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C57bl 6 male and female mice

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C57BL/6 male and female mice are a commonly used inbred mouse strain. They are widely utilized in biomedical research due to their well-characterized genetic and physiological traits.

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Lab products found in correlation

Rosa cag lsl zsgreen1 mice, by Jackson ImmunoResearch (2 mentions) Td 09766, by Inotiv (1 mentions) Td 08810, by Inotiv (1 mentions) Chatbac egfp mice, by Jackson ImmunoResearch (1 mentions) Fibronectin, by Cell Signaling Technology (1 mentions) Smad2 3, by Cell Signaling Technology (1 mentions) α sma, by Cell Signaling Technology (1 mentions) E cadherin, by Cell Signaling Technology (1 mentions) Vimentin, by Cell Signaling Technology (1 mentions) Micro filter topped cages, by Ancare (1 mentions)

24 protocols using c57bl 6 male and female mice

1

Murine Behavioral Research Protocol

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Young adult 10–12-week-old C57BL6 male and female mice were obtained from the Jackson Laboratory (N = 80 totals, half female). Animals were group housed on a 14:10 light/dark cycle with free access to food and water. All experimental protocols were approved by the University of Michigan Institutional Animal Care and Use Committee and conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals.
Hill A., Johnston C., Agranoff I., Gavade S, & Spencer-Segal J. (2023). Corticosterone enhances formation of non-fear but not fear memory during infectious illness. Frontiers in Behavioral Neuroscience, 17, 1144173.
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2

C57BL/6 Mice for Animal Studies

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C57BL/6 male and female mice were purchased from The Jackson Laboratory (Bar Harbor, ME) and used at a minimum of 6 weeks old, with approval from the Virginia Commonwealth University institutional animal care and use committee (IACUC).
Abebayehu D., Spence A.J., Qayum A.A., Taruselli M.T., McLeod J.J., Caslin H.L., Chumanevich A.P., Kolawole E.M., Paranjape A., Baker B., Ndaw V.S., Barnstein B.O., Oskeritzian C.A., Sell S.A, & Ryan J.J. (2016). Lactic Acid Suppresses IL-33-mediated Mast Cell Inflammatory Responses via Hypoxia Inducible Factor (HIF)-1α-dependent miR-155 Suppression. Journal of immunology (Baltimore, Md. : 1950), 197(7), 2909-2917.
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3

High-Fat Diet Induces Colon Changes

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In all studies, C57BL/6 male and female mice (Jackson Laboratory, Bar Harbor, ME, USA) were given water and chow ad libitum. High fat diet (HFD, 60% of calories from fat, TD.09766) and an isocaloric low fat diet (16.8% of calories from fat, TD.08810) were purchased from Envigo, Inc. (Indianapolis, IN, USA). For the HFD studies, six 6-week-old male mice were placed in each group and maintained on the diets for a total of 18 weeks. At 18 weeks colons were isolated, snap-frozen, and homogenized for analysis. All animal procedures were approved by the Ralph H Johnson VA Medical Center and Medical University of South Carolina Institutional Animal Care and Use Committees (IACUC) and all studies conducted were based on NIH and the American Veterinary Medical Association guidelines.
Choi S., Snider J.M., Cariello C.P., Lambert J.M., Anderson A.K., Cowart L.A, & Snider A.J. (2020). Sphingosine kinase 1 is required for myristate-induced TNFα expression in intestinal epithelial cells. Prostaglandins & other lipid mediators, 149, 106423.
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4

Habituation of C57Bl/6 Mice

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Adult (8 weeks) C57Bl/6 male and female mice were used (Jackson Laboratory, Bar Harbor, ME, USA). Mice were group-housed per sex in our facility (four to five mice/cage unless specified otherwise) and maintained on a 12-h reverse light-dark cycle with food and water ad libitum. Animals were allowed 1 week of habituation to our facility before beginning experiments. All procedures were approved by the Office of Responsible Research Practices of the researchers’ institution and conformed to the U.S. National Institutes of Health Guide for the Care and Use of Laboratory Animals.
Okine T., Shepard R., Lemanski E, & Coutellier L. (2020). Sex Differences in the Sustained Effects of Ketamine on Resilience to Chronic Stress. Frontiers in Behavioral Neuroscience, 14, 581360.
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5

Transgenic Mouse Model Husbandry

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C57Bl/6 male and female mice (2–6 months of age, n = 110) were purchased from Jackson Labs (Bar Harbor, ME). All animals were acclimated in a colony room at a constant temperature (21–23°C) and humidity (45–50%) on a 12-:12-hour light-dark cycle (lights on 6:00 am–6:00 pm) and housed five per cage with chow and water ad libitum. Male and female 3XTg-AD [19] (link) transgenic mice were purchased from Jackson Labs and maintained (n = 36 animals including wild-type siblings) through a breeding program at University of Texas Medical Branch. The study was approved by the University of Texas Medical Branch Institutional Animal Care and Use Committee as per the National Institutes of Health Guidelines [23] on the use of laboratory animals.
Krishnan B., Kayed R, & Taglialatela G. (2018). Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits. Alzheimer's & Dementia : Translational Research & Clinical Interventions, 4, 89-102.
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6

Ethical Mouse Experimentation Protocol

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All animal experiments were conducted in accordance with the “Guide for the Care and Use of Laboratory Animals of US National Institutes of Health”. The experimental protocols were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Missouri, Columbia, MO, United States (protocol number 9227). Six-week-old C57BL/6 male and female mice were purchased from Jackson Laboratory (Bar Harbor, ME, United States), and were housed under standard laboratory conditions (22 ± 1°C, 12:12-h light/dark cycle).
Wu H., Hu T., Zhang L., Xia X., Liu X., Zhu Q., Wang M., Sun Z., Hao H., Cui Y., Parrish A.R., Li D.P., Hill M.A., Xu C, & Liu Z. (2022). Abdominal Aortic Endothelial Dysfunction Occurs in Female Mice With Dextran Sodium Sulfate-Induced Chronic Colitis Independently of Reactive Oxygen Species Formation. Frontiers in Cardiovascular Medicine, 9, 871335.
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7

C57BL/6 Mouse Animal Model

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C57BL/6 male and female mice were purchased from The Jackson Laboratory (Bar Harbor, ME) and were approved for use by the Virginia Commonwealth University Institutional Animal Care and Use Committee (IACUC #AM10340). NIH guidelines for the care and use of laboratory animals (NIH Publication #85-23 Rev. 1985) were observed.
Abebayehu D., Spence A., Boyan B.D., Schwartz Z., Ryan J.J, & McClure M.J. (2017). Galectin-1 Promotes an M2 Macrophage Response to Polydioxanone Scaffolds. Journal of biomedical materials research. Part A, 105(9), 2562-2571.
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8

Conditional BMPRII Knockout in Mouse DG

Cited 1 time
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All animal procedures were performed in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals and were approved by the Northwestern University Institutional Animal Care and Use Committee. Eight to ten week old C57Bl/6 male and female mice (Jackson Laboratory) were used for antidepressant treatment experiments as well as DG virus injection experiments. For antidepressant and virus injection experiments, animals were allocated to experimental groups by randomly assigning each cage to an experimental treatment. BMPRII floxed mice (BMPRIIfx/fx)22 (link) were mated to mice containing tamoxifen-inducible Cre recombinase under the control of the Ascl1 promoter (Ascl1-CreER™)23 (link). To monitor Cre expression, these mice were crossed with Rosa-CAG-LSL-ZsGreen1 mice (RosaZG/ZG, Jackson Laboratory)24 (link). Tamoxifen-induced ablation of BMPRII was performed at 8–10 weeks of age in BMPRIIfx/fx; Ascl1-CreER™; RosaZG/ZG mice. BMPRII+/+; Ascl1-CreER™; RosaZG/ZG littermates were used as controls. All mice were housed 3–5 per cage under a 14:10 hour light:dark cycle with ad libitum access to food and water.
Brooker S.M., Gobeske K.T., Chen J., Peng C.Y, & Kessler J.A. (2016). Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment. Molecular psychiatry, 22(6), 910-919.
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9

Immunohistochemical Analysis of Celiac Ganglia

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For immunohistochemical analysis of celiac ganglia and spleen sections, a total of 7 adult (3–5 months old) male and female transgenic B6·Cg-Tg(RP23–268L19 EGFP)2Mik/J (RRID: IMSR_JAX:007902), also known as ChATBAC-eGFP mice (The Jackson Laboratory, Bar Harbor, ME, USA) were used. We previously established that these transgenic mice express green fluorescent protein (GFP) in most cholinergic neurons and nerve fibers of the periphery and can therefore be used to easily locate and dissect the celiac ganglion based on preganglionic cholinergic innervation (Brown et al., 2018 (link)). After familiarization with the location of the celiac ganglion, the study was continued with 16 adult (3–10 month old) C57BL/6 male and female mice (The Jackson Laboratory) and one additional transgenic mouse. Animal protocols were approved by the East Tennessee State University Animal Care and Use Committee and conformed to guidelines of the National Institutes of Health as published in the Guide for the Care and Use of Laboratory Animals (Eighth Edition, National Academy of Sciences, 2011).
Kaestner C.L., Smith E.H., Peirce S.G, & Hoover D.B. (2019). Immunohistochemical analysis of the mouse celiac ganglion: An integrative relay station of the peripheral nervous system. The Journal of comparative neurology, 527(16), 2742-2760.
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10

Conditional BMPRII Knockout in Mouse DG

Cited 1 time
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All animal procedures were performed in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals and were approved by the Northwestern University Institutional Animal Care and Use Committee. Eight to ten week old C57Bl/6 male and female mice (Jackson Laboratory) were used for antidepressant treatment experiments as well as DG virus injection experiments. For antidepressant and virus injection experiments, animals were allocated to experimental groups by randomly assigning each cage to an experimental treatment. BMPRII floxed mice (BMPRIIfx/fx)22 (link) were mated to mice containing tamoxifen-inducible Cre recombinase under the control of the Ascl1 promoter (Ascl1-CreER™)23 (link). To monitor Cre expression, these mice were crossed with Rosa-CAG-LSL-ZsGreen1 mice (RosaZG/ZG, Jackson Laboratory)24 (link). Tamoxifen-induced ablation of BMPRII was performed at 8–10 weeks of age in BMPRIIfx/fx; Ascl1-CreER™; RosaZG/ZG mice. BMPRII+/+; Ascl1-CreER™; RosaZG/ZG littermates were used as controls. All mice were housed 3–5 per cage under a 14:10 hour light:dark cycle with ad libitum access to food and water.
Brooker S.M., Gobeske K.T., Chen J., Peng C.Y, & Kessler J.A. (2016). Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatment. Molecular psychiatry, 22(6), 910-919.
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