The largest database of trusted experimental protocols

Tracheotomy

Tracheotomy is a surgical procedure that involves creating an opening in the neck to access the trachea.
This procedure is often performed to facilitate breathing in patients with obstructed airways, such as those with tumors, trauma, or respiratory diseases.
The tracheotomy opening, called a stoma, allows for the insertion of a tracheostomy tube, which can be used for long-term ventilation or to clear secretions from the airway.
This important surgical intervention can be life-saving, but requires careful planning and execution to minimize potential complications.
Researchers and clinicians must continuously optimize tracheotomy protocols to ensure the safest and most effective procedures for their patients.

Most cited protocols related to «Tracheotomy»

From January 1, 2010, to June 30, 2012, adults 18 years of age or older were enrolled at three hospitals in Chicago (John H. Stroger, Jr., Hospital of Cook County, Northwestern Memorial Hospital, and Rush University Medical Center) and at two in Nashville (University of Tennessee Health Science Center–Saint Thomas Health and Vanderbilt University Medical Center). We sought to enroll all eligible adults; therefore, trained staff screened adults for enrollment at least 18 hours per day, 7 days per week. Written informed consent was obtained from all the patients or their caregivers before enrollment. The study protocol was approved by the institutional review board at each participating institution and at the CDC. Weekly teleconferences, enrollment reports, data audits, and annual study-site visits were conducted to ensure uniform procedures among the study sites. Patients or their caregivers provided demographic and epidemiologic data, and medical charts were abstracted for clinical data. All the authors vouch for the accuracy and completeness of the data and analyses reported and for the fidelity of the study to the protocol. All the authors made the decision to submit the manuscript for publication.
Adults were eligible for enrollment if they were admitted to a study hospital on the basis of a clinical assessment by the treating clinician; resided in the study catchment area (see the Supplementary Appendix, available with the full text of this article at NEJM.org); had evidence of acute infection, defined as reported fever or chills, documented fever or hypothermia, leukocytosis or leukopenia, or new altered mental status; had evidence of an acute respiratory illness, defined as new cough or sputum production, chest pain, dyspnea, tachypnea, abnormal lung examination, or respiratory failure; and had evidence consistent with pneumonia as assessed by means of chest radiography by the clinical team within 48 hours before or after admission.
Patients were excluded if they had been hospitalized recently (<28 days for immunocompetent patients and <90 days for immunosuppressed patients), had been enrolled in the EPIC study within the previous 28 days, were functionally dependent nursing home residents,14 (link) or had a clear alternative diagnosis (see the Supplementary Appendix). Patients were also excluded if they had undergone tracheotomy, if they had a percutaneous endoscopic gastrostomy tube, if they had cystic fibrosis, if they had cancer with neutropenia, if they had received a solid-organ or hematopoietic stem-cell transplant within the previous 90 days, if they had active graft-versus-host disease or bronchiolitis obliterans, or if they had human immunodeficiency virus infection with a CD4 cell count of less than 200 per cubic millimeter.10 (link)
Publication 2015
Adult Bronchiolitis Obliterans CD4+ Cell Counts Chest Pain Chills Cough Cuboid Bone Cystic Fibrosis Diagnosis Dyspnea Endoscopy Ethics Committees, Research Fever Gastrostomy Graft-vs-Host Disease HIV Infections Immunocompetence Infection Leukocytosis Leukopenia Lung Malignant Neoplasms Patients Pneumonia Radiography, Thoracic Respiratory Diaphragm Respiratory Failure Respiratory Rate Sputum Tracheotomy Transplantation, Hematopoietic Stem Cell
This study was a longitudinal analysis of a representative sample of nursing home residents in one US state. MDS assessments for residents with a length of stay of greater than 90 days in the year 2002 were collected from a US National Resident Assessment Instrument database (n = 66,742) and follow-up data were extracted at three and six months [21 ]. We chose three month intervals between assessments to enable more precise examination of the rate and direction of change than is available in many longitudinal studies with assessment intervals of a year or more [22 (link),23 ]. Residents with an expectation of being discharged prior to 90 days were excluded (n = 1998).
In order to minimise the effect of factors, other than cognitive impairment, in relation to change in ADL, residents were excluded if they had specific co-morbid diseases or conditions, or received specific treatments. These included history of learning disability, decreased auditory and visual acuity, problems with expressive speech, hypotension, seizure disorder, traumatic brain injury, manic depression, schizophrenia, HIV infection, septicaemia, weight fluctuation, inability to lay flat due to shortness of breath, dehydration, insufficient fluid consumption, internal bleeding, recurrent lung aspiration, end stage of disease, feeding by parenteral/IV or feeding tube, treatment including chemotherapy, radiation, tracheotomy care, transfusion, ventilator, for alcohol/drug problems, hospice care and respite care. Residents with concurrent or pre-existing limitations to mobility such as hip fracture, missing limb, bone fracture, cerebral palsy, stroke, hemiplegia/paresis, multiple sclerosis, paraplegia, Parkinson disease, or quadriplegia were also excluded. After applying these exclusions, the total number of residents available for study was 21,670. The most common reasons for exclusion were stroke (23%), presence of a learning disability (19%), impaired vision (10%) and hip fracture (5%). Nearly 40% of the sample had two or more of these exclusion criteria.
Publication 2006
Alcohol Problem Aspiration Pneumonia Auditory Perception Bipolar Disorder Blood Transfusion Cerebral Palsy Cerebrovascular Accident Dehydration Disorders, Cognitive Dyspnea Epilepsy Fracture, Bone Hemiplegia Hip Fractures HIV Infections Hospice Care Learning Disabilities Mobility Limitation Multiple Sclerosis Paraplegia Paresis Parkinson Disease Pharmaceutical Preparations Pharmacotherapy Quadriplegia Radiotherapy Respite Care Schizophrenia Septicemia Speech Tracheotomy Traumatic Brain Injury Tube Feeding Visual Acuity
Eligible studies included health technology assessments (HTAs), systematic reviews, meta-analyses, randomized controlled trials, and non-randomized studies. The study population involved HCWs caring for patients with acute respiratory infections. The intervention was the provision of care to patients undergoing aerosol generating procedures (exposed to the procedures). The comparator was the provision of care to patients not undergoing aerosol generating procedures (unexposed to the procedures). The outcome of interest was the risk of transmission of acute respiratory infections from patients to HCWs. Procedures that might promote the generation of droplets or aerosols (non-exhaustive list) included non-invasive ventilation (CPAP and BiPAP), endotracheal intubation, airway suctioning, high frequency oscillatory ventilation, bag-valve mask ventilation, chest physiotherapy, nebulizer therapies, aerosol humidification, bronchoscopy or other upper airway endoscopy, tracheotomy, and open thoracotomy.
Publication 2012
Biphasic Continuous Positive Airway Pressure Bronchoscopy Chest Continuous Positive Airway Pressure Endoscopy High-Frequency Oscillation Ventilation Intubation, Intratracheal Nebulizers Noninvasive Ventilation Patients Respiratory Tract Infections Technology Assessment, Biomedical Therapy, Physical Thoracotomy Tracheotomy Transmission, Communicable Disease
Data were collected from electronic medical records of patients older than 19 years who received ECMO support. Included variables were as follows: demographic information, Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at intensive care unit (ICU) admission, etiology of respiratory failure, cardiac arrest, immunocompromised status, central nervous system (CNS) dysfunction, pre-ECMO hemodynamic data, mechanical ventilation parameters, and arterial blood gas data. Immunocompromised status and CNS dysfunction were defined according to the RESP study [12 (link)]. Immunocompromised status included hematological malignancies, solid tumors, solid-organ transplantation, high-dose or long-term corticosteroid and/or immunosuppressant use, and human immunodeficiency virus infection. CNS dysfunction included diagnoses of neurotrauma, stroke, encephalopathy, cerebral embolism, seizure, and epileptic syndrome. We collected information on adjunctive therapy such as the use of vasopressors, steroids, continuous renal replacement therapy (CRRT), prone positioning, nitric oxide, bicarbonate infusion, and neuromuscular blockers. We also collected data such as the ECMO mode, ECMO duration, duration of mechanical ventilation to ECMO initiation, hospital stay, and tracheotomy. The ECMO mode was categorized as veno-venous, veno-arterial, and veno-arteriovenous. Outcome variables of the study were survival at discharge and ECMO weaning (survival within 48 h after weaning from ECMO).
Publication 2019
Adrenal Cortex Hormones Arteries Bicarbonates Cardiac Arrest Central Nervous System Cerebral Embolism Cerebrovascular Accident Continuous Renal Replacement Therapy Diagnosis Encephalopathies Epileptic Syndromes Extracorporeal Membrane Oxygenation Hematologic Neoplasms Hemodynamics HIV Infections Immunosuppressive Agents Mechanical Ventilation Neoplasms Neuromuscular Blocking Agents Organ Transplantation Oxide, Nitric Patient Discharge Patients physiology Respiratory Failure Respiratory Rate Seizures Steroids Therapeutics Tracheotomy Vasoconstrictor Agents Veins
Male, C57Bl/6 mice aged 8 weeks were given 20% ethanol (EtOH) in their drinking water along with ad lib access to standard mouse chow. Mice were acclimated to EtOH by increasing the EtOH concentration in 5% increments from 0% to the target 20% (w/v) over the course of two weeks then maintaining the 20% concentration for an additional ten weeks. This regimen replicates blood alcohol levels following chronic EtOH ingestion in human subjects (Jerrells et al., 2007 (link), Song et al., 2002 (link)). In preliminary studies, blood alcohol concentrations were measured with a rapid, high-performance plasma alcohol analyzer (Analox Instruments Ltd., London, UK) according to the manufacturer's protocol. These analyses confirmed that this ethanol regimen produced clinically relevant elevations in blood alcohol concentration (0.12% ± 0.03, n=24). During the final week of EtOH treatment, all mice were gavaged daily for 7 days with either rosiglitazone (10 mg/kg/day in 100 μl methylcellulose vehicle) or vehicle alone as previously reported (Hwang et al., 2007 (link), Nisbet et al., 2010 (link)). Selected mice were treated with Escherichia coli lipopolysaccharide (Sigma-Aldrich, St. Louis MO, 2 mg/kg IP at 6 and 3 hours prior to sacrifice) as an inflammatory stimulus to promote pulmonary dysfunction. The timing of these studies was based on recent reports showing significant LPS-mediated increases in lung leak in C57Bl/6 mice 6-hours after LPS administration (Rojas et al., 2005 (link)). After sacrifice, blood was collected via cardiac puncture, and bronchoalveolar lavage (BAL) performed via tracheotomy. Protein concentration in the BAL fluid was measured using the bicinchoninic acid (BCA) assay (Thermo Scientific, Rockford IL), and values were corrected for dilution based on the ratio of blood to BAL urea nitrogen, assayed with a commercially available kit (Pointe Scientific, Inc., Canton MI) as previously reported (Rennard et al., 1986 (link)). Lung tissue was collected for subsequent analyses as described below following perfusion of the pulmonary artery with sterile phosphate buffered saline (PBS, Cellgro, Manassas, VA). All animal studies were approved by the Atlanta Veteran's Affairs Medical Center Animal Care and Use Committee.
Publication 2011
Animals bicinchoninic acid BLOOD Bronchoalveolar Lavage Fluid Dimercaprol Escherichia coli Ethanol Heart Inflammation Lung Males Methylcellulose Mice, Inbred C57BL Mus Nitrogen Perfusion Phosphates Plasma Proteins Pulmonary Artery Punctures Rosiglitazone Saline Solution Sterility, Reproductive Technique, Dilution Tissues Tracheotomy Treatment Protocols Urea

Most recents protocols related to «Tracheotomy»

The Thromcco database comprises 478 variables composed of hospital and ICU records collected retrospectively. To perform this study, we selected the following variables: sociodemographic data (age, sex, race, and smoking habit), body mass index (BMI), blood type, previous comorbidities (hypertension, diabetes, obesity (divided into categories as class 1: BMI 30–34.9, class 2: BMI 35–39.9, and class 3: BMI >40), asthma, chronic obstructive pulmonary disease (COPD), and ischemic and valvular heart disease), length of hospital and ICU stays, number of venous doppler ultrasounds of the lower limbs performed, anticoagulant regimen received (prophylactic, intermediate, and therapeutic), blood components transfused (red cells, fresh-frozen plasma, and platelets), and requirements of invasive and noninvasive mechanical ventilation, tracheotomy, or prone positions. We also included the blood test results (D-dimer, fibrinogen, leucocytes, lymphocytes, platelets, ferritin, C-reactive protein (CRP), and interleukin 6 (IL6)), prothrombin time (PT), procalcitonin, creatinine, lactate dehydrogenase (LDH), aspartate dehydrogenase (AST), and alanine transaminase*(ALT)) that were collected at admission and on days 1, 2, 5, and 10 of hospitalization. Adverse outcomes such as sepsis and death were also gathered.
Publication 2023
Alanine Transaminase Anticoagulants aspartate dehydrogenase Asthma Blood Component Transfusion Blood Platelets Chronic Obstructive Airway Disease Condoms C Reactive Protein Creatinine Diabetes Mellitus Erythrocytes Ferritin fibrin fragment D Fibrinogen Hematologic Tests High Blood Pressures Hospitalization Index, Body Mass Interleukin-6 Lactate Dehydrogenase Leukocytes Lower Extremity Lymphocyte Noninvasive Ventilation Obesity Plasma, Fresh Frozen Procalcitonin Septicemia Therapeutics Times, Prothrombin Tracheotomy Treatment Protocols Ultrasounds, Doppler Valve Disease, Heart Veins
AHR was assessed in vivo using the forced oscillation technique in FlexiVent system (SCIREQ, Montreal, QC, Canada). Twenty-four hours after the last challenge, the mice were anesthetized using a ketamine/xylazine mix. Tracheotomy was performed, and the trachea was cannulated using a G20 stainless catheter and connected to the FlexiVent machine for airway resistance measurements. Increasing doses of methacholine (MCh, Sigma Aldrich), 0, 3, 6, 12.5, 25, and 50 mg/mL in PBS, were aerosolized using an ultrasonic nebulizer connected to the FlexiVent system and administrated following the manufacturer’s instructions. Lung function measurements were recorded, and airway resistances were presented as the maximum resistance (Max Rrs) values recorded for increasing MCh doses.
Publication Preprint 2023
Catheters Ketamine Mus Nebulizers Resistances, Airway Respiratory Physiology Trachea Tracheotomy Ultrasonics Xylazine
Between November 2021 and July 2022, endotracheal aspirate (ETA) samples were collected from 74 patients with a clinical suspect of VAP admitted to the ICU of the Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. Based on clinical criteria, a clinical suspect of VAP was defined as follows: (1) duration of the mechanical ventilation treatment performed with tracheal intubation or tracheotomy >48 h, (2) chest X-ray or CT (computed tomography) demonstrating new or progressive infiltration, consolidation or ground glass shadow, associated with at least one of following four clinical criteria: (1) fever >38°C; (2) cough, expectoration and/or dyspnea; (3) purulent airway secretion; (4) peripheral white blood count >10 × 109/L or <4 × 109/L. (American Thoracic Society, 2005)24 (link) After that, only the samples that meet the following criteria were included: (i) consistency with the clinical standards of suspected VAP; (ii) presence of comprehensive information regarding anamnesis, signalment, and clinical data; (iii) age ≥18 years old. On the other side, the following exclusion criteria were followed: (i) presence of other intercurrent infections; (ii) pregnancy and lactation. Based on the inclusion and exclusion criteria, 63 patients were finally enrolled in this study (Figure 1). The clinical data of patients were collected from the electronic medical records, avoiding the record of their identity. Information regarding tests for clinical respiratory viruses was also recorded for each patient. ETA samples were collected within 12 h after the suspect of diagnosis. This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Fifth Medical Center of Chinese PLA General Hospital [ky-2019-1-4], and all samples were obtained following the patients’ consents.

Schematic of samples inclusion and exclusion.

Publication 2023
Blood Cell Count Breast Feeding Chinese Cough Diagnosis Dyspnea Ethics Committees, Clinical Fever Immunologic Memory Intubation, Intratracheal Mechanical Ventilation Patients Pregnancy Complications, Infectious Radiography, Thoracic Respiratory Function Tests secretion Tracheotomy Virus X-Ray Computed Tomography
Patients with acute stroke admitted to the intensive care unit (ICU) or stroke unit at University Hospital Münster between 12/2021 and 02/2022, in whom FEES was indicated according to our in-house standard (i.e., failure of swallowing screening test or symptoms predictive of dysphagia e.g., severe dysarthria, aphasia, National Institute of Health Stroke Scale [NIHSS] > 9) were prospectively included in the study. Patients were excluded if prior strokes or other premorbid conditions associated with dysphagia were known. As part of the review process, the number of patients that dropped out before study incusion were retrospectively recored and illustrated in a flow-diagram. All patients underwent FEES in the acute stage of disease including two different sensory test procedures according to the protocols described below. The following clinical data were recorded during acute hospitalization: type of stroke, aetiology of stroke, stroke severity (National Institute of Health Stroke Scale [NIHSS], Modified Rankin Scale [mRS]), therapeutic interventions, lesion location, intensive care interventions (intubation and tracheotomy), complications (pneumonia, death), and length of stay in the ICU/stroke unit and in the hospital overall. The study design was approved by the local ethics committee.
Publication 2023
Acute Cerebrovascular Accidents Acute Disease Aphasia Cerebrovascular Accident Deglutition Disorders Dysarthria Hospitalization Intensive Care Intubation Patients Pneumonia Regional Ethics Committees Therapeutics Tracheotomy
Patients who qualified the following criteria were included in the study: (1) age > 18 years and < 80 years; (2) ICU length of stay > 48 h. Patients who qualified any of the following criteria were excluded: (1) nervous system diseases such as cerebral infarction, cerebral hemorrhage, meningitis, intracranial infection, craniocerebral injury, Parkinson’s, and brain tumor; (2) post-cardiopulmonary resuscitation or cardiac arrest; (3) pulmonary encephalopathy, hepatic encephalopathy, diabetic hyperosmolar coma, unexplained coma, and other diseases that may affect cognitive function; (4) patients with mental disorder, dementia/pre-dementia, or intellectual disability; (5) history of pesticide poisoning, drug poisoning, chronic alcohol abuse (consumption of alcohol for > 5 years, daily ethanol intake ≥ 80 g, calculation formula: ethanol volume (g) = consumed volume (mL) × ethanol concentration × 0.8); (6) Abuse of drugs such as hypnotics and anesthetics; (7) hearing impairment or visual impairment and inability to complete the cognitive assessment; (8) accepted pharmacological or non-pharmacological cognitive interventions; unwilling or unable to cooperate with assessment (e.g., due to tracheotomy).
Publication 2023
Alcoholic Intoxication, Chronic Anesthetics Brain Neoplasms Cardiac Arrest Cardiopulmonary Resuscitation Cerebral Hemorrhage Cerebral Infarction Cognition Comatose Craniocerebral Trauma Dementia Drug Abuse Encephalopathies Ethanol Hearing Impairment Hepatic Encephalopathy Hyperglycemic Hyperosmolar Nonketotic Coma Hypnotics Infection Intellectual Disability Low Vision Lung Meningitis Mentally Ill Persons Nervous System Disorder Patients Pesticides Psychotic Disorders Tracheotomy

Top products related to «Tracheotomy»

Sourced in Canada, Macao, United States
The FlexiVent system is a precision lung function measurement device. It is designed to assess the mechanical properties of the respiratory system in small laboratory animals. The FlexiVent system uses the forced oscillation technique to provide detailed measurements of lung function parameters.
Sourced in Canada
The FlexiVent is a precision lung function testing system developed by SCIREQ. It is designed to measure respiratory mechanics in small laboratory animals, providing researchers with detailed information about lung function. The FlexiVent utilizes forced oscillation techniques to assess parameters such as airway resistance, tissue elastance, and lung volumes. This advanced equipment allows for accurate and reproducible measurements, enabling researchers to gain valuable insights into respiratory physiology and disease models.
The Invasive Pulmonary Function Device is a piece of lab equipment designed to measure various parameters related to a patient's respiratory function. It is used to assess lung capacity, airflow, and other pulmonary metrics through direct measurements within the respiratory system.
Sourced in United States, Germany, China, Sao Tome and Principe, United Kingdom, Japan, Italy, Canada, Hungary, Macao
Pentobarbital sodium is a laboratory chemical compound. It is a barbiturate drug that acts as a central nervous system depressant. Pentobarbital sodium is commonly used in research and scientific applications.
Mechanical ventilation is a device that assists or replaces the spontaneous breathing function of the lungs. It provides a controlled flow of air or oxygen-enriched gas into and out of the lungs.
Sourced in United States
The mouse adaptor is a device designed to connect a mouse to a computer or other compatible device. It serves as an interface, allowing the mouse to communicate with the system and provide input control functionality.
Sourced in United States
The Model 683 is a syringe pump that is designed for precise fluid delivery in laboratory applications. It features a microprocessor-controlled stepper motor drive and can accommodate a wide range of syringe sizes. The pump can deliver flow rates from 0.001 μL/hr to 220.8 mL/min, with an accuracy of ±0.5%.
Sourced in United States, Japan, United Kingdom, Germany, Austria, Canada, Belgium, Spain
SPSS version 26 is a statistical software package developed by IBM. It is designed to perform advanced statistical analysis, data management, and data visualization tasks. The software provides a wide range of analytical tools and techniques to help users understand and draw insights from their data.
Sourced in Australia, United States, United Kingdom, New Zealand, Germany, Japan, Spain, Italy, China
PowerLab is a data acquisition system designed for recording and analyzing physiological signals. It provides a platform for connecting various sensors and transducers to a computer, allowing researchers and clinicians to capture and analyze biological data.
The ADVantage P-V Control Unit is a lab equipment product designed to provide precise control and monitoring of pressure and volume parameters. It serves as a core component for various experimental setups that require accurate pressure and volume regulation. The device's primary function is to enable the user to precisely control and monitor these critical parameters in their research or testing applications.

More about "Tracheotomy"

Tracheotomy, also known as tracheostomy, is a critical surgical procedure that involves creating an opening in the neck to access the trachea.
This life-saving intervention is often performed on patients with obstructed airways, such as those with tumors, trauma, or respiratory conditions like COPD or lung cancer.
The tracheotomy opening, called a stoma, allows for the insertion of a tracheostomy tube, which can be used for long-term mechanical ventilation or to clear airway secretions.
Researchers and clinicians must continuously optimize tracheotomy protocols to ensure the safest and most effective procedures for their patients.
This includes understanding the latest advancements in related technologies, such as the FlexiVent system, an invasive pulmonary function device used to measure lung mechanics in animal models.
The FlexiVent, along with pentobarbital sodium for anesthesia and mechanical ventilation, can be used to assess the impact of tracheotomy procedures on lung function in mouse models.
When evaluating tracheotomy protocols, it's important to utilize advanced data analysis tools like SPSS version 26 and PowerLab to ensure accurate and reproducible results.
The ADVantage P–V Control Unit, for example, can be integrated with the FlexiVent system to provide precise pressure-volume measurements during mechanical ventilation.
By staying up-to-date on the latest tracheotomy research and leveraging cutting-edge technologies, clinicians and researchers can optimize tracheotomy procedures, minimize complications, and improve patient outcomes.
Continuous protocol refinement is crucial in this field, as every improvement can mean the difference between life and death for those with critical airway obstructions.