Cirrus hd oct

Manufactured by Zeiss

Sourced in United States, Germany, Ireland, Japan

The Cirrus HD-OCT is a diagnostic imaging device developed by Zeiss. It utilizes optical coherence tomography (OCT) technology to capture high-resolution, cross-sectional images of the eye's internal structures, including the retina, optic nerve, and anterior segment. The device provides detailed visualization of these structures, enabling healthcare professionals to assess and monitor various ocular conditions.

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Lab products found in correlation

Spectralis hra oct, by Heidelberg Engineering (8 mentions) Iol master, by Zeiss (7 mentions) Spectralis oct, by Heidelberg Engineering (6 mentions) Oct hs100, by Canon (4 mentions) Heidelberg retina angiograph, by Heidelberg Engineering (4 mentions) Bx 900 slit lamp, by Haag-Streit (4 mentions) Spectralis hra, by Heidelberg Engineering (4 mentions) Humphrey field analyzer hfa 2, by Zeiss (3 mentions) Spectralis hra oct, by Zeiss (3 mentions) Pentacam hr, by Oculus (3 mentions) Pentacam hr version 70700, by Oculus (3 mentions) Sd oct, by Bioptigen (3 mentions) Heidelberg spectralis hra oct, by Heidelberg Engineering (3 mentions) Dri oct triton, by Topcon (2 mentions) Macular cube, by Zeiss (2 mentions) Optic disc cube, by Zeiss (2 mentions) Heidelberg spectralis hra oct, by Zeiss (2 mentions) Iolmaster 700, by Zeiss (2 mentions) Pentacam, by Oculus (2 mentions) Kr 8900, by Topcon (2 mentions)

210 protocols using cirrus hd oct

AMD Structural Markers and Diagnostics

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Available patient characteristics including date of birth, sex, ethnicity, systemic disease status, visual acuity, refractive error, date of consultation, study and fellow eye diagnosis, and self-reported ethnicity were extracted from clinical records and patient reports using practice management software, Bp VIP.net (Version 2.1.530.017; Best Practice Software, Hamilton, New Zealand) and recorded in Microsoft Excel.
Eyes were also classified for the presence of key AMD structural markers: pigmentary abnormalities, reticular pseudodrusen and drusen volume. Color fundus and the highest quality en face macular OCT scan available (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA) were graded manually for the presence of pigmentary abnormalities. Macular OCT B-scans were graded for presence of reticular pseudodrusen using previously established definitions for OCT grading, that is, reticular lesions defined as five or more hyper-reflective mounds or triangular lesions above the RPE on one or more B-scans (Spectralis OCT).²⁶ (link) Drusen volume within the central 5mm was recorded using advanced RPE analysis software (Cirrus HD-OCT, Carl Zeiss Meditec).

Cheung R., Trinh M., Tee Y.G, & Nivison-Smith L. (2024). RPE Curvature Can Screen for Early and Intermediate AMD. Investigative Ophthalmology & Visual Science, 65(2), 2.

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Ganglion Cell-Inner Plexiform Layer Thickness Measurement

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The OCT measurements were performed by a skilled examiner with a 512 × 128 macular cube and 200 × 200 optic cube scanning protocol using a Cirrus HD OCT (Carl Zeiss Meditec, Dublin, CA, USA).
The thickness of the GC-IPL was measured using a ganglion cell analysis (GCA) algorithm from the Cirrus HD OCT. The ganglion cell analysis algorithm automatically measured GC-IPL thickness by identifying the outer boundaries of the RNFL and inner plexiform layer of the macula using three-dimensional information from the macular cube. Mean, minimal, and six-sector (i.e., superior, superotemporal, superonasal, inferior, inferotemporal, and inferonasal) GC-IPL thicknesses were measured by the algorithm (Fig. 3), and the central macular thickness (CMT) was measured using a retinal map analysis system. Cases that showed a signal strength <5 after examination were excluded.

Lee M.W., Park K.S., Lim H.B., Jo Y.J, & Kim J.Y. (2018). Long-term reproducibility of GC-IPL thickness measurements using spectral domain optical coherence tomography in eyes with high myopia. Scientific Reports, 8, 11037.

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Ophthalmic Examination and Cataract Surgery

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Visual acuity assessment, refraction, slit-lamp examination, intraocular pressure measurement by Goldmann Applanation Tonometer, and optic disc assessment were performed (Table 1). Axial lengths were determined with IOL Master V.5 (Carl Zeiss Meditec, Dublin, CA, USA). Corneal topography, pachymetry, anterior chamber depth, and anterior chamber angle were assessed using a swept-source OCT (CASIA SS-1000, Tomey, Japan). Retinal nerve fiber layer was evaluated with a spectral domain OCT (Cirrus HD-OCT, Carl Zeiss Meditec). Fasting-serum lipid profile was performed for all 14 members who attended the clinic. Patient I-1 underwent bilateral extracapsular cataract extraction for senile cataract treatment. Preoperative keratometry and refraction of patient I-1 were traced from patient records for analysis. Anterior chamber depth measurements of patient I-1 were excluded because of the pseudophakic status. In addition, one unaffected case (III-9) had received bilateral laser-assisted in situ keratomileusis (LASIK) refractive surgery. The keratometry, refraction, pachymetry, and intraocular pressure data of this case were excluded from statistical analysis.

Zhang B.N., Chan T.C., Tam P.O., Liu Y., Pang C.P., Jhanji V., Chen L.J, & Chu W.K. (2019). A Cohesin Subunit Variant Identified from a Peripheral Sclerocornea Pedigree. Disease Markers, 2019, 8781524.

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Comprehensive Retinal Imaging Protocol

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The OCT parameters were measured by an experienced examiner with a 512 × 128 macular cube and a 200 × 200 optic cube scanning protocol using a Cirrus HD-OCT instrument (Carl Zeiss Meditec, Dublin, CA, USA). The macular cube scan was assessed using ganglion cell analysis, which automatically measured the GC-IPL thickness by identifying the layer between the outer boundaries of the RNFL and the inner plexiform layer in three dimensions. The elliptical annulus was defined by the vertical radii (outer radius and inner radius of 2.0 and 0.5 mm, respectively) and horizontal radii (outer radius and inner radius of 2.4 and 0.6 mm, respectively) The average, minimum, and six sectoral (superior, superotemporal, superonasal, inferior, inferonasal, and inferotemporal) GC-IPL thicknesses were measured. The CMT was measured using retinal map analysis. The average and four sectoral (superior, temporal, inferior, and nasal) RNFL thicknesses were also evaluated. Optic nerve head parameters, such as the rim area, disc area, average cup/disc ratio, and cup volume were measured as well. The CMT and GC-IPL thicknesses were measured with the image centered on the fovea. Two researchers (H.B.L. and S.E.L.) reviewed the image, and if there were problems such as signal strength < 7, segmentation error, motion artifact or misalignment, they were excluded from the study.

Lee S.E., Lim H.B., Shin Y.I., Ryu C.K., Lee W.H, & Kim J.Y. (2020). Characteristics of the inner retinal layer in the fellow eyes of patients with unilateral exudative age-related macular degeneration. PLoS ONE, 15(9), e0239555.

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Circumpapillary ONH OCT and Visual Fields in Glaucoma

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Circumpapillary ONH optical coherence tomography (OCT) scans and accompanying VFs (SITA Standard 24-2 protocol) of all patients who presented at MEE glaucoma service between January 2011 and 2014 were initially selected and electronically transferred from the machines (Humphrey Field Analyzer HFA-II and Cirrus HD-OCT, Software version 6.5; Carl Zeiss Meditec AG, Jena, Germany). The initial data selection criteria for VF were fixation loss ≤33%, false-negative rates ≤20%, and false-positive rates ≤20%. The data selection criteria for Cirrus OCT scan (Optic Disc Cube protocol with pixel resolution 200 × 200 within an area of 6 mm × 6 mm) were signal strength ≥6 and within 1 year from the VF measurement. If more than 1 measurement per eye met the criteria, the most recent measurement was selected. If both eyes of a patient met the selection criteria, only 1 eye was included randomly to avoid potential bias of data samples. As such, we had 2161 pairs of OCT and VF measurement of 2161 eyes from 2161 patients, which satisfied the criteria of the initial data reliability check.

WANG M., WANG H., PASQUALE L.R., BANIASADI N., SHEN L.Q., BEX P.J, & ELZE T. (2017). Relationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma. American journal of ophthalmology, 176, 53-60.

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Analyzing Glaucoma Progression from OCT and VF

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The OCT ONH scans and the accompanying visual fields (SITA Standard 24-2 protocol) of all patients who presented at MEE glaucoma service between 2011 and 2014 were initially selected and transferred from the machines (Humphrey Field Analyzer HFA-II and Cirrus HD-OCT, Software version 6.5, Carl Zeiss Meditec AG, JENA, Germany). The data selection criteria for visual fields were fixation loss ≤ 33%, false negative rates ≤ 20% and false positive rates ≤ 20%. The data selection criteria for Cirrus OCT scan (Optic Disc Cube protocol with A-scan resolution 200×200 within an area of 6 mm×6 mm) were signal strength ≥ 6 and within one year from the visual field measurement. If more than one measurement per eye met the criteria, the most recent measurement was selected. If both eyes of a patient met the selection criteria, only one eye was included randomly to avoid potential bias of data samples. As such, we had 2,161 pairs of OCT and visual field measurement of 2,161 eyes from 2,161 patients which passed the initial data reliability check.

Wang M., Jin Q., Wang H., Baniasadi N, & Elze T. (2018). Quantifying positional variation of retinal blood vessels in glaucoma. PLoS ONE, 13(3), e0193555.

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Diagnosis of Neovascular Age-related Macular Degeneration

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Diagnosis of nAMD was based on a full ophthalmological examination including BCVA test using a decimal chart, intraocular pressure measurement, slit-lamp biomicroscopy, dilated fundus examination, color fundus photography, fundus fluorescein and indocyanine green angiographies, and SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA). Neovascular AMD was classified according to the classification and diagnostic criteria of AMD into type 1 nAMD, type 2 nAMD, PCV, and RAP^{2 (link),22 (link)}. BCVA was converted to logMAR units (logMAR VA) for statistical analysis. For measurement of CRT, the ETDRS grid was employed^{23 (link)}. In this study, CRT was defined as the mean retinal thicknesses of a central 1-mm circle on the ETDRS grid in the macula^{65 (link)}.

Sato T., Takeuchi M., Karasawa Y., Takayama K, & Enoki T. (2019). Comprehensive expression patterns of inflammatory cytokines in aqueous humor of patients with neovascular age-related macular degeneration. Scientific Reports, 9, 19447.

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Severe NPDR Retrospective Study

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This retrospective study included patients with severe NPDR who were treated at Qilu Hospital of Shandong University between August 2018 and October 2018. The Ethics Committee of Qilu Hospital of Shandong University approved this study. The requirement for informed patient consent was waived due to the retrospective study design.
The inclusion criteria were: 1) presence of type 2 DM with hemoglobin A1c <10% and blood pressure <160/90 mmHg; 2) diagnosis of severe NPDR (at least 20 bleeding points in a single quadrant of the retina, visible vein beads in at least two quadrants, or retinal capillary non-perfusion area exceeding five disc areas^{8 (link),10 (link)}) on the basis of fundus examination with a VISCAM200 Fundus camera (Carl Zeiss GmbH, Oberkochen, Germany), fundus fluorescein angiography with a Heidelberg SPECTRALIS (INNOVA Medical Ophthalmics, North York, Canada), and optical coherence tomography with a CIRRUS HD-OCT (Carl Zeiss GmbH); and 3) no previous fundus treatment such as retinal photocoagulation or intravitreal injection of anti-VEGF drugs or hormones. The exclusion criteria were poor image quality due to media turbidity and/or concurrent non-diabetic retinal vascular disease.

Tao Y., Jiang P., Liu M., Liu Y., Song L, & Wang H. (2021). Intravitreal aflibercept partially reverses severe non-proliferative diabetic retinopathy in treatment-naïve patients. The Journal of International Medical Research, 49(1), 0300060520985369.

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En-face OCT Analysis of BVMD Lesions

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Spectral domain optical coherence tomography line and volumetric scans were
performed using the Cirrus HD-OCT (Carl Zeiss Meditec). The location of the
fovea was determined using the fovea-finder function of the Cirrus HD-OCT, and
marked on the line scan ophthalmoscope image. Additional high-density volumetric
scans acquired using the Bioptigen spectral domain optical coherence tomography
(Bioptigen Inc, Morrisville, NC) nominally covering 7 × 7 mm (1000
A-scans/B-scan, 250 B-scans) were used to create en-face OCT
sections with custom software (Java, Oracle; Redwood City, CA).^{26 (link)}En-face projections of the ellipsoid zone were generated to
display the extent of BVMD lesions (Figures 1 and 2). Multiple horizontal
and vertical macular B-scans nominally covering 7 mm (1000 A-scans/B-scan;
Bioptigen) were registered and averaged to increase the signal-to-noise ratio.
All OCT images are displayed on logarithmic intensity scale.

Scoles D., Sulai Y.N., Cooper R.F., Higgins B.P., Johnson R.D., Carroll J., Dubra A, & Stepien K.E. (2017). PHOTORECEPTOR INNER SEGMENT MORPHOLOGY IN BEST VITELLIFORM MACULAR DYSTROPHY. Retina (Philadelphia, Pa.), 37(4), 741-748.

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Multimodal Imaging for Comprehensive Ophthalmological Evaluation

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All patients underwent an extensive ophthalmological evaluation and multimodal imaging at diagnosis and during follow-up: Early Treatment of Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) measurement (a previously published method was used to convert Snellen BCVA to ETDRS BCVA, when this was not available),24 (link) slit-lamp examination, and/or color fundus photography (Topcon Corp; Tokyo, Japan, or Carl Zeiss Meditec; Dublin, CA, USA), either time-domain OCT (Cirrus HD-OCT; Carl Zeiss Meditec, or OCT-HS100; Canon Inc, Tokyo, Japan) or spectral-domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany), FA (Topcon Corp or Spectralis HRA+OCT, or Carl Zeiss Meditec), and ICGA (Topcon Corp or Spectralis HRA+OCT, or Carl Zeiss Meditec).

Mohabati D., van Dijk E.H., van Rijssen T.J., de Jong E.K., Breukink M.B., Martinez-Ciriano J.P., Dijkman G., Hoyng C.B., Fauser S., Yzer S, & Boon C.J. (2018). Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clinical Ophthalmology (Auckland, N.Z.), 12, 2167-2176.

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