1 cyano 2 ethoxy 2 oxoethylidenaminooxy dimethylaminomorpholinocarbeniumhexafluorophosphate comu

Manufactured by Merck Group

Sourced in Sweden

COMU is a reagent used in organic synthesis for the coupling and activation of carboxylic acids. It is a white crystalline solid that is soluble in common organic solvents. The core function of COMU is to facilitate the formation of amide bonds between carboxylic acids and amines.

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Lab products found in correlation

Ethanol, by Avantor (1 mentions) Sodium chlorite, by Avantor (1 mentions) Phenol, by Merck Group (1 mentions) N n dimethylformamide (dmf), by Thermo Fisher Scientific (1 mentions) Pyridine, by Merck Group (1 mentions) Piperidine, by Thermo Fisher Scientific (1 mentions) Ethanedithiol, by Merck Group (1 mentions) Diisopropylethylamine, by Merck Group (1 mentions) Trifluoracetic acid, by Merck Group (1 mentions) Thioanisole, by Merck Group (1 mentions)

2 protocols using 1 cyano 2 ethoxy 2 oxoethylidenaminooxy dimethylaminomorpholinocarbeniumhexafluorophosphate comu

Oxidative Delignification of Birch Wood

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2,2,6,6-Tetramethyl-1-piperidinyloxy (TEMPO),
sodium bromide (NaBr), 1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium
hexafluorophosphate (COMU), and trifluoroethylamine hydrochloride
(TFEA·HCl) were purchased from Sigma-Aldrich, Sweden, and used
as received. Sodium hydroxide (NaOH), sodium hypochlorite (NaOCl),
sodium acetate trihydrate, sodium chlorite, ethanol, and acetonitrile
were purchased from VWR, Sweden. Deionized water was used from a laboratory
setup. The birch wood (Betula pendula) was purchased from Fredricsons Trä, Sweden.

Ram F., Garemark J., Li Y., Pettersson T, & Berglund L.A. (2022). Functionalized Wood Veneers as Vibration Sensors: Exploring Wood Piezoelectricity and Hierarchical Structure Effects. ACS Nano, 16(10), 15805-15813.

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Solid-Phase Peptide Synthesis Protocol

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Fluorenylmethyloxycarbonyl (Fmoc) amino acid derivatives, di-isopropylethylamine, trifluoracetic acid, pyridine, phenol, ethanedithiol, thioanisole, (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate (COMU), and rink amide 9H-fluoren-9-ylmethyl N-[[4-[2-[bis(4-methylphenyl)methylamino]-2-oxoethoxy]phenyl]-(2,4-dimethoxyphenyl)methyl]carbamate (MBHA) resin (0.5 mmol/g) were purchased from Sigma-Aldrich. Caplugs Evergreen 5-inch chromatography columns, piperidine, DMF, and all other solvents (HPLC grade) were purchased from Thermo Fisher Scientific.

Dudem S., Boon P.X., Mullins N., McClafferty H., Shipston M.J., Wilkinson R.D., Lobb I., Sergeant G.P., Thornbury K.D., Tikhonova I.G, & Hollywood M.A. (2023). Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels. The Journal of Biological Chemistry, 299(3), 102975.

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