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Kribb11

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KRIBB11 is a small molecule that inhibits the activity of Akt, a protein kinase involved in cellular signaling pathways. It is commonly used in research applications to study the role of Akt in various biological processes.

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Lab products found in correlation

Kn 93, by Bio-Techne (2 mentions) Rp camp, by Merck Group (2 mentions) U0126, by Cell Signaling Technology (2 mentions) Carfilzomib, by Selleck Chemicals (1 mentions) Oprozomib, by Selleck Chemicals (1 mentions) Ixazomib, by Selleck Chemicals (1 mentions) Harmine, by Bio-Techne (1 mentions) Bortezomib, by Selleck Chemicals (1 mentions) Curcumin, by Merck Group (1 mentions)

3 protocols using kribb11

1

Preparing and Evaluating Proteasome Inhibitors

Cited 1 time
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Harmine (Tocris 5075), LDN-192960 (Sigma-Millipore SML0755), KRIBB11 (Tocris 5480), bortezomib (Selleckchem S1013), carfilzomib (Selleckchem S2853), ixazomib (Selleckchem S2180), and oprozomib (Selleckchem S7049) were dissolved in DMSO at a stock concentration of 10 mM and treatments were carried out as indicated. Curcumin (Sigma-Millipore 08511) was diluted in DMSO at a stock concentration of 5 mM in the dark and prepared fresh prior to each experiment and the excess solution was never stored. Curcumin treatment at a final concentration of 5 µM was always carried out in media containing either 1% bovine serum albumin (BSA) or 10% fetal bovine serum (FBS) to maintain maximum stability and to avoid aggregation [15 (link),19 (link)].
Tandon V., Moreno R., Allmeroth K., Quinn J., Wiley S.E., Nicely L.G., Denzel M.S., Edwards J., de la Vega L, & Banerjee S. (2023). Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Bioscience Reports, 43(1), BSR20222102.
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2

Pharmacological Inhibitors of Signaling Pathways

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OS47720 (abbreviated as OS47720), was initially provided by NexGenenix Pharmaceutical, Inc., NY with an original name of NXD30020, later by OncoSynergy, San Francisco, CA. KRIBB11, KN92 and KN93 was purchased from Tocris; RpcAMP and H89 was purchased from Sigma; LY294002 was purchased from LC labs; U0126 was purchased from Cell signal.
Wang B., Liu Y., Huang L., Chen J., Li J.J., Wang R., Kim E., Justicia C., Sakata K., Chen H., Planas A., Ostrom R.S., Li W., Yang G., McDonald M.P., Chen R., Heck D, & Liao F.F. (2016). A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism. Molecular psychiatry, 22(7), 990-1001.
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3

Pharmacological Inhibitors of Signaling Pathways

Check if the same lab product or an alternative is used in the 5 most similar protocols
OS47720 (abbreviated as OS47720), was initially provided by NexGenenix Pharmaceutical, Inc., NY with an original name of NXD30020, later by OncoSynergy, San Francisco, CA. KRIBB11, KN92 and KN93 was purchased from Tocris; RpcAMP and H89 was purchased from Sigma; LY294002 was purchased from LC labs; U0126 was purchased from Cell signal.
Wang B., Liu Y., Huang L., Chen J., Li J.J., Wang R., Kim E., Justicia C., Sakata K., Chen H., Planas A., Ostrom R.S., Li W., Yang G., McDonald M.P., Chen R., Heck D, & Liao F.F. (2016). A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer’s mouse model via an HSF1-mediated mechanism. Molecular psychiatry, 22(7), 990-1001.
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