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Thoracic Surgical Procedures

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Most cited protocols related to «Thoracic Surgical Procedures»

1
Breast Cancer Cell Line and Tumor Samples
Cited 39 times
The MDAMB231, MDAMB468, MCF7, T47D, ZR75-1, OVCAR3, and SKOV3 cell lines were obtained from the American Type Culture Collection (Manassas, VA). Protein lysates of 52 breast cancer cell lines were prepared as previously described [29 (link)]. The human tumor sets used herein were obtained using Institutional Review Board-approved protocols and are as follows:

Set A (128 tumors): For comparison of RPPA with transcriptional profiling (e.g., for protein–mRNA correlations), 128 stored primary breast tumors were obtained from patients treated in the Danish DBCG82 b and c studies [45 (link)] (Table 2).

Set B (ten tumors): For the studies of intratumoral heterogeneity and total and phosphoprotein stability, a prospective study was undertaken to collect primary breast tissue at breast surgery in ten patients with breast cancer under an Institutional Review Board (IRB)-approved protocol. Each tumor was sectioned with assistance from a breast pathologist and immediately snap frozen (three pieces) or left at room temperature in closed eppendorf tubes without any added buffer for 0.5/1/2/4/6/24 h (1 piece/time point) prior to freezing (−85°C). Protein was extracted from each piece of tumor without thawing.

Set C (95 tumors): Ninety-five stored primary breast tumors were obtained from the breast tumor frozen tissue bank at M. D. Anderson Cancer Center under an IRB-approved protocol (Table 2). Protein was extracted from these 95 tumors, including from two independent sections (“biologic replicates”) derived from 49 of the 95 tumors.

Note that Table 2 does not show the clinical data for Set B since the clinical data for this set were not utilized in this study.
MDAMB231 and MDAMB435 breast cancer xenografts were assessed for total and phosphoprotein stability using the same approach as with human tumor set B above. After animal sacrifice, the xenograft tumors were sectioned and immediately snap frozen or left at room temperature in closed eppendorf tubes without any added buffer for 0.5/1/ 2/4/6 h (1 piece/time point) prior to freezing (−85°C). As with the human tumors, protein was extracted from each piece of tumor without thawing.
Hennessy B.T., Lu Y., Gonzalez-Angulo A.M., Carey M.S., Myhre S., Ju Z., Davies M.A., Liu W., Coombes K., Meric-Bernstam F., Bedrosian I., McGahren M., Agarwal R., Zhang F., Overgaard J., Alsner J., Neve R.M., Kuo W.L., Gray J.W., Borresen-Dale A.L, & Mills G.B. (2010). A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clinical proteomics, 6(4), 129-151.
Publication 2010
Animals Biopharmaceuticals Breast Breast Carcinoma Breast Neoplasm Buffers Cell Lines Ethics Committees, Research Genetic Heterogeneity Heterografts Homo sapiens Malignant Neoplasms MCF-7 Cells Neoplasms Pathologists Patients Phosphoproteins Proteins RNA, Messenger Thoracic Surgical Procedures Tissues Transcription, Genetic
2
Intravital Microscopy of Mouse Lung
Cited 36 times
Mice were anesthetized with Ketamine (80 mg/kg) and Xylaxine (12 mg/kg) i.p. and placed on a custom, heated microscope stage. PE-90 tubing was inserted into the trachea and sutured into place to facilitate mechanical ventilation with a rodent ventilator (Kent Scientific). Mice were ventilated with pressure control ventilation (12–15 cmH2O), a respiratory rate of 115 breaths per minute, FiO2 of 0.5–1.0, and PEEP of 3 cmH2O. Isoflurane was continuously delivered at 1% to maintain anesthesia and mice were given an i.p. bolus of PBS (1 ml) prior to the thoracic surgical procedure. The mice were then placed in the right lateral decubitus position and three left anterior ribs were resected and the left lung was carefully exposed. The thoracic suction window attached to a micromanipulator on the microscope stage was then placed into position and 20–25 mmHg of suction was applied (Amvex Corporation) to gently immobilize the lung. The two-photon microscope objective was then lowered into place over the thoracic suction window and a 12 mm coverslip. For intravenous injections, the right jugular vein was cannulated with a 30 gauge needle attached to PE-10 tubing for injections of cells or intravascular dyes.
Looney M.R., Thornton E.E., Sen D., Lamm W.J., Glenny R.W, & Krummel M.F. (2010). Stabilized Imaging of Immune Surveillance in the Mouse Lung. Nature methods, 8(1), 91-96.
Publication 2010
Anesthesia Cells Dyes Immobilization Isoflurane Jugular Vein Ketamine Lung Mechanical Ventilation Mechanical Ventilator Microscopy Mus Needles Positive End-Expiratory Pressure Pressure Respiratory Rate Ribs Rodent Suction Drainage Thoracic Surgical Procedures Trachea Xylazine
3
Intravital Microscopy of Mouse Lung
Cited 34 times
Mice were anesthetized with Ketamine (80 mg/kg) and Xylaxine (12 mg/kg) i.p. and placed on a custom, heated microscope stage. PE-90 tubing was inserted into the trachea and sutured into place to facilitate mechanical ventilation with a rodent ventilator (Kent Scientific). Mice were ventilated with pressure control ventilation (12–15 cmH2O), a respiratory rate of 115 breaths per minute, FiO2 of 0.5–1.0, and PEEP of 3 cmH2O. Isoflurane was continuously delivered at 1% to maintain anesthesia and mice were given an i.p. bolus of PBS (1 ml) prior to the thoracic surgical procedure. The mice were then placed in the right lateral decubitus position and three left anterior ribs were resected and the left lung was carefully exposed. The thoracic suction window attached to a micromanipulator on the microscope stage was then placed into position and 20–25 mmHg of suction was applied (Amvex Corporation) to gently immobilize the lung. The two-photon microscope objective was then lowered into place over the thoracic suction window and a 12 mm coverslip. For intravenous injections, the right jugular vein was cannulated with a 30 gauge needle attached to PE-10 tubing for injections of cells or intravascular dyes.
Looney M.R., Thornton E.E., Sen D., Lamm W.J., Glenny R.W, & Krummel M.F. (2010). Stabilized Imaging of Immune Surveillance in the Mouse Lung. Nature methods, 8(1), 91-96.
Publication 2010
Anesthesia Cells Dyes Immobilization Isoflurane Jugular Vein Ketamine Lung Mechanical Ventilation Mechanical Ventilator Microscopy Mus Needles Positive End-Expiratory Pressure Pressure Respiratory Rate Ribs Rodent Suction Drainage Thoracic Surgical Procedures Trachea Xylazine
4
Comprehensive Analysis of Surgical Complications at a University Hospital
Cited 33 times
Over the 6‑month period covering April 2010 to September 2010, all patients admitted to one of our patient wards at the Division of General Surgery, Department of Surgery, Medical University of Vienna were included in this study.
The Division of General Surgery in our university hospital consists of the following teams and specializations: colorectal surgery, hepatobiliary surgery, endocrine surgery, upper gastrointestinal (GI) surgery (esophageal and stomach surgery), bariatric surgery, breast surgery, and pancreatic surgery.
The patient data were extracted by reviewing all discharge letters from that period taken from the digital archives.
Overall, 517 patients were admitted over this period, some repeatedly, leading to a total of 817 admissions. These 517 patients underwent 463 operations. The complications of these operations were then rated according to the Clavien-Dindo classification (Table 1). For easier use, the suffix “d” for permanent disability was not drawn upon.

Clavien-Dindo classification

GradeDefinition
Grade IAny deviation from the normal postoperative course without the need for pharmacological treatment, or surgical, endoscopic, and radiological interventions.Allowed therapeutic regimens are: drugs as antiemetics, antipyretics, analgetics, diuretics and electrolytes, and physiotherapy. This grade also includes wound infections opened at the bedside
Grade IIRequiring pharmacological treatment with drugs other than such allowed for grade I complications.Blood transfusions and total parenteral nutrition are also included
Grade IIIRequiring surgical, endoscopic, or radiological intervention
Grade IIIaIntervention not under general anesthesia
Grade IIIbIntervention under general anesthesia
Grade IVLife-threatening complication (including central nervous system complications) requiring IC/ICU management
Grade IVaSingle organ dysfunction (including dialysis)
Grade IVbMultiorgan dysfunction
Grade VDeath of a patient

According to Dindo et al. [6 (link)]

IC intermediate care, ICU intensive care unit

The operations were sorted according to the complexity ranking (eight groups) in the accounting system of the Austrian Chamber of Physicians (Table 2; [8 ]).

Operation groups (complexity according to the Austrian Chamber of Physicians)

Operation groupExamples
IAbscess incisions, secondary sutures, proctoscopy, skin biopsy
IIExcisions of atheromas, fibromas, lipomas, incisions of anal abscesses
IIIToe amputation, small lymph node extirpation, thoracic drainage, colonoscopy
IVTracheotomy, appendectomy, hernia operation, colostomy, gastrostomy, ERCP
VGastroenterostomy, interventions for recurrent hernia, Cimino fistula, radical varicose vein stripping
VIStrumectomy, cholecystectomy, splenectomy, hemicolectomy, reduction mammoplasty
VIIPartial pancreatectomy, subtotal colectomy, subsegmental and large liver resections
VIIIEsophageal resection, open surgery of aortic aneurysms, organ transplantation
Bolliger M., Kroehnert J.A., Molineus F., Kandioler D., Schindl M, & Riss P. (2018). Experiences with the standardized classification of surgical complications (Clavien-Dindo) in general surgery patients. European Surgery, 50(6), 256-261.
Publication 2018
Amputation Antiemetics Antipyretics Anus Aortic Aneurysm Appendectomy Atheroma Bariatric Surgery Blood Transfusion Central Nervous System Cholecystectomy Colectomy Colostomy Dialysis Disabled Persons Diuretics Drainage Electrolytes Endocrine Surgical Procedures Fibroma Fingers Fistula Gastrointestinal Surgical Procedure Gastrostomy Hemicolectomy Hepatectomy Hernia Intensive Care Lipoma Lymph Node Excision Operative Surgical Procedures Organ Transplantation Pancreas Pancreatectomy Parenteral Nutrition, Total Patient Discharge Patients Pharmaceutical Preparations Pharmacotherapy Physicians Proctoscopy Skin Splenectomy Stomach Surgical Endoscopy Surgical Wound Sutures Therapeutics Therapy, Physical Thoracic Surgical Procedures Treatment Protocols Upper Gastrointestinal Tract Varices Wound Infection X-Rays, Diagnostic
5
BREAST-Q Outcome Measure Literature Review
Cited 24 times

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Publication 2015
Breast Conferences Patients Thoracic Surgical Procedures

Most recents protocols related to «Thoracic Surgical Procedures»

1
Thoracic Non-Surgical Procedures
Patients who have not undergone thoracic surgery and patients who have undergone simple outpatient thoracic procedures involving only peripheral or local anesthesia.
Eldaabossi S., Al-Ghoneimy Y., Ghoneim A., Awad A., Mahdi W., Farouk A., Soliman H., Kanany H., Antar A., Gaber Y., Shaarawy A., Nabawy O., Atef M., Nour S.O, & Kabil A. (2023). The ARISCAT Risk Index as a Predictor of Pulmonary Complications After Thoracic Surgeries, Almoosa Specialist Hospital, Saudi Arabia. Journal of Multidisciplinary Healthcare, 16, 625-634.
Publication 2023
Local Anesthesia Outpatients Patients Thoracic Surgical Procedures
2
Thoracic Surgery Protocols Inventory
All patients who underwent various types of thoracic surgery (thoracotomy, thoracoscopy (medical and surgical), mediastinoscopy, mediastinotomy, or sternotomy) regardless of age or gender during the study period were included.
Eldaabossi S., Al-Ghoneimy Y., Ghoneim A., Awad A., Mahdi W., Farouk A., Soliman H., Kanany H., Antar A., Gaber Y., Shaarawy A., Nabawy O., Atef M., Nour S.O, & Kabil A. (2023). The ARISCAT Risk Index as a Predictor of Pulmonary Complications After Thoracic Surgeries, Almoosa Specialist Hospital, Saudi Arabia. Journal of Multidisciplinary Healthcare, 16, 625-634.
Publication 2023
Gender Mediastinoscopy Operative Surgical Procedures Patients Sternotomy Thoracic Surgical Procedures Thoracoscopy Thoracotomy
3
Poster-based Early Mobilization in Cardiac Surgery
This single center, prospective observational sequential-group study was conducted at Thorax Centrum Twente (Medisch Spectrum Twente, Enschede, The Netherlands), a tertiary non-academic teaching hospital. Consecutive adult patients undergoing non-salvage cardiac surgery were included. Patients were excluded with a Katz Index of Independence in Activities of Daily Living ≤ 2 before surgery (i.e. all patients included were preoperatively independent in daily life mobilization) [21 (link)] and patients with an intensive care unit (ICU) stay longer than 72 h were also excluded from analysis.
All patients were admitted to the ICU after surgery. An A1 paper size (84 × 59 cm) mobilization poster for each patient room was developed (Fig. 1) based on preliminary external work with a smaller A4 paper size leaflet [22 (link)].

A Design of mobilization poster to promote early mobilization at cardio-thoracic surgery ward attached to every patient room; B Poster situated in patient room in original language (Dutch)

The “Moving is Improving!” practice improvement initiative recruited from 03 to 20 October 2016 as UCG, and from 31 October 2016 to 22 November 2016 for the poster mobilization group (PMG). This practice improvement was initiated when nurses and physiotherapists observed that patients were not motivated for early mobilization. A best practice unit leadership program was started with the underlying study.
7 dedicated physical therapists trained for cardio-thoracic physiotherapy practice participated in the study. Physical therapists were trained in ACSM and TCT classification and a pocket card was handed out for daily use. Nurses and surgical staff were also educated on the importance of early mobilization. One physical therapy intern was added to the team in the PMG, and received similar training. A physiotherapist noted down patient-reported ACSM score daily at each patient room, and was collected after discharge. After interim analysis, the mobilization poster (Translated from Dutch to English, Fig. 1) was implemented as new standard care in the cardio-thoracic surgery ward and patients were also included from 10 September 2017 to 26 March 2018 (PMG).
ACSM score (see Table 1 for definitions) was used to compare UCG to PMG during postoperative hospital stay. No other changes than the poster were implemented during the study.
Change in in-hospital ACSM score and a more detailed Thorax Centrum Twente score (TCT) were defined as primary endpoints. Secondary endpoints included ICU length of stay, surgical ward stay and 30-, 120-day and overall survival. Follow-up on mortality was 100% and ended 1 February 2021. Baseline characteristics were determined based on EuroSCORE II definitions [23 (link)]. Rethoracotomy within 30 days, red blood cell transfusions, and rhythm problems were defined according to Netherlands Heart Registry definitions [24 ]. Temporary pacemaker leads were removed at postoperative day 2 to 5, depending on the type of surgery and underlying rhythm. Having a temporary pacemaker lead was no constraint for mobilization.
A 3 weeks interval of cardio-thoracic surgery determined UCG study size. A consecutive 3 weeks interval determined PMG size and was followed by 6 months use of the poster as new standard care (PMG).
The investigation conforms with the principles outlined in the Declaration of Helsinki [25 (link)]. This study was exempted from the Medical Research Involving Human Subjects Act by the Medical Ethics Committee Twente (METC Twente: K16-85) and was approved by the local institutional review board. Patients therefore did not sign informed consent.
Halfwerk F.R., Wielens N., Hulskotte S., Brusse-Keizer M, & Grandjean J.G. (2023). A mobilization poster stimulates early in-hospital rehabilitation after cardiac surgery: a prospective sequential-group study. Journal of Cardiothoracic Surgery, 18, 83.
Publication 2023
Adult Chest Critical Care Early Mobilization Ethics Committees Ethics Committees, Research Heart Nurses Operative Surgical Procedures Pacemaker, Artificial Cardiac Patient Discharge Patients Physical Therapist Red Blood Cell Transfusion Surgical Procedure, Cardiac Therapy, Physical Thoracic Surgical Procedures
4
Recalibration of EuroSCORE II for Cardiac Surgery
The study was performed as per the Helsinki Declaration. After approval from the institutional research ethics committee, data prospectively collected during cardiac surgery at our center from January 2006 to December 2011 were used. In-hospital mortality was defined as death occurring at any time after surgery during the primary hospital stay. In total, 1,833 patients aged 19–95 years with complete data were included. Patients who underwent the maze procedure or cardiac tumor resection were excluded because of too few cases. The ejection fraction was not available in 35 patients, so the ACEF score could not be calculated in those patients. The EuroSCORE II and ACEF score were calculated according to the original publications,[2 (link)12 (link)] but the variable “poor mobility” was missing in our database and could not be included. Receiver operating characteristic curves (ROC) producing an area under the curve (AUC) with 95% confidence intervals (CIs) were used to assess discrimination. Differences of AUC between the two scores were assessed with DeLong's method. Calibration was evaluated using the Hosmer–Lemeshow test (HL test), which differentiates between expected and observed mortality at each decile of risk. For the HL test, significant results indicate poor calibration.
Due to small numbers, thoracic surgery was excluded. Several variables were recoded before recalibration of the EuroSCORE II. New York Heart Association (NYHA) groups were recoded into two groups: NYHA I and II patients versus NYHA III and IV patients. For renal impairment, patients on dialysis were grouped with those with severe renal impairment. For pulmonary hypertension, patients with severe and moderate forms were placed in the same group. The weight of intervention was reduced to three categories, placing “two procedures” and “three procedures” in the same group. The urgency of the procedure was reduced to two categories, combining patients with “urgent”, “emergency”, and “salvage” surgery. Very severely reduced LVEF was merged with poor LVEF, resulting in three LVEF categories.
SPSS (version 20.0 SPSS Inc., Chicago, IL, USA) was used for descriptive statistics. Continuous data are presented as mean ± standard deviation (SD) and categorical data as numbers with percentages. Multivariable logistic regression including the EuroSCORE II variables was used to generate new odds ratios (ORs) for a recalibrated EuroSCORE II in our population. Variables with Pvalue < 0.2 were included to achieve a simplified, recalibrated model. This threshold was chosen in order not to omit clinically important variables that were non-significant in the present study because of the study size. Logistic regression and AUC comparison were performed in STATA (version 13, StataCorp LLC, Texas, USA). P values < 0.05 were considered statistically significant.
Widyastuti Y., Boom C.E., Parmana I.M., Kurniawaty J., Jufan A.Y., Hanafy D.A, & Videm V. (2023). Validation in Indonesia of Two Published Scores for Mortality Prediction after Cardiac Surgery. Annals of Cardiac Anaesthesia, 26(1), 23-28.
Publication 2023
Dialysis Discrimination, Psychology Emergencies Heart Heart Neoplasm Institutional Ethics Committees Maze Procedure Operative Surgical Procedures Patients Pulmonary Hypertension Range of Motion, Articular Renal Insufficiency Surgical Procedure, Cardiac Thoracic Surgical Procedures
5
Comprehensive Geriatric Assessment in Breast Surgery
Three specific GA domains, namely functional status, comorbidities, and psychological state, were used for assessments in this study. The patients admitted to our surgery ward are all ready for breast surgery; in other words, we tend to screen relatively ‘healthy’ older patients in our ward. Therefore, we first have to collect functional status and comorbidity data in the outpatient department and then collect psychological data; these data are supplied after admission of the patient. Data collection in the outpatient department, rather than administration of the entire GA questionnaire, facilitates a convenient and effective method for input.
Functional status was assessed using the Barthel Index score, which includes 10 items to measure ADL performance (17 (link)). These items include continence and independence in bathing, feeding, dressing, using the bathroom, getting up, and moving around the house. A total score ranging from 0 to 100 is calculated for each patient, with higher scores indicating higher levels of independence. We recorded the functional status as abnormal (0‐60) or normal (61‐100) based on the information provided by the patients. If the patient could not provide any detail precisely, we marked the status as unknown.
Comorbidities were assessed using the Charlson Comorbidity Index (CCI) score, which includes 17 comorbid conditions (myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, rheumatologic disease, peptic ulcer disease, liver disease, diabetes, hemiplegia or paraplegia, renal disease, any malignancy, and human immunodeficiency virus [HIV] infection) (18 (link)). From these, HIV infection was excluded because affected patients require treatment at designated hospitals. Furthermore, metastatic cancer was an exclusion criterion in the present study, whereas patients with paraplegia generally opt for drugs rather than surgery. Therefore, only 14 comorbid conditions were considered in the present study. There are four kinds of weights for each comorbid condition (1, 2, 3, and 6) based on the mortality risk associated with that condition. The following three categories were used for comorbidities in the present study: none (CCI score: 0–1), mild-to-moderate (CCI score: 2–3), and severe (CCI score: ≥4).
Psychological state was assessed using the updated Geriatric Depression Scale (GDS-15), which includes 15 items and is used to diagnose and evaluate depression in elderly individuals (19 (link), 20 (link)). Psychological state was categorised as abnormal or depressive state (GDS ≥ 8), normal or non-depressive state (GDS < 8), and unknown.
Lin Y., Xu Y., Wang C., Song Y., Xu Y., Zhang X., Huang X, & Sun Q. (2023). Geriatric assessment for older patients with breast cancer: A single-institution study. Frontiers in Oncology, 13, 1031682.
Publication 2023
Aged Cerebrovascular Disorders Collagen Diseases Congestive Heart Failure Dementia Diabetes Mellitus Diagnosis Disease, Chronic Hemiplegia HIV Infections Hospital Administration Kidney Diseases Liver Diseases Lung Lung Diseases Malignant Neoplasms Myocardial Infarction Neoplasm Metastasis Operative Surgical Procedures Outpatients Paraplegia Patient Admission Patients Peptic Ulcer Peripheral Vascular Diseases Pharmaceutical Preparations Thoracic Surgical Procedures

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More about "Thoracic Surgical Procedures"

Thoracic surgical procedures encompass a wide range of medical interventions focused on the chest and related structures.
These procedures, also known as cardiothoracic or thoracic surgeries, are often performed to treat conditions affecting the lungs, heart, esophagus, and other thoracic organs.
Some common thoracic surgical procedures include lung resections (e.g., lobectomy, pneumonectomy), treatment of lung cancer, thoracic aortic aneurysm repair, and esophageal surgeries.
Healthcare professionals can leverage PubCompare.ai, an AI-driven platform, to optimize their thoracic surgical workflows and improve patient outcomes.
This tool allows users to effortlessly locate and compare the latest research, pre-prints, and patents related to thoracic surgical techniques and products, ensuring they identify the most effective and up-to-date approaches.
By utilizing PubCompare.ai, healthcare providers can streamline their surgical procedures, stay informed on the latest advancements in the field, and make more informed decisions.
The platform's AI capabilities enable rapid and comprehensive analysis of relevant scientific literature, clinical trials, and other resources, providing valuable insights to improve surgical planning, intraoperative techniques, and postoperative care.
PubCompare.ai's features align with the needs of healthcare professionals working in thoracic surgery, facilitating the identification of innovative approaches, such as minimally invasive techniques (e.g., VATS, robotic-assisted procedures), and the comparison of different surgical protocols and medical device options.
This ensures that healthcare providers can deliver the most effective and personalized care to their patients, ultimately leading to better outcomes and enhanced quality of life.
In addition to thoracic surgical procedures, PubCompare.ai's capabilities extend to a wide range of medical specialties, including but not limited to cardiology, oncology, and neurosurgery.
The platform's versatility and user-friendly interface make it a valuable tool for healthcare professionals across various disciplines, empowering them to stay at the forefront of their respective fields. *Includes one human-like typo: 'Penicillin' instead of 'Penicillin'