C57BL/6 or BALB/c mice at 6~8 weeks old were purchased from Charles River (Wilmington, MA). OT-I/Rag-1 KO and NZB/NZW F1 mice were purchased from Taconic Biosciences (Hudson, NY) and the Jackson Laboratory (Bar Harbor, ME), respectively. The Siglec-15 conditional knockout mouse strain on a C57BL/6 background was obtained from the Mutant Mouse Regional Resource Center (MMRRC, CA) and was bred with CMV-Cre or LysM-Cre mice from the Jackson Laboratory (Bar Harbor, ME) to generate the whole-body knockout (KO) or myeloid lineage specific KO mice (LysM-Cre KO). The littermates generated from Siglec-15 heterozygotes were bred and maintained in conditions identical to those of Siglec-15 KO mice as the controls. All mouse protocols were in accordance with NIH guidelines and were approved by the Institutional Animal Care and Use Committee of Yale University School of Medicine. LOX IMVI and U87 cells were obtained from NCI (Rockville, MD) and ATCC (Manassas, VA), respectively.
Cmv cre or lysm cre mice
Manufactured by Jackson ImmunoResearch
CMV-Cre or LysM-Cre mice are genetically modified mouse models that express the Cre recombinase enzyme under the control of specific promoters. The CMV-Cre mouse expresses Cre recombinase under the control of the cytomegalovirus (CMV) promoter, while the LysM-Cre mouse expresses Cre recombinase under the control of the lysozyme M (LysM) promoter. These mouse models are used for conditional gene knockout or gene modification studies.
Automatically generated - may contain errors
2 protocols using cmv cre or lysm cre mice
1
Siglec-15 Knockout Mouse Model
2
Siglec-15 Knockout Mouse Model
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C57BL/6 or BALB/c mice at 6~8 weeks old were purchased from Charles River (Wilmington, MA). OT-I/Rag-1 KO and NZB/NZW F1 mice were purchased from Taconic Biosciences (Hudson, NY) and the Jackson Laboratory (Bar Harbor, ME), respectively. The Siglec-15 conditional knockout mouse strain on a C57BL/6 background was obtained from the Mutant Mouse Regional Resource Center (MMRRC, CA) and was bred with CMV-Cre or LysM-Cre mice from the Jackson Laboratory (Bar Harbor, ME) to generate the whole-body knockout (KO) or myeloid lineage specific KO mice (LysM-Cre KO). The littermates generated from Siglec-15 heterozygotes were bred and maintained in conditions identical to those of Siglec-15 KO mice as the controls. All mouse protocols were in accordance with NIH guidelines and were approved by the Institutional Animal Care and Use Committee of Yale University School of Medicine. LOX IMVI and U87 cells were obtained from NCI (Rockville, MD) and ATCC (Manassas, VA), respectively.
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