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C57bl 6j rosa26 creert2

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The C57BL/6J Rosa26-CreERT2 is a transgenic mouse line that expresses a tamoxifen-inducible Cre recombinase under the control of the Rosa26 locus. This genetic tool allows for conditional gene manipulation in a spatio-temporal manner.

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Lab products found in correlation

C57bl 6j strain mice, by Jackson ImmunoResearch (2 mentions) 129s4 svjae ptenfl fl, by Jackson ImmunoResearch (2 mentions)

Spelling variants of this product

C57BL/6J (4187 citations) Rosa26-CreERT2 (21 citations) C57BL/6J Rosa26-CreERT2 mice (2 citations)

3 protocols using c57bl 6j rosa26 creert2

1

Genetically Engineered Mouse Models

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This study utilized commercially available C57BL/6J Rosa26-CreERT2 (catalog 008463, RRID:IMSR_JAX:008463) and 129S4/SvJae PTENfl/fl(catalog 004597, RRID:IMSR_JAX:004597) mice from The Jackson Laboratory. A Prl2fl/fl mouse was generated within WT C57BL/6J strain mice from The Jackson Laboratory in house using CRISPR/Cas9 recombination as described. Animals were backcrossed for 3 generations onto a C57BL/6J background prior to inclusion in study. Equal numbers of male and female mice were enrolled in each study; unless otherwise noted, no statistical difference between sexes was observed.
Carlock C., Bai Y., Paige-Hood A., Li Q., Nguele Meke F, & Zhang Z.Y. (2023). PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia. JCI Insight, 8(19), e170065.
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2

Genetic Engineering of Mouse Models

Cited 1 time
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This study utilizes commercially available C57BL/6J Rosa26-CreERT2 (Strain# 008463, RRID: IMSR_JAX:008463) and C57BL/6J Tp53flox (Strain# 008462, RRID: IMSR_JAX:008462) mice from Jackson Labs. A Prl2flox mouse was generated within C57BL/6J strain mice in-house using CRISPR/Cas9 recombination as recently described by Carlock and colleagues (25 (link)). Comparable numbers of male and female mice were enrolled in each study. Animals were housed and cared for in accordance with Purdue University Institutional Animal Care and Use Committee guidelines and all experiments conducted followed our approved protocol (protocol number 1511001324).
Nguele Meke F., Bai Y., Ruiz-Avila D., Carlock C., Ayub J., Miao J., Hu Y., Li Q, & Zhang Z.Y. (2024). Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models. Cancer Research Communications, 4(1), 5-17.
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3

Genetically Engineered Mouse Models

Check if the same lab product or an alternative is used in the 5 most similar protocols
This study utilized commercially available C57BL/6J Rosa26-CreERT2 (catalog 008463, RRID:IMSR_JAX:008463) and 129S4/SvJae PTENfl/fl(catalog 004597, RRID:IMSR_JAX:004597) mice from The Jackson Laboratory. A Prl2fl/fl mouse was generated within WT C57BL/6J strain mice from The Jackson Laboratory in house using CRISPR/Cas9 recombination as described. Animals were backcrossed for 3 generations onto a C57BL/6J background prior to inclusion in study. Equal numbers of male and female mice were enrolled in each study; unless otherwise noted, no statistical difference between sexes was observed.
Carlock C., Bai Y., Paige-Hood A., Li Q., Nguele Meke F, & Zhang Z.Y. (2023). PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia. JCI Insight, 8(19), e170065.
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