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Resiquimod r848

Manufactured by Selleck Chemicals
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Resiquimod (R848) is a synthetic small-molecule agonist of Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). It is primarily used in laboratory research settings to study the activation and signaling of these innate immune receptors.

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Lab products found in correlation

2 mercaptoethanol, by Thermo Fisher Scientific (1 mentions) Nile red, by Thermo Fisher Scientific (1 mentions) Ovalbumin (ova), by Merck Group (1 mentions) Triethylamine, by Merck Group (1 mentions) Alexa fluor 488, by Thermo Fisher Scientific (1 mentions) Polyvinyl alcohol (pva), by Merck Group (1 mentions) Ir 780 iodide, by Merck Group (1 mentions) 2 hydroxypropyl β cyclodextrin 2hp β cd, by Merck Group (1 mentions) Hoechst 33342, by Yeasen (1 mentions) Lysotracker red dnd 99, by Yeasen (1 mentions)

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Resiquimod (3 citations)

3 protocols using resiquimod r848

1

Topical TLR-7 Agonist R848 in Mice

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Female Balb/c mice at 8 weeks old were purchased from SLAC laboratories (Changsha, China). The mice were divided into control group and R848 group. The topical TLR-7 agonist resiquimod R848 (Selleck) was dissolved in DMSO, and 100 μg of R848 in 100 μL of DMSO was administered to the ear 3 times weekly [25 (link)]. The control mice received DMSO. The mice were sacrificed at the age of 16 weeks.
Wang X., Lin T., He Y., Zhou Y., Peng Y., Zhang W, & Ni X. (2023). Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis. Biology, 12(2), 318.
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2

Synthesis and Characterization of Thiol-Reactive Polymer Particles

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2-(Diisopropylamino) ethyl methacrylate (DPA) (CAS 16715–83-6, code 730971, lot# MKCM8495), glucosamine HCl 99% crystalline (CAS 66–84-2, code G4875–25 g lot# BCCD2896), methacryloyl chloride (CAS 920–46-7, code 523216–100 mL lot# MKCJ5699), 2-iminothiolane hydrochloride (98% (TLC) powder), 5,5′-Dithiobis(2-nitrobenzoic acid) (Ellman’s Reagent), 2,2′-Azobis(2-methylpropionitrile) (AIBN, 98%), reversible addition-fragmentation chain transfer (RAFT) agent 4-cyano-4([(ethylsulfanyl)carbonothioyl]sulfanyl) pentanoic acid (ECT, CAS 1137725–46-2), Triethylamine (TEA, ≥ 99.5%), deuterium oxide (D2O), chloroform-d (CDCl3) dimethyl sulfoxide-d6 (DMSO-d6), and ovalbumin (> 98% powder) were purchased from Millipore Sigma. 2, 2’-dipyridyl disulfide (98%, Alfa Aesar), Nile Red (99%, Acros Organics), 2- Mercaptoethanol (98%, Fisher Chemical), Alexa Fluor® 488 (Thermo Fisher Scientific), and L-Cysteine HCl.H2O (> 99%, Thermoscientific) were purchased through Fisher Scientific. Mouse blood (BALB/C Mouse whole blood K2EDTA lot# MSE 397738) was generously provided by the Tanner Lab for hemolysis experiments. Resiquimod (R848) was purchased from Selleckchem (Cat.No. S8133, Lot #S813302, MW 314.38 g/mol, purity 99.8%) and was stored at −20 °C until use. Attune™ Focusing Fluid 1x and fluorescence-activated cell sorting (FACS) Buffer 1x were purchased from Thermo Fisher Scientific.
De Mel J., Hossain M., Shofolawe-Bakare O., Mohammad S.A., Rasmussen E., Milloy K., Shields M., Roth E.W., Arora K., Cueto R., Tang S.C., Wilson J.T., Smith A.E, & Werfel T.A. (2022). Dual-Responsive Glycopolymers for Intracellular Co-Delivery of Antigen and Lipophilic Adjuvants. Molecular pharmaceutics, 19(12), 4705-4716.
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3

Resiquimod-loaded PLGA Nanoparticle Synthesis

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Resiquimod (R848) was purchased from Selleck (Houston, TX, USA). Poly(D, L-lactic-co-glycolic acid) (PLGA) (LA: GA = 50:50, 10–20 kDa) and cell counting kit-8 (CCK-8) were purchased from MedChenExpress (Monmouth Junction, NJ, USA). Poly(vinyl alcohol) (PVA), the heptamethine indocyanine dye IR-780 iodide, and 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD) were obtained from Sigma-Aldrich Co. (St Louis, MO, USA). The anti-mouse TNFR2 (CD120b) antibody was purchased from Bio X Cell (West Lebanon, NH). Hoechst 33,342 and LysoTracker Red DND-99 were purchased from Yeasen Biotechnology (Shanghai, China). All other reagents used were of the highest commercially available grade.
Yuan H., Gui H., Chen S., Zhu L., Wang C., Jing Q., Lv H., Wan Q., Wang S., Zhou S., Ren X., Nie Y, & Li L. (2024). Regulating Tumor-Associated Macrophage Polarization by Cyclodextrin-Modified PLGA Nanoparticles Loaded with R848 for Treating Colon Cancer. International Journal of Nanomedicine, 19, 3589-3605.
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