Tp1020 automatic benchtop tissue processor

Manufactured by Leica Biosystems

Sourced in United Kingdom

The TP1020 Automatic Benchtop Tissue Processor is a laboratory equipment designed for the automated processing of tissue samples. It performs the necessary steps to prepare tissue samples for subsequent analysis, including dehydration, clearing, and infiltration with paraffin. The TP1020 is a benchtop model, making it suitable for use in small to medium-sized laboratories.

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Lab products found in correlation

Histostar embedding workstation, by Thermo Fisher Scientific (2 mentions) St5020, by Leica camera (2 mentions)

2 protocols using tp1020 automatic benchtop tissue processor

Histological Evaluation of Intestinal Inflammation

Cited 1 time

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Intestinal sections were fixed in 10% NBF, processed overnight on a 14 h programme in a TP1020 Automatic Benchtop Tissue Processor (Leica Biosystems, Newcastle, UK), paraffin embedded in a Histostar Embedding Workstation (Thermo Fisher Scientific) and sectioned at 5 µm, mounted on glass slides and Hematoxylin and Eosin (H&E) stained (Leica ST 5020). Blinded analysis was conducted by an experienced pathologist using an established scoring system [51 (link)]. Sections were assessed for oedema (0–3), neutrophil infiltration (0–3) and epithelial tissue damage (0–3) with 0, normal and 3, severe.

Karyal C., Hughes J., Kelly M.L., Luckett J.C., Kaye P.V., Cockayne A., Minton N.P, & Griffin R. (2021). Colonisation Factor CD0873, an Attractive Oral Vaccine Candidate against Clostridioides difficile. Microorganisms, 9(2), 306.

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Histological Assessment of Ileum Injury

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Sections of the ileum were fixed in 10% (v/v) neutral buffered formalin (NBF) (Sigma Merck Group, Feltam, UK) and then processed overnight on a 14 h programme in a TP1020 Automatic Benchtop Tissue Processor (Leica Biosystems, Newcastle, UK). Processed tissue was paraffin-embedded in a Histostar Embedding Workstation (Thermo Fisher Scientific) and sectioned at 5 µm, then mounted on glass slides and Hematoxylin and Eosin (H&E) stained (Leica ST 5020). Blinded analysis was conducted by an experienced pathologist using an established scoring system. Sections were assessed for oedema (0–3), neutrophil infiltration (0–3) and epithelial tissue damage (0–3), with 0 normal and 3 severe.

Karyal C., Palazi P., Hughes J., Griffiths R.C., Persaud R.R., Tighe P.J., Mitchell N.J, & Griffin R. (2021). Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine against Clostridioides difficile. Vaccines, 9(12), 1453.

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