Cobas mira s chemistry analyzer

Manufactured by Roche

Sourced in United Kingdom

The COBAS Mira S is a fully automated chemistry analyzer designed for clinical diagnostic laboratories. It is capable of performing a wide range of photometric and enzymatic clinical chemistry tests on a variety of sample types, including serum, plasma, and urine. The COBAS Mira S is equipped with a high-performance photometric system and can handle multiple sample and reagent volumes to provide accurate and reliable results.

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Lab products found in correlation

K 1000, by Sysmex (1 mentions)

2 protocols using cobas mira s chemistry analyzer

Hematological and Biochemical Analyses in Fasted Rats

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After 45 days, 12 h-fasted animals were anesthetized with ether and the blood collected with and without anticoagulant (ethylene diamine tetra acetate) by retro-orbital puncture, using capillary tubes for hematological and biochemical studies, respectively (10 (link)). The following hematological parameters were determined with the Sysmex K-1000 fully automated hematology analyzer: Erythrocyte (RBC), total and differential leukocyte (WBC), neutrophil, lymphocyte, eosinophil, basophil, hematocrit (Hct), hemoglobin (Hb), platelet count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean platelet volume (MPV), platelet distribution width (PDW), and red distribution width (RDW).
Blood samples for biochemical analyses were centrifuged at 3,000 × g for 5 min and plasma was collected and analyzed for glucose, creatinine, albumin, cholesterol, triglycerides, aspartate amino-transferase (AST), alanine aminotransferase (ALT), phosphorus, potassium, sodium, calcium, urea and total protein using a COBAS Mira S chemistry analyzer (Roche Diagnostic Systems, West Sussex, England).

Modarresi M., Hosseinzadeh L., Nematy N., Siavash-Haghighi Z.M, & Ghanbari K. (2014). Acute and subchronic toxicological evaluation of Stachys lavandulifolia aqueous extract in Wistar rats. Research in Pharmaceutical Sciences, 9(3), 165-172.

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Blood Analysis of Experimental Subjects

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On the final day, whole blood samples were collected through cardiac puncture. Each sample was transferred to a glass tube and mixed well with K3 EDTA and sodium fluoride as an anticoagulant and a glycolytic inhibitor, respectively. Therefore, blood biochemical parameters including non-fasting blood sugar, total cholesterol, triglyceride, uric acid, BUN, creatinine, total protein, albumin, total bilirubin, direct bilirubin, SGOT (serum glutamic oxaloacetic transaminase), SGPT (serum glutamic pyruvic transaminase), alkaline phosphatase, sodium and potassium were analyzed using Roche Cobas Mira S Chemistry Analyzer in the Central Laboratory (Hatyai, Songkhla, Thailand). Hematology was promptly conducted with an automatic analyzer. Morphology of blood cells was also thoroughly investigated by visual inspection for atypical lymphocyte, anisocytosis, hypochromia, microcyte, poikilocytosis, ovalocytosis and platelet on smear. Values of these parameters were immediately measured using Abbott Cell-Dyn CD-1800 Hematology Analyzer in the same laboratory to the blood biochemical test.

Kumarnsit E., Keawpradub N., Sengnon N., Wungsintaweekul J., & Cheaha D. (2021). Anorectic Effect, Biochemical and Hematological Profiles of Alkaloid Extract from Mitragyna speciosa Korth. in Rats. Sains Malaysiana, 50(3), 779-790.

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