The heart preparation was described previously (10 (link),21 (link)). The fresh hearts were imaged without formalin fixation by using a 64–detector row CT scanner (High-Definition, GE Discovery, or CT 750HD; GE Healthcare, Milwaukee, Wis). For coronary CT angiography, a 3% mixture of iodinated contrast material (iopamidol [Isovue 370; Bracco Diagnostics, Milan, Italy]) and methylcellulose (Methocel; Dow Chemical, Midland, Mich) was used. All data sets were acquired in the sequential acquisition mode with collimation of 64 × 0.625 mm, rotation time of 0.35 second, tube voltage of 120 kV, and tube current–time product of 500 mAs. The images were reconstructed with a section thickness of 0.6 mm and an increment of 0.4 mm by using an adaptive iterative reconstruction technique (ASIR, GE Healthcare). Images from coronary CT angiography were analyzed with an offline workstation (Leonardo; Siemens Healthcare, Erlangen, Germany). After CT imaging, the coronary arteries were excised with surrounding tissue and the side branches were ligated. Specimen preparation and coronary CT angiography were performed within 4 hours after receiving the heart to avoid potential postmortem tissue changes.
Ct750hd
Manufactured by GE Healthcare
Sourced in United States
The CT750HD is a computed tomography (CT) imaging system manufactured by GE Healthcare. It is designed to capture high-quality, detailed images of the body's internal structures. The core function of the CT750HD is to provide healthcare professionals with the necessary imaging data to support medical diagnoses and treatment planning.
Automatically generated - may contain errors
Lab products found in correlation
Aquilion one, by Toshiba (2 mentions)
Iopamidol, by Bracco (1 mentions)
Methocel, by Dow (1 mentions)
Isovue 370, by Bracco (1 mentions)
Somatom definition flash, by Siemens (1 mentions)
Brilliance ict, by Philips (1 mentions)
Aquilion one, by Canon (1 mentions)
Lightspeed vct 64, by GE Healthcare (1 mentions)
Lightspeed 16, by GE Healthcare (1 mentions)
Advantage workstation, by GE Healthcare (1 mentions)
Lightspeed vct, by GE Healthcare (1 mentions)
Mimics 15, by Materialise (1 mentions)
10 protocols using ct750hd
1
Coronary CT Angiography of Fresh Hearts
2
Thoracic CT Imaging with Dose Reduction
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Thoracic CT examinations were performed using four CT systems (CT 750 HD, GE Healthcare; Brilliance iCT, Philips Healthcare; Somatom Definition Flash, Siemens Healthineers and Aquilion One, Canon Medical Systems). In the remainder of this paper, the four CT systems are denoted as CT-A to CT-D, respectively (Additional file 1 : Table S2). All images were reconstructed using filtered back projection (FBP) and three levels of iterative reconstruction (IR). Each examination was performed at a clinical radiation dose. Subsequently, the radiation dose was reduced by 40% and 80% [19 (link)]. Each combination of acquisition settings was repeated five times on every CT scan. In between each scan, the phantom was randomly translated by 2 mm.
3
Liver Attenuation Index Determination
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The CT scanning in the first institute was performed on a 64-slice dual-energy GE scanner (CT750HD) and in the second institute on a 128-slice GE scanner (Revolution).
CT-LAI calculation was done as described in the literature [13 (link)]. Twenty-five ROIs each measuring 1 cm2 were placed over the liver parenchyma (non-enhanced phase) in both lobes, avoiding the inclusion of any large vessels or biliary structures. The average of the values was taken as the mean liver parenchymal attenuation. Similarly, 5 ROIs were placed in the splenic parenchyma, avoiding large vessels, and the averages of the values were calculated as the splenic parenchymal attenuation index. The liver attenuation index was calculated as the difference of the hepatic and splenic attenuation index.
CT-LAI calculation was done as described in the literature [13 (link)]. Twenty-five ROIs each measuring 1 cm2 were placed over the liver parenchyma (non-enhanced phase) in both lobes, avoiding the inclusion of any large vessels or biliary structures. The average of the values was taken as the mean liver parenchymal attenuation. Similarly, 5 ROIs were placed in the splenic parenchyma, avoiding large vessels, and the averages of the values were calculated as the splenic parenchymal attenuation index. The liver attenuation index was calculated as the difference of the hepatic and splenic attenuation index.
4
Standardized MDCT Imaging Protocol
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CT examinations were performed with 640-slice MDCT (Aquilion ONE, Toshiba, Japan) or 64-slice MDCT (CT750 HD, GE Healthcare, Wisconsin, USA) systems. Patients were required to fast for more than 4 h before examination. The tube voltage was 120 kV, the tube current was automatic milliamps, the layer thickness was 5 mm, and the reconstruction layer interval was 5 mm. After plain scanning, arterial phase (25–30 s), portal venous phase (60–70 s), and delayed phase (3 min) scans were performed. With a power injector, contrast agent (Iohexol, 300 mg iodine/ml, Beijing Beilu Pharmaceutical Co., Ltd.) was administered intravenously at a rate of 3 ml/s for a total dose of 80–85 ml, followed by a 20-ml saline flush. Furthermore, patients took 500–1,000 ml of pure water orally as a negative contrast agent before image acquisition.
5
Contrast-Enhanced CT Pulmonary Angiography
6
Upper Abdominal CT Contrast Imaging
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GE CT750HD CT machine was used for upper abdominal CT plain scan and multi-phase dynamic enhanced scan; 0.5 mL/kg contrast agent (60% meglumine diatrizoate) was injected through lower extremity vein at a flow rate of 0.5 mL/s, and then enhanced scan was performed. Arterial phase and venous phase scanning were started at 18 s and 48 s after injection of contrast agent. Parameters: tube voltage 120 kV, tube current 150 MV, slice spacing 1.25 mm, slice thickness 1.25 mm.
7
Cardiac CT Angiography with Optimized Contrast Protocol
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Scanning was performed on a 64-section cardiac CT scanner (CT750 HD, GE, America) with a standardized optimized contrast-enhanced protocol (120 kV [peak]; 180 mAs; collimation, 64 × 0.625 mm; rotation time, 0.5 s; pitch, 1.375). The head CT scanning range was from the carotid bifurcation to the parietal. All subjects were injected with 60 mL contrast agent (iopromide 370 mg/mL, Bayer) followed by a 40 mL saline bolus chaser both at an injection rate of 4 mL/s. Image reconstructions were made with a field of vision of 250 mm, matrix size of 512 × 512, and section thickness of 0.625 mm. The scan delay time was determined by a bolus-tracking technique with a region of interest at one internal carotid artery. When a threshold of 50 HU was exceeded, the spiral scan was automatically started; then, coronal and sagittal multiplanar reformats as well as maximum intensity projections (MIP) and 3D volume-rendered (VR) images were created at a GE Advantage Workstation.
8
Contrast-Enhanced Head CTA Protocol
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This part of the method has been described in detail in previous studies (14 (link)). Briefly, participants underwent head CTA. All participants were injected with 60 mL of contrast agent (iodide 370 mg/mL, Bayer, Germany), followed by 40 mL of normal saline collection agent at an injection rate of 4 mL/s. The scan was performed with a 64-section cardiac CT scanner (CT750 HD, GE, USA) using a standardized optimized contrast-enhanced protocol (120 kV [peak]; 180 mAs; collimation, 64 × 0.625 mm; rotation time, 0.5 s; pitch, 1.375). The head CT scan range was from the carotid bifurcation to the parietal region. An aneurysm was defined as an abnormal swelling or bulge of an intracranial artery (16 (link)). Aneurysms were jointly diagnosed by a senior radiologist and senior neurosurgeon. None of the patients included in this study had a high suspicion intracranial aneurysm.
9
Chest CT Imaging Protocol for Research
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CT of the chest was acquired using 64-detector row CT scanners: CT750HD (General Electric Medical Systems, Milwaukee, WI, USA), n=50, LightSpeed VCT (General Electric Medical Systems), n=8, and Aquilion ONE (Toshiba Medical Systems, Otawara, Japan), n=3. The following parameters were used: collimation, 0.5 or 0.625 mm; pitch, 0.828–1.375; rotation time, 0.4–0.5 s per rotation; field of view, 345 mm; tube voltage, 120 kVp with automatic tube current control. All CT images of 0.5–0.625 mm section thickness were reconstructed with a standard kernel using 30% adaptive statistical iterative reconstruction. All images were obtained 60 s after injection of 2 mL/kg bodyweight of contrast material (IOHEXOL, 300 mg I/cc; Daiichi Sankyo Company, Limited, Tokyo, Japan).
10
Computed Tomography and MRI-Based Fracture Modeling
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Computed tomography (CT) imaging of the left lower limb were taken using a GE CT750 HD (750 High Definition), with 1-mm slice interval, and a pixel size of 0.5 mm. Meanwhile, sagittal MRI images were also obtained using a Siemens magnetic resonance imaging (MRI) Skyra 3.0 at a layer thickness of 1.25 mm and a pixel size of 0.68mm. The CT and MRI images were processed by medical image processing software (MIMICS 15.0, Materialise Leuven, Belgium) to reconstruct the geometry of the lower limb musculoskeletal model which comprised of 32 foot bones (tibia, fibula, talus, calcaneus with 5 fracture fragments, navicular, cuboid, 3 cuneiforms, 5 metatarsals, 12 phalanges), muscles (gastrocnemius and soleus), 46 ligament bundles with 127 truss units, 5 plantar fascia bundles, and encapsulated soft tissues, as shown in Fig. 1a.
Fracture (Sanders III ab) was made on the model geometry by osteotomizing a 0.1 mm fracture gap (Fig. 1b). The fracture model then underwent a simulated MIF procedure using five crossing screws. As shown in Fig. 1c, two short cannulated screws (diameter: 3.5 mm) were inserted to the sustentaculum tali in transverse direction. Two longitudinal screws (diameter: 6.5 mm) were placed obliquely from the calcaneal tuberosity to the calcaneocuboid joint, and another screw was fixed to the fragment of the posterior joint facet.
Fracture (Sanders III ab) was made on the model geometry by osteotomizing a 0.1 mm fracture gap (Fig. 1b). The fracture model then underwent a simulated MIF procedure using five crossing screws. As shown in Fig. 1c, two short cannulated screws (diameter: 3.5 mm) were inserted to the sustentaculum tali in transverse direction. Two longitudinal screws (diameter: 6.5 mm) were placed obliquely from the calcaneal tuberosity to the calcaneocuboid joint, and another screw was fixed to the fragment of the posterior joint facet.
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