Under an institutional review board-approved protocol (PA18-1113), we extracted MRI data from 30 patients treated for GBM at the University of Texas MD Anderson Cancer Center who had experienced recurrence after RT. All patients had anatomical T1 and DTI brain imaging at four time points: at 1 month after RT (baseline), 4 months before recurrence, 2 months before recurrence, and at recurrence. The average time between baseline and recurrence was 13 months with a standard deviation of 12 months.
All scans were obtained according to a standard protocol developed for GBM follow-up at the University of Texas MD Anderson Cancer Center and were acquired on 1.5 T/3T MRI scanners (GE Medical Systems) with axial orientation. T1 images had a 256 × 256/512 × 512 in-plane acquisition matrix and a voxel resolution of 0.86 × 0.86 × 6.5 mm3 (TR/TE = 550/8 ms)/0.43 × 0.43 × 5 mm3 (TR/TE = 967/12 ms). DTI images consisted of 28 volumes with a 256 × 256 in-plane acquisition matrix and a voxel resolution of 0.86 × 0.86 × 6.5 mm3 (TR/TE = 1000/99 ms)/0.86 × 0.86 × 5 mm3 (TR/TE = 10,250/94 ms), including one non-diffusion sensitization volume, i.e., T2-weighted b0 volume, and 27 diffusion-weighted volumes (b = 1200 s/mm2).
All scans were obtained according to a standard protocol developed for GBM follow-up at the University of Texas MD Anderson Cancer Center and were acquired on 1.5 T/3T MRI scanners (GE Medical Systems) with axial orientation. T1 images had a 256 × 256/512 × 512 in-plane acquisition matrix and a voxel resolution of 0.86 × 0.86 × 6.5 mm3 (TR/TE = 550/8 ms)/0.43 × 0.43 × 5 mm3 (TR/TE = 967/12 ms). DTI images consisted of 28 volumes with a 256 × 256 in-plane acquisition matrix and a voxel resolution of 0.86 × 0.86 × 6.5 mm3 (TR/TE = 1000/99 ms)/0.86 × 0.86 × 5 mm3 (TR/TE = 10,250/94 ms), including one non-diffusion sensitization volume, i.e., T2-weighted b0 volume, and 27 diffusion-weighted volumes (b = 1200 s/mm2).