15 deoxy δ12 14 prostaglandin j2 pgj2

Manufactured by Cayman Chemical

Sourced in United States

15-deoxy-Δ12,14-Prostaglandin J2 (PGJ2) is a naturally occurring cyclopentenone prostaglandin. It is a bioactive lipid mediator that can regulate various cellular processes.

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Lab products found in correlation

2 protocols using 15 deoxy δ12 14 prostaglandin j2 pgj2

Palmitic Acid-Induced Stress Signaling

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All chemicals and buffers were of analytical grade and purchased from ThermoFisher Scientific (Massachusetts, USA). Palmitic acid (A3803) and fatty acid free bovine serum albumin (BSA, P5585) were obtained from MilliporeSigma, St. Louis, MS. 15-deoxy-Δ12,14-Prostaglandin J2 (PGJ2) and GSK2606414 (GSK260) were purchased from Cayman, Ann Arbor, MI. SP600125 (JNKi), STF-083010 (IRE1αi, endonuclease inhibitor), Salubrinal (eIF2αi, dephosphorylation inhibitor), U0126 (ERKi, MEK1/2 or ERK1/2 Inhibitor) were obtained from Selleck Chemicals, Houston, TX.

Sahoo P.K., Krishnamoorthy C., Wood J.R., Hanson C., Anderson-Berry A., Mott J.L, & Natarajan S.K. (2024). Palmitate induces integrated stress response and lipoapoptosis in trophoblasts. Cell Death & Disease, 15(1), 31.

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Peroxisome Proliferator-Activated Receptor Agonists and Antioxidants

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Peroxisome proliferator-activated receptor (PPAR) agonists fenofibrate, troglitazone, bezafibrate, 15-deoxy-Δ^12,14-Prostaglandin J₂ (PGJ2), ciglitazone, rosiglitazone, pioglitazone, and MCC-555 were from Cayman Chemical (Ann Arbor, MI, USA). Antioxidants 2,2,5,7,8-Pentamethyl-6-chromanol (PMC), 4-hydroxy-TEMPO (TEMPO, a superoxide dismutase mimic) and Tiron were from Sigma (St. Louis, MO), MCI-186 (MCI), Trolox and DL-a-lipoic acid (lipoic acid) were from Cayman Chemical, N-Acetyl-L-cysteine (NAC) was from Abcam (Cambridge, MA), and elamipretide (ELAM) was from Muse Chem (Fairfield, NJ). Trolox amide analogs (669, 738, 829) were from ChemBridge (San Diego, CA). Inflammasome inhibitors MCC950 and Isoliquiritigenin were from Cayman Chemical. The NADPH-oxidases inhibitor apocynin (APO) was from Abcam and diphenyleneiodonium (DPI) was from Sigma.

Gnanaguru G., Mackey A., Choi E.Y., Arta A., Rossato F.A., Gero T.W., Urquhart A.J., Scott D.A., D’Amore P.A, & Ng Y.S. (2021). Discovery of sterically-hindered phenol compounds with potent cytoprotective activities against ox-LDL–induced retinal pigment epithelial cell death as a potential pharmacotherapy. Free radical biology & medicine, 178, 360-368.

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