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Ns19504

Manufactured by Bio-Techne
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Sourced in United Kingdom

NS19504 is a lab equipment product from Bio-Techne. It is a device designed for use in scientific research and laboratory settings. The core function of this product is to perform specific tasks or procedures related to the analysis or manipulation of biological samples.

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Lab products found in correlation

Xe991, by Bio-Techne (2 mentions) Ucl1684, by Bio-Techne (1 mentions) Acetylcholine ach, by Merck Group (1 mentions) Nnc 55 0396, by Bio-Techne (1 mentions) Ns6180, by Bio-Techne (1 mentions) Penitrem a, by Bio-Techne (1 mentions) D apv, by Bio-Techne (1 mentions) Tta p2, by Alomone (1 mentions) Picrotoxin, by Abcam (1 mentions) Methoxamine, by Merck Group (1 mentions) Iberiotoxin, by Alomone (1 mentions) Retigabine, by Bio-Techne (1 mentions) Acetylcholine, by Merck Group (1 mentions)

2 protocols using ns19504

1

Pharmacological Modulation of Gamma Oscillations

Cited 1 time
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Physostigmine (Phys), NS309, NS6180, UCL1684, NS19504, Penitrem A, XE991, ICA110381, SAK3, and NNC55-0396, CNQX, D-APV, and TTX were obtained from Tocris Bioscience (Bristol, UK). Acetylcholine (ACh) was purchased from Sigma-Aldrich (Taufkirchen, Germany), TTA-P2 from Alomone Labs (Jerusalem, Israel), picrotoxin from Abcam (Cambridge, UK). Drugs were dissolved in water or DMSO and further diluted with ACSF to achieve the respective drug concentrations. Final DMSO concentration was held below 0.02% or DMSO control experiments were carried out. We did not investigate the effect of DMSO on gamma oscillation power systematically; however, it is known that DMSO reduces neuronal excitability (Tamagnini et al., 2014 (link)), which can explain the lower normalized DMSO control values. In patch clamp experiments, the final DMSO concentration was 0.2%.
Klemz A., Wildner F., Tütüncü E, & Gerevich Z. (2022). Regulation of Hippocampal Gamma Oscillations by Modulation of Intrinsic Neuronal Excitability. Frontiers in Neural Circuits, 15, 778022.
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2

Ion Channel Modulation in Cells

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Methoxamine, acetylcholine as well as the salts for the solutions were obtained from Sigma (Germany). Iberiotoxin was purchased from Alomone Labs (Israel). NS19504, Retigabine and XE991 were obtained from Tocris (United Kingdom).
Ma D., Gaynullina D., Schmidt N., Mladenov M, & Schubert R. (2020). The Functional Availability of Arterial Kv7 Channels Is Suppressed Considerably by Large-Conductance Calcium-Activated Potassium Channels in 2- to 3-Month Old but Not in 10- to 15-Day Old Rats. Frontiers in Physiology, 11, 597395.
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