Infusion harness

Manufactured by Instech

Sourced in Panama, United States

The Infusion Harness is a device used to secure intravenous (IV) lines and other medical tubing during patient care. It is designed to hold and manage the placement of these lines, ensuring they remain in the desired position and prevent unintended movement or dislodgement.

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Lab products found in correlation

Ketorolac, by Merck Group (4 mentions) Equithesin, by Merck Group (3 mentions) Ketamine hydrochloride, by Vedco (2 mentions) Ketamine, by Vedco (2 mentions) Male sprague dawley rat, by Charles River Laboratories (1 mentions)

6 protocols using infusion harness

Cocaine Self-Administration in Rats

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For cocaine self-administration and yoked saline controls, rats underwent catheter implantation 5 to 7 days before the start of self-administration as previously described (Zhou et al., 2012 (link)). Briefly, rats were anesthetized (IP) using a mixture of ketamine hydrochloride (66 mg/kg; Vedco Inc., St. Joseph, MO) and xylazine (1.33 mg/kg; Lloyd Laboratories, Shenandoah, IA), followed by Equithesin (0.5 mL/kg) and Ketorolac (2 mg/kg; Sigma Aldrich) as a preoperative analgesic. One end of a silastic catheter was implanted into the right jugular vein, and the other end was attached to an infusion harness (Instech Solomon, Plymouth Meeting, PA) for IV drug delivery.

Zhou L., Sun W.L., Young A.B., Lee K., McGinty J.F, & See R.E. (2014). Oxytocin Reduces Cocaine Seeking and Reverses Chronic Cocaine-Induced Changes in Glutamate Receptor Function. International Journal of Neuropsychopharmacology, 18(1), pyu009.

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Surgical Implantation for Cocaine Self-Administration

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For cocaine self-administration and yoked saline controls, rats underwent catheter implantation 5 to 7 days before the start of self-administration as previously described (Zhou et al., 2012 (link)). Briefly, rats were anesthetized (IP) using a mixture of ketamine hydrochloride (66mg/kg; Vedco Inc., St. Joseph, MO) and xylazine (1.33mg/kg; Lloyd Laboratories, Shenandoah, IA), followed by Equithesin (0.5mL/kg) and Ketorolac (2mg/kg; Sigma Aldrich) as a preoperative analgesic. One end of a silastic catheter was implanted into the right jugular vein, and the other end was attached to an infusion harness (Instech Solomon, Plymouth Meeting, PA) for IV drug delivery.

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Surgical Implantation of Jugular Catheter in Rats

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Rats were anesthetized with intraperitoneal injections of ketamine (66
mg/kg; VedcoInc, St Joseph, MO, USA), xylazine (1.3 mg/kg; Lloyd Laboratories,
Shenandoah, IA, USA), and equithesin (0.5 ml/kg; sodium pentobarbital 4 mg/kg,
chloral hydrate 17 mg/kg, and 21.3 mg/kg magnesium sulfate heptahydrate
dissolved in 44% propylene glycol, 10 % ethanol solution).
Ketorolac (2.0 mg/kg, intraperitoneal; Sigma, St. Louis, MO, USA) was given just
prior to surgery as an analgesic. One end of a silastic catheter was inserted 33
mm into the external right jugular and secured with 4.0 silk sutures. The other
end ran subcutaneously and exited from a small incision just below the scapula.
That end was attached to an infusion harness (Instech Solomon, Plymouth Meeting,
PA, USA) that provided access to an external port for IV drug delivery.
Following that surgical procedure, rats were given a subcutaneous injection of
an antibiotic solution Cefazolin (10 mg/0.1 ml; Schein Pharmaceuticals, Florham
Park, NJ, USA) and were allowed to recover for 5 days.

Mishra D., Pena-Bravo J.I., Leong K.C., Lavin A, & Reichel C.M. (2016). Methamphetamine self-administration modulates glutamate neurophysiology. Brain structure & function, 222(5), 2031-2039.

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CSMG Denervation Procedure Protocol

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A CSMG was performed as above (n = 6) with control animals (n = 6) undergoing a sham operation.
Following denervation procedures, the stomach and intestines were returned to the abdominal cavity and the abdominal musculature sutured to close the cavity. Ventral skin incisions were closed separately with individual sutures, reinforced with suture glue (Nexaband) and swabbed with an antibacterial agent (Betadine). Cannulas were tunneled subcutaneously, exteriorized at the back of the neck, and incased in an infusion harness (Instech Laboratories). Animals were allowed 6 days to recover from surgery and to regain their original body weight. No significant differences in body weight were observed between experimental groups on the day of experiments. Sixteen hours prior to experiments, all access to food (but not water) was removed.

Bohland M., Matveyenko A.V., Saberi M., Khan A.M., Watts A.G, & Donovan C.M. (2014). Activation of Hindbrain Neurons Is Mediated by Portal-Mesenteric Vein Glucosensors During Slow-Onset Hypoglycemia. Diabetes, 63(8), 2866-2875.

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Surgical Implantation of Jugular Catheters in Rats

Cited 2 times

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Male Sprague Dawley rats (N=71) were obtained from Charles River (300g), and were individually housed in a 12:12 reverse light:dark cycle room with ad lib access to food and water. Prior to implantation of jugular catheters, animals were anesthetized with ketamine (66 mg/kg), xylazine (1.3 mg/kg), and equithesin (all administered i.p), and given Ketorolac (analgesic; 4.0 mg/kg, s.c.). Silastic catheters were inserted into the right jugular vein. The catheter was guided subcutaneously to the back and attached to an infusion harness (Instech Solomon) for i.v. drug delivery. Cefazolin (antibiotic) (10 mg/0.1 ml) was infused post-surgically, and for 3 days during recovery with 0.1 ml 70 U/ml heparinized saline. Given the ability of β-lactam antibiotics to influence GLT-1 expression (Rasmussen et al., 2011 (link)), it is important to note that the cefazolin treatment regimen used in our study is below the necessary dose (100 mg/kg) to impact GLT-1 expression (Rao et al., 2015 (link)), and was administered prior to methamphetamine SA and extinction.

Siemsen B., Reichel C., Leong K., Garcia-Keller C., Gipson C., Spencer S., McFaddin J., Hooker K., Kalivas P, & Scofield M. (2019). Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core. Neuroscience, 406, 528-541.

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Rat Jugular Vein Catheterization Protocol

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Rats were anesthetized with intraperitoneal injections of ketamine (66 mg/kg; Vedco Inc.), xylazine (1.3 mg/kg; Lloyd Laboratories), and equithesin (0.5 ml/kg; 4 mg/kg sodium pentobarbital, 17 mg/kg chloral hydrate, and 21.3 mg/kg magnesium sulfate heptahydrate dissolved in 44% propylene glycol and 10% ethanol solution). Ketorolac (2.0 mg/kg, i.p.; Sigma) was given just before surgery as an analgesic. One end of a SILASTIC catheter was inserted 33 mm into the external right jugular and secured with 4.0 silk sutures. The other end ran subcutaneously and exited from a small incision just below the scapula. That end was attached to an infusion harness (Instech Solomon) that provided access to an external port for intravenous drug delivery. Following that surgical procedure, rats were given a subcutaneous injection of an antibiotic solution cefazolin (10 mg/0.1 ml; Schein Pharmaceuticals) and were allowed to recover for 5 d.

Pena-Bravo J.I., Penrod R., Reichel C.M, & Lavin A. (2019). Methamphetamine Self-Administration Elicits Sex-Related Changes in Postsynaptic Glutamate Transmission in the Prefrontal Cortex. eNeuro, 6(1), ENEURO.0401-18.2018.

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