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Simple Mastectomy

Simple mastectomy is a surgical procedure in which the entire breast, including the nipple and areola, is removed.
This procedure is commonly used to treat breast cancer, especially in early-stage cases.
The goal of simple mastectomy is to remove the cancerous tissue and minimize the risk of the cancer spreading.
The procedure is typically performed under general anesthesia and may involve the removal of some lymph nodes as well.
Recovery time can vary, but patients typically experience some pain, swelling, and bruising after the surgery.
It's important for patients to follow their healthcare provider's instructions for post-operative care and to attend regular follow-up appointments to monitor their health.
Simple mastectomy is an important treatment option for many breast cancer patients, and can help improve outcomes and quality of life.

Most cited protocols related to «Simple Mastectomy»

We constructed a sample consisting of patients who underwent 1 of 11 surgical procedures during the sample period: total knee arthroplasty (TKA), total hip arthroplasty (THA), laparoscopic cholecystectomy, open cholecystectomy, laparoscopic appendectomy, open appendectomy, cesarean delivery, FESS, cataract surgery, transurethral prostate resection (TURP), or simple mastectomy. We chose these procedures because they are commonly performed. In addition, with the exception of TKA and THA, these procedures are not indicated to relieve pain and are not thought to place patients at risk for long-term pain. We identified patients who underwent these procedures by identifying inpatient or outpatient claims with a CPT code for the given procedure (eTable 1 in the Supplement). We restricted our analysis to patients aged 18 to 64 years who were continuously enrolled for a period of at least 3 calendar years, encompassing the year before the procedure and the year after. For example, for patients who received their procedure in 2003, we required that the patient be continuously enrolled for at least the time period January 1, 2002, through December 31, 2004. In addition, we excluded patients who underwent 2 or more of the 11 studied surgical procedures. Using data from pharmacy claims, we further restricted our analysis to opioid-naive patients, defined as patients who did not fill a prescription for an opioid in the 12 months prior to their procedure. A flowchart outlining the construction of the sample is provided in the eFigure in the Supplement.
Publication 2016
Appendectomy Cataract Extraction Cesarean Section Cholecystectomy Cholecystectomy, Laparoscopic Dietary Supplements Inpatient Knee Replacement Arthroplasty Laparoscopy Operative Surgical Procedures Opioids Outpatients Pain Patients Simple Mastectomy Total Hip Arthroplasty Transurethral Resection of Prostate
The SEER database was used to identify 49,084 patients older than 18 years of age who had been treated for ILC from January 1998 to November 2009 using the International Classification of Diseases (ICD) code 8520/3. Patients were excluded if they had stage III (n = 4,191) or IV disease (n = 2,761), unknown stage (n = 3,365), had a follow-up duration of <24 months (n = 11,010), did not undergo surgical resection (n = 294), underwent total mastectomy (n = 13,767), did not receive post-operative radiotherapy (n = 3,888), were node negative (n = 7,573) or had 3 or more positive lymph nodes (n = 966). The remaining 1,269 ILC patients— those who had T1–T2 tumors and 1 or 2 positive lymph nodes and underwent BCT— were included in our study. The SEER database does not specify the axillary lymph node surgery performed; therefore, surrogates were used to categorize patients as having undergone SLND or ALND. Patients with 1–5 lymph nodes removed were considered to have undergone SLND alone, whereas patients with more than 5 lymph nodes removed were considered to have undergone ALND. These definitions were based on the American Joint Committee on Cancer (AJCC) definition of a standard low axillary lymph node dissection (at least 6 lymph nodes) [5] . Using these definitions, we assigned 393 patients to the SLND group and 876 patients to the ALND group (Figure 1).
The SEER database also does not provide specific information regarding LRR. Therefore, we identified patients with 2 or more registered entries after the primary surgery. If the same breast was affected, it was counted as an ipsilateral breast tumor recurrence (IBTR); if the lymph nodes were affected, it was counted as an ipsilateral regional recurrence.
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Publication 2014
Axilla Breast Breast Neoplasm Joints Lymph Node Dissection Malignant Neoplasms Neoplasms Nodes, Lymph Operative Surgical Procedures Patients Radiotherapy Recurrence Simple Mastectomy

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Publication 2012
4-propionyloxy-4-phenyl-N-methylpiperidine Biopsy Breast Cancer Pain Ethics Committees, Research Immune Tolerance Malignant Neoplasm of Breast Malignant Neoplasms Mastodynia Operative Surgical Procedures Pain Patient Participation Patients Segmental Mastectomy Simple Mastectomy Surgeons Woman
The data source for this study was the National Cancer Data Base (NCDB) maintained by the American College of Surgeons and the American Cancer Society. The NCDB data are derived from hospital registry data on more than 1500 CoC-accredited facilities and represents 70% of newly diagnosed cancers in the United States.4 Following IRB approval, the database was queried for all adults (men and women) between the ages of 18 and 90 years who were diagnosed with unilateral stage 0-III in situ or invasive breast cancer from 2004 to 2012. Patients who had bilateral breast cancers or unknown laterality were excluded. Information on epidermal growth factor Her-2 status was omitted due to limited data availability in the NCDB database. The consort diagram describing inclusion and exclusion criteria is included as Fig. 1.
Collected covariates included age at diagnosis, gender, race, education, ethnicity, insurance status, income level, comorbidity score, stage at diagnosis, hormone receptor status, surgery type, hormone therapy after surgery, hospital type and geographic location, time from diagnosis to surgery (in days), use of radiation, use of chemotherapy, distance traveled to treating hospital, treatment received at more than 1 CoC facility, and tumor size. Race and ethnicity were combined to create 6 categories: non-Hispanic White, non-Hispanic Black, non-Hispanic other, Hispanic White, Hispanic Black, and Hispanic other. Due to the paucity of data on Asians, American Indians/Alaskan Natives, and Native Hawaiian/Pacific Islanders, these racial categories were collapsed into non-Hispanic other and Hispanic other. Insurance status was composed of 3 categories—private, government, and none. Income level was dichotomized into <$35,000 and ≥$35,000.
Hormone receptor status was based on estrogen (ER) and progesterone (PR) receptors and was coded as a combined ER/PR status with 4 possible values: ER+/PR+, ER+/PR−, ER−/PR+, or ER−/PR−. Surgery type included lumpectomy, unilateral mastectomy, and contralateral mastectomy. The use of radiation, chemotherapy, and hormone therapy was dichotomized as yes or no. Chemotherapy was further divided into neoadjuvant and adjuvant. NCDB designations of hospital type as academic, comprehensive, community, or integrated were applied. Twenty-five hospitals had multiple hospital type designations, and among these, the most representative designation was selected. Hospital locations were based on the 4 NCDB assigned geographic regions of Midwest, Northeast, South, and West. Comorbidity score was based on the Charlson-Deyo score and divided into 3 groups with scores of 0, 1, and ≥2. Age, distance travelled to treating hospital, and tumor size remained as continuous variables throughout the analysis.
The average annual hospital volume was calculated as the number of breast cancer cases treated at a given facility divided by the number of years the facility had participated in the NCDB. OS was defined as time from diagnosis to death or last follow-up. Patients who did not die were censored at the date of last follow-up. Mortality was not limited to breast cancer related mortality but rather defined as all-cause mortality.
Publication 2018
Adult American Indian or Alaska Native Asian Americans Diagnosis Epidermal growth factor erbb2 Gene Estrogens Ethnicity Gender Hispanics Hormones Lumpectomy Malignant Neoplasm of Breast Malignant Neoplasms Mastectomy Native Hawaiians Neoadjuvant Therapy Neoplasms Operative Surgical Procedures Pacific Islander Americans Patients Pharmaceutical Adjuvants Pharmacotherapy Progesterone Radiotherapy Receptors, Progesterone Simple Mastectomy Surgeons Therapeutics Woman
This study was conducted in accordance with Helsinki Declaration and all patients signed a consent form approved by the Research Ethics Committee of King Faisal Specialist Hospital and Research Center (KFSH&RC). The study was approved by the Research Advisory Council (RAC) of KFSH&RC (RAC# 2030 034).
Breast cancer specimens were collected from primary tumors of 68 patients including the 44 patients reported in our previous study [18 (link)] (median age 44 years) who were seeking treatments and had to undergo surgery (breast conservative surgery or total mastectomy) at KFSH&RC from 2003 to 2006. From the selected patients, 6 patients were removed from the study as they had no detectable TIL. Normal breast tissues were also obtained from 2 healthy women undergoing a plastic surgery and designated as BP. Upon excision of tissues by a surgeon, an anatomical pathologist obtained sample of the tumor tissue, denoted T, and an adjacent normal breast tissue from the same breast having the tumor, denoted N. Tissues from both T and N were processed as described before [18 (link)]. Briefly, they were fixed in formalin and embedded in paraffin for routine histopathological analysis while other piece was snap frozen in liquid nitrogen, preserved at -80°C and sectioned using a cryostat.
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Publication 2008
Breast Ethics Committees, Research Formalin Freezing Malignant Neoplasm of Breast Neoplasms Nitrogen Operative Surgical Procedures Paraffin Embedding Pathologists Patients Plastic Surgical Procedures Simple Mastectomy Specialists Surgeons Thoracic Surgical Procedures Tissues Woman

Most recents protocols related to «Simple Mastectomy»

This was quantitative research in the form of prospective cohort observations at Dr. Moewardi Hospital between April 2021 and May 2022. This study observed changes in estradiol levels before and after adjuvant chemotherapy in breast cancer patients. The inclusion criteria were breast cancer patients who had undergone modified radical mastectomy or simple mastectomy, planned to undergo six cycles of chemotherapy, and had never received hormonal therapy or neoadjuvant chemotherapy. The exclusion criteria were comorbidities or conditions that could increase estradiol levels; patients lost to follow-up, namely, chemotherapy was not on schedule; incomplete chemotherapy; and death during chemotherapy.
Primary data collection included age, sex, and risk factors for breast cancer. Data on cancer included cancer stage, cell type, grade, subtype, and chemotherapy regimen. The estradiol levels were taken in the morning regarding the patient’s menopausal status, with normal values of 90 - 270 pg/mL using the DRG Estradiol ELISA, an immunoassay enzyme used for measuring the in vitro diagnostic quantity of estradiol in serum and plasma [6 ]. The estradiol levels were taken twice. The first was before the patient underwent the first cycle, and the second was 3 weeks after the patient went through the sixth cycle of chemotherapy.
Publication 2023
Breast Cells Chemotherapy, Adjuvant Diagnosis Enzyme-Linked Immunosorbent Assay Enzymes Estradiol Immunoassay Malignant Neoplasm of Breast Malignant Neoplasms Menopause Modified Radical Mastectomy Neoadjuvant Chemotherapy Patients Pharmacotherapy Plasma Serum Simple Mastectomy Staging, Cancer Therapeutics Treatment Protocols
This study involved a retrospective chart review of a prospectively maintained database and was approved by the respective Institutional Review Board (IRB No. 3-2022-0162). We identified patients diagnosed with primary breast cancer, who had undergone mastectomy with DTI breast reconstruction at our hospital between August 2011 and June 2021. The exclusion criteria were previous breast surgery, refusal to sign the consent form, previous radiotherapy, follow-up period < 6 months, and missing data for the pertinent variables.
Each breast was considered individually and categorized according to the type of implant surface as textured anatomical implant or smooth round implant. The implant brands used were Mentor MemoryGel (Mentor Worldwide LLC, Irvine, USA), Allegan (Allergan plc, Dublin, Ireland), and BellaGel (Hans Biomed Corp., Seoul, Korea). Patient demographics, operative characteristics, radiation therapy, medical oncology treatments, and relevant data for the analysis of risk factors were collected by reviewing the medical records. The parameters included age, body mass index (BMI), pathologic tumor stage, mastectomy type (nipple-sparing, skin-sparing, or total mastectomy), axillary surgery (sentinel lymph node biopsy or axillary lymph node dissection), implant size, implant insertion plane, ADM use, laterality, number of dissected lymph nodes or positive lymph nodes, chemotherapy (neoadjuvant or adjuvant), target therapy (trastuzumab), hormone therapy, radiotherapy, comorbidities (diabetes mellitus or hypertension), smoking (non-smoker, ex-smoker, or active smoker), follow-up duration, and drainage duration. Furthermore, complications including capsular contracture, infection, seroma, hematoma, implant rupture, implant exposure, rippling, implant malposition, and nipple-areolar complex (NAC) necrosis were analyzed. Capsular contracture was evaluated by reconstruction surgeons. Any incidence of clinically relevant capsular contracture, defined as Spear–Baker grade III or IV, occurring during the study period was recorded.
Variables were compared between the groups using Pearson χ2 test or Fisher exact test to examine the associations of the categorical variables. The independent t-test or Mann-Whitney U test was used for continuous variables. Logistic regression models were used to evaluate the risk factors associated with the development of complications and capsular contracture. Multiple logistic regression analyses were performed using a stepwise model selection method to predict the risk factors for overall complications and capsular contracture based on the age, BMI, pathologic tumor stage, mastectomy type, axillary surgery, implant-based breast reconstruction (size, surface, and insertion plane), number of positive lymph nodes, number of dissected lymph nodes, neoadjuvant and adjuvant chemotherapy, target treatment, hormone therapy, radiotherapy, comorbidities of diabetes mellitus or hypertension, smoking, drainage duration, and follow-up duration. Further subgroup analyses were conducted to determine whether the impact of the implant surface on the risk of capsular contracture varies with higher BMI or adjuvant radiotherapy after adjusting for risk factors. We divided the patients into the following two BMI categories according to the World Health Organization classification: < 25 kg/m2 and ≥ 25 kg/m2. Statistical significance was set at p-value < 0.05. All statistical analyses were conducted using Statistical Product and Service Solutions (version 24.0; SPSS Inc., Chicago, USA).
Publication 2023
Areola Axilla Breast Capsule Chemotherapy, Adjuvant Contracture Diabetes Mellitus Drainage Ex-Smokers Functional Laterality Hematoma High Blood Pressures Hormones Index, Body Mass Infection Kidney Papillary Necrosis Lymph Node Dissection Malignant Neoplasm of Breast Mammaplasty Mastectomy Mentors Neoadjuvant Therapy Neoplasms Nipples Nodes, Lymph Non-Smokers Operative Surgical Procedures Patients Pharmaceutical Adjuvants Pharmacotherapy Radiotherapy Radiotherapy, Adjuvant Reconstructive Surgical Procedures Sentinel Lymph Node Biopsy Seroma Simple Mastectomy Skin Surgeons Therapeutics Thoracic Surgical Procedures Trastuzumab
Data were collected from 766 patients with breast cancer treated with total mastectomy (TM)/NSM + immediate breast reconstruction (IBR) between January 2016 and January 2021 at a single institute. The exclusion criteria: (1) unclear NAC pathological results, (2) abnormal clinical NAC (inverted nipples, ulcer changes, eczematoid changes, and palpable masses behind the nipple) [21 (link)], (3) incomplete imaging data of MG and US, and (4) neoadjuvant chemotherapy. According to these criteria, a total of 578 patients who underwent TM between January 2016 and January 2020 formed the development cohort, and those who underwent NSM + IBR between January 2020 and January 2021 formed the validation cohort to confirm the model’s performance (Fig. 1).

Study flowchart showing patients in development cohort and validation cohort

Database research indicators include age, multifocal/single lesions, menopausal status, tumor location, nipple discharge, family history of cancer, clinical tumor size (CTS), TND, clinical nodal status (cN), mixed carcinoma in situ (MCIS), histological grade, pathological type, estrogen receptor (ER), progesterone receptor (PR), human-epidermal growth factor receptor 2 (HER2), and KI-67. Each variable can be accurately obtained preoperatively.
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Publication 2023
Breast Carcinoma Carcinoma in Situ Eczema ERBB2 protein, human Estrogen Receptors Malignant Neoplasms Mammaplasty Menopause Neoadjuvant Chemotherapy Neoplasms Neoplasms by Site Nipple Discharge Nipples Patients Receptors, Progesterone Simple Mastectomy Ulcer
A single-center, prospective, comparative, patient-reported outcomes study was performed in patients who underwent fat grafting as an ancillary treatment after breast reconstruction at the Centre Hospitalier de l’Université de Montréal. This study was approved by the institutional ethics review board, and recruited patients scheduled for fat grafting after breast reconstruction between February 2016 and July 2018.
The same group of plastic surgeons performed all procedures. The indications for lipofilling were one or more of the following: hollowness (cavity), deformity (disruption of the form or shape of the breast), asymmetry, volume deficit, visible implant, rippling, or lack of projection.
Eligible patients included patients aged 18 years and older with an indication of fat grafting after breast-conserving surgery or total mastectomy with an implant or flap-based reconstruction. Patients who did not provide consent for the study, did not complete preoperative and postoperative BREAST-Q questionnaires, or were lost to follow-up were excluded.
Publication 2023
Breast Breast-Conserving Surgery Congenital Abnormality Dental Caries Mammaplasty Patients Reconstructive Surgical Procedures Simple Mastectomy Surgeons Surgical Flaps
A total mastectomy will be performed in the control breast: a procedure which includes removal of the breast glandular tissue including the PF and subcutaneously excision of the nipple–areolar complex, while the pectoralis muscle will be spared. As much of the healthy skin envelope will be preserved to enable the performance of an effective breast reconstruction afterwards. When a nipple-sparing mastectomy is performed, the skin envelope together with the nipple–areolar complex will be spared. The investigational part of the operation is preservation of the PF. Dissection of cutaneous flaps and the breast with or without the PF will be performed with electrocautery. In the breast that is randomised to PF removal, the PF will be removed by electrocautery according to standard procedure. The procedure will be followed by an immediate reconstruction, either an autologous or implant-based reconstruction. In case of an implant-based reconstruction, the implants will be placed below the pectoral chest muscle (retropectoral). A closed suction drain will be placed bilaterally in the surgical wound bed at the end of the surgical procedure. The type of drain tube will be selected according to the attending surgeon’s preference. For wound closure, one or two layers of (absorbable) sutures will be placed. No compression bandage will be used. The institution’s guideline for drain removal will be followed postsurgery (see the section Outcome measurements).
Publication 2023
Areola Biologic Preservation Breast Chest Compression Bandages Dissection Electrocoagulation Mammaplasty Mammary Gland Mastectomy Nipples Operative Surgical Procedures Pectoralis Muscles Reconstructive Surgical Procedures Simple Mastectomy Suction Drainage Surgeons Surgical Flaps Surgical Wound Sutures Tissues Wounds

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More about "Simple Mastectomy"

Simple mastectomy, also known as total mastectomy or radical mastectomy, is a common surgical procedure used to treat breast cancer.
This procedure involves the complete removal of the entire breast, including the nipple, areola, and surrounding tissue.
It is often recommended for early-stage breast cancer patients, as it helps minimize the risk of the cancer spreading and can improve overall outcomes.
The surgery is typically performed under general anesthesia, and may also involve the removal of some lymph nodes in the underarm area.
Patients may experience some pain, swelling, and bruising after the procedure, and it's important to follow their healthcare provider's instructions for post-operative care and attend regular follow-up appointments to monitor their health.
Similar surgical procedures include modified radical mastectomy, which also removes the lymph nodes, and skin-sparing mastectomy, which preserves more of the skin.
Breast reconstruction surgery is often an option for patients after a mastectomy, using techniques like tissue expanders, implants, or autologous tissue transfer.
Researchers and clinicians may utilize various tools and technologies in the assessment and treatment of breast cancer, such as the SAS 9.4 statistical software, the Perilipin protein involved in adipocyte metabolism, the Ab28364 and Ab13970 antibodies, the CL8942AP cell line, the LSM 510 confocal microscope, the Selenia Dimensions and Senographe DS mammography systems, and the Stata 12.0 data analysis software.
These resources can help optimize research protocols, improve diagnostic capabilities, and enhance patient outcomes related to simple mastectomy and other breast cancer treatments.