After obtaining images, the raw image files will be de-identified and processed by an experienced nuclear medical physician using dedicated customized software [30 (link)] Cedar Sinai AutoSPECT 3.5 in Phillips Intellispace Portal v6.0.3.12200. An iterative maximum likelihood estimation method algorithm (12 iterations) starting out with a filtered back projection and using a Butterworth analytic filter with a cut off of 0.5 and order of 5.0 will be applied. Motion correction is added if the successive projections move more than 1 pixel in the y axis. Transmission data will be reconstructed similarly except for the use of a cut off of 0.6 and an order of 1.0. After the reconstruction, the left ventricle will be reoriented in short, vertical, and horizontal long axes, and these images will be saved for analysis.
Autospect 3
Manufactured by Philips
Sourced in United States
The AutoSPECT 3.5 is a compact and automated single-photon emission computed tomography (SPECT) imaging system designed for preclinical research applications. It provides three-dimensional imaging of small animals to support various types of studies.
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Lab products found in correlation
2 protocols using autospect 3
1
Nuclear Medicine Image Processing Protocol
2
Quantifying Cardiac Activity in SPECT Imaging
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Using the AutoSPECT 3.5 software of the Phillips JetStream software suite, (Milpitas, California, USA) the MPS raw data were analyzed by a technologist and displayed as sequential tomographic slices in the short, vertical long, and horizontal long axes. For each of the included studies, three sets of images were obtained. The first image was the initial image with interfering subdiaphragmatic activity. The second was the delayed repeated image of the same patient after the cleared subdiaphragmatic activity. The third image was essentially identical to the first image except for eliminating the unwanted radioactivity around the heart using the mask-out function of the software [Figure 1 ]. The lung-to-heart ratio (LHR) was semiautomatically calculated by placing identical ROIs around the left lung and the heart. To assess the severity of subdiaphragmatic activity for more objectivity, a subdiaphragmatic activity-to-heart ratio (SHR) was also calculated in the same fashion as the LHR by placing the ROIs around the subdiaphragmatic activity and the inferior wall of the left ventricle [Figure 2 ].
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