Signa hdxt 3.0t scanner

Manufactured by GE Healthcare

Sourced in United States

The Signa HDxt 3.0T scanner is a magnetic resonance imaging (MRI) system designed by GE Healthcare. It operates at a magnetic field strength of 3.0 Tesla, which allows for high-quality imaging of the human body.

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Lab products found in correlation

Eight channel phased array head coil, by GE Healthcare (1 mentions) Origin 7, by OriginLab (1 mentions)

Spelling variants of this product

Signa HDxt (563 citations) Signa scanner (128 citations) Signa HDxt 3.0T (40 citations) Signa HDxt scanner (33 citations) 3.0T scanner (23 citations) Signa HDxT 3.0T MRI scanner (10 citations) GE Signa HDXT 3.0T MRI scanner (4 citations) 3.0T HDXT scanner (2 citations) Scanners (2 citations) Signa 3.0T Twin speed HDxt scanner (2 citations)

12 protocols using signa hdxt 3.0t scanner

3T MRI Acquisition of T1 and T2-FLAIR Images

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All the MRI data were acquired on a GE Signa Hdxt 3.0T scanner with an eight-channel phased-array head coil. High-resolution 3D-T1 images were obtained with the following parameters: TR = 8.3 ms, TE = 3.3 ms, flip angle = 15°, thickness/gap = 1.0/0 mm, field of view (FOV) = 240 × 240 mm, matrix = 240 × 240, voxel = 1 × 1 × 1 mm³, and scanning time = 6.45 min. The scan parameters of the T2-FLAIR-weighted images were acquired as follows: TR = 8000 ms, TE = 126 ms, TI = 1500 ms, thickness/gap = 5.0/1.5 mm, FOV = 240 × 240 mm, and matrix = 256 × 192. The subjects were told to keep their eyes closed and to remain awake throughout the scanning session.

Cheng R., Chen L., Liu X., Luo T., Gong J, & Jiang P. (2021). Changes in Gray Matter Asymmetries of the Fusiform and Parahippocampal Gyruses in Patients With Subcortical Ischemic Vascular Disease. Frontiers in Neurology, 11, 603977.

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Resting-state fMRI Acquisition Protocol

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All MR images were acquired using the GE Signa HDxt 3.0T scanner (General Electric Medical Systems, USA) with a standard 8-channel head coil. Resting-state fMRI data were acquired using an echo-planar image (EPI) pulse sequence with 33 axial slices, thickness/gap = 4.0/0 mm, matrix = 64 × 64, TR = 2000 ms, TE = 40 ms, flip angle = 90°, FOV = 240 × 240 mm. A total of 210 time points was obtained in 7 min. High-resolution three-dimensional T1 (TR = 5.8 ms, TE = 1.8 ms, flip angle = 12°, thickness/gap = 1.0/0 mm, 196 sagittal slices, FOV = 256 × 256 mm, matrix = 256 × 256) data were also acquired.

Tu Y., Wei Y., Sun K., Zhao W, & Yu B. (2015). Altered Spontaneous Brain Activity in Patients with Hemifacial Spasm: A Resting-State Functional MRI Study. PLoS ONE, 10(1), e0116849.

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Multimodal Neuroimaging Protocol for Brain Assessment

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The MRI data of all participants were gained on a GE Signa Hdxt 3.0 T scanner with an eight-channel phased-array head coil. High-resolution 3D-T1 images were acquired using the following parameters: repetition time (TR) = 8.3 ms, echo time (TE) = 3.3 ms, flip angle = 15°, slice thickness/gap = 1/0 mm, field of view (FOV) = 240 × 240 mm2, matrix = 240 × 240, resolution = 1 × 1 × 1 mm3, and scanning time = 6.45 min. The scan parameters of the T2-FLAIR weighted images were as follows: TR = 8,000 ms, TE = 126 ms, inversion time (TI) = 1,500 ms, slice thickness/gap = 5/1.5 mm, FOV = 240 × 240 mm², and matrix = 256 × 192. diffusion tensor imaging (DTI) images were acquired using the following parameters: TR = 1,100 ms, TE = 77.6 ms, flip angle =15°, slice thickness/gap = 3/0 mm, FOV = 256 × 256 mm2, matrix = 128 × 128, resolution = 1 × 1 × 1 mm3, diffusion gradient encoding direction = 30, b-value = 1,000/0 s/mm², and B0 was obtained 8 times. Resting-state functional MRI images were obtained using the following parameters: an echo-planar imaging (EPI) sequence, TR = 2,000 ms, TE = 40 ms, flip angle = 90°, slice thickness = 4 mm, FOV = 240 × 240 mm2, matrix = 64 × 64, scanning time point = 240, and scanning time = 8 min. All participants were asked to hold still, close their eyes and remain awake during the MRI scan.

Huang J., Cheng R., Liu X., Chen L, & Luo T. (2024). Unraveling the link: white matter damage, gray matter atrophy and memory impairment in patients with subcortical ischemic vascular disease. Frontiers in Neuroscience, 18, 1355207.

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Multimodal brain imaging protocol for healthy subjects

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Images were acquired in the Signa HDxt 3.0 T scanner (GE Healthcare) at North Shore University Hospital, with an 8-channel head coil. For fMRI scans, the field of view (FOV) was 240 mm, 40 slices were acquired with 3 mm thickness, the imaging matrix was 64 × 64, flip angle = 77°, repetition time (TR) = 2 s, echo time (TE) = 27.2 ms, with total scan acquisition time of 320 s. The healthy subjects were scanned in two trial blocks in a single imaging session. For high resolution T1-weighted structural scans, the FOV was 240 mm, 176 slices were acquired with 1 mm thickness, the imaging matrix was 256 × 256, flip angle = 8°, TR = 7.6 ms, TE = 2.9 ms, inversion time = 650 ms, with resolution of 0.9 × 0.9 × 1 mm³. For DTI, a single-shot spin-echo echo planar imaging sequence was used with 33 diffusion gradient directions and 5 b0 images. The b-value in the diffusion-weighted images was 800 s/mm². The FOV was 240 mm, 55 slices were acquired with 2.5 mm thickness, TE = 82.7 ms, TR = 15 s, flip angle = 90°, and scan time = 9.5 min. The images were zero filled to a matrix size 256 × 256, yielding an image resolution of 0.9 × 0.9 × 2.5 mm³.

Fujita K., Sako W., Vo A., Bressman S.B, & Eidelberg D. (2017). Disruption of network for visual perception of natural motion in primary dystonia. Human Brain Mapping, 39(3), 1163-1174.

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Resting-State fMRI Acquisition with 3T MRI

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All MR images were acquired using a GE Signa HDxt 3.0T scanner (General Electric Medical Systems, USA) with a standard 8-channel head coil. Foam padding was used to minimize head motion. Apart from this, no other special methods were employed to prevent head movement. During RS-fMRI acquisition, all subjects were instructed to relax and to keep still with eyes closed but to remain awake (confirmed with post-scan debriefing).
RS-fMRI data were acquired using an echo-planar image (EPI) pulse sequence and the following parameters: 33 axial slices; thickness/gap = 4.0/0 mm; matrix = 64 × 64; TR = 2000 ms; TE = 40 ms; flip angle = 90°; and FOV = 240 × 240 mm. A total of 240 time points were obtained in 8 min. High-resolution 3D-T1 images were also acquired (repetition time [TR] = 8.3 ms; echo time [TE] = 3.3 ms; flip angle = 15°; thickness/gap = 1.0/0 mm; field of view [FOV] = 240 × 240 mm; matrix = 256 × 192).

Sheng K., Fang W., Zhu Y., Shuai G., Zou D., Su M., Han Y, & Cheng O. (2016). Different Alterations of Cerebral Regional Homogeneity in Early-Onset and Late-Onset Parkinson's Disease. Frontiers in Aging Neuroscience, 8, 165.

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MT-Prepared MRI for Collagen Quantification

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MRI studies were performed on a GE Signa HDxt 3.0T scanner using an MT-prepared gradient echo sequence. To select the appropriate offset frequency, an MT-MRI study was initially performed on a phantom containing collagen types I and III (NeoCell, Newport Beach, CA) at 40%, 30%, 20%, 10% and 0% concentrations in pure water (Fig. 1). Images without MT preparation (M_o) were first acquired with the following parameters: TR 300ms; TE 3.4ms; flip angle 30°; slice thickness 4mm; slice number 5; FOV 15×15cm²; matrix size 128×128; number of averages 1. Then MT-weighed images (M_t) were acquired by adding Fermi pulses prior to image acquisition with offset frequencies from -1600 to +1600Hz with an increment step of 200Hz. Other MT parameters were empirically set as pulse width 16ms, flip angle 800°, and one pulse per repetition.

Jiang K., Ferguson C.M., Woollard J.R., Zhu X, & Lerman L.O. (2017). Magnetization Transfer MRI Noninvasively Detects Renal Fibrosis in Swine Atherosclerotic Renal Artery Stenosis at 3.0 T. Investigative radiology, 52(11), 686-692.

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Multimodal MRI Neuroimaging Protocol

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MRI scanning was performed on a GE Signa Hdxt 3.0 T scanner. rs-fMRI data was acquired using an echo-planar imaging (EPI) pulse sequence: repetition time (TR) = 2,000 ms; echo time (TE) = 40 ms; flip angle (FA) = 90°; slice thickness = 4 mm, no gap; field of view (FOV) = 240 × 240 mm²; matrix = 64 × 64; and timepoints = 240. A pseudo continuous ASL (pcASL) sequence with a 3D fast spin-echo acquisition and background suppression was applied for the perfusion imaging: TR = 5,216 ms; TE = 9.8 ms; spiral in readout of eight arms with 512 sample points; FOV = 240 × 240 mm²; post-label delay (PLD) = 2,525 ms; reconstruction matrix = 128 × 128; slice thickness = 4 mm, no gap; and number of excitations = 3. 3D-T1 weighted images were scanned as follows: TR = 8.3 ms; TE = 3.3 ms; flip angle = 15°; thickness = 1 mm, no gap; FOV = 240 × 240 mm²; matrix = 240 × 240, and voxel = 1 × 1 × 1 mm³. The scan parameters of the T2-FLAIR weighted images were scanned as follows: TR = 8,000 ms; TE = 26 ms; TI = 1,500 ms; thickness = 5 mm, no gap; FOV = 240 × 240 mm²; and matrix = 256 × 192.

Liu X., Cheng R., Chen L., Gong J., Luo T, & Lv F. (2021). Altered Neurovascular Coupling in Subcortical Ischemic Vascular Disease. Frontiers in Aging Neuroscience, 13, 598365.

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3T Neuroimaging Acquisition Protocol

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Images were acquired with a General Electric Signa HDxt 3.0T scanner (GE Healthcare) using an 8-channel receive-only head coil. A high-resolution T1-weighted anatomical image (MPRAGE, magnetization-prepared rapid gradient-echo) was obtained for each participant (124 axial slices, 1.2 mm slice thickness, field of view = 24 cm, 224 × 224 acquisition matrix). Functional (T2*-weighted) images were acquired using a gradient-echo echo-planar imaging (EPI) sequence [Array Spatial Sensitivity Encoding Technique, ASSET, acceleration factor = 2, TR = 2000 ms, TE = 27 ms, flip angle = 60^o, 40 sagittal slices (3.5 mm slice thickness), field of view = 216 mm, 72 × 72 acquisition matrix, voxel resolution = 3.5 × 3.0 × 3.0 mm³]. Each experimental task run lasted 7 min 40 s for a total of 230 consecutive whole-brain volumes, with each participant receiving a total of 5 runs. Foam earplugs were worn by participants to attenuate scanner noise and participants’ head positions were stabilized using foam pillows. All EPI data were evaluated for transient head motion artifacts, with included scans required to be ≤0.3 mm/TR using AFNI’s @1dDiffMag function (comparable to mean Framewise Displacement^{59 (link)}). Independent measures of cardiac and respiration cycles were recorded during the task scans for later removal.

Gotts S.J., Milleville S.C, & Martin A. (2021). Enhanced inter-regional coupling of neural responses and repetition suppression provide separate contributions to long-term behavioral priming. Communications Biology, 4, 487.

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Quantitative MRI Evaluation of Cerebral Infarction

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The cortical infarction was verified by brain magnetic resonance imaging (MRI) examination, which was performed with a GE Signa HDxt 3.0 T scanner (GE, Fairfield, USA) equipped with a 3 inches animal coil (Chenguang, Shanghai, China). Quantitative T2 measurements were performed with the following acquisition parameters: FOV = 40 × 40 mm², TR/TE = 3,040 ms/133 ms, image matrix = 192 × 160, NEX = 12, slice thickness 1.0 mm, space 0.2 mm, time: 6 min 09 s. The infarct volume was calculated according to MRI T2 weighted phase, while the lesion volume was quantified by the summation of areas of hyperintensity on each slice, multiplied by slice thickness.

Jin H.J., Pei L., Li Y.N., Zheng H., Yang S., Wan Y., Mao L., Xia Y.P., He Q.W., Li M., Yue Z.Y, & Hu B. (2017). Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression. Scientific Reports, 7, 14926.

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Multi-Modal Neuroimaging and Physiological Monitoring

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Magnetic resonance images were obtained with a GE Signa HDxt 3.0 T scanner (GE Healthcare, USA). The CT perfusion images were obtained with a Toshiba Aquilion ONE volume CT scanner (Toshiba America Medical Systems, Inc., CA, USA) and processed using Vitrea fX 6.1 software. All blood pressure measurements were obtained from a radial arterial line. The patient was spontaneously breathing room air. Regional cerebral oximetry measurements (rSO₂) were taken using the Nonin EQUANOX 7600, sensor model 8004ca (Nonin Medical, Inc., USA).^{11 (link)} Leads were applied after cleaning the skin and in the case of the occipital sensor shaving the area prior to application. Data collection was obtained using a centralized server and compiled with ICUpilot v2.0 (CMA/Microdialysis, Sweden). Data analysis including smoothing and chart generation was performed using Origin 7 (OriginLab, Northampton, Massachusetts).

Chung D.Y., Claassen J., Agarwal S., Schmidt J.M, & Mayer S.A. (2016). Assessment of Noninvasive Regional Brain Oximetry in Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome. Journal of intensive care medicine, 31(6), 415-419.

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