Shr 7700

Manufactured by Hamamatsu Photonics

Sourced in Japan

The SHR-7700 is a high-resolution spectroradiometer designed for accurate measurement of optical radiation. It features a high-sensitivity silicon photodiode detector and a precision monochromator to provide detailed spectral data over the 350 to 1100 nm wavelength range.

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Lab products found in correlation

Signa excite hdxt, by GE Healthcare (1 mentions)

2 protocols using shr 7700

Nasal Delivery of [18F]-PspA Nanoparticles

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Because the half-life of [¹⁸F] is only 110 min, we used the same naive macaque for nasal [¹⁸F]-PspA-nanogel or [¹⁸F]-PspA-PBS administration with a 1-week interval between administrations. After nasal administration of 50 MBq per 700 μl of [¹⁸F]-PspA-nanogel or [¹⁸F]-PspA-PBS (350 μl in each nostril), the macaque's head was tilted back for 10 min and then scanned in an upright position. PET scans were conducted for 345 min with frames of 25 × 3 min, followed by 27 × 10 min, with the use of a high-resolution animal PET scanner (SHR-7700; Hamamatsu Photonics, Shizuoka, Japan). MRI images were recorded with Signa Excite HDxt (3T; GE Healthcare) to identify the cerebrum regions.

Fukuyama Y., Yuki Y., Katakai Y., Harada N., Takahashi H., Takeda S., Mejima M., Joo S., Kurokawa S., Sawada S., Shibata H., Park E.J., Fujihashi K., Briles D.E., Yasutomi Y., Tsukada H., Akiyoshi K, & Kiyono H. (2015). Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunology, 8(5), 1144-1153.

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Primate PET Imaging of Brain Function

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After overnight fasting, monkeys were tracheostomized, immobilized with pancuronium bromide (0.05 mg/kg intramuscularly), and artificially ventilated (Cato; Drager). Anesthesia was continued with 0.4-0.8 vol% isoflurane in a N 2 O/O 2 /N 2 (1:1:1) gas mixture. A venous cannula for PET probe injection and an arterial cannula for blood sampling (only for 18 F-BCPP-EF measurements) were inserted in both inferior limbs. The animal's head was set in a supine position on a bed with stereotactic coordinates aligned parallel to the orbitomeatal line plane. In PET measurements using b-11 C-L-DOPA, 18 F-FDOPA, and 11 C-6MemTyr, carbidopa, an inhibitor of peripheral aromatic L-amino acid decarboxylase, was administered at a dose of 5 mg/kg, by mouth, 1 h before each PET probe injection. After a transmission scan, emission scans were obtained for 91 min after the injection of each PET probe using an animal PET scanner (SHR-7700; Hamamatsu Photonics) (15) . PET data were reconstructed by the filtered backprojection method, and individual PET and MR images were coregistered. Volumes of interest in brain regions were drawn manually on MR images by referring to regional information from BrainMaps.org (16) .

Tsukada H., Kanazawa M., Ohba H., Nishiyama S., Harada N, & Kakiuchi T. (2016). PET Imaging of Mitochondrial Complex I with 18F-BCPP-EF in the Brains of MPTP-Treated Monkeys. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 57(6).

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