Avizo lite 9

This study was approved by the Duke University Health System Institutional Review Board for Clinical Investigations. Subjects in this study were drawn from the existing database utilized in our previous works.^{47 , 59 (link)} Chart review of medical records from 2010 to 2017 was performed to categorize these subjects into two groups:
Following the practice adopted by our earlier studies, ^{47 , 60 (link)} CT imaging for each subject was imported into the 3D visualization software Avizo Lite 9.5.0 (Thermo Fisher Scientific, Waltham, Massachusetts, USA), from which subject-specific and anatomically realistic 3D models of the nasal passages were created.

This is a retrospective study approved by the Duke University Health System Institutional Review Board for Clinical Investigations. Eighteen subjects with high resolution computed tomography (CT) scans were selected based on a chart review of medical records from 2010 to 2017. Eleven of these subjects (15–35 years, 4 males, and 7 females; Table 1) had a clinical diagnosis of uCLND with cleft type as unilateral complete cleft lip, alveolus, and palate (Veau 3) or unilateral complete cleft lip alveolus or unilateral incomplete cleft lip. These subjects had not had definitive cleft rhinoplasty or septoplasty for correction of nasal airway obstruction. The other seven subjects (25–70 years, 3 males, and 4 females) have radiographically healthy normal nasal cavity and sinus anatomy, which will serve as the control group. DICOM images from head computed tomographic (CT) scans in all subjects were imported into image analysis software, Avizo Lite 9.5.0 (Thermo Fisher Scientific, Waltham, Massachusetts, USA) for creation of anatomically accurate three-dimensional (3D) reconstructions of the nasal airways and olfactory region.