Both male and female adult mice, 2 to 5 months of age, were used in accordance with institutional guidelines, as approved by the Institutional Animal and Care Committee (IACUC) animal care and use committee at the Mayo Clinic and Rutgers University. Heterozygous (CX3CR1GFP/+) GFP reporter mice expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jung et al., 2000 (link)) and transgenic mice (Thy1YFP/+) expressing YFP (Feng et al., 2000 (link)) in a subset of pyramidal neurons under the control of the Thy1 promoter were purchased from the Jackson Laboratory. For some experiments, CX3CR1GFP/GFP mice were used as CX3CR1−/− mice. P2Y12−/− mice were originally donated by Dr. Michael Dailey at the University of Iowa (Iowa City, IA, USA) and have now been established in our lab. Trem2−/− mice were donated by Dr. Marco Colonna at Washington University (St. Louis, MO, USA).
Heterozygous cx3cr1gfp gfp reporter mice expressing
Manufactured by Jackson ImmunoResearch
Heterozygous (CX3CR1GFP/+) GFP reporter mice express green fluorescent protein (GFP) under the control of the CX3CR1 gene promoter. This allows for the visualization of CX3CR1-expressing cells, such as microglia and certain subsets of monocytes and dendritic cells, in living tissues.
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2 protocols using heterozygous cx3cr1gfp gfp reporter mice expressing
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Transgenic Mice for Neuroscience Research
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Transgenic Mice for Neuroscience Research
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Both male and female adult mice, 2 to 5 months of age, were used in accordance with institutional guidelines, as approved by the Institutional Animal and Care Committee (IACUC) animal care and use committee at the Mayo Clinic and Rutgers University. Heterozygous (CX3CR1GFP/+) GFP reporter mice expressing GFP under control of the fractalkine receptor (CX3CR1) promoter (Jung et al., 2000 (link)) and transgenic mice (Thy1YFP/+) expressing YFP (Feng et al., 2000 (link)) in a subset of pyramidal neurons under the control of the Thy1 promoter were purchased from the Jackson Laboratory. For some experiments, CX3CR1GFP/GFP mice were used as CX3CR1−/− mice. P2Y12−/− mice were originally donated by Dr. Michael Dailey at the University of Iowa (Iowa City, IA, USA) and have now been established in our lab. Trem2−/− mice were donated by Dr. Marco Colonna at Washington University (St. Louis, MO, USA).
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