Syngo mi workplace

We performed a phantom experiment to calculate the cross-calibration factor (CCF) for converting SPECT count images to SPECT SUV images. The radioactivity of the [¹²³I]-MIBG syringe was measured before injection of [¹²³I]-MIBG into the cylindrical phantom (20 cm in diameter and 20 cm in height; Anzai Medical, Tokyo, Japan) with the measured time recorded. The [¹²³I]-MIBG was injected into the cylindrical phantom, and the time of the [¹²³I]-MIBG injection was recorded. The radioactivity of the [¹²³I]-MIBG syringe was also measured after [¹²³I]-MIBG injection while recording the measured time. After that, we scanned the cylindrical phantom in which 109.5 MBq of [¹²³I]-MIBG was diluted uniformly by adding water, recorded the scan starting time, and reconstructed the images according to the above clinical protocol. We calculated the CCF using a workstation (syngo MI Workplace; Siemens Medical Solutions USA, Inc.).

All patients received a single intravenous dose of 740 MBq of ^99mTc-HSAD (Poolscinti, Nihon Medi-Physics, Tokyo, Japan), and static images (both anterior and posterior images) were obtained 24 hours after the administration of the radiopharmaceutical with the patient being kept in the supine position for eight minutes. The radiochemical purity level of 99mTc-HSAD was higher than 90% [6 (link)].
Scintigraphy was performed using a digital gamma camera (Symbia E, Siemens Japan K.K., Tokyo, Japan) with a rectangular field detector attached to a low-energy, high-resolution collimator. A 15% energy window centered over 140 keV (99mTc photopeak) with a matrix of 512 ×512 and magnification of 1.45x was used. We processed the images and analyzed the results using the Syngo MI Workplace (Siemens Japan K.K., Tokyo, Japan).

PET/CT images were analyzed using parameters quantified on a Syngo MI Workplace software platform (Siemens Healthcare). The presence of positive PLN and/or PALN was investigated. The PET voxel standardized uptake value (SUV) was calculated by normalizing the image‐derived radioactivity concentration to the whole‐body concentration (i.e., injected dose divided by patient body weight). SUV_max was defined as the maximum SUV in the volume of interest (VOI). MTV was defined as the volume of estimated tumor voxels with increased radioactivity uptake. The VOIs for the primary tumor and positive lymph nodes were manually drawn on the images displayed on the workstation; SUV_max was recorded for each VOI. The MTV of the cervical tumor was measured using a fixed boundary SUV of 3.0. Nodal SUV_max was defined as the maximum SUV_max of all positive PLNs and PALNs.