Olanzapine

Manufactured by Abcam

Sourced in United States

Olanzapine is a chemical compound used as a reference standard in analytical procedures. It is commonly used in the testing and verification of pharmaceutical and biological samples.

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Lab products found in correlation

3 protocols using olanzapine

Neurochemical Screening for Drug Evaluation

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Aripiprazole, Clozapine, Quetiapine, Olanzapine, Paliperidone, Risperidone and Rotenone (Abcam), DehydroAripiprazole (Santa Cruz Biotechnology), DidesmethylCariprazine (Clearsynth), Haloperidol, Iloperidone, Lurasidone, Zotepine (Sigma), Brexpiprazole and Cariprazine (Cayman Chemicals) were dissolved to desired stock concentrations in DMSO. Chlorpromazine (Sigma) was dissolved in distilled water, while Antimycin A, FCCP, Oligomycin A (Sigma) and Piericidin A (Cayman Chemicals) were dissolved in ethanol. All drug stock solutions were diluted into appropriate cell culture media to desired concentrations.

Hardy R.E., Chung I., Yu Y., Loh S.H., Morone N., Soleilhavoup C., Travaglio M., Serreli R., Panman L., Cain K., Hirst J., Martins L.M., MacFarlane M, & Pryde K.R. (2023). The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors. Biology Direct, 18, 43.

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Antipsychotic Drugs Preparation and Dosing

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Clozapine (Sigma, St. Louis, MO) and olanzapine (AbCamBiochemicals, Sapphire Biosciences, Redfern, NSW, Australia) were dissolved using pure acetic acid diluted to make 10% acetic acid solution and adjusted to pH 6.0. Haloperidol solution (Sigma) was diluted in 0.9% saline. Drug doses were informed from previous studies in mice (McOmish et al., 2008 (link); Mutlu et al., 2011 (link)).

Hudson M.R., Hannan A.J., O’Brien T.J, & Jones N.C. (2018). High-Frequency Neuronal Oscillatory Abnormalities in the Phospholipase C-β1 Knockout Mouse Model of Schizophrenia. International Journal of Neuropsychopharmacology, 22(3), 221-231.

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Dissolving Psychoactive Compounds for Research

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Clozapine (Sigma, St. Louis, MO, USA) and olanzapine (AbcamBiochemicals, Sapphire Biosciences, Redfern, NSW, Australia) were dissolved using pure acetic acid, diluted to make a 10% acetic acid solution adjusted to pH 6.0. NFPS (AbcamBiochemicals) was dissolved in a 10% solution of 2-hydroxypropyl-β-cyclodextrin. d-serine (Sigma), haloperidol (Sigma), LY379268 (AbcamBiochemicals), ketamine hydrochloride (racemic mixture, Troy Laboratories, Glendenning, NSW, Australia) and MK-801 (Sigma) were all dissolved in 0.9% saline.

Hudson M.R., Rind G., O'Brien T.J, & Jones N.C. (2016). Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine. Translational Psychiatry, 6(4), e784-.

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