PET/CT imaging was performed 67.0±33.1 min after intravenous injection of 125.9±26.9 MBq of 68Ga-PSMA-HBED-CC. PET scans were acquired using a Gemini Astonish TF 16 PET/CT scanner (Phillips Medical Systems) in 3D acquisition mode [25 (link)]. Axial, sagittal and coronal slices were reconstructed (144 voxels with 4mm3, isotropic). Prior to each PET scan, a CT was performed for anatomical mapping and attenuation correction (30 mAs, 120 kVp). Each bed position was acquired for 1.5 min with a 50% overlap. In nineteen patients, contrast-enhanced CT (CE-CT, 162 - 215 mAs, 120 kVp, slide thickness 3.0 mm) was performed using 70-120 ml of contrast agent (Ultravist® 370, Bayer Schering Pharma, Berlin, Germany), which was injected intravenously with a delay of 70 seconds for the venous phase. In fifteen patients, only unenhanced CT was available.
Gemini astonish tf 16 pet ct scanner
Manufactured by Philips
The Gemini Astonish TF 16 PET/CT scanner is a medical imaging device that combines positron emission tomography (PET) and computed tomography (CT) technologies. The core function of this equipment is to acquire and integrate PET and CT images for diagnostic purposes.
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4 protocols using gemini astonish tf 16 pet ct scanner
1
Ga-PSMA-HBED-CC PET/CT Imaging Protocol
2
PET/CT Imaging Protocol for 68Ga-PSMA Evaluation
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PET/CT imaging was performed 75.8 ± 18.2 min after intravenous injection of 120.5 ± 25.7 MBq of 68Ga-PSMA. PET scans were acquired using a Gemini Astonish TF 16 PET/CT scanner (Phillips Medical Systems) in 3D acquisition mode [21 (link)]. Axial, sagittal and coronal slices were reconstructed (144 voxels with 4mm3, isotropic). Before PET scan, a low-dose CT was performed for anatomical mapping and attenuation correction (30 mAs, 120 kVp). Each bed position was acquired for 1.5 min with a 50% overlap. In case contrast-enhanced CT (CE-CT) was performed, 80–120 ml of contrast agent (Ultravist® 370, Bayer Schering Pharma, Berlin, Germany) was injected intravenously with a delay of 70 s for the venous phase.
3
PET/CT Imaging of PSMA-HBED-CC Tracer
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PET/CT imaging was performed 75.4 ± 27.5 min after intravenous injection of 122.4 ± 19.7 MBq of [68Ga]-PSMA-HBED-CC. A 3D acquisition mode was used on a Gemini TF 16 Astonish PET/CT scanner (Philips Medical Systems) [25 (link)]. Default parameter settings were used in the system software to reconstruct the transaxial slices (144 × 144 voxels, 4 mm3). Immediately before the PET scan, a low-dose CT was acquired for attenuation correction (120 kVp, 30 mAs) and anatomical mapping.
4
Standardized Radiolabeling and PET/MRI Imaging Protocol
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A standard 68Ge/68Ga generator (Eckert and Ziegler) was used for elution of 68Ga prior to labelling with PSMA-HBED-CC (ABX GmbH, Radeberg, Germany)22 (link),23 (link),34 (link). After injection of 129.0 ± 26.2MBq of 68Ga-PSMA-HBED-CC, a low dose CT for attenuation correction (120 kVp, 30 mAs) and anatomical mapping was acquired within 89.0 ± 42.5 min immediately before the PET scan, using a Gemini TF 16 Astonish PET-CT scanner (Philips medical systems)35 (link). All 130 patients underwent a non-contrast-enhanced prostate multiparametric MRI at our institution at 3T (Magentom Skyra, Siemens Healthcare, Erlangen, Germany). Standard prostate MRI acquisition protocol included high resolution T2 weighted high resolution turbo spin echo sequences (T2 HR TSE, 25 slices, thickness 3 mm, gap 3 mm, TR 4040 ms, TE 116 ms, resolution: 0.47 × 0.47 mm), including DWI sequences (DWI, 25 slices, thickness 3 mm, gap 3 mm, TR 4800 ms, TE 58 ms, resolution 1.4 × 1.4 mm and b-factors 0/160/1200 s/mm2) with generation of an ADC map from b 0, b 160 and b 1200 images of the DWI. Native T1 high resolution isotropic volume sequences (T1 TSC, 49 slices thickness 5 mm, gap 6 mm, TE 11 ms, TR 800 ms, resolution 0.63 × 0.63 mm). No endorectal coils were used throughout all exams.
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