Caffeic acid and CAPE were purchased from Tocris Bioscience (Bristol, UK). EGCG was purchased from Sigma-Aldrich. iE-DAP was purchased from InvivoGen (San Diego, CA, USA). Recombinant rat tumor necrosis factor-α (TNF-α) was obtained from Peprotech (Rocky Hill, NJ, USA). SN50 was obtained from Santa Cruz Biotechnology, CA, USA. SR11302 was purchased from R&D Systems (Minneapolis, MN, USA). Recombinant rat VEGF was obtained from Wako.
Sr11302
Manufactured by R&D Systems
Sourced in United States, United Kingdom
The SR11302 is a lab equipment product manufactured by R&D Systems. It is designed to perform a specific function in a laboratory setting. The core function of this product is to provide a controlled environment for conducting experiments or analyses, but a detailed description of its intended use cannot be provided while maintaining an unbiased and factual approach.
Automatically generated - may contain errors
Lab products found in correlation
Epigallocatechin gallate (egcg), by Merck Group (1 mentions)
Ie dap, by InvivoGen (1 mentions)
D glucose, by Merck Group (1 mentions)
Mannitol, by Merck Group (1 mentions)
Interleukin 6 il 6, by Thermo Fisher Scientific (1 mentions)
L glucose, by Merck Group (1 mentions)
Sb202190, by Bio-Techne (1 mentions)
Ro5 3335, by Merck Group (1 mentions)
Aflibercept, by Regeneron Pharmaceuticals (1 mentions)
Anisomycin, by Santa Cruz Biotechnology (1 mentions)
Sp600125, by Bio-Techne (1 mentions)
Recombinant human vegf 165 protein, by R&D Systems (1 mentions)
Sb259063, by Bio-Techne (1 mentions)
Withaferin a, by Bio-Techne (1 mentions)
3 protocols using sr11302
1
Molecular Modulators of Inflammation
2
Inhibitors and Activators of Key Signaling Pathways
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Tumor Necrosis Factor‐alpha (TNF‐α), Transforming Growth Factor beta 1 (TGFβ1), Transforming Growth Factor beta 2 (TGFβ2) and Interleukin 6 (IL‐6) were purchased from PeproTech (Rocky Hill, NJ, USA). Recombinant human VEGF 165 protein was purchased from R&D Systems (Minneapolis, MN, USA). Aflibercept (Eylea) was purchased from Regeneron Pharmaceuticals (Tarrytown, NY, USA). d ‐glucose, mannitol, L‐glucose, and RUNX1 inhibitor Ro5‐3335 were purchased from Millipore‐Sigma (Burlington, MA, USA). Small‐molecule inhibitors and activators purchased from commercial sources included TNF‐α‐TNFR1 binding inhibitor CAY10500 and JNK activator anisomycin, (Santa Cruz Biotechnology, Dallas, TX, USA); NF‐κB inhibitors Caffeic acid phenethyl ester (CAPE) and Honokiol; dual NF‐κB and JNK inhibitor Withaferin A, JNK inhibitors SP600125 and TCS JNK 6o; p38/MAPK inhibitors SB259063 and SB202190 (Tocris Bioscience, Bristol, UK); and AP‐1 inhibitor, SR11302 (R&D Systems). The CBFβ‐RUNX1 protein–protein interaction inhibitor, AI‐14‐91, and an inactive control compound of similar chemical structure, AI‐4‐88, were synthesized as described previously.36
3
AP-1 Inhibition Modulates IL-17A-Induced MMP-3 Expression
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HS-SY-II cells were cultured with inhibitor of AP-1 (SR11302, 0.1-1 μM; R&D systems) for 1 h, then incubated in the presence or absence of IL-17A (10 ng/ml) for 12 h. The mRNA level of MMP-3 was measured by real-time RT-PCR.
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