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4 protocols using kollisolv peg 400

1

Formulation and Characterization of Topical Diclofenac Sodium Gel

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Diclofenac sodium and benzoic acid were purchased from Sigma Aldrich (St. Louis, MO, USA). Kollisolv® PEG 400 (polyethylene glycol 400), Pluriol E®, PEG 3350 (polyethylene glycol 3350), Kolliwax® CSA 50 (cetostearyl alcohol), Kollisolv®, and PG (propylene glycol) were kindly provided by BASF (Tarrytown, NY, USA). Liquid paraffin was obtained from EMD Millipore (Burlington, MA, USA). Span™ and Tween™ 60 were samples from Croda Inc. (Princeton, NJ, USA), Klucel® (hydroxypropyl cellulose) was provided by Ashland Inc. (Bridgewater Township, NJ, USA), and Transcutol® (Diethylene glycol monoethyl ether) was provided by Gattefosse Corp. (Paramus, NJ, USA). All other reagents used were of high purity or HPLC grade.
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2

Formulation and Characterization of Lipid-Based Nano-Carriers

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PZH was purchased from Hangzhou Royall Import and Export Co., Ltd. (Hangzhou, China). Kolliphor EL (polyoxyl 35 castor oil), Kolliphor HS15 (polyoxyl 15 hydroxystearate), Kolliphor RH40 (polyoxyl 40 hydrogenated castor oil), Kolliphor PS80 (polysorbate 80), Kollisolv PG (propylene glycol), Kollisolv MCT70 (medium-chain triglyceride), and Kollisolv PEG400 (polyethylene glycol 400) were provided by BASF (Ludwigshafen, Germany). Capmul MCM C8 (glyceryl monocaprylate) and Capmul MCM C10 (glyceryl monocaprate) were provided by ABITEC (Columbus, OH, USA). Castor oil was provided by DongYang Oil Chemical (Anseong, Korea). All other chemicals were of reagent grade and were used without further purification.
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3

Fucoidan-Based Nanoformulation Development

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Fucoidan with the average molecular mass 735 kDa was obtained from MMBI KSC RAS, Murmansk, Russia. Fucoidan was extracted from F. vesiculosus as described previously [25 (link)]. Poloxamer 407 (Kolliphor® P 407), Polyoxyl 40 hydrogenated castor oil (Kolliphor® RH40), polyethylene glycol 400 (Kollisolv® PEG 400) were provided by BASF (Ludwigshafen, Germany). Extra-virgin olive oil was purchased at a local market. Diethylene glycol monoethyl ether (Transcutol® P) was a gift from Gattefossé (Saint-Priest, France). Acepromazine (Fermenta Animal Health Co., Kansas City, MO, USA), ketamine (Fort Dodge Laboratories, Inc., Fort Dodge, IA, USA), xylazine (Miles Inc., Shawnee Mission, KS, USA), and other chemicals were used as received from the suppliers.
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4

Formulation Development of Alectinib Hydrochloride

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Alectinib hydrochloride was purchased from Wuhan Vanz Pharm Inc. (Wuhan, China). Kolliphor HS 15 (polyoxyl 15 hydroxy stearate), Kollisolv PEG 300 (polyethylene glycol 300), Kollisolv PEG 400 (polyethylene glycol 400), Kolliphor EL (polyoxyl 35 castor oil), Kolliphor PS 20 (Polysorbate 20), Kolliphor PS 80 (polysorbate 80), Kolliphor RH 40 (polyoxyl 40 hydrogenated castor oil), and Kollisolv MCT 70 (medium-chain capric triglyceride) were kindly provided by BASF (Ludwigshafen, Germany). Transcutol P (diethylene glycol monoethyl ether) and Capryol 90 (propylene glycol monocaprylate (type II)) were kindly provided by Gattefosse (Saint-Priest, France). Capmul MCM C8 (mono/diglycerides of caprylic acid) and Capmul MCM C10 (mono/diglycerides of capric acid) were kindly provided by ABITEC Corporation (Janesville, WI, USA). Sodium lauryl sulfate (SLS) was kindly provided by DUKSAN Pure Chemical (Ansan, Korea). All other chemicals were of reagent grade and were thus used without further purification.
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