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6 n n diethyl d β γ dibromomethylene atp trisodium salt arl 67156 trisodium salt

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6-N,N-Diethyl-D-β,γ-dibromomethylene ATP trisodium salt is a chemical compound used in research settings. It inhibits the enzyme ectonucleoside triphosphate diphosphohydrolase (E-NTPDase), which is involved in the hydrolysis of extracellular nucleotides. This compound is commonly used as a research tool to study the role of purinergic signaling and nucleotide metabolism in biological systems.

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Lab products found in correlation

8 cyclopentyl 1 3 dipropylxanthine dpcpx, by Bio-Techne (3 mentions) Cdcl2, by Merck Group (2 mentions) 2 arachidonylglycerol, by Bio-Techne (2 mentions) 1 2 4 dichlorophenyl 5 4 iodophenyl 4 methyl n 4 morpholinyl 1h pyrazole 3 carboxamide am281, by Merck Group (2 mentions) Bf150 86 7, by Sutter Instruments (2 mentions) Tetrodotoxin, by Alomone (2 mentions) Bapta, by Thermo Fisher Scientific (1 mentions)

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ARL 67156 trisodium salt (5 citations)

3 protocols using 6 n n diethyl d β γ dibromomethylene atp trisodium salt arl 67156 trisodium salt

1

Purinergic Receptor Inhibition Assay

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The following drugs were used: BAPTA (30 mM; Invitrogen, Carlsbad, CA, USA), 6-N, N-Diethyl-D-β,γ-dibromomethylene ATP trisodium salt (ARL 67156 trisodium salt, 50 μM; Tocris Bioscience, UK), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, 5 μM; Tocris Bioscience, UK).
Carlsen E.M, & Perrier J.F. (2014). Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Frontiers in Neural Circuits, 8, 60.
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2

Cannabinoid-Mediated Signaling Modulation

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2-Arachidonylglycerol (10 µM in 0.01% DMSO, Tocris Bioscience, UK) was puff applied for 1s (14–35 Pa) by a homemade time-controlled pressure device. Puff pipettes were made from borosilicate capillaries (tip diameter ranging from 1.5–2 μm; BF150-86-7.5, Sutter Instrument, USA). The following compounds were applied to the bath: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide (AM281; 1µM for in vitro experiments and 0.5mg/kg for in vivo experiments; Sigma–Aldrich, USA), CdCl2, (100µM, Sigma–Aldrich, St. Louis, MO, USA), Tetrodotoxin (1 µM; Alomone Labs, Israel), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, 5 μM in 0.1% DMSO; Tocris Bioscience, UK), 6-N,N-Diethyl-D-β,γ-dibromomethylene ATP trisodium salt (ARL 67156 trisodium salt, 50 μM; Tocris Bioscience, UK).
Carlsen E.M., Falk S., Skupio U., Robin L., Zottola A.C., Marsicano G, & Perrier J.F. (2021). Spinal astroglial cannabinoid receptors control pathological tremor. Nature neuroscience, 24(5), 658-666.
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3

Cannabinoid-Mediated Signaling Modulation

Check if the same lab product or an alternative is used in the 5 most similar protocols
2-Arachidonylglycerol (10 µM in 0.01% DMSO, Tocris Bioscience, UK) was puff applied for 1s (14–35 Pa) by a homemade time-controlled pressure device. Puff pipettes were made from borosilicate capillaries (tip diameter ranging from 1.5–2 μm; BF150-86-7.5, Sutter Instrument, USA). The following compounds were applied to the bath: 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide (AM281; 1µM for in vitro experiments and 0.5mg/kg for in vivo experiments; Sigma–Aldrich, USA), CdCl2, (100µM, Sigma–Aldrich, St. Louis, MO, USA), Tetrodotoxin (1 µM; Alomone Labs, Israel), 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, 5 μM in 0.1% DMSO; Tocris Bioscience, UK), 6-N,N-Diethyl-D-β,γ-dibromomethylene ATP trisodium salt (ARL 67156 trisodium salt, 50 μM; Tocris Bioscience, UK).
Carlsen E.M., Falk S., Skupio U., Robin L., Zottola A.C., Marsicano G, & Perrier J.F. (2021). Spinal astroglial cannabinoid receptors control pathological tremor. Nature neuroscience, 24(5), 658-666.
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