Vitros 4600 analyzer

Manufactured by Ortho Clinical Diagnostics

Sourced in United States

The Vitros 4600 Analyzer is a clinical chemistry and immunoassay instrument used for in-vitro diagnostic testing. It performs automated chemical and immunological analyses on patient samples to aid in the diagnosis and monitoring of various medical conditions.

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Lab products found in correlation

Cobas e411, by Roche (1 mentions)

Spelling variants of this product

Vitros 4600 (10 citations) VITROS analyzer (8 citations)

5 protocols using vitros 4600 analyzer

Metabolic Biomarker Measurement Protocol

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Glucose and glycosylated hemoglobin (HbA1c) were measured on a Vitros 4600 Analyzer (Ortho Clinical Diagnostics, Rochester, NY). High-sensitivity C-reactive protein was measured by immunoturbidmetric assay. Enzyme-linked immunosorbent assays were used to measure insulin, IL-6, IL-8, TNF-a, leptin, and adiponectin. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance using the validated equation: Fasting Plasma Insulin × Fasting Plasma Glucose (mmol/l)/22.5 (needs ref). Duplicate testing was performed with coefficients of variation for all samples < 10%.

Dieli-Conwright C.M., Sami N., Norris M.K., Wan J., Kumagai H., Kim S.J, & Cohen P. (2021). Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Scientific Reports, 11, 16916.

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Fasting Blood Biomarker Profiling

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A 12-hour fasting blood sample was obtained for glucose, insulin, lipid profile (total cholesterol [TC], HDL-C, low-density lipoprotein cholesterol [LDL-C], and TRI), glycated hemoglobin (HbA1c), and C-reactive protein (CRP). Insulin resistance was calculated using the homeostatic model assessment (HOMA-IR): (fasting glucose [mg/dL] × fasting insulin [mg/dL]/405) [14 (link)]. Blood samples were analyzed at the COH Clinical Pathology Laboratory. Lipids, glucose, insulin, and CRP assays were analyzed on the Vitros 4600 Analyzer (Ortho Clinical Diagnostics, Rochester, NY) using microslide technology. HbA1c was determined using high performance liquid chromatography (Diazyme, Poway, CA).

Dieli‐Conwright C.M., Wong L., Waliany S., Bernstein L., Salehian B, & Mortimer J.E. (2016). An observational study to examine changes in metabolic syndrome components in patients with breast cancer receiving neoadjuvant or adjuvant chemotherapy. Cancer, 122(17), 2646-2653.

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Comprehensive Metabolic Blood Panel Analysis

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A 12‐hour fasting blood sample was obtained for glucose, insulin, lipid profile (total cholesterol, HDL‐C, low‐density lipoprotein cholesterol, and TRI levels), glycated hemoglobin (HbA1c), and C‐reactive protein (CRP). Insulin resistance was calculated using the homeostatic model assessment (HOMA‐IR) as fasting glucose in mg/dL multiplied by fasting insulin in mg/dL divided by 405.14 Blood samples were analyzed at the clinical pathology laboratory at COH. Lipids, glucose, insulin, and CRP assays were analyzed on the Vitros 4600 Analyzer (Ortho Clinical Diagnostics, Rochester, NY) using microslide technology. HbA1c was determined using high‐performance liquid chromatography (Diazyme, Poway, Calif).

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Biochemical Markers in Pediatric Care

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Biochemical parameters were measured on a daily basis in the Department of Laboratory Medicine (National Institute of Childhood Diseases Bratislava, Slovakia). C-reactive protein (CRP) levels were determined using in vitro immune kinetic enzymatic assay in human serum on layered reagent media with reflectometry measurements on a Vitros 4600 analyzer (Ortho-Clinical Diagnostics, Inc., Rochester, NY, USA). Procalcitonin (PCT) levels were measured by an electrochemiluminescence immunoassay (ECLIA) in human serum for quantitative determination in a Cobas e411 immunoassay analyzer (Roche Diagnostics GmbH, Mannheim, Germany).

Ugrayová S., Švec P., Hric I., Šardzíková S., Kubáňová L., Penesová A., Adamčáková J., Pačesová P., Horáková J., Kolenová A., Šoltys K., Kolisek M, & Bielik V. (2022). Gut Microbiome Suffers from Hematopoietic Stem Cell Transplantation in Childhood and Its Characteristics Are Positively Associated with Intra-Hospital Physical Exercise. Biology, 11(5), 785.

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Biomarker Analysis of Fasted Plasma

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Blood (~30 cc) was drawn from the antecubital vein by trained phlebotomists after a 12 hour fast. Plasma was derived from whole peripheral blood samples, immediately processed within taking the blood sample, transported on ice (for ~5minutes) to freezer storage at −80 for analyses of biomarkers after completion of last study participant. Plasma levels of high sensitivity C-reactive protein (CRP), glycosylated hemoglobin (HbA1c), leptin, adiponectin, IL-6, and IL-8, fasting blood glucose, insulin, HDL-cholesterol, and triglycerides were measured at the Clinical Reference Laboratory on the Vitros 4600 Analyzer (Ortho Clinical Diagnostics, Rochester, NY) and microslide technology.

Dieli-Conwright C.M., Parmentier J.H., Sami N., Lee K., Spicer D., Mack W.J., Sattler F, & Mittelman S.D. (2017). Adipose Tissue Inflammation in Breast Cancer Survivors: Effects of a 16-week Combined Aerobic and Resistance Exercise Training Intervention. Breast cancer research and treatment, 168(1), 147-157.

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