Phosphorus oxychloride

Manufactured by Merck Group

Sourced in United States, Japan

Phosphorus oxychloride is a clear, colorless, and fuming liquid chemical compound. It is a commonly used reagent and precursor in organic synthesis and other industrial processes. Phosphorus oxychloride has a molecular formula of POCl3 and a molar mass of 153.33 g/mol.

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5 protocols using phosphorus oxychloride

Synthesis and Purification of Heterocyclic Compounds

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2-Aminobenzylamine,
phosphorus oxychloride, 1-methylpiperazine, and iron powder were purchased
from Sigma-Aldrich (St. Louis, MO), while isatin, 5-nitroisatin, and
2-pyridinecarboxaldehyde were purchased from Acros (Geel, Belgium).
All chemicals, as well as the synthesized precursors, were used without
further purification. 2-Amino-5-nitrobenzylamine hydrochloride was
synthesized according to a procedure published elsewhere.⁴⁶ The free amine was obtained by the dissolution
of the hydrochloride in a minimal amount of water, addition of 4 equiv
of aqueous ammonia, and collection of the formed precipitate by filtration.
Ethanol was dried over molecular sieves (3 Å), and tetrahydrofuran
(THF) was dried by using a standard procedure (Na/benzophenone).⁴⁷

Filak L.K., Kalinowski D.S., Bauer T.J., Richardson D.R, & Arion V.B. (2014). Effect of the Piperazine Unit and Metal-Binding Site Position on the Solubility and Anti-Proliferative Activity of Ruthenium(II)- and Osmium(II)- Arene Complexes of Isomeric Indolo[3,2-c]quinoline—Piperazine Hybrids. Inorganic Chemistry, 53(13), 6934-6943.

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Lipid Membrane Composition Analysis

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1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1-(12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl)-2-hydroxy-sn-glycero-3-phosphocholine (NBD-LPC) were purchased from Avanti Polar Lipids, Inc. Chloroform was purchased from Macron Fine Chemicals and used as received. 2,4,6-collidine (99%), acetonitrile (HPLC), calcium chloride dihydrate (99%), and phosphorus oxychloride (99%), were purchased from Sigma Aldrich and used as received. Sodium chloride was used to maintain constant ionic strength in a 10 mM citric acid-sodium phosphate buffer (ACS grade). The buffer was used to maintain pH and tested prior to use in all experiments using a pH meter (Thermo Fisher). Water was obtained from a Barnstead water purification system and used for all experiments.

Baumler S.M., McHale A.M, & Blanchard G.J. (2017). Surface Charge and Overlayer pH Influence the Dynamics of Supported Phospholipid Films. Journal of electroanalytical chemistry (Lausanne, Switzerland), 812, 159-165.

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Synthesis and Characterization of Organic Compounds

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P-phenylenediamine and 2-hydroxy-5-nitrobenzenaldehyde were purchased from Thermo Fisher Scientific (Morris Plains, NJ, USA). Shanghai Makclin Biochemical Co., Ltd. (Shanghai, China) provided the glycidyl trimethyl ammonium chloride (95%), AlCl₃, and NaOH. Phosphorus oxychloride, sodium tungstate (Na₂WO₄⋅2H₂O), NaCl, CHCl₃, CDCl₃, dimethyl sulfoxide, and CH₃OH were purchased from Sigma-Aldrich (St. Louis, MO, USA). All chemicals were of a very high purity level and required no further processing before use. All the experimental solutions were prepared using ultrapure water of 18.2 MΩ·cm. Thin paper chromatography (PC) was utilized to explore the synthesis process. Furthermore, a basic UV lamp set to 250 nm and an eluent comprising a combination of 1:1 v/v ethanol and ethyl acetate were used to identify spots formed on the PC.

Elbshary R.E., Gouda A.A., El Sheikh R., Alqahtani M.S., Hanfi M.Y., Atia B.M., Sakr A.K, & Gado M.A. (2023). Recovery of W(VI) from Wolframite Ore Using New Synthetic Schiff Base Derivative. International Journal of Molecular Sciences, 24(8), 7423.

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Synthesis of Organic Compounds

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The chemicals used in this study, such as phenothiazine, allyl bromide, 2-pyridyl acetonitrile, and phosphorus oxychloride, were purchased from Sigma-Aldrich in Bangalore. Solvents, including dimethylformamide, chloroform, acetonitrile, acetone, tetrahydrofuran, hexane, and ethyl acetate, were purchased from Avra and used without further purification.

Vinayagam D, & Subramanian K. (2024). A phenothiazine-functionalized pyridine-based AIEE-active molecule: a versatile molecular probe for highly sensitive detection of hypochlorite and picric acid. RSC Advances, 14(8), 5149-5158.

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Synthesis and Analysis of HQ-2P

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hydroquinone (HQ) and arbutin (Arb) were obtained from Wako Pure Chemical Industries, Ltd. (Osaka, Japan) . Phosphorus oxychloride and isostearyl alcohol were purchased from Sigma-Aldrich Co., Ltd., and from Nissan Chemical Industries, Ltd. (Tokyo, Japan) , respectively. Phosphatase inhibitor cocktail II (PIC II) was obtained from Merck Co. Disodium phenylene diphosphate (HQ-2P) was synthesized from hydroquinone and phosphoryl chloride.

Hisama M., Matsuda S., Arai J., Masui K, & Yamamura H. (2015). Synthesis and Characterization of a New Hydroquinone Derivative: Disodium p-Phenylene Diisostearyl Diphosphate. Journal of oleo science, 64(9).

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