence of an alternative more probable diagnosis: major criteria (at least one): fever > 37.5 °C, cough, dyspnea, anosmia and/or ageusia; minor criteria (at least two): sore throat, bilateral conjunctivitis, generalized weakness, rhinorrhea, headache, diffuse musculoskeletal pain, gastrointestinal symptoms (diarrhea, nausea, vomiting); (2) age ≥ 18 years. Exclusion criteria were: (1) a previous diagnosis of COVID-19 pneumonia; (2) a previous pneumonectomy, pleurodesis, or history of fibrothorax.
All the enrolled patients were examined by LUS and received a nasopharyngeal swab for SARS-CoV-2 RT-PCR. Oxygen saturation and/or arterial blood gas analysis were measured in all patients.
Volpicelli G., Gargani L., Perlini S., Spinelli S., Barbieri G., Lanotte A., Casasola G.G., Nogué-Bou R., Lamorte A., Agricola E., Villén T., Deol P.S., Nazerian P., Corradi F., Stefanone V., Fraga D.N., Navalesi P., Ferre R., Boero E., Martinelli G., Cristoni L., Perani C., Vetrugno L., McDermott C., Miralles-Aguiar F., Secco G., Zattera C., Salinaro F., Grignaschi A., Boccatonda A., Giostra F., Infante M.N., Covella M., Ingallina G., Burkert J., Frumento P., Forfori F, & Ghiadoni L. (2021). Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study. Intensive Care Medicine, 47(4), 444-454.
Publication 2021
Ageusia Arteries Blood Gas Analysis Conjunctivitis Cough COVID 19 Debility Diagnosis Diarrhea Dyspnea Fever Headache Inpatient Nasopharynx Nausea Oxygen Saturation Patients Pleurodesis Pneumonectomy Pneumonia Reverse Transcriptase Polymerase Chain Reaction Rhinorrhea SARS-CoV-2 Sore Throat

Most recents protocols related to «Pneumonectomy»

1
Lung Transplant Vasoplegia Management in Cystic Fibrosis
The protocols and policies followed in this study were approved by our Institutional Review Board (IRB # 47289). Due to the retrospective nature and minimal risk of our study, individual participant consent was waived. Retrospective analysis of the database identified 342 lung transplant procedures between January 1, 2010 and July 1, 2018. The electronic health record was queried to identify patients who underwent lung transplants and also received MB for vasoplegia within 72 h of the procedure. To minimize the heterogeneity of preoperative diagnoses, we chose to focus on CF patients—a population that we have empirically seen to be prone to VS during native lung pneumonectomy. This is likely secondary to chronic bacterial colonization that, when coupled with the inflammatory response generated by CPB, makes them high risk for intraoperative vasoplegia. Vasoplegia while on CPB was defined as a MAP ≤60 mmHg for greater than 5 min requiring treatment with two or more vasopressors. Those who did not meet the criteria for receiving MB were excluded, resulting in a total of 13/342 (3.8%) patients. Demographic data, basic health information, hemodynamic data, and factors associated with lung transplant rejection were collected for each patient.
Washington G.C., O’Donnell C.T., Madhok J., Williams K.M, & Hill C.C. (2023). Use of Methylene Blue to Treat Vasoplegia Syndrome in Cystic Fibrosis Patients Undergoing Lung Transplantation: A Case Series. Annals of Cardiac Anaesthesia, 26(1), 36-41.
Publication 2023
Bacteria Diagnosis Genetic Heterogeneity Graft Rejection Hemodynamics Inflammation Lung Lung Transplantation Patients Pneumonectomy Vasoconstrictor Agents Vasoplegia Vision
2
Neoadjuvant Chemoimmunotherapy for Lung Cancer
All patients received PD-1/PD-L1 immune checkpoint inhibitors combined with platinum-based doublet chemotherapy as neoadjuvant chemoimmunotherapy. Chemoimmunotherapy drugs were given on the first day of each treatment cycle (21 days per cycle). A standard staging evaluation was performed before and after neoadjuvant chemoimmunotherapy, including a computed tomography (CT) scan (11 (link)); 18-F-fluorodeoxyglucose positron emission tomography/CT scan; magnetic resonance imaging or CT for the brain; and a bronchoscopy examination. All patients received 18-F-fluorodeoxyglucose positron emission tomography/CT scan to assess the presence of mediastinal involvement before and after neoadjuvant chemoimmunotherapy. Surgery was planned 3–7 weeks after the first day of the last treatment cycle. If there were progressive M1 or N3 metastasis after neoadjuvant chemoimmunotherapy, patients would continue medical therapy and be excluded from this study. The type of resection for the primary tumor was determined according to standard institutional procedures, including lobectomy, bronchial or vascular sleeve lobectomy, bilobectomy, and pneumonectomy. Systematic lymphadenectomy was performed in every patient. Decisions of conversion to thoracotomy were made by surgeons during operation whenever they felt necessary. Pathological responses and yield pathologic stage (yp-stage) were determined by the Department of Pathology according to resected samples.
Patients were divided into the VATS or RATS groups according to the initial surgery approach. Surgery approach was determined by patients’ will. All surgeries were performed by surgeons with extensive experience. VATS was performed in a two-port or three-port approach liberally. RATS was performed using the Da Vinci Xi surgery system (Intuitive Surgical, Inc., Mountain View, CA, USA), using the three-arm method. Patients without viable tumor cells in resected lymph nodes and primary lung cancer were defined as pCR, while less than 10% of viable tumor cells were defined as MPR, and more than 10% were defined as an incomplete pathological response (IPR) (12 (link)).
Zeng J., Yi B., Chang R., Chen Y., Yu Z, & Gao Y. (2023). Safety and feasibility of robotic-assisted thoracic surgery after neoadjuvant chemoimmunotherapy in non-small cell lung cancer. Frontiers in Oncology, 13, 1134713.
Publication 2023
Antineoplastic Combined Chemotherapy Protocols Blood Vessel Brain Bronchi Bronchoscopy CD274 protein, human Cells F18, Fluorodeoxyglucose Feelings Immune Checkpoint Inhibitors Lung Cancer Lymph Node Excision Mediastinum Neoadjuvant Therapy Neoplasm Metastasis Neoplasms Operative Surgical Procedures Patients Pharmaceutical Preparations Platinum Pneumonectomy Radionuclide Imaging Rattus norvegicus Scan, CT PET Surgeons Therapeutics Thoracic Surgery, Video-Assisted Thoracotomy X-Ray Computed Tomography
3
Histopathological Analysis of M. tuberculosis-Infected Lung Tissues
The human study was approved as stated in the ethics statement. The samples used in the present studies were obtained from HIV-negative individuals. These human samples were procured from the period 2009–2010, and therefore were from the time before the onset of the COVID-19 pandemic. M. tuberculosis-infected human lung tissues are routinely obtained following surgery for removal of irreversibly damaged lobes or lungs (bronchiectasis and/or cavitary lung disease). Patients were assessed for extent of pulmonary disease (cavitation and or bronchiectasis) via HRCT. The fitness of each patient to withstand a thoracotomy and lung resection was determined by Karnofsky score, six-minute walk test, spirometry, and arterial blood gas. Assessment of patients with massive hemoptysis included their general condition, effort tolerance prior to hemoptysis, arterial blood gas measurement, serum albumin level and HRCT imaging of the chest. On gross assessment, all pneumonectomies or lobectomies were bronchiectatic, hemorrhagic, variably fibrotic and atelectatic and contained visible tubercles (Table 1). Written informed consent was obtained from patients recruited from King DinuZulu Hospital Complex, a tertiary center for TB patients in Durban, South Africa. Detailed methods for histopathological studies, including histology slide digitization and protocols for immunohistochemistry are presented in S1 Text.
Chen Y., Bharrhan S., Xu J., Sharma T., Wang Y., Salgame P., Zhang J., Nargan K., Steyn A.J., Maglione P.J, & Chan J. (2023). B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice. PLOS Pathogens, 19(3), e1011187.
Publication 2023
6-Minute Walk Test Arteries Atelectasis Blood Gas Analysis Bronchiectasis Chest COVID 19 Fibrosis Hemoptysis Hemorrhage Homo sapiens Immune Tolerance Immunohistochemistry Lung Lung Diseases Mycobacterium tuberculosis Operative Surgical Procedures Patients Pneumonectomy Serum Albumin Spirometry Thoracotomy Tissues
4
Lung Cancer Specimen Handling
Ten percent buffered formalin was injected into wedge resection specimens using needle, or into segmentectomy, lobectomy, and pneumonectomy specimens from the bronchial stump soon after excision. After inflation of the lung, the specimen was soaked in 10% buffered formalin. All specimens were evaluated by three pathologists. Pathological tumor size was evaluated with hematoxylin and eosin staining (H&E) microscopically. We reviewed all pathological reports and restaged the cases after 2018 according to the 7th Edition of TNM in IASLC.
Ishizawa H., Matsuda Y., Ohno Y., Sakurai E., Ota A., Hattori H., Tsukamoto T., Matsunaga M., Kawai H., Suzuki Y., Nagano H., Negi T., Tochii D., Tochii S., Suda T, & Hoshikawa Y. (2023). Honeycomb lung is a major risk factor for preoperative radiological tumor size underestimation in patients with primary lung cancer. Journal of Thoracic Disease, 15(2), 516-528.
Publication 2023
Amputation Stumps Bronchi Eosin Formalin Hematoxylin Lung Needles Neoplasms Pathologists Pneumonectomy Segmental Mastectomy
5
Incidence of Postoperative Delirium in Elderly Lung Cancer Patients
This study is a pilot study to observe the incidence of POD in lung cancer patients ≥60 years from September 2019 to May 2020. All patients who met the inclusion criteria during this time period were observed in this study. And the investigator will guide the next multi-center two-arm prospective study design according to the incidence and risk factors of this study. The data of 208 patients admitted to the ICU after lung tumor resection at the Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University were included in this analysis. To be eligible for inclusion in this study, the patients had to meet the following inclusion criteria: (I) be aged ≥60 years; (II) have been sent directly from the operating room to the ICU after surgery; and (III) have a diagnosis of lung cancer confirmed by intraoperative pathology. Patients were excluded from the study if they met any of the following exclusion criteria: (I) could not verbally communicate with the staff; and/or (II) had a postoperative ICU stay <24 hours or >7 days. Video-assisted thoracic surgery (including da Vinci robotic surgery) and/or open surgery were performed, and the specific surgical procedures included wedge resection, lobectomy, segmentectomy, sleeve resection, and total pneumonectomy. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by institutional ethics committee of Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University (No. IS22077) and informed consent was taken from all the patients.
Lu Y, & Liu X. (2023). Postoperative delirium and its influencing factors in elderly patients with lung cancer in the intensive care unit. Journal of Thoracic Disease, 15(2), 701-710.
Publication 2023
Chest Diagnosis Institutional Ethics Committees Lung Cancer Lung Neoplasms Operative Surgical Procedures Patients Pneumonectomy Robotic Surgical Procedures Segmental Mastectomy Thoracic Surgery, Video-Assisted

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1
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2
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4
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More about "Pneumonectomy"

Pneumonectomy is a major surgical procedure that involves the complete removal of an entire lung, typically performed to treat lung cancer, infections, or other respiratory disorders.
This procedure can have a significant impact on a patient's respiratory function and overall health.
Synonyms for Pneumonectomy include Lung Resection, Lobectomy, and Thoracotomy.
Related terms and abbreviations include Lung Cancer (LC), Non-Small Cell Lung Cancer (NSCLC), Chronic Obstructive Pulmonary Disease (COPD), and Pulmonary Fibrosis (PF).
Key subtopics in Pneumonectomy research include surgical techniques, postoperative complications, patient outcomes, and recovery processes.
Researchers may utilize specialized equipment like the FlexiVent system for lung function analysis, Small Animal 7T MRI units for imaging, and the DELFIA cell proliferation kit for assessing cellular responses.
To enhance the reproducibility and accuracy of Pneumonectomy studies, researchers can leverage AI-driven technology like PubCompare.ai to easily locate the most reliable protocols from literature, preprints, and patents.
This cutting-edge approach can help advance the field of Pneumonectomy research and provide better treatment options for patients.
When preparing Pneumonectomy samples, researchers may use reagents such as Medium 199 and Neutral buffered 10% formalin.
For surgical procedures, the Da Vinci Surgical System may be employed to perform minimally invasive, robotic-assisted Pneumonectomies.
By combining specialized equipment, informative research resources, and innovative technologies, researchers can optimize Pneumonectomy studies and drive progress in this critical area of respiratory medicine.
Experience the future of Pneumonectomy research with PubCompare.ai today.