Over the course of the time of patient care since initiation of the repository, several different Tg (Tg IMA) and Tg antibody (Anti-TgAb) assays were utilized. Prior to 2006, various assays for Tg and Tg antibodies were utilized as previously described (18 (link)). After 2006, Tg was measured using the following assays and for the following time periods: 1) 2006–2013: Immulite 2000 XPi Thyroglobulin assay (Siemens Inc., Deerfield, IL, Tg-I) which has a functional sensitivity with a CV <20% of 0.9 ng/mL. 2) 2013–2016: Beckman Access Tg (Beckman Coulter, Tg-B) with a functional sensitivity of 0.1 ng/mL. For anti-TgAb the following assays were utilized 1) 2006–2013: Immulite 2000 XPi anti-Thyroglobulin Antibody assay (Siemens Inc., Deerfield IL; catalog no. L2KTG2; anti-Tg Abs-I) with an analytical functional sensitivity of 20 IU/mL or 2) 2013–2015: Roche assay (Anti-Tg Abs-R) with functional sensitivity of 20 IU/ml and 3) 2015–2016: Access Thyroglobulin Antibody II assay (Beckman Coulter, Anti Tg Abs-B.) with a functional sensitivity of 1.8 IU/ml. For the statistical analysis, a detectable level, as defined with the cut-points above for each assay was considered to be a positive result was utilized. In some cases, it was not possible to ascertain the precise assay used for some of the measurements (n=6), as these measurements were performed at outside labs.
Beckman access tg
Manufactured by Beckman Coulter
The Beckman Access Tg is a laboratory instrument used for the measurement of triglyceride levels in biological samples. It utilizes established analytical methods to provide accurate and reliable triglyceride concentration data.
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2 protocols using beckman access tg
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Thyroglobulin and Antibody Assay Changes
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Harmonizing Thyroglobulin Measurement Methods
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All TgIMAs were run with the Beckman Access Tg immunoassay (Beckman Coulter, Inc.). The limit of quantitation (LOQ) for this assay is 0.1 ng/mL. All TgMS assays were run with the Mayo Clinic Laboratories assay as previously described [9 (link), 22 (link)]. The LOQ of the TgMS assay was 0.5 ng/mL. For statistical and plotting purposes all values Table 2 describes the various assays for TgAbs used in this study. The cut-off provided with each method was utilized to label patients as TgAb positive or negative. When patient sera from 2 different dates were considered, the patient was categorized as TgAb positive if either 1 of the 2 tests were positive. Only 1 case had such a discrepancy, in which the 2 TgAb measurements were run with different assays. Because of the different LOQ between Tg assays, TgIMA with detectable results of >0.5 ng/mL were considered concordant with TgMS results of >0.5 ng/mL.
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