Female fvbn mice

Manufactured by Charles River Laboratories

Sourced in United States, Montenegro

Female FVBn mice are a widely used mouse strain in biomedical research. They are an inbred strain that is known for its high fertility and large litter sizes. These mice can be used for a variety of studies, including genetic, immunological, and cancer research.

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Lab products found in correlation

Anti nkg2d clone hmg2d, by BioXCell (1 mentions) Wild type balb c mice, by Charles River Laboratories (1 mentions) Female scid mice, by Jackson ImmunoResearch (1 mentions)

4 protocols using female fvbn mice

FVBn and C57BL/6J Mice Maintenance

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Female FVBn mice (8 weeks old) were obtained from a breeding colony that was generated using mice purchased from Charles River. C57BL/6J wild-type (WT) C57BL/6-Trim21^tm1Hm/J (T21^−/−) mice were obtained from The Jackson Laboratories. All mice were maintained in a specific pathogen-free environment according to UK Home Office regulations. The experiments involving mice have been approved by the MRC Cambridge Ethical Review Committee and the UK Home Office under project license numbers PPL 70/8087 and PPL PCF3F9520.

Clift D., McEwan W.A., Labzin L.I., Konieczny V., Mogessie B., James L.C, & Schuh M. (2017). A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell, 171(7), 1692-1706.e18.

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Anti-NKG2D Immunotherapy in KB1P Mice

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Female FVB/n mice at 8–10 weeks old (purchased from Charles River) were orthotopically transplanted in their mammary fat pat with 1 × 1 mm tumor pieces from syngeneic K14-Cre;Brca1^F/F;Trp53^F/F (KB1P) mice. Once tumors reached 1 cm, animals were injected intraperitoneally with a single dose of 200 μg anti-NKG2D (Clone HMG2D, BioXCell) on day 1 followed by individual injections of 100 μg on two consecutive days. Control mice followed the same dosage regime with Armenian hamster IgG isotype control (Clone Polyclonal, Bio X Cell). Tumor growth was measured by calipers and mice were euthanized 1 day after final antibody injection.

Curio S., Edwards S.C., Suzuki T., McGovern J., Triulzi C., Yoshida N., Jonsson G., Glauner T., Rami D., Wiesheu R., Kilbey A., Violet Purcell R., Coffelt S.B, & Guerra N. (2022). NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology, 1(1), kyac002.

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Topical Vemurafenib for Cutaneous Carcinogenesis

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Female FVB/N mice were purchased from Charles River Laboratory (Wilmington, MA, USA). Tumour induction procedures were carried out in accordance with ARC protocol #2013-066. The two-stage carcinogenesis procedures were performed as described previously24 (link)25 (link) with 8 mice per group. DMBA and TPA were purchased from Sigma. Clinical grade vemurafenib pills were grinded and dissolved in DMSO; to a concentration of 0.02 and 0.04 mg μl⁻¹ and 100 μl of the mixtures (or DMSO as vehicle control) was added topically on the back of the mice. Vemurafenib suspension (2 or 4 mg) or vehicle control was re-applied topically to the back of the mice twice a week for 15 weeks.

Escuin-Ordinas H., Li S., Xie M.W., Sun L., Hugo W., Huang R.R., Jiao J., de-Faria F.M., Realegeno S., Krystofinski P., Azhdam A., Komenan S.M., Atefi M., Comin-Anduix B., Pellegrini M., Cochran A.J., Modlin R.L., Herschman H.R., Lo R.S., McBride W.H., Segura T, & Ribas A. (2016). Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. Nature Communications, 7, 12348.

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SCID Mice Experiment Protocol

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Female SCID mice were purchased from the Jackson Laboratory (Bar harbor, ME), female FVB/N mice and BALB/c wild-type mice were purchased from Charles River Laboratories (Wilmington, MA). All the animals used in this study were 8–12 weeks old. At least five mice per experiment were used for this study. Mice were housed in the Kansas City Veteran Administration Medical Center (KCVAMC) animal care facility. Mice were fed commercial mouse diet food (Envigo, Indianapolis, IN) with a 12-hour light-dark cycle under pathogen-free conditions. Experimental animals were carefully monitored throughout the course of the experiment and if they showed signs of distress including, but not limited to, reduced food or water intake, reduced activities, hunched posture, weight loss, vocalization, irritability or lack of grooming, they were euthanized. Euthanasia was performed using CO2 inhalation followed by cervical dislocation.

Ghosh A., Sarkar S., Banerjee S., Behbod F., Tawfik O., McGregor D., Graff S, & Banerjee S.K. (2018). MIND model for triple-negative breast cancer in syngeneic mice for quick and sequential progression analysis of lung metastasis. PLoS ONE, 13(5), e0198143.

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