Achieva 1.5t high field mri scanner

Manufactured by Philips

The Philips Achieva 1.5T high field MRI scanner is a magnetic resonance imaging system that operates at a magnetic field strength of 1.5 Tesla. It is designed to capture detailed images of the body's internal structures and functions.

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Lab products found in correlation

Zoletil 50, by Virbac (1 mentions) Nsg10 tips, by NT-MDT (1 mentions) Zetasizer nano zs instrument, by Malvern Panalytical (1 mentions) Em 912 omega, by Zeiss (1 mentions) Ntegra spectra, by NT-MDT (1 mentions)

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3 protocols using achieva 1.5t high field mri scanner

Magnetic Microcarrier Imaging in Mice

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MRI was conducted with a Philips Achieva 1.5 T high-field MRI scanner equipped with a phased array coil. The T2- and T1-weighted quick spin-echo protocols (turbo spin echo, TSE) were applied. Measurements were made with the following parameters: for theT1-weighted pulse sequence, the repetition time (TR) was 450 ms and the echo time (TE) was 15 ms; for theT2-weighted pulse sequence, the TR was 3000 ms and the TE was 47.7 ms.
MRI was conducted before injection of microcarriers (precontrast) and after 1 h and 2, 4, and 25 days. To this end, 200 μL of a suspension containing 1 × 10⁹ carriers was injected into the mouse tail vein. The left paw was fixed on the magnet, and the right one served as the control (no external magnetic field). The mice were fixed on the magnet for 1 h, after which MRI images were taken.

Novoselova M.V., German S.V., Sindeeva O.A., Kulikov O.A., Minaeva O.V., Brodovskaya E.P., Ageev V.P., Zharkov M.N., Pyataev N.A., Sukhorukov G.B, & Gorin D.A. (2019). Submicron-Sized Nanocomposite Magnetic-Sensitive Carriers: Controllable Organ Distribution and Biological Effects. Polymers, 11(6), 1082.

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In Vivo MRI Imaging with Contrast Agents

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Magnetic resonance imaging in vivo was performed using a Philips Achieva 1.5T high field MRI scanner with a phased array coil. Immobilization of animals was carried out for 60 min in the supine position with the fixation of the limbs. Zoletil 50 (Virbac, France) was administered intramuscularly at a dose of 40 µg/kg for anesthesia. T1 and T2-weighted quick “Spin Echo” protocols (Turbo Spin Echo–TSE), and T1-weighted “Fast Field Echo” (is equal to the “Gradient Echo”) were used. The presence of contrast agents in the test object which mainly reduces the longitudinal relaxation time T1 (substances containing gadolinium, for example, gadobutrol [37 (link)]), in the tissue causes a hyperintense signal on T1-weighted images (lighter staining). Contrast agents which mainly reduce the transverse relaxation time T2 (iron oxides) cause a hypointense signal on T2-weighted images. After in vivo MRI study, the animals were decapitated.

Navolokin N.A., German S.V., Bucharskaya A.B., Godage O.S., Zuev V.V., Maslyakova G.N., Pyataev N.A., Zamyshliaev P.S., Zharkov M.N., Terentyuk G.S., Gorin D.A, & Sukhorukov G.B. (2018). Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study. Nanomaterials, 8(10), 812.

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Characterization of Nanomedicine Microcapsules

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The measurements of ζ -potential and size distribution of nanoparticles were performed using a Zetasizer Nano ZS instrument (Malvern Instruments Ltd., UK).
Atomic Force Microscopy (AFM) images were taken by using a NT-MDT Ntegra Spectra instrument operating in the tapping mode with NSG-10 tips from NT-MDT (Russia). TEM imaging was performed using a Zeiss EM 912 Omega (Zeiss, Germany) transmission electron microscope.
The thickness of the microcapsule shell is a half of double the shell thickness. The double shell thickness was measured by AFM method using the flat regions of the microcapsule shell profile by approach described in ref 47 .
MRI was performed using a Philips Achieva 1.5T high field MRI scanner equipped with a phased array coil. T2-and T1-weighted quick "spin-echo" protocols (turbospinecho, TSE) were applied. Measurements were carried out with following parameters: the repetition time (TR) is 450 ms and the echo time (TE) is 15 ms for T1-weighted pulse sequence; the TR is 3000 ms, the TE is 47.7 ms for T2-weighted pulse sequence.
Decreasing of T1 relaxation time leads to increasing of MR signal in T1-weighted images. At the same time decreasing of T2 relaxation time falls to MR signal in T2-weighted images. 48

German S.V., Bratashov D.N., Navolokin N.A., Kozlova A.A., Lomova M.V., Novoselova M.V., Burilova E.A., Zyev V.V., Khlebtsov B.N., Bucharskaya A.B., Terentyuk G.S., Amirov R.R., Maslyakova G.N., Sukhorukov G.B, & Gorin D.A. (2016). In vitro and in vivo MRI visualization of nanocomposite biodegradable microcapsules with tunable contrast. Physical chemistry chemical physics : PCCP, 18(47).

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